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HandWiki. Cytopathic Effect. Encyclopedia. Available online: https://encyclopedia.pub/entry/37257 (accessed on 24 September 2026).
HandWiki. Cytopathic Effect. Encyclopedia. Available at: https://encyclopedia.pub/entry/37257. Accessed September 24, 2026.
HandWiki. "Cytopathic Effect" Encyclopedia, https://encyclopedia.pub/entry/37257 (accessed September 24, 2026).
HandWiki. (2022, November 30). Cytopathic Effect. In Encyclopedia. https://encyclopedia.pub/entry/37257
HandWiki. "Cytopathic Effect." Encyclopedia. Web. 30 November, 2022.
Cytopathic Effect
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The content is sourced from: https://handwiki.org/wiki/Biology:Cytopathic_effect

Cytopathic effect or cytopathogenic effect (abbreviated CPE) refers to structural changes in host cells that are caused by viral invasion. The infecting virus causes lysis of the host cell or when the cell dies without lysis due to an inability to reproduce. Both of these effects occur due to CPEs. If a virus causes these morphological changes in the host cell, it is said to be cytopathogenic. Common examples of CPE include rounding of the infected cell, fusion with adjacent cells to form syncytia, and the appearance of nuclear or cytoplasmic inclusion bodies. CPEs and other changes in cell morphology are only a few of the many effects by cytocidal viruses. When a cytocidal virus infects a permissive cell, the viruses kill the host cell through changes in cell morphology, in cell physiology, and the biosynthetic events that follow. These changes are necessary for efficient virus replication but at the expense of the host cell.

morphological changes cytocidal structural changes

References

  1. Suchman, Erica; Blair, Carol. "Cytopathic Effects of Viruses Protocols". American Society for Microbiology. Archived from the original on 2 June 2012. https://web.archive.org/web/20120602171845/http://microbelibrary.org/component/resource/laboratory-test/2875-cytopathic-effects-of-viruses-protocols. Retrieved 20 November 2014. 
  2. Baron, Samuel (1996). Medical Microbiology (4th ed.). TX: University of Texas Medical Branch at Galveston. https://www.ncbi.nlm.nih.gov/books/NBK7979/. Retrieved 19 November 2014. 
  3. Rubbia-Brandt, Laura; Quadri, Rafael; Abid, Karim; Giostra, Emiliano; Male, Pierre-Jean; Mentha, Gilles; Spahr, Laurent; Zarski, Jean-Pierre et al. (2000). "Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3". Journal of Hepatology 33 (1): 106–115. doi:10.1016/S0168-8278(00)80166-X.  https://dx.doi.org/10.1016%2FS0168-8278%2800%2980166-X
  4. McCormick, Kevin; Liu, Shufeng; Jacobs, Jana; Marques, Ernesto; Sluis-Cremer, Nicolas; Wang, Tianyi (2012). "Development of a Robust Cytopathic Effect-Based High-Throughput Screening Assay to Identify Novel Inhibitors of Dengue Virus". Antimicrobial Agents and Chemotherapy 56 (6): 3399–3401. doi:10.1128/AAC.06425-11. PMID 22391547.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3370735
  5. Carson, Steven; Pirruccello, Samuel (2013). "HeLa cell heterogeneity and coxsackievirus B3 cytopathic effect: Implications for inter-laboratory reproducibility of results". Journal of Medical Virology 85 (4): 677–683. doi:10.1002/jmv.23528. PMID 23408555.  https://dx.doi.org/10.1002%2Fjmv.23528
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