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Topic Review
Epigenetic Aberrations in Extranodal NK/T-Cell Lymphoma
Extranodal NK/T-cell lymphoma (ENKTL) is a rare extranodal non-Hodgkin lymphoma (NHL) that primarily occurs in the upper aerodigestive tract and has an aggressive presentation, with locoregional invasion in the nasopharynx causing necrosis, hemorrhage, and impingement on anatomic structures including the orbits.
  • 301
  • 02 Mar 2023
Topic Review
Machine Learning Applications in Antimicrobial Resistance
Machine learning (ML) algorithms are increasingly applied in medical research and in healthcare, gradually improving clinical practice. Among various applications of these novel methods, their usage in the combat against antimicrobial resistance (AMR) is one of the most crucial areas of interest, as increasing resistance to antibiotics and management of difficult-to-treat multidrug-resistant infections are significant challenges for most countries worldwide, with life-threatening consequences. ML methods have been developed to analyze bacterial genomes, forecast medication susceptibility, recognize epidemic patterns for surveillance purposes, or propose new antibacterial treatments or vaccines. In addition to developing new antibiotics, optimizing the use of current drugs has also been a key priority in stopping the spread of AMR, as one of the main drivers of AMR is the inappropriate use of antibiotics.
  • 666
  • 01 Mar 2023
Topic Review
Liver Metabolism Regulation by Transcriptional Factors and Coactivators
The liver is one of the main organs that contributes to the regulation of blood glucose levels by releasing the glucose into circulation when blood glucose levels are low and stores along skeletal muscles excess of glucose as glycogen in postprandial states. In mammals, the liver is the central organ for fatty acid metabolism and a key player in glucose metabolism. The liver acts as a crossroad, which metabolically connects various organs, especially skeletal muscle, and adipose tissues, in the endeavor to maintain the long-term energy supply to the body. The regulation of liver glucose metabolism and lipid metabolism is tightly controlled by dietary, hormonal, and neural signals through the activation of various transcriptional factors and coactivators.
  • 554
  • 01 Mar 2023
Topic Review
Antibiotics in Animal Origin Food
Antibiotics are antimicrobial substances formed by or obtained from microorganisms that kill or inhibit the growth of other microorganisms. Antibiotics were first approved for use in livestock by the US Food and Drug Administration (FDA) in 1951. The European Union has forbidden the use of antibiotics as growth promoters since 2006. Its abusive use leads to the presence of antibiotic residues (AR) in foods of animal origin which is associated with antibiotic resistance.
  • 373
  • 01 Mar 2023
Topic Review
Regulation of Dietary Energy Intake
Obesity is one of the most important factors responsible for the marked increase in both the incidence and prevalence of type 2 diabetes mellitus (T2DM) in recent decades. Addressing the lifestyle factors associated with the progression to T2DM would present a potential rational early prevention strategy. 
  • 296
  • 28 Feb 2023
Topic Review
Controlling Upper Limb Prostheses Using Sonomyography
A ground-breaking study by Zheng et al. investigated whether ultrasound imaging of the forearm might be used to control a powered prosthesis, and the term “sonomyography” (SMG) was coined by the group. Ultrasound signals have recently garnered the interest of researchers in the area of HMIs because they can collect information from both superficial and deep muscles and so provide more comprehensive information than other techniques. Due to the great spatiotemporal resolution and specificity of ultrasound measurements of muscle deformation, researchers have been able to infer fine volitional motor activities, such as finger motions and the dexterous control of robotic hands.
  • 342
  • 27 Feb 2023
Topic Review
Psychometric Properties of Suboptimal Health Status Instruments
Suboptimal health status (SHS) measurement has now been recognized as an essential construct in predictive, preventive, and personalized medicine. Currently, there are limited tools, and an ongoing debate about appropriate tools.
  • 261
  • 27 Feb 2023
Topic Review
Electrochemical Sensors for Quantification of Glycated Hemoglobin
Glycated hemoglobin (HbA1c), one of the many variants of hemoglobin (Hb), serves as a standard biomarker of diabetes, as it assesses the long-term glycemic status of the individual for the previous 90–120 days. HbA1c levels in blood are stable and do not fluctuate when compared to the random blood glucose levels. The normal level of HbA1c is 4–6.0%, while concentrations > 6.5% denote diabetes. 
  • 520
  • 25 Feb 2023
Topic Review
Novel Therapeutic Devices in Heart Failure
Heart failure (HF) constitutes a significant clinical problem and is associated with a sizeable burden for the healthcare system. Numerous novel techniques, including device interventions, are investigated to improve clinical outcome. Interventions regarding autonomic nervous system imbalance, i.e., baroreflex activation therapy; vagus, splanchnic and cardiopulmonary nerves modulation; respiratory disturbances, i.e., phrenic nerve stimulation and synchronized diaphragmatic therapy; decongestion management, i.e., the Reprieve system, transcatheter renal venous decongestion system, Doraya, preCardia, WhiteSwell and Aquapass, are presented.
  • 275
  • 24 Feb 2023
Topic Review
Effects of Alcohol Withdrawal in Hypertension
Alcoholic beverages are common components of diets worldwide and understanding their effects on humans’ health is crucial. Because hypertension is the leading risk factor for cardiovascular diseases and all-cause mortality. Two different clinical conditions can result from the interruption of alcohol consumption. In heavy alcohol drinkers, abrupt interruption of alcohol intake might result in an alcohol withdrawal syndrome (AWS), with a critical condition that might require hospitalization. Alternatively, chronic reduction/interruption of alcohol intake could be part of the lifestyle changes that are recommended for the achievement of better blood pressure control in hypertensive patients.
  • 1.4K
  • 24 Feb 2023
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