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Topic Review
The Mediterranean Diet
A cornerstone of any healthy lifestyle program is the inclusion of a balanced diet that can prevent various diseases, including cardiovascular conditions. The Mediterranean diet (MD) has become one of the most studied and widely reported diets and has received a lot of attention. The MD is a dietary plan based on Crete’s traditional eating habits. 
  • 335
  • 25 Oct 2023
Topic Review
The Medicinal Mushroom Cordyceps militaris
Cordyceps militaris is an entomopathogenic ascomycete with similar pharmacological importance to that of the wild caterpillar fungus Ophiocordyceps sinensis C. militaris has attracted significant research and commercial interest due to its content in bioactive compounds beneficial to human health and the relative ease of cultivation under laboratory conditions. 
  • 623
  • 29 Mar 2022
Topic Review
The Mechanisms of cGAS-STING Pathway-Induced Apoptosis
The cGAS–STING signaling axis can be activated by cytosolic DNA, including both non-self DNA and self DNA. This axis is used by the innate immune system to monitor invading pathogens and/or damage. Increasing evidence has suggested that the cGAS-STING pathway not only facilitates inflammatory responses and the production of type I interferons (IFN), but also activates other cellular processes, such as apoptosis.
  • 292
  • 23 Apr 2023
Topic Review
The Marine Actinomycetes
The phylum Actinomycetota (Actinobacteria) is one of the main branches or lineages of bacteria gifted with antibiotic producing capabilities. Marine actinomycetes are emerging as a promising candidate for bioactive metabolites, encompassing very complex compounds with pharmacological activities. Genomic insights of marine actinomycetes further revealed their immense biosynthetic potential. Cultivation and fermentation of marine actinomycetes requires expertise on their physiological characteristics and optimum growth conditions or requirements. 
  • 1.5K
  • 19 Jul 2022
Topic Review
The MAMs Structure
Mitochondria-associated membranes (MAMs) play a vital role in the complex crosstalk between the ER and mitochondria. MAMs are known to play an important role in lipid synthesis, the regulation of Ca2+ homeostasis, the coordination of ER-mitochondrial function, and the transduction of death signals between the ER and the mitochondria. 
  • 506
  • 10 May 2021
Topic Review
The Mammalian Thioredoxin Reductase Probes
The cardinal component of the thioredoxin system, mammalian thioredoxin reductase (TrxR) plays a vital role in supporting various physiological functions; however, its malfunction, disrupting redox balance, is intimately associated with the pathogenesis of multiple diseases. Fluorescent probes offer several advantages for in situ imaging and the quantification of biological targets, such as non-destructiveness, real-time analysis, and high spatiotemporal resolution. These benefits facilitate the transition from a poise to a flux understanding of cellular targets, further advancing scientific studies in related fields. The TrxR fluorescent probes have contributed significantly to the investigation of TrxR’s biological functions and have been valuable tools in TrxR-related research.
  • 172
  • 24 Aug 2023
Topic Review
The MAL Protein
The MAL gene encodes a 17-kDa protein containing four putative transmembrane segments whose expression is restricted to human T cells, polarized epithelial cells and myelin-forming cells. It organizes condensed membranes to make them functional in specialized pathways of membrane trafficking and cell signaling.
  • 530
  • 20 May 2021
Topic Review
The Major Types of Non-Coding RNAs
Non-coding RNAs (ncRNAs) encompass all RNAs that are not translated into proteins. They are classified by features such as length and structure, and include microRNAs (miRs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs).
  • 450
  • 01 Feb 2023
Topic Review
the Major Facilitator Superfamily
Bacterial pathogens are serious causative agents of infectious disease. Such microorganisms are resistant to multiple antimicrobial agents, thereby compromising the therapeutic efficacy of treatment.  Multidrug-resistant pathogens harbor antimicrobial efflux pumps, many transporters of which are members of the extensive major facilitator superfamily of proteins. These bacterial multidrug efflux pumps are good molecular targets for modulation and possible inhibition.  This entry briefly discusses several current developments for drug efflux pump modulation. 
  • 1.2K
  • 27 Oct 2020
Topic Review
The Main Protease of SARS-CoV-2 and its inhibitors
Mpro, also known as 3-chymotrypsin-like protease (3CLpro), is a 33.8 kDa, three-domain cysteine protease, essential for proteolytic maturation and viral replication of coronaviruses. This enzyme is an excellent target for a potential drug, as it is essential for viral replication and has no closely related homologues in humans, making its inhibitors unlikely to be toxic. 
  • 586
  • 08 Aug 2022
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