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Topic Review
The Role of Calcium in Cytosolic Protein-Mediated Apoptosis
Calcium is an essential intracellular messenger that plays a vital role in controlling a broad range of cellular processes, including apoptosis. Cytosolic calcium levels are tightly regulated, and an imbalance in calcium concentrations can trigger apoptosis through various mechanisms involving cytosolic proteins.
  • 548
  • 30 May 2023
Topic Review
Biological Activities of Some Species of Genus Eryngium
There are approximately 250 species of Eryngium L. distributed throughout the world, with North America and South America being centers of diversity on this continent. In the central-western region of Mexico there may be around 28 species of this genus. Some Eryngium species are cultivated as leafy vegetables, ornamental, and medicinal plants. In traditional medicine they are used to treat respiratory and gastrointestinal conditions, diabetes, and dyslipidemia, among others. 
  • 421
  • 30 May 2023
Topic Review
Pulmonary Fibrosis
Pulmonary fibrosis (PF) is the end-stage consequence of various interstitial lung diseases (ILD). It is a chronic progressive disease with an average survival of 3–5 years after diagnosis. The pathological features of PF are the abnormal activation and proliferation of myofibroblasts and the extraordinary deposition of the extracellular matrix (ECM). 
  • 369
  • 30 May 2023
Topic Review
Molecular Mechanisms of Cancer Immunotherapy
The cancer-immunity cycle is characterized by various stimulatory and inhibitory factors, which together regulate the immune response and halt the extreme response that may lead to autoimmune disease. Immunotherapy of cancer has rejuvenated the field of tumor immunology and revolutionized treatment options.
  • 895
  • 30 May 2023
Topic Review
Diversity of Mycogenic Oxide and Chalcogenide Nanoparticles
Oxide and chalcogenide nanoparticles have great potential for use in biomedicine, engineering, agriculture, environmental protection, and other research fields. The myco-synthesis of nanoparticles with fungal cultures, their metabolites, culture liquids, and mycelial and fruit body extracts is simple, cheap and environmentally friendly. The characteristics of nanoparticles, including their size, shape, homogeneity, stability, physical properties and biological activity, can be tuned by changing the myco-synthesis conditions.
  • 363
  • 30 May 2023
Topic Review
Agar-Agar in the Synthesis of Functional Film
The food industry produces an exorbitant amount of solid waste of petrochemical origin as a result of the increase in the development of new products. Natural polymers are an alternative to this theme; however, their development with adequate properties is a challenge. The union of different polymers in the synthesis of packaging is usually carried out to improve these properties. The combination of agar-agar and chitosan biopolymers show particular advantages through hydrogen bonds and electrostatic attraction between oppositely charged groups, presenting a promising source of studies for the synthesis of green packaging. When combined with natural extracts with active properties, these polymers allow an increase in the microbiological stability of foods associated with lower chemical preservative content and greater environmental sustainability.
  • 748
  • 30 May 2023
Topic Review
Antisense Long Non-Coding RNAs in Hepatocellular Carcinoma
Transcriptome complexity is emerging as an unprecedented and fascinating domain, especially by high-throughput sequencing technologies that have unveiled a plethora of new non-coding RNA biotypes. Several sense–antisense transcript pairs have been recently annotated, especially from mammalian genomes, and an understanding of their evolutionary sense and functional role for human health and diseases is only beginning. Antisense long non-coding RNAs ((lncRNAs) dysregulation is significantly involved in hepatocarcinogenesis, where they can act as oncogenes or oncosuppressors, thus playing a key role in tumor onset, progression, and chemoradiotherapy response. Mechanistically, antisense lncRNAs regulate gene expression by exploiting various molecular mechanisms shared with other ncRNA molecules, and exploit special mechanisms on their corresponding sense gene due to sequence complementarity, thus exerting epigenetic, transcriptional, post-transcriptional, and translational controls.
  • 270
  • 29 May 2023
Topic Review
Therapeutic Potential of Polyphenols of Marine Origin
Polyphenols are compounds found in various plants and foods, known for their antioxidant and anti-inflammatory properties. These compounds have unique chemical structures and exhibit diverse biological properties, including anti-inflammatory, antioxidant, antimicrobial and antitumor action. Due to these properties, marine polyphenols are being investigated as possible therapeutic agents for the treatment of a wide variety of conditions, such as cardiovascular disease, diabetes, neurodegenerative diseases and cancer. 
  • 450
  • 29 May 2023
Topic Review
Human Dental Pulp Stem Cells
Human dental pulp stem cells (hDPSCs) are adult mesenchymal stem cells (MSCs) obtained from dental pulp and derived from the neural crest. They can differentiate into odontoblasts, osteoblasts, chondrocytes, adipocytes and nerve cells, and they play a role in tissue repair and regeneration.
  • 549
  • 29 May 2023
Topic Review
Eumelanin in the Living World
A lot of still unexplained aspects characterize eumelanin, a macromolecule able to play in living organisms several, sometimes conflicting, roles. This contribution aims  to emphasize the unique characteristics and the consequent unusual behaviors of a molecule that in an evolutionary context survived natural selection and still holds the main chemical/physical features detected in fossils dating to the late Carboniferous. 
  • 358
  • 29 May 2023
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