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Topic Review
The Gut Microbiome in NAFLD
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease in which environmental and genetic factors are involved. Although the molecular mechanisms involved in NAFLD onset and progression are not completely understood, the gut microbiome (GM) is thought to play a key role in the process, influencing multiple physiological functions. 
  • 1.2K
  • 30 Oct 2020
Topic Review
The Guanyl Radical
Guanyl radical or neutral guanine radical G(-H)• results from the loss of a H-atom or an electron/proton (e–/H+) couple from the guanine structures (G). Guanyl radical G(-H)• exists in two tautomeric forms and its role in single- and double-stranded oligonucleotides, in DNA and G-quadruplex, attracted considerable attention since directly connected to the damage of genetic material and its biological consequences. The emerging picture is still incomplete and extrapolation of its chemistry from nucleosides to more complex environment like DNA can be misleading.
  • 721
  • 20 Jul 2021
Topic Review
The Growing Trend toward Organic Potato Practice
Organic farming differs from conventional agriculture in not using synthetic chemicals. There is no doubt that plant protection issues are the most significant problems encountered in organic potato production. Developing a rotation plan and placing the potato crop in the rotation is critical to growing organic potatoes. The rotational design prevents crop diseases and pest outbreaks.
  • 284
  • 27 Jul 2023
Topic Review
The Golgi Associated Retrograde Protein Complex
The Golgi associated retrograde protein complex (GARP) is an evolutionarily conserved component of Golgi membrane trafficking machinery that belongs to the Complexes Associated with Tethering Containing Helical Rods (CATCHR) family.
  • 690
  • 31 Mar 2023
Topic Review
The Glyoxalase System
The glyoxalase system was discovered over a hundred years ago and since then it has been claimed to provide the role of an indispensable enzyme system in order to protect cells from a toxic byproduct of glycolysis.
  • 1.2K
  • 27 Jan 2021
Topic Review
The Glymphatic System and Neuropathologies
The lack of a conventional lymphatic system that permeates throughout the entire human brain has encouraged the identification and study of alternative clearance routes within the cerebrum. In 2012, the concept of the glymphatic system, a perivascular network that fluidically connects the cerebrospinal fluid to the lymphatic vessels within the meninges via the interstitium, emerged. Although its exact mode of action has not yet been fully characterized, the key underlying processes that govern solute transport and waste clearance have been identified. 
  • 561
  • 02 Feb 2023
Topic Review
The Glycerolipid/NEFA Cycle
Lipotoxicity and glucotoxicity emerged as established mechanisms participating in the pathophysiology of obesity-related type 2 diabetes in general, and in the loss of β-cell function in particular. Glycerolipid/free fatty acid cycle as a protective pathway mediating active storage and recruitment of lipids.
  • 795
  • 29 Mar 2022
Topic Review
The Genus Candida auris
C. auris has unprecedently emerged as a multi-drug resistant fungal pathogen considered a serious global threat due to its potential to cause nosocomial outbreaks and deep-seated infections with staggering transmissibility and mortality, that has put in check the health authorities and institutions worldwide for more than a decade now. Due to its unique features not observed in other yeasts, it has been categorized as an urgent threat by the Centers for Disease Control and Prevention and the rest of international agencies. Moreover, epidemiological alerts have been released in view of the increase of healthcare-associated C. auris outbreaks in the context of the COVID-19 pandemic. This review summarizes the current evidence on C. auris since its first description, from virulence to treatment and outbreak control, and highlights the knowledge gaps and future directions for research efforts. 
  • 862
  • 17 Nov 2021
Topic Review
The Genus Eranthis
Despite the limited geographic range of Eranthis plants, it is possible to search for active substances, develop methods for biological and chemical synthesis of the isolated substances, and create a finished therapeutic substance based on them. Seven out of ~14 species found in Asia and parts of Europe have been studied to various degrees. Here, data are presented on the diversity of sets of chromones, furochromones, triterpene saponins, coumarins, and other classes of secondary metabolites of Eranthis species according to the literature. For new compounds—isolated from Eranthis for the first time—structural formulas are also provided. 
  • 194
  • 23 Nov 2023
Topic Review
The Genus Capsicum
Chili is one of the world’s most widely used horticultural products. Many dishes around the world are prepared using this fruit. The chili belongs to the genus Capsicum and is part of the Solanaceae family. This fruit has essential biomolecules such as carbohydrates, dietary fiber, proteins, and lipids. In addition, chili has other compounds that may exert some biological activity (bioactivities).
  • 545
  • 09 Jun 2023
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