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Topic Review
Burn Wound Infections
The most recent advances on the use of nanoparticles in wound dressing formulations and in tissue engineering for the treatment of burn wound infections.
  • 1.1K
  • 02 Nov 2020
Topic Review
Baijiu
Baijiu is a type of distilled liquors and is made from grain fermentation induced by Daqu, Xiaoqu and Fuqu as possible sacchariferous agents through solid saccharification, fermentation, distillation in barrels (named Zengtong), long-time storage in porcelain jars and blending processes.
  • 1.1K
  • 20 Apr 2021
Topic Review
Intra-Arterial Delivery of Therapeutics
Diseases of the kidney contribute a significant morbidity and mortality burden on society. Localized delivery of therapeutics directly into the kidney, via its arterial blood supply, has the potential to enhance their therapeutic efficacy while limiting side effects associated with conventional systemic delivery. Targeted delivery in humans is feasible given that we can access the renal arterial blood supply using minimally invasive endovascular techniques and imaging guidance. Techniques to reproduce or mimic this approach in a small animal model  will allow for further pre-clinical translational studies investigating therapies for the treatment of renal pathologies.
  • 1.1K
  • 30 Oct 2020
Topic Review
Neuropharmacological Effects of Terpenoids
Terpenoids are widely distributed in nature, especially in the plant kingdom, and exhibit diverse pharmacological activities. In recent years, screening has revealed a wide variety of new terpenoids that are active against different psychiatric disorders.
  • 1.1K
  • 28 Sep 2022
Topic Review
Fluoride as an Environmental Toxin
Fluorine in its elemental form is practically not found on Earth, but it is present in the ecosphere in the form of fluorine compounds. A growing body of literature suggests that labelling fluorides as an environmental toxin appears to be correct.
  • 1.1K
  • 03 Feb 2023
Topic Review
Miscanthus Giganteus
Miscanthus × giganteus, the giant miscanthus, is a sterile hybrid of Miscanthus sinensis and Miscanthus sacchariflorus. It is a perennial grass with bamboo-like stems that can grow to heights of more than 4 metres (13 ft) in one season (from the third season onwards). Just like Pennisetum purpureum, Arundo donax and Saccharum ravennae, it is also called elephant grass. Miscanthus × giganteus' perennial nature, its ability to grow on marginal land, its water efficiency, non-invasiveness, low fertilizer needs, significant carbon sequestration and high yield have sparked a lot of interest among researchers, with some arguing that it has "ideal" energy crop properties. Some argue that it can provide negative emissions, while others highlight its water cleaning and soil enhancing qualities. There are practical and economic challenges related to its use in the existing, fossil based combustion infrastructure, however. Torrefaction and other fuel upgrading techniques are being explored as countermeasures to this problem.
  • 1.1K
  • 03 Nov 2022
Topic Review
Dermo-Cosmetic Benefits of Marine Macroalgae-Derived Phenolic Compounds
Marine macroalgae have an interesting profile of bioactive compounds and have gained tremendous attention in cosmeceuticals with negligible toxicity effects (cytotoxicity, reproductive toxicity, genotoxicity, mutagenicity, carcinogenicity, etc.) on humans and exhibit strong benefits for the skin. Among the diversified compounds, phenolic compounds are the group of phytochemicals found in high amounts with great structural diversity. Phlorotannin is the most studied polyphenol compound in brown algae, but besides there are some other phenolic compounds observed and studied in macroalgae such as terpenoids, bromophenols, mycosporine amino acids (MAAs), and flavonoids. These compounds are already characterized and studied for their full range of cosmeceutical benefits such as skin whitening, moisturizing, photoprotection, antiaging, antiwrinkle, anti-melanogenic, and antioxidant activities as well as in the treatment of pruritus (caused by acne, eczema, dermatitis, hives, psoriasis), photoaging, and skin pigmentation disorders (hypopigmentation due to the absence of melanocytes and hyperpigmentation caused by skin irritation or metabolic disorders). 
  • 1.1K
  • 05 Dec 2022
Topic Review
Antimicrobial Potential of Curcumin
Curcumin is a bioactive compound that is extracted from Curcuma longa and that is known for its antimicrobial properties. Curcuminoids are the main constituents of curcumin that exhibit antioxidant properties. It has a broad spectrum of antibacterial actions against a wide range of bacteria, even those resistant to antibiotics. Curcumin has been shown to be effective against the microorganisms that are responsible for surgical infections and implant-related bone infections, primarily Staphylococcus aureus and Escherichia coli. The efficacy of curcumin against Helicobacter pylori and Mycobacterium tuberculosis, alone or in combination with other classic antibiotics, is one of its most promising antibacterial effects. Curcumin is known to have antifungal action against numerous fungi that are responsible for a variety of infections, including dermatophytosis. Candidemia and candidiasis caused by Candida species have also been reported to be treated using curcumin. Life-threatening diseases and infections caused by viruses can be counteracted by curcumin, recognizing its antiviral potential.
  • 1.1K
  • 16 Mar 2022
Topic Review
Methylation
Methylation is a universal biochemical process which covalently adds methyl groups to a variety of molecular targets. It plays a critical role in two major global regulatory mechanisms, epigenetic modifications and imprinting, via methyl tagging on histones and DNA. During reproduction, the two genomes that unite to create a new individual are complementary but not equivalent. Methylation determines the complementary regulatory characteristics of male and female genomes. DNA methylation is executed by methyltransferases that transfer a methyl group from S-adenosylmethionine, the universal methyl donor, to cytosine residues of CG (also designated CpG). Histones are methylated mainly on lysine and arginine residues. The methylation processes regulate the main steps in reproductive physiology: gametogenesis, and early and late embryo development, and thus play a crucial role in the transmission of life. 
  • 1.0K
  • 17 Dec 2020
Topic Review
Cytopathic Effect
Cytopathic effect or cytopathogenic effect (abbreviated CPE) refers to structural changes in host cells that are caused by viral invasion. The infecting virus causes lysis of the host cell or when the cell dies without lysis due to an inability to reproduce. Both of these effects occur due to CPEs. If a virus causes these morphological changes in the host cell, it is said to be cytopathogenic. Common examples of CPE include rounding of the infected cell, fusion with adjacent cells to form syncytia, and the appearance of nuclear or cytoplasmic inclusion bodies. CPEs and other changes in cell morphology are only a few of the many effects by cytocidal viruses. When a cytocidal virus infects a permissive cell, the viruses kill the host cell through changes in cell morphology, in cell physiology, and the biosynthetic events that follow. These changes are necessary for efficient virus replication but at the expense of the host cell.
  • 1.1K
  • 30 Nov 2022
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