Topic Review
Volumetric Muscle Loss
Volumetric muscle loss (VML) is the massive wasting of skeletal muscle tissue due to traumatic events or surgical ablation. This pathological condition exceeds the physiological healing process carried out by the muscle itself, which owns remarkable capacity to restore damages but only when limited in dimensions. Upon VML occurring, the affected area is severely compromised, heavily influencing the affected person’s quality of life. Overall, this condition is often associated with chronic disability, which makes the return to duty of highly specialized professional figures (e.g., military personnel or athletes) almost impossible. The actual treatment for VML is based on surgical conservative treatment followed by physical exercise; nevertheless, the results, in terms of either lost mass and/or functionality recovery, are still poor. On the other hand, the efforts of the scientific community are focusing on reconstructive therapy aiming at muscular tissue void volume replenishment by exploiting biomimetic matrix or artificial tissue implantation. Reconstructing strategies represent a valid option to build new muscular tissue not only to recover damaged muscles, but also to better socket prosthesis in terms of anchorage surfaces and reinnervation substrates for reconstructed mass. 
  • 751
  • 26 May 2021
Topic Review
Vascularization of the Thyroid Gland
The thyroid gland is a richly vascularized endocrine gland. It is an uneven organ located in a median position in the antero-lower region of the neck, between the fifth cervical vertebra and the first thoracic vertebra.
  • 385
  • 29 Jan 2022
Topic Review
Vascular Access in Children with Short Bowel Syndrome
Short Bowel Syndrome and intestinal failure are chronic and severe conditions that may require life-long parenteral nutrition in children. Survival of these children relies on the correct functioning of central venous catheters; therefore, careful management, prevention, and treatment of complications is of paramount importance. Despite a growing awareness on preserving the vascular real estate, a certain number of patients still experience a progressive and life-threatening exhaustion of vascular access. 
  • 216
  • 31 May 2022
Topic Review
Urethral Strictures Treatment in Transmasculine
Genital gender-affirming surgery can be part of the transition process in transgender patients. The 2 standard options for transmasculine patients are phalloplasty and metoidioplasty. These complex procedures brings along the risk of complications such as fistulas or urethral strictures at the level of the neo-urethra. Urethral strictures pose a specific challenge to the reconstructive urologist, and studies that focus on the management of urethral strictures are scarce. This systematic review gives an overview of the known literature about strictures in transmasculine patients, the different treatments and the outcome . 
  • 224
  • 28 Sep 2021
Topic Review
Treatment of Peritoneal Metastasis
Surgical and locoregional treatments of peritoneal metastasis have gained increasing acceptance. Apart from systemic chemotherapy and surgical removal of the tumor, locoregional therapies such as cytoreductive surgery (CRS)/hyperthermic intraperitoneal chemotherapy (HIPEC) or pressurized intraperitoneal aerosol chemotherapy (PIPAC) may improve tumor control. 
  • 292
  • 25 Feb 2022
Topic Review
Treatment of Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer, the fifth most frequently diagnosed cancer in men and the eighth most frequently diagnosed cancer in women in the United States. It is also the fourth leading cause of cancer-related death in developed countries.
  • 188
  • 25 Apr 2021
Topic Review
Transarterial Chemoembolization for Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. It is principally associated with liver cirrhosis and chronic liver disease. The major risk factors for the development of HCC include viral infections (HBV, HCV), alcoholic liver disease (ALD,) and non-alcoholic fatty liver disease (NAFLD). The optimal treatment choice is dictated by multiple variables such as tumor burden, liver function, and patient’s health status. Surgical resection, transplantation, ablation, transarterial chemoembolization (TACE), and systemic therapy are potentially useful treatment strategies. TACE is considered the first-line treatment for patients with intermediate stage HCC. 
  • 430
  • 24 Mar 2022
Topic Review
Tissue Senescence Reversing Techniques Modalities
Senescent cells and fibrosis are important components that impact the regenerative capacity of skin, particularly when considering chronic non-healing wounds. Anoderm and perianal fistulas in the setting of Crohn’s disease are clinically pathophysiological extremes with consequently different healing processes which impact treatment modalities.
  • 94
  • 27 Feb 2023
Topic Review
Thrombin-Gelatin Matrix in Breast Tumor Hemostasis
Improved hemostasis during acute bleeding and a trend to prevent hematoma were observed after the TGM injection. TGM could be an alternative method to achieve better post-VABB hemostasis.
  • 198
  • 02 Mar 2022
Topic Review
The History of Blood Vessel Anastomosis
Surgical technique and technology frequently coevolve. The brief history of blood vessel anastomosis is full of famous names. While the techniques pioneered by these surgeons have been well described, the technology that facilitated their advancements and their inventors deserve recognition. The mass production of laboratory microscopes in the mid-1800s allowed for an explosion of interest in tissue histology. This improved understanding of vascular physiology and thrombosis laid the groundwork for Carrel and Guthrie to report some of the first successful vascular anastomoses. In 1916, McLean discovered heparin. Twenty-four years later, Gordon Murray found that it could prevent thrombosis when performing end-to-end anastomosis. These discoveries paved the way for the first-in-human kidney transplantations. Otolaryngologists Nylen and Holmgren were the first to bring the laboratory microscope into the operating room, but Jacobson was the first to apply these techniques to microvascular anastomosis. His first successful attempt in 1960 and the subsequent development of microsurgical tools allowed for an explosion of interest in microsurgery, and several decades of innovation followed.
  • 321
  • 15 Mar 2022
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