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Topic Review
Stimuli-Responsive Hydrogels for Protein Delivery
Proteins and peptides are potential therapeutic agents, but their physiochemical properties make their use as drug substances challenging. Hydrogels are hydrophilic polymeric networks that can swell and retain high amounts of water or biological fluids without being dissolved. Due to their biocompatibility, their porous structure, which enables the transport of various peptides and proteins, and their protective effect against degradation, hydrogels have gained prominence as ideal carriers for these molecules’ delivery. Particularly, stimuli-responsive hydrogels exhibit physicochemical transitions in response to subtle modifications in the surrounding environment, leading to the controlled release of entrapped proteins or peptides. 
  • 105
  • 18 Dec 2023
Topic Review
Imine-Based Adaptive Covalent Chemistry
The imine bond, also referred to as the Schiff base, is one of the reversible covalent bonds that can participate in both associative and dissociative reactions. This opens up possibilities for mechanical and chemical recycling as well as self-healing.
  • 180
  • 12 Dec 2023
Topic Review
Moss-Based Biocomposites
Mosses have a large surface area of densely packed leaves that allows them to effectively trap air pollutants. This enables them to exhibit filtration efficiencies comparable to those of man-made filters. However, within the context of a circular economy, moss fibers integrated into a biocomposite matrix provide the added advantage of being reusable, facilitating the development of closed systems without waste generation.
  • 141
  • 12 Dec 2023
Topic Review
Light-Based 3D Bioprinting
The emergence of additive manufacturing, commonly referred to as 3D printing, has led to a revolution in the field of biofabrication. Numerous types of 3D bioprinting, including extrusion bioprinting, inkjet bioprinting, and lithography-based bioprinting, have been developed and have played pivotal roles in driving a multitude of pioneering breakthroughs in the fields of tissue engineering and regenerative medicine.
  • 166
  • 12 Dec 2023
Topic Review
Nanotechnology-Based Tumor Tissue-Specific Drug Targeting Delivery Systems
Owing to high efficacy and safety, natural medicines have found their way into the field of cancer therapy over the past few decades. However, the effective ingredients of natural medicines have shortcomings of poor solubility and low bioavailability. Nanoparticles can not only solve the problems above but also have outstanding targeting ability. Targeting preparations can be classified into three levels, which are target tissues, cells, and organelles. On the premise of clarifying the therapeutic purpose of drugs, one or more targeting methods can be selected to achieve more accurate drug delivery and consequently to improve the anti-tumor effects of drugs and reduce toxicity and side effects. 
  • 126
  • 12 Dec 2023
Topic Review
Corrosion of Fixed Orthodontic Appliances
The orthodontic supply market is a prosperous billion-dollar industry, driven by an increasing demand for orthodontic appliances. The supremacy of metallic first-generation biomaterials is evident for manufacturing brackets, archwires, bands, and other components due to their well-recognized chemical inertness, spontaneous passivation, biocompatibility, and favorable mechanical properties combination. However, the oral cavity is the ultimate corrosion-promoting environment for any metallic material.
  • 178
  • 06 Dec 2023
Topic Review
Silk Fibroin in Human and Veterinary Medicine
The properties of silk make it a promising material for medical applications, both in human and veterinary medicine. Its predominant amino acids, glycine and alanine, exhibit low chemical reactivity, reducing the risk of graft rejection, a notable advantage over most synthetic polymers. Hence, silk is increasingly used as a material for 3D printing in biomedicine. It can be used to build cell scaffolding with the desired cytocompatibility and biodegradability. In combination with gelatine, silk can be used in the treatment of arthritis, and as a hydrogel, to regenerate chondrocytes and mesenchymal cells. When combined with gelatine and collagen, it can also make skin grafts and regenerate the integumentary system. In the treatment of bone tissue, it can be used in combination with polylactic acid and hydroxyapatite to produce bone clips having good mechanical properties and high immunological tolerance.
  • 193
  • 04 Dec 2023
Topic Review
Lyotropic Liquid Crystals for Efficient Intestinal Lymphatic Targeting
Lyotropic liquid crystals (LLCs) are liquids that have crystalline structures. LLCs as drug delivery systems that can deliver hydrophobic, hydrophilic, and amphiphilic agents. Due to their unique phases and structures, LLCs can protect both small molecules and biologics from the gastrointestinal tract’s harsh environment, thus making LLCs attractive as carriers for oral drug delivery.
  • 251
  • 30 Nov 2023
Topic Review
Biomedical Device Related Complications
In 1987, the European Society for Biomaterials coined the term “biomaterial”, defining it as a non-biological material used in medical devices with the specific purpose of interacting with biological systems. Over time, this definition of biomaterial has evolved, adapting to various contexts. Currently, biomaterials are described as materials that actively interact with biological system to assess, treat, promote healing or even replace any tissue or body function.
  • 275
  • 29 Nov 2023
Topic Review
Silk Proteins with Metal Ions and Factors
Silk secreted by Bombyx mori L. silkworm has become one of the most important biomaterials, due to its excellent biocompatibility, controllable biodegradability, superior processability, and unique mechanical properties. Silk fibroin and sericin, as the two components of silk, contain abundant polar functional groups, and thus can bind metal ions through electrostatic interaction and chelation.
  • 229
  • 28 Nov 2023
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