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Topic Review
Bezold’s Abscess
Bezold’s abscess is a deep neck abscess related to otomastoiditis. Due to the insidious clinical presentation, diagnosis can be extremely challenging, leading to delays in treatment and possible life-threatening complications. Bezold’s abscess is found at any age, with overt male prevalence among adults. The clinical presentation, as well as the causative pathogens, are strikingly heterogeneous. Otomastoiditis and cholesteatoma are major risk factors.
  • 805
  • 23 Jun 2022
Topic Review
Intracellular pH Regulation in Muscle
Here we talk about the effects of acidosis on insulin signaling and glucose uptake in skeletal muscle and whether correcting defects that maintain [pH]i within the muscle, such as carnosine, could alleviate insulin resistance improve insulin responses during metabolic syndrome.
  • 804
  • 22 Oct 2020
Topic Review
Gastric Cancer Screening in Japan
Gastric cancer is the second leading cause of cancer incidence in Japan, although gastric cancer mortality has decreased over the past few decades. This decrease is attributed to a decline in the prevalence of H. pylori infection. Radiographic examination has long been performed as the only method of gastric screening with evidence of reduction in mortality in the past. The revised 2014 Japanese Guidelines for Gastric Cancer Screening approved gastric endoscopy for use in population-based screening, together with radiography. While endoscopic gastric cancer screening has begun, there are some problems associated with its implementation, including endoscopic capacity, equal access, and cost-effectiveness. As H. pylori infection and atrophic gastritis are well-known risk factors for gastric cancer, a different screening method might be considered, depending on its association with the individual’s background and gastric cancer risk.
  • 803
  • 08 Oct 2022
Topic Review
Mediterranean Diet and Potential Drug-Food Interactions
There is a growing interest among people in western countries for adoption of healthier lifestyle habits and diet behaviors with one of the most known ones to be Mediterranean diet (Med-D). Med-D is linked with daily consumption of food products such as vegetables, fruits, whole grains, seafood, beans, nuts, olive oil, low-fat food derivatives and limited consumption of meat or full fat food products. Med-D is well-known to promote well-being and lower the risk of chronic conditions such as cardiovascular diseases, diabetes, and metabolic syndrome. On the other hand, bioactive constituents in foods may interfere with drugs’ pharmacological mechanisms, modulating the clinical outcome leading to drug-food interactions (DFIs). This text discusses current evidence for food products that are included within the Med-D and available scientific data suggest a potential contribution in DFIs with impact on therapeutic outcome. Proper patient education and consultation from healthcare providers is important to avoid any conflicts and side effects due to clinically significant DFIs.
  • 805
  • 08 Nov 2022
Topic Review
Conventional Event Tree Analysis on Liquefied Natural Gas
Liquefied natural gas (LNG) is stored in facilities located in urban areas and transported over public roads. A shift towards the broader use of LNG is economically and environmentally justified. Conventional event trees for LNG emergency release in three different units is a concept that is based on the physical and chemical properties of LNG. It has been designed with deep consideration and analysis of past experiences and real cases of LNG incidents. The idea of having training checkpoints, such as ‘decision points’ and ‘learning curve points’ in the continuum of a training or exercise enable the achievement of optimal learning objectives in a flexible way which take into account the trainee individual mental and physical disposition on a day, scalability of difficulty level as well as realistic scenario paths determined by the performance of the trainees facing concrete operational problems.
  • 801
  • 07 Mar 2022
Topic Review
Aging of BM-MSCs
Aging of bone marrow is a complex process that is involved in the development of many diseases, including hematologic cancers. The results obtained in this field of research, year after year, underline the important role of cross-talk between hematopoietic stem cells and their close environment. In bone marrow, mesenchymal stromal cells (MSCs) are a major player in cell-to-cell communication, presenting a wide range of functionalities, sometimes opposite, depending on the environmental conditions. Although these cells are actively studied for their therapeutic properties, their role in tumor progression remains unclear. One of the reasons for this is that the aging of MSCs has a direct impact on their behavior and on hematopoiesis. In addition, tumor progression is accompanied by dynamic remodeling of the bone marrow niche that may interfere with MSC functions.
  • 799
  • 06 May 2021
Topic Review
Gender Differences in Cannabis Use
Gender differences in psychiatric disorders and drug use are well known. Cannabis is the most widely used illegal drug among young people. In recent years, its use has been related to the development of psychiatric pathologies; however, few studies have incorporated the gender perspective as of yet. Men have a higher prevalence using cannabis; however, women show a faster transition from recreational use to compulsive use, higher levels of craving with more relapses, and higher prevalence of dual pathology. Clinical studies clearly show the existence of gender differences in psychiatric symptoms associated with cannabis use. Although these results are not conclusive, they seem to indicate a higher vulnerability of women in the development of psychosis and anxiety, while men seem to be more vulnerable to developing depressive symptoms with long-term cannabis misuses. 
  • 798
  • 02 Apr 2022
Topic Review
Natural Language Processing for the COVID-19 Pandemic
The COVID-19 pandemic is the most devastating public health crisis and has affected the lives of billions of people worldwide in unprecedented ways. Compared to pandemics of this scale in the past, societies are now equipped with advanced technologies that can mitigate the impacts of pandemics if utilized appropriately. However, opportunities are not fully utilized, particularly at the intersection of data science and health. Health-related big data and technological advances have the potential to significantly aid the fight against such pandemics, including the pandemic’s ongoing and long-term impacts. Specifically, the field of natural language processing (NLP) has enormous potential at a time when vast amounts of text-based data are continuously generated from a multitude of sources, such as health/hospital systems, published medical literature, and social media. Effectively mitigating the impacts of the pandemic requires tackling challenges associated with the application and deployment of NLP systems.
  • 797
  • 24 Nov 2022
Topic Review
Malnutrition in Hospitalized Old Patients
Malnutrition in hospitalized patients represents a heavy healthcare burden worldwide. Indeed, malnutrition in hospitalized patients worsens both prognosis and quality of life by increasing mortality, morbidity, and infection rate, extending the hospital stay, reducing the response to medical treatment, and increasing both the re-hospitalization rate and health expenditure.
  • 797
  • 01 Mar 2022
Topic Review
Zearalenone and the Immune Response
Zearalenone (ZEA) is an estrogenic fusariotoxin, being classified as a phytoestrogen, or as a mycoestrogen. ZEA and its metabolites are able to bind to estrogen receptors, 17β-estradiol specific receptors, leading to reproductive disorders which include low fertility, abnormal fetal development, reduced litter size and modification at the level of reproductive hormones especially in female pigs. ZEA has also significant effects on immune response with immunostimulatory or immunosuppressive results. This review presents the effects of ZEA and its derivatives on all levels of the immune response such as innate immunity with its principal component inflammatory response as well as the acquired immunity with two components, humoral and cellular immune response. The mechanisms involved by ZEA in triggering its effects are addressed. 
  • 797
  • 26 Apr 2021
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