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Topic Review
Evaluation of Traumatic Spinal Cord Injury
Spinal cord injury (SCI) refers to the damage suffered in the spinal cord by any trauma or pathology. This work determined whether 99mTc-GA-5, a radiotracer targeting Glial Fibrillary Acidic Protein (GFAP), can reveal in vivo the reactivation of astrocytes in a murine model with SCI.
  • 364
  • 28 Mar 2022
Topic Review
Functionalized Nanomaterials as Theranostic Agents in Brain Imaging
Theranostic nanoparticles in molecular imaging significantly impact non-invasive strategies to understand biological and biochemical events in intact cells within living subjects. It plays a prominent role in disease diagnosis and therapeutic monitoring outcomes in vivo. The theranostic application of nanomaterials can be classified into morphological and functional imaging based on their roles in image contrast abilities during applicable imaging methods.
  • 418
  • 08 Apr 2022
Topic Review
Glioblastoma Radiomics
Glioblastoma (GBM) is a cancer with poor prognosis, its 5-year survival expectation is approximately 5%. Radiomics is a field of medical imaging analysis that focuses on the extraction of many quantitative imaging features related to shape, intensity and texture. These features are incorporated into models designed to predict important clinical or biological endpoints for patients. Glioblastoma multiforme (GBM) patients stand to benefit from this emerging research field as radiomics has the potential to assess the biological heterogeneity of the tumour, which contributes significantly to the inefficacy of current standard of care therapy.
  • 393
  • 13 Sep 2022
Topic Review
Glioma and Glioblastoma Multiforme
Glioma and glioblastoma multiform (GBM) remain among the most debilitating and life-threatening brain tumors. Despite advances in diagnosing approaches, patient follow-up after treatment (surgery and chemoradiation) is still challenging for differentiation between tumor progression/recurrence, pseudoprogression, and radionecrosis. Radiomics emerges as a promising tool in initial diagnosis, grading, and survival prediction in patients with glioma and can help differentiate these post-treatment scenarios.
  • 230
  • 19 Sep 2023
Topic Review
Hippocampal Malrotation
Hippocampal malrotation (HIMAL) is an increasingly recognized neuroimaging feature but the clinical correlation and significance in epilepsies remain under debate.
  • 1.1K
  • 27 Apr 2021
Topic Review
Imaging Biomarkers in Chronic Neuropathic Pain Management
Chronic neuropathic pain is a very important public health issue with profound negative implications in many aspects of patients’ individual lives, as well as society, health systems, productivity, and macroeconomics. The development of imaging, especially molecular and functional imaging, provides objectivity and makes the connection between structural changes, receptors involved in the mechanisms of action, and potentially therapeutic or diagnostic molecules by highlighting the place of action and the involved systems. The approval of composite biomarkers, including serological, genetic, clinical, and imaging markers, with high sensitivity and specificity will accelerate and improve diagnosis, staging, predictive and prognostic evaluation, stratification (phenotyping) and inclusion in trials, and the development of therapeutic options (pharmacological, biomedical) through preclinical, translational, clinical studies. 
  • 413
  • 06 Jan 2023
Topic Review
In Vivo Brain Glutathione
Glutathione (GSH) is an important antioxidant implicated in several physiological functions, including the oxidation−reduction reaction balance and brain antioxidant defense against endogenous and exogenous toxic agents. Altered brain GSH levels may reflect inflammatory processes associated with several neurologic disorders. An accurate and reliable estimation of cerebral GSH concentrations could give a clear and thorough understanding of its metabolism within the brain, thus providing a valuable benchmark for clinical applications. 
  • 624
  • 21 Apr 2022
Topic Review
Interaction between AD and Cerebral Small Vessel Disease
Alzheimer’s disease (AD) is characterized by the presence of β-amyloid (Aβ) and tau, and subcortical vascular cognitive impairment (SVCI) is characterized by cerebral small vessel disease (CSVD). They are the most common causes of cognitive impairment in the elderly population. Concurrent CSVD burden is more commonly observed in AD-type dementia than in other neurodegenerative diseases. The developments in Aβ and tau positron emission tomography (PET) have enabled the investigation of the relationship between AD biomarkers and CSVD in vivo.
  • 490
  • 23 Sep 2022
Topic Review
Lung Ultrasound
Lung ultrasound has become increasingly used in both adult and pediatric populations, allowing the rapid evaluation of many lung and pleura diseases. 
  • 671
  • 08 Apr 2021
Topic Review
Machine Learning in Image-Based Glioma Grading
Technological innovation has enabled the development of machine learning (ML) tools that aim to improve the practice of radiologists. In the last decade, ML applications to neuro-oncology have expanded significantly, with the pre-operative prediction of glioma grade using medical imaging as a specific area of interest. 
  • 564
  • 02 Jun 2022
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