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Topic Review
Citrus Fruit Loss Caused by Pathogens
The Sustainable Development Goals (SDGs) contribute to the improvement of production and consumption systems, hence, assisting in the eradication of hunger and poverty. As a result, there is growing global interest in the direction of economic development to create a zero-waste economy or circular economy. Citrus fruits are a major fruit crop, with annual global production surpassing 100 million tons, while orange and tangerine production alone account for more than half of the overall production. During pre- and postharvest stages of citrus fruit production, it is estimated that more than 20% of fruit biomass is lost, due, primarily, to biotic stresses. Due to substantial changes in fruit characteristics and environmental conditions, some of the most economically significant pathogens infect fruits in the field during the growing season and remain dormant or inactive until they resume growth after harvest. 
  • 1.2K
  • 31 Aug 2022
Topic Review
BMSC Osteogenic or Adipogenic Differentiation
Bone marrow stromal cells (BMSCs) are multipotent cells in the bone marrow which can differentiate into chondrocytes, osteoblasts, adipocytes (fat cells) and other cell types. Many factors have been identified to control the process of BMSC osteogenic or adipogenic differentiation in the bone.
  • 1.2K
  • 12 Aug 2021
Topic Review
O-Acetyl Sialylation
The recently emerged SARS-CoV-2 is the cause of the global health crisis of the coronavirus disease 2019 (COVID-19) pandemic. No evidence is yet available for CoV infection into hosts upon zoonotic disease outbreak, although the CoV epidemy resembles influenza viruses, which use sialic acid (SA). Currently, information on SARS-CoV-2 and its receptors is limited. O-acetylated SAs interact with the lectin-like spike glycoprotein of SARS CoV-2 for the initial attachment of viruses to enter into the host cells. SARS-CoV-2 hemagglutinin-esterase (HE) acts as the classical glycan-binding lectin and receptor-degrading enzyme. Most β-CoVs recognize 9-O-acetyl-SAs but switched to recognizing the 4-O-acetyl-SA form during evolution of CoVs. Type I HE is specific for the 9-O-Ac-SAs and type II HE is specific for 4-O-Ac-SAs. The SA-binding shift proceeds through quasi-synchronous adaptations of the SA-recognition sites of the lectin and esterase domains. The molecular switching of HE acquisition of 4-O-acetyl binding from 9-O-acetyl SA binding is caused by protein–carbohydrate interaction (PCI) or lectin–carbohydrate interaction (LCI). The HE gene was transmitted to a β-CoV lineage A progenitor by horizontal gene transfer from a 9-O-Ac-SA–specific HEF, as in influenza virus C/D. HE acquisition, and expansion takes place by cross-species transmission over HE evolution. This reflects viral evolutionary adaptation to host SA-containing glycans. Therefore, CoV HE receptor switching precedes virus evolution driven by the SA-glycan diversity of the hosts. The PCI or LCI stereochemistry potentiates the SA–ligand switch by a simple conformational …
  • 1.2K
  • 26 Oct 2020
Topic Review
Coffee Chlorogenic Acids Incorporation
The main CGA in coffee is 5-O-caffeoylquinic acid (5-CQA). Coffee extracts are currently the most widely used source to enhance the antioxidant activity of foods. Due to the solubility of CGAs, their extraction is mainly performed with organic solvents. CGAs have been associated with health benefits, such as antioxidant, antiviral, antibacterial, anticancer, and anti-inflammatory activity, and others that reduce the risk of cardiovascular diseases, type 2 diabetes, and Alzheimer’s disease.
  • 1.2K
  • 27 Jun 2022
Topic Review
Golden Berry Fruit and Insulin
La baya dorada (Physalis peruviana L.) es una fruta de gran importancia comercial en algunos países africanos y latinoamericanos, donde se consume localmente y con frecuencia se exporta a los mercados del norte, principalmente Europa y Estados Unidos. Esta fruta tradicionalmente reporta características nutricionales, antioxidantes y fitoquímicas en múltiples países, variedades y estados de madurez. El fruto de Physalis peruviana L. contiene una amplia variedad de compuestos bioquímicos.Los witanólidos y sus derivados son los metabolitos más emblemáticos de la especie Physalis, y se ha demostrado que ejercen una amplia gama de actividades farmacológicas in vitro, como inmunomoduladores, inhibidores de la angiogénesis, anticolinesterasa, antioxidantes, antibacterianos y en algunos casos, sus extractos han mostrado citotoxicidad. hacia las células cancerosas. Esta familia de compuestos con columna vertebral esteroidal ha llamado la atención de los farmacólogos, ya que estas lactonas esteroides llamadas conhanólidos y sus derivados se concentran principalmente en las partes aéreas de las plantas, como las hojas. También se detectaron en la pulpa de la fruta, pero en concentraciones bajas y probablemente no estén biodisponibles como tales después de la ingestión oral.Pero la baya dorada es rica en carotenoides, sesquiterpenoides, fitoesteroles entre otros que pueden ser responsables del efecto en la salud observado.
  • 1.2K
  • 30 Sep 2021
Topic Review
Transglutaminase 2
Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme catalyzing the crosslinking between Gln and Lys residues and involved in various pathophysiological events. Besides this crosslinking activity, TG2 functions as a deamidase, GTPase, isopeptidase, adapter/scaffold, protein disulfide isomerase, and kinase. It also plays a role in the regulation of hypusination and serotonylation.
  • 1.2K
  • 11 Aug 2021
Topic Review
Genetic Engineering of Eggplant
Eggplant (Solanum melongena) is the third most important vegetable in Asia and of considerable importance in the Mediterranean belt. Although global eggplant production has been increasing in recent years, productivity is limited due to insects, diseases, and abiotic stresses. Genetic engineering offers new traits to eggplant, such as seedless parthenocarpic fruits, varieties adapted to extreme climatic events (i.e., sub- or supra-optimal temperatures), transcription factor regulation, overexpressing osmolytes, antimicrobial peptides, Bacillusthuringiensis (Bt) endotoxins, etc. 
  • 1.2K
  • 04 Aug 2021
Topic Review
The Proteasome System
The proteasome system is a large and complex molecular machinery responsible for the degradation of misfolded, damaged, and redundant cellular proteins. When proteasome function is impaired, unwanted proteins accumulate, which can lead to several diseases including age-related and neurodegenerative diseases. Enhancing proteasome-mediated substrate degradation with small molecules may therefore be a valuable strategy for the treatment of various neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and Huntington’s diseases. 
  • 1.2K
  • 24 Mar 2022
Topic Review
Bacterial Cellulose
Bacterial cellulose (BC) is a natural polymer that has fascinating attributes, such as biocompatibility, low cost, and ease of processing, being considered a very interesting biomaterial due to its options for moldability and combination. 
  • 1.2K
  • 28 Jan 2021
Biography
Marco Visconti
Marco Visconti (born 4 June 1978) is an Italian occultist and musician.[1] He is known for his work with the musical group XP8[2] and Faderhead.[3] Under the name Azrael[4] Visconti is an past officer[5] of the Thelemic organisation Ordo Templi Orientis (O.T.O.) in London,[6] and scholar of the occult works of English author Aleister Crowley, the founder of the philosophy and religion of Thelema
  • 1.2K
  • 22 Nov 2022
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