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Topic Review
Holobiont
A holobiont is an assemblage of a host and the many other species living in or around it, which together form a discrete ecological unit, though there is controversy over this discreteness. The components of a holobiont are individual species or bionts, while the combined genome of all bionts is the hologenome. The concept of the holobiont was initially defined by Dr. Lynn Margulis in her 1991 book Symbiosis as a Source of Evolutionary Innovation, though the concept has subsequently evolved since the original definition. Holobionts include the host, virome, microbiome, and other members, all of which contribute in some way to the function of the whole. Well-studied holobionts include reef-building corals and humans.
  • 5.7K
  • 14 Oct 2022
Topic Review
Vitamin D Synthesis and Metabolism
Vitamin D, conventionally considered a nutrient, is a potent hormone regulating many physiological functions. Vitamin D exists as a prohormone that needs to be transformed into biologically active products that bind to their cognate nuclear receptors to regulate diverse physiological processes.
  • 5.7K
  • 13 Apr 2022
Topic Review
Land Suitability Assessment
Land suitability assessment is a method of land evaluation, which identifies the major limiting factors for planting a particular crop. Land suitability assessment includes qualitative and quantitative evaluation. In the qualitative land suitability evaluations, information about climate, hydrology, topography, vegetation, and soil properties is considered and in quantitative assessment, the results are more detailed and yield is estimated. At present study we prepared land suitability assessment map for rain-fed wheat and barley crops based on FAO "land suitability assessment framework" using parametric method and machine learning algorithms in Kurdistan Province, located in west of Iran. This is a unique study that compared two machine learning-based and traditional-based approaches for mapping current and potential future land suitability classes. Moreover, potential yield of rain-fed wheat and barley crop were computed by FAO model.
  • 5.7K
  • 30 Oct 2020
Topic Review
Melatonin Protects Mitochondria and Adenosine Triphosphate Production
Melatonin (N-acetyl-5-methoxytryptamine) is a ubiquitous, mitochondria-targeted molecule present in all tested eukarya and bacteria. In March 2022, the first discovery of the serotonin N-acetyltransferase (SNAT) gene—responsible for the penultimate formation of N-acetylserotonin (NAS) before its final conversion into melatonin — in archaea further consolidates the status of melatonin as a regulator of biomolecular condensates in all three domains of life in the cellular empire. RNA viruses including SARS-CoV-2 contain proteins with intrinsically disordered regions that undergo liquid-liquid phase separation (LLPS). Liquid-liquid phase separation (LLPS) of these proteins form membraneless condensates that act as “viral factories” to facilitate and enhance replication. Phase separation of the SARS-CoV-2 nucleocapsid (N) protein is associated with mitochondrial dysfunction and rewiring of energy production away from oxidative phosphorylation (OXPHOS) to favor aerobic glycolysis in cytoplasm. Increased adenosine triphosphate (ATP) in cytoplasm supports viral replication. Melatonin protects mitochondria from damage, maintains adequate levels to disassemble “viral factories”, and prevents suppression of host antiviral immune responses by inhibiting nucleocapsid phase separation via antioxidant-dependent and -independent means.
  • 5.6K
  • 05 Sep 2022
Topic Review
Brainstem Encephalitis
Brainstem encephalitis refers to inflammatory diseases affecting the midbrain, pons, and medulla oblongata. The causes of brainstem encephalitis include infections, autoimmune diseases, and paraneoplastic syndromes. Listeria is a common etiology of infectious rhombencephalitis. The trigeminal nerve has been proposed as a pathway through which Listeria monocytogenes reaches the brainstem after entering damaged oropharyngeal mucosa or periodontal tissues. Listeria monocytogenes may also invade the brainstem along the vagus nerve after it infects enteric neurons in the walls of the gastrointestinal tract.
  • 5.6K
  • 22 Oct 2020
Topic Review
Intercropping
Intercropping ensures multiple benefits like enhancement of yield, environmental security, production sustainability and greater ecosystem services. In intercropping, two or more crop species are grown concurrently such that they coexist for a significant part of the crop cycle and interact among themselves and with agro-ecosystems.
  • 5.6K
  • 09 Jan 2022
Topic Review
Type 3 Diabetes
The exact connection between Alzheimer’s disease (AD) and type 2 diabetes is still in debate. However, poorly controlled blood sugar may increase the risk of developing Alzheimer’s. This relationship is so strong that some have called Alzheimer’s “diabetes of the brain” or “type 3 diabetes (T3D)”. Given more recent studies continue to indicate evidence linking T3D with AD, this state-of-the-art aimed to demonstrate the relationship between T3D and AD based on the fact that both the processing of amyloid-β (Aβ) precursor protein toxicity and the clearance of Aβ are attributed to impaired insulin signaling, and that insulin resistance mediates the dysregulation of bioenergetics and progress to AD. 
  • 5.6K
  • 29 Oct 2020
Topic Review
Inocybe Mushrooms Poisoning
Mushroom poisoning has always been a threat to human health. There are a large number of reports about ingestion of poisonous mushrooms every year around the world. It attracts the attention of researchers, especially in the aspects of toxin composition, toxic mechanism and toxin application in poisonous mushroom. Inocybe is a large genus of mushrooms and contains toxic substances including muscarine, psilocybin, psilocin, aeruginascin, lectins and baeocystin. In order to prevent and remedy mushroom poisoning, it is significant to clarify the toxic effects and mechanisms of these bioactive substances. 
  • 5.5K
  • 10 Mar 2021
Topic Review
Sweet Corn
Sweet corn (Zea mays convar. saccharata var. rugosa; also called sweetcorn, sugar corn and pole corn) is a cereal with a high sugar content. Sweet corn is the result of a naturally occurring recessive mutation in the genes which control conversion of sugar to starch inside the ENO of the corn kernel. Unlike field corn varieties, which are harvested when the kernels are dry and mature (dent stage), sweet corn is picked when immature (milk stage) and prepared and eaten as a vegetable, rather than a grain. Since the process of maturation involves converting sugar to starch, sweet corn stores poorly and must be eaten fresh, canned, or frozen, before the kernels become tough and starchy. It is one of the six major types of corn, the others being dent corn, flint corn, pod corn, popcorn, and flour corn.
  • 5.5K
  • 09 Oct 2022
Topic Review
Fruit Carving
Fruit carving is the art of carving fruit, a very common technique in Europe and Asian countries, and particularly popular in Thailand, China and Japan. There are many fruits that can be used in this process; the most popular one that artists use are watermelons, apples, strawberries, pineapples, and cantaloupes.
  • 5.5K
  • 11 Nov 2022
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