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Topic Review
Protein- and Peptide-Based Chemical Conjugates
The complexity of molecular entities being advanced for therapeutic purposes has continued to evolve. A main propellent fueling innovation is the perpetual mandate within the pharmaceutical industry to meet the needs of novel disease areas and/or delivery challenges. As new mechanisms of action are uncovered, and as our understanding of existing mechanisms grows, the properties that are required and/or leveraged to enable therapeutic development continue to expand.
  • 437
  • 12 May 2023
Topic Review
Types of Senescent Cells in Cardiovascular Diseases
Senescent cell accumulation has been observed in age-associated diseases including cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence-associated secretory phenotype (SASP) factors that may cause or worsen many cardiovascular diseases. Therapies targeting senescent cells, especially senolytic drugs that selectively induce senescent cell removal, have been shown to delay, prevent, alleviate, or treat multiple age-associated diseases in preclinical models. 
  • 369
  • 12 May 2023
Topic Review
Cell Cycle Checkpoints
Studies have shown that during early embryogenesis, preimplantation embryos exhibit higher levels of chromosomal abnormalities in the initial stages of cleavage compared to the late morula stage or blastocysts. Thus, preimplantation embryos can acquire an aneuploidy phenotype already in early developmental stages, which points to the fact that these first mitotic cycles are more susceptible to chromosomal aberrations. The monitoring of chromatin damage, the so-called cell cycle checkpoint, is therefore an essential aspect of the cell cycle.
  • 709
  • 12 May 2023
Topic Review
Galectin-3 Targeting Drugs in Various Diseases
Galectin-3 (Gal3) is one of the most studied members of the galectin family that mediate various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Since Gal3 is pro-inflammatory, it is involved in many diseases that are associated with chronic inflammation such as cancer, organ fibrosis, and type 2 diabetes.
  • 428
  • 12 May 2023
Topic Review
Transport through the Blood–Brain Barrier
The blood–brain barrier (BBB) is a complex structure present in mammalian organisms and is responsible for maintaining the parameters of the internal environment of the central nervous system (CNS).
  • 609
  • 12 May 2023
Topic Review
Pulses as Ingredients for Processed Meats
Pulses are in the forefront as protein-rich sources to aid in providing sufficient daily protein intake and may be used as binders to reduce meat protein in meat product formulations. Use of pulse-derived ingredients in meat processing can lower formulation costs, improve nutritional value and enhance meat product quality. Pulses are seen as clean-label multi-functional ingredients that bring benefits to meat products beyond protein content. Their broader use as ingredients in meat products may be enhanced by various processes such as thermal pre-treatment.
  • 859
  • 11 May 2023
Topic Review
Health Effects of Metabolites from Probiotic Bacteria
Probiotics have been extensively studied within the medical, pharmaceutical, and food fields, as it has been revealed that these microorganisms can provide health benefits from their consumption. Bacterial probiotics comprise species derived from lactic acid bacteria (LAB) (genus Lactobacillus, Leuconostoc, and Streptococcus), the genus Bifidobacterium, and strains of Bacillus and Escherichia coli, among others. The growth of bacterial probiotics is involved in fermentation, which metabolizes the nutrients of the medium and produces a wide variety of metabolic compounds. Probiotics are defined as microorganisms that, when consumed in adequate doses or concentrations, can benefit the consumer’s health. 
  • 526
  • 11 May 2023
Topic Review
Thrombosis Models
Occlusions in the blood vessels caused by blood clots, referred to as thrombosis, and the subsequent outcomes are leading causes of morbidity and mortality worldwide. In vitro and in vivo models of thrombosis have advanced the understanding of the complex pathways involved in its development and allowed the evaluation of different therapeutic approaches for its management.
  • 361
  • 11 May 2023
Topic Review
Antioxidant Peptides from Corn Silk Tryptic Hydrolysate
Corn silk (CS) is an agro-by-product from corn cultivation. It is used in folk medicines in some countries, besides being commercialized as health-promoting supplements and beverages. Unlike CS-derived natural products, their bioactive peptides, particularly antioxidant peptides, are understudied.
  • 997
  • 11 May 2023
Topic Review
Core Collections of Plant Genetic Resources
The core collection is a small subset that minimizes genetic redundancy while preserving the maximum genetic diversity of the entire population. Research on the core collection is crucial for the efficient management and utilization of germplasm resources.
  • 416
  • 11 May 2023
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