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Topic Review
Synanthropic Flies
The significance of non-blood feeding cyclorrhaphan flies with some synanthropic, dipteran families (i.e., Calliphoridae, Sarcophagidae, and Muscidae) in transmitting pathogens to humans and their food sources needs a lot of focused research. People often overlook the small things in life. However, they can have a major impact on things that they have contacted. Synanthropic flies have been ignored in most epidemiological studies and models. An attempt has been made in this research to convince you that synanthropic flies can play and do play a major role in transmitting numerous pathogens to humans, domestic animals, and wildlife. The majority of zoonoses have been reported to take place between wildlife and various synanthropic flies. Prior to the origin of humans, insects evolved around 400 million years ago. They certainly had contact with the feces and mouth secretions of other animals. What took place people may never know but for certain, these flies were involved in the uptake and transmission of the numerous pathogens they acquired with their meal.
  • 906
  • 15 Sep 2022
Topic Review
Symptomatic Huntington’s Disease
This entry used a publically available dataset to perform in silico analysis using different bioinformatics tools (PathwayConnector, PathWalks, DyNet). The DEGs were identifed for the pre-symptomatic and symptomatic HD stages. The CACNA1I gene was the mostly highly rewired node among pre-symptomatic and symptomatic HD network. Prominent molecular pathways for each HD stage were then obtained, and metabolites related to each pathway for both disease stages were identified. The transforming growth factor beta (TGF- ) signaling (pre-symptomatic and symptomatic stages of the disease), calcium (Ca2+) signaling (pre-symptomatic), dopaminergic synapse pathway (symptomatic HD patients) and Hippo signaling (pre-symptomatic) pathways.  The genes, pathways and metabolites identified for each HD stage can provide a better understanding of the mechanisms that become altered in each disease stage. Our results can guide the development of therapies that may target the altered genes and metabolites of the perturbed pathways, leading to an improvement in clinical symptoms and hopefully a delay in the age of onset.
  • 583
  • 20 Jan 2021
Topic Review
Symptomatic Heterozygosity
As a rule of thumb, heterozygous carriers of variants associated with recessive diseases are asymptomatic. This can be confirmed by large population genetic studies and the asymptomatic status of heterozygous family members in segregation analyses. Symptomatic heterozygotes, defined as symptomatic carriers of a recessive autosomal disease, are individuals carrying only one copy of the pathogenic/likely pathogenic variant in biallelic autosomal Mendelian diseases. Considering the available literature, a symptomatic heterozygous status in autosomal diseases is extremely rare and has been based on case reports only, although some large studies have suggested an increased risk for some diseases among heterozygotes. Also, individuals who carry just one variant of the disease-causing gene and who display quite a severe phenotype are often not defined as symptomatic carriers per se; rather, they are classified as an example of a dominant inheritance with a milder disease form. Indeed, sometimes only a fine line exists between these two conditions. In addition, recent population studies investigating links between genetic variants and quantitative traits have shown a spectrum of subclinical phenotypes associated with heterozygosity in some disease variants. A broad range of intermediate subclinical phenotypes has suggested significant heterozygous phenotypic effects in some Mendelian biallelic diseases.
  • 352
  • 17 Aug 2023
Topic Review
Sympathetic Nerve in Chronic Pain-Associated Cardiovascular Disease
Chronic pain affects many people world-wide, and this number is continuously increasing. There is a clear link between chronic pain and the development of cardiovascular disease through activation of the sympathetic nervous system.
  • 472
  • 13 Apr 2023
Topic Review
Symmetric and Asymmetric Synapses Driving Neurodegenerative Disorders
In 1959, E. G. Gray described two different types of synapses in the brain for the first time: symmetric and asymmetric. Later on, symmetric synapses were associated with inhibitory terminals, and asymmetric synapses to excitatory signaling. The balance between these two systems is critical to maintain a correct brain function. Likewise, the modulation of both types of synapses is also important to maintain a healthy equilibrium. Cerebral circuitry responds differently depending on the type of damage and the timeline of the injury. For example, promoting symmetric signaling following ischemic damage is beneficial only during the acute phase; afterwards, it further increases the initial damage. Synapses can be also altered by players not directly related to them; the chronic and long-term neurodegeneration mediated by tau proteins primarily targets asymmetric synapses by decreasing neuronal plasticity and functionality. Dopamine represents the main modulating system within the central nervous system. Indeed, the death of midbrain dopaminergic neurons impairs locomotion, underlying the devastating Parkinson’s disease.
  • 1.2K
  • 10 Dec 2021
Topic Review
Symbiotic Bacillota (Firmicutes) of Marine Macroalgae
The shift from the terrestrial to the marine environment to discover natural products has given rise to novel bioactive compounds, some of which have been approved for human medicine. However, the ocean, which makes up nearly three-quarters of the Earth’s surface, contains macro- and microorganisms whose natural products are yet to be explored. Among these underexplored marine organisms are macroalgae and their symbiotic microbes, such as Bacillota, a phylum of mostly Gram-positive bacteria previously known as Firmicutes. Macroalgae-associated Bacillota often produce chemical compounds that protect them and their hosts from competitive and harmful rivals.
  • 334
  • 13 Nov 2023
Topic Review
Symbiodiniaceae in Antipatharians (Black Corals)
Antipatharians are understudied ecosystem engineers of shallow (<30 m depth), mesophotic (30–150 m) and deep-sea (>200 m) reefs. They provide habitat to numerous organisms, enhancing and supporting coral reef biodiversity globally. Nonetheless, little biological and ecological information exists on antipatharians, including the extent to which global change disturbances are threatening their health. The previous assumption that they were exempted from threats related to the phenomenon known as bleaching was challenged by the recent findings of high densities of dinoflagellates within three antipatharian colonies. 
  • 508
  • 02 Dec 2021
Biography
Sylvester James Gates
Sylvester James Gates Jr. (born December 15, 1950), known as S. James Gates Jr. or Jim Gates, is an American theoretical physicist who works on supersymmetry, supergravity, and superstring theory. He retired from the physics department and Center for Fundamental Physics at the University of Maryland College of Computer, Mathematical, and Natural Sciences in 2017,[1] and he is now the Brown Theor
  • 846
  • 24 Nov 2022
Topic Review
Swyer Syndrome
Swyer syndrome is a condition that affects sexual development. Sexual development is usually determined by an individual's chromosomes; however, in Swyer syndrome, sexual development does not match the affected individual's chromosomal makeup.  
  • 2.3K
  • 23 Dec 2020
Topic Review
Swine Influenza
Swine influenza is an infection caused by any of several types of swine influenza viruses. Swine influenza virus (SIV) or swine-origin influenza virus (S-OIV) refers to any strain of the influenza family of viruses that is endemic in pigs. As of 2009, identified SIV strains include influenza C and the subtypes of influenza A known as H1N1, H1N2, H2N1, H3N1, H3N2, and H2N3. Swine influenza virus is common throughout pig populations worldwide. Transmission of the virus from pigs to humans is rare, and does not always lead to human flu, often resulting only in the production of antibodies in the blood. If transmission causes human flu, it is called zoonotic swine flu. People with regular exposure to pigs are at increased risk of swine flu infections. Around the mid-20th century, identification of influenza subtypes was made possible, allowing accurate diagnosis of transmission to humans. Since then, only 50 such transmissions have been confirmed. These strains of swine flu rarely pass from human to human. Symptoms of zoonotic swine flu in humans are similar to those of influenza and of influenza-like illness in general, namely chills, fever, sore throat, muscle pains, severe headache, coughing, weakness, shortness of breath, and general discomfort. It is estimated that, in the 2009 flu pandemic, 11–21% of the then global population (of about 6.8 billion), equivalent to around 700 million to 1.4 billion people, contracted the illness—more, in absolute terms, than the Spanish flu pandemic. There were 18,449 confirmed fatalities. However, in a 2012 study, the CDC estimated more than 284,000 possible fatalities worldwide, with numbers ranging from 150,000 to 575,000. In August 2010, the World Health Organization declared the swine flu pandemic officially over. Subsequent cases of swine flu were reported in India in 2015, with over 31,156 positive test cases and 1,841 deaths.
  • 1.5K
  • 21 Nov 2022
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