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Topic Review
Nonparametric Limits of Agreement
The assessment of agreement in method comparison and observer variability analysis of quantitative measurements is usually done by the Bland-Altman Limits of Agreement, where the paired differences are implicitly assumed to follow a normal distribution. Whenever this assumption does not hold, the 2.5% and 97.5% percentiles are obtained by quantile estimation. In the literature, empirical quantiles have been used for this purpose. In this simulation study, we applied both sample, subsampling, and kernel quantile estimators as well as other methods for quantile estimation to sample sizes between 30 and 150 and different distributions of the paired differences. The performance of 15 estimators in generating prediction intervals was measured by their respective coverage probability for one newly generated observation. Our results indicated that sample quantile estimators based on one or two order statistics outperformed all the other estimators and can be used for deriving nonparametric Limits of Agreement. For sample sizes exceeding 80 observations, more advanced quantile estimators, such as the Harrell-Davis and estimators of Sfakianakis-Verginis type, which use all the observed differences, performed likewise well, but may be considered intuitively more appealing than simple sample quantile estimators that are based on only two observations per quantile.
  • 3.1K
  • 27 Oct 2020
Topic Review
Antibacterial Designs for Implantable Medical Devices
The uses of implantable medical devices are safer and more common since sterilization methods and techniques were established a century ago; however, device-associated infections (DAIs) are still frequent and becoming a leading complication as the number of medical device implantations keeps increasing.
  • 3.1K
  • 01 Aug 2022
Topic Review Video
Plastic Waste Governance in Bangladesh
Plastic, an offer of modernity, is presenting a massive threat in altered forms, to our health and environment. Plastic does not only pollute the surface environment, fresh water, and marine ecosystems, but toxic elements released from plastics also percolate down the surface and contaminate groundwater, which we often use as ‘safe’ drinking water. This probable future risk is deeply rooted in the entire governance infrastructure of plastic waste which could potentially lead to contamination of groundwater. A recent study finds 81% of tap water samples collected worldwide contained plastic pollutants, which means that annually we may be ingesting between 3000 and 4000 microparticles of plastic from tap water.
  • 3.0K
  • 04 Mar 2022
Topic Review
Clinical Overview of Oral Cavity Cancer
Head and neck cancers are the 6th most common cancers in the United States and responsible for nearly 2% of all deaths related to cancer. Approximately 95% of all head and neck cancers are squamous cell carcinoma (SCC); of which, oral cavity SCC is the most common (excluding non-melanoma cutaneous cancers). The incidence of oral cavity cancer has gradually increased over the past 20 years. Globally, there were more than 375,000 new cases of oral cavity cancers (including cancers of the lip) and more than 175,000 deaths in 2020.
  • 3.0K
  • 10 Jan 2022
Topic Review
Detection and Diagnosis of SARS-CoV-2/COVID-19
Latest weeks the humanity is faced with the spread of a new coronavirus, SARS-CoV-2 that causes a respiratory illness with high mortality rates, COVID-19. Since there is no approved treatment or vaccination against that specific coronavirus the reduce in virus spread is essential. That is based in the use of appropriate tools, enabling the accurate and early detection. Molecular biology and immunological techniques are widely used in order to predict the COVID-19 cases in a very short period of time. These are commonly based either in identification of the SARS-CoV-2’s genetic material or in detection of antibodies that have been produced by the immune system against the virus. Many of the above mentioned tests have been validated and approved by local authorities. However, there are much more companies that provide detection tests, without basic validation processes, contributing in non-precise data. The present review aim to analyze the most common platforms that are used in COVID-19 detection, analyzing their advantages and weaknesses. Therefore, each physician will be equipped with appropriate information required for each test.
  • 2.8K
  • 29 Oct 2020
Topic Review
Integrated Blockchain-Cloud Architecture for Healthcare
Blockchain is a disruptive technology for shaping the next era of a healthcare system striving for efficient and effective patient care. This is thanks to its peer-to-peer, secure, and transparent characteristics. On the other hand, cloud computing made its way into the healthcare system thanks to its elasticity and cost-efficiency nature. However, cloud-based systems fail to provide a secured and private patient-centric cohesive view to multiple healthcare stakeholders. In this situation, blockchain provides solutions to address security and privacy concerns of the cloud because of its decentralization feature combined with data security and privacy, while cloud provides solutions to the blockchain scalability and efficiency challenges. Therefore a novel paradigm of blockchain-cloud integration (BcC) emerges for the domain of healthcare.
  • 2.8K
  • 14 Sep 2021
Topic Review Peer Reviewed
Benefits of Table Tennis for Brain Health Maintenance and Prevention of Dementia
Table tennis is an extremely popular sport throughout the world as it requires no expensive equipment, specialized amenities, or physical contact among players, and the pace of play can be adapted to allow participation by players of all skill levels, ages, and abilities. It is an aerobic-dominant sport driven primarily by the phosphagen system because rallies are relatively brief (several seconds) and separated by longer rest periods. Several studies have shown that physical interventions including table tennis can help prevent cognitive decline and dementia. Accordingly, the present paper provides an overview of the basic physical and cognitive demands of table tennis, reviews previous studies reporting improvements in physical and brain health across different non-clinical and clinical populations, and critically evaluates the usefulness of table tennis intervention for the prevention of cognitive decline and dementia. This review suggests that table tennis intervention could be a powerful strategy to prevent cognitive decline and dementia in the elderly. 
  • 2.8K
  • 26 Sep 2022
Topic Review
Mechanism of CRISPR/Cas Based Detection
In the pace of time, numerous platforms for rapid nucleic acid (NA) detection have been developed; however, they may not be able to satisfy the ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free and Deliverable to end-users) parameters set by the World Health of Organization at the same time. Recent studies have established that the CRISPR/Cas system possesses the potential to fulfil ASSURED criteria and demonstrated that it may be repurposed for the detection of contaminants, enzymes, proteins, analytes, and plant diseases, rather than being limited to clinical settings and nucleic acids. Several platforms have yet to be translated into clinical applications and must be brought into clinical settings from the laboratory. 
  • 2.7K
  • 08 Jun 2022
Topic Review
Thyroid Function and Suicidal Behavior
Thyroid disease is a very common condition that influences the entire human body, including cognitive function and mental health. As a result, thyroid disease has been associated with multiple neuropsychiatric conditions. However, the relationship between thyroid dysfunction and suicide is still controversial. 
  • 2.6K
  • 28 Jul 2021
Topic Review
Indoor Air Quality in Healthcare Units
Indoor air quality (IAQ) in Healthcare Units is a complex and dynamic issue of utmost importance for patient safety and occupational health purposes, since healthcare providers, medical practitioners, staff and patients spend long hours in the facilities subject to their inherent air quality. IAQ is affected by outdoor air quality, indoor activities, indoor occupant density, ventilation practices, indoor intrinsic emissions (e.g., equipment/furniture/coatings). The presence of vulnerable individuals and the characteristics of the ongoing activities highlight the importance of adequately managing IAQ in healthcare facilities. Headaches, fatigue, dryness and irritation of the eyes and skin are common complaints of healthcare professionals, which have often been associated with poor IAQ. In addition, hospitals operate on a full-time basis (24 h per day, seven days a week), with no idle time to recover from activities’ emissions and consequent impact on IAQ.
  • 2.6K
  • 20 Jan 2022
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