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Topic Review
Human Respiratory Infections in Nigeria
The outbreak of zoonotic diseases presents challenging times for nations and calls for a renewed effort to disrupt the chain of events that precede it. Nigeria’s response to the 2006 bird flu provided a platform for outbreak response, yet it was not its first experience with Influenza. Nigeria’s interest in animal influenza research was triggered by its negative economic consequence on poultry. This is because the poultry industry is a fast-growing sector and an effective tool for poverty alleviation in Nigeria.
  • 306
  • 14 Oct 2022
Topic Review
The Microbiota–Gut–Brain Axis in Psychiatric Disorders
The microbiota is a group of microorganisms that colonize the human body, and the composition of this group is not accidental; in turn, the term microbiome covers the genomes of all microorganisms in a particular environment. This complex ecosystem is characterized by a complicated network of positive and negative interrelationships that significantly impact the host’s health. Notably, the microbiota currently depends not only on the interdependencies occurring in this specific ecosystem but also on the cells of the macroorganism. Microorganisms inhabit various areas of the human body, ranging from the skin, through the mouth, the upper respiratory tract, the ear canal, and the vagina. However, 90% of all microorganisms colonize the initial sections of the small and large intestines. Many data indicate that the number of microorganisms that inhabit a macroorganism exceeds ten times the number of its cells.
  • 926
  • 13 Oct 2022
Topic Review
Drama Therapy for Children Adolescents with Psychosocial Problems
Drama therapy is applied to children and adolescents with psychosocial problems. Drama therapy is an experiential form of treatment which methodologically uses drama and theatre processes to achieve psychological growth. Positive effects were found on overall psychosocial problems, internalizing and externalizing problems, social functioning, coping and regulation processes, social identity, and cognitive development. An adaptive approach was mentioned as the therapeutic attitude. The means established contribute to a dramatic reality, which triggers the mechanisms of change. These are processes that arise during treatment and which facilitate therapeutic change. 
  • 693
  • 12 Oct 2022
Topic Review
Genesis of Endotheliopathy
Endotheliopathy, according to the “two-activation theory of the endothelium”, is triggered by the activated complement system in critical illnesses, such as sepsis, diabetes and polytrauma, leading to two distinctly different molecular dysfunctions: (1) the activation of the inflammatory pathway due to the release of inflammatory cytokines, such as interleukins, interferons and tumor necrosis factors, and (2) the activation of the microthrombotic pathway due to the exocytosis of hemostatic factors, including ultra-large von Willebrand factor (ULVWF) multimers and FVIII. These lead to inflammation and microthrombogenesis. The former produces inflammatory diseases, and the latter produces endotheliopathy-associated vascular microthrombotic disease (EA-VMTD), which orchestrates not only TTP-like syndrome characterized by the triad of consumptive thrombocytopenia, microangiopathic hemolytic anemia and multiorgan dysfunction syndrome, but also many other endotheliopathic syndromes. The diagnostic features of EA-VMTD are well established now and therapeutic strategies are being formulated. 
  • 748
  • 11 Oct 2022
Topic Review
Oral Microbiome Dysbiosis in Tongue Squamous Cell Carcinoma
Tongue squamous cell carcinoma(TSCC),as the most common  oral squamous cell carcinoma (OSCC), is associated with numerous risk factors. Among which oral microbiota is recognized by more and more scholars. In the oral cavity, bacteria can aggregate into colonies to form functional biofilms, and the synergistic interaction of polymicroorganisms can maintain homeostasis with the host. However, Changes in specific individual bacterial components may cause colony effects that disrupt homeostasis, which would contribute to the initiation and progression of TSCC. For instance,the change of  relative abundance of Firmicutes, Actinobacteria, Proteobacteria, Bacteroidetes, Fusobacteria and related bacteria can cause the occurrence of tongue cancer by mediating chronic inflammatory states, suppressing immune responses, synthesizing carcinogens, attenuating synthesis of anticancer agents and promoting cancer cell invasion. Therefore, the management of the  special microbiome associated with tumour microenvironments may be a promising treatment strategies for tumors in the future.
  • 450
  • 11 Oct 2022
Topic Review
Technology Usage for Parkinson’s Disease
Parkinson’s disease (PD) is a neurological disorder with complicated and disabling motor and non-motor symptoms. The complexity of PD pathology is amplified due to its dependency on patient diaries and the neurologist’s subjective assessment of clinical scales. 
  • 310
  • 11 Oct 2022
Topic Review
Vagus Nerve Stimulation in Chronic Inflammatory Bowel Disease
Vagus nerve stimulation (VNS) is an accepted therapy for the treatment of refractory forms of epilepsy and depression. The brain–gut axis is increasingly being studied as a possible etiological factor of chronic inflammatory diseases, including inflammatory bowel diseases (IBD). 
  • 544
  • 11 Oct 2022
Topic Review
The Banyan (NGO)
The Banyan is an non-governmental organization based in Chennai, India was founded in 1993 by Vandana Gopikumar and Vaishnavi Jayakumar to cater to the mentally ill and homeless women in the city. Over the past two decades, has expanded to offer a range of comprehensive mental health solutions for men and women who are either homeless, or living in a state of abject poverty. This includes emergency care and critical time interventions offered across 2 hospital based settings, and one shelter for homeless persons with psychosocial disabilities, operated in collaboration with the Corporation of Chennai under the National Urban Livelihoods Mission (NULM), reaching out to 162 individuals in distress at any given point of time. Over 3400 individuals have accessed these services since 1993. The Banyan's NALAM programme offers well-being oriented outpatient clinics and community based mental health care in both urban and rural areas. These clinics provide free of charge and mental health and social care services, address distress, common mental disorders and severe mental disorders. They are offered across 15 service access points, reaching out to a population of approximately 7 lakhs. NALAM has reached out to over 10,000 individuals and has a current active registry of 2000 individuals. For those who experience high support needs, The Banyan offers a range of inclusive living options, over 200 individuals with moderate to severe mental health issues, today live in communities & homelike environments with supportive services across 6 districts in 3 States (Tamil Nadu, Kerala, Maharashtra). The Banyan's sister organisation - The Banyan Academy of Leadership in Mental Health (BALM), was founded in 2007, and works towards consolidating findings and experiences from The Banyan, and disseminating it across multiple stakeholders within the mental health and development spaces. BALM works on building practice based evidence and contributing to a knowledge base, that aids in addressing treatment and care gaps, particularly in the context of vulnerable individuals and groups. It uses capacity building, education programmes (diploma, masters’, and PhD programmes) in collaboration with the Tata Institute of Social Sciences (TISS), research, collaborative work (with civil society organisations, local governments, disability movements, mental health user-caregiver groups, and Central and State Government) and construction of think tanks, as strategies to influence progressive policies and plans.
  • 870
  • 10 Oct 2022
Topic Review
Gastric Cancer Screening in Japan
Gastric cancer is the second leading cause of cancer incidence in Japan, although gastric cancer mortality has decreased over the past few decades. This decrease is attributed to a decline in the prevalence of H. pylori infection. Radiographic examination has long been performed as the only method of gastric screening with evidence of reduction in mortality in the past. The revised 2014 Japanese Guidelines for Gastric Cancer Screening approved gastric endoscopy for use in population-based screening, together with radiography. While endoscopic gastric cancer screening has begun, there are some problems associated with its implementation, including endoscopic capacity, equal access, and cost-effectiveness. As H. pylori infection and atrophic gastritis are well-known risk factors for gastric cancer, a different screening method might be considered, depending on its association with the individual’s background and gastric cancer risk.
  • 815
  • 08 Oct 2022
Topic Review
COVID-19 Vaccine Uptake among Healthcare Workers
The vaccine-induced immunity of healthcare workers (HCWs) is crucial to controlling the COVID-19 pandemic. The overall prevalence of COVID-19 vaccine uptake was 83.6% and 77.4% for physicians and nurses, respectively. Older age, white race, physicians’ profession, seasonal influenza vaccine, direct COVID-19 patient care, and confidence in COVID-19 vaccine safety and effectiveness were positive predictors of vaccine uptake, while history of SARS-CoV-2 infection was a negative predictor. Deep understanding of the factors that influence HCWs’ decisions to receive a COVID-19 vaccine is critical to implementing tailored communication strategies for HCWs who are at risk for not getting vaccinated. 
  • 384
  • 08 Oct 2022
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