Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
Preimplantation Genetic Testing for Cancer Predisposition Syndromes
Cancer Predisposition Syndromes (CPSs), also known as Hereditary Cancer Syndromes (HCSs), represent a group of genetic disorders associated with an increased lifetime risk of developing cancer.
  • 267
  • 20 Nov 2023
Topic Review
Bioactive Compounds of Portuguese Fruits
The European Union has established two designations, Protected Designation of Origin (PDO) and Protected Geographical Indication (PGI), to guarantee the authenticity of products with valued specificities associated with the regions where they are produced. The valorization of these products, particularly fruits, not only preserves their natural origins but also promotes the cultivalion of specific regional fruit varieties. This contributes to the preservation of biodiversity and the development of innovative bio-based products in the regions of production. Substantial efforts have been made to characterize PDO and PGI fruits, particularly in relation to the presence of bioactive compounds with antioxidant and antimicrobial properties. 
  • 293
  • 20 Nov 2023
Topic Review
Neurological Effects of Kratom
Kratom (Mitragyna speciosa Korth. Havil) has been considered a narcotic drug for years, barred by the law in many parts of the world, while extensive research over the past few decades proves its several beneficial effects, some of which are still in ambiguity. In many countries, including Thailand, the indiscriminate use and abuse of kratom have led to the loss of life. Nonetheless, researchers have isolated almost fifty pure compounds from kratom, most of which are alkaloids. The most prevalent compounds, mitragynine and 7-hydroxy mitragynine, are reported to display agonist morphine-like effects on human μ-opioid receptors and antagonists at κ- and δ-opioid receptors with multimodal effects at other central receptors.
  • 846
  • 20 Nov 2023
Topic Review
PTSD Understanding and Treatment
Memories are a central aspect of our lives, but the mechanisms underlying their formation, consolidation, retrieval, and extinction remain poorly understood.
  • 120
  • 20 Nov 2023
Topic Review
From Shallow to Deep Bioprocess Hybrid Modeling
Hybrid neural network (HNN)  modeling is the combination of artificial neural networks (ANNs) with prior knowledge in a mathematical framework. There are two main approaches to incorporating prior knowledge: design and training methods. Design approaches use prior knowledge to define the network structure, while training approaches use it to guide parameter estimation. Both approaches reduce data dependency, making models less sensitive to sparse and noisy data, and improving their descriptive and predictive capabilities compared to pure ANNs. HNNs are a powerful tool for understanding complex processes like bioprocesses and accelerating product development. Bioprocess modeling is challenging due to nonlinearity, dynamics, and uncertainty. Traditional models based on physical and chemical laws can be overly simplistic or hard to calibrate. Data-driven ANN models lack interpretability and generalization. HNNs combine the strengths of both approaches, enhancing the accuracy, robustness, and efficiency of bioprocess modeling by integrating prior knowledge with ANNs.
  • 243
  • 20 Nov 2023
Topic Review
Use of Aptamers for Targeted Theranostic in Cancer
Aptamers are short, single-stranded oligonucleotides synthesized in vitro from a randomized oligonucleotide library against a specific target. These molecules are capable of binding to a wide range of biological targets with high specificity and affinity. They present great advantages over antibodies with potential applications in research, diagnosis, and therapeutics. Specifically for tumors with late-stage identification and poor prognosis, like pancreatic cancer, the study of novel aptamers holds tremendous potential for cancer diagnosis and treatment. Along with cancer treatment, aptamers have also shown high potential in regulating the immune response and modulating several critical steps of signaling cascades, such as in immune checkpoints.
  • 153
  • 20 Nov 2023
Topic Review
Implications of Rectal Cancer Radiotherapy on Immune Microenvironment
The efficiency of (chemo-)radiotherapy for rectal cancer is not only determined by the impact on the tumor cells themselves, but also by the highly individual surrounding tumor microenvironment, including immune cells. However, many aspects of the radiation-induced immune response remain to be fully understood. 
  • 222
  • 20 Nov 2023
Topic Review
Biomimetic Nerve Guidance Conduits for Peripheral Nerve Regeneration
Injuries to the peripheral nervous system are a common clinical issue, causing dysfunctions of the motor and sensory systems. Surgical interventions such as nerve autografting are necessary to repair damaged nerves. Even with autografting, i.e., the gold standard, malfunctioning and mismatches between the injured and donor nerves often lead to unwanted failure. Thus, there is an urgent need for a new intervention in clinical practice to achieve full functional recovery. Nerve guidance conduits (NGCs), providing physicochemical cues to guide neural regeneration, have great potential for the clinical regeneration of peripheral nerves. Typically, NGCs are tubular structures with various configurations to create a microenvironment that induces the oriented and accelerated growth of axons and promotes neuron cell migration and tissue maturation within the injured tissue. Once the native neural environment is better understood, ideal NGCs should maximally recapitulate those key physiological attributes for better neural regeneration.
  • 204
  • 20 Nov 2023
Topic Review
Transformations of Elemental Sulfur in Soil
Sulfur is an essential element in determining the productivity and quality of agricultural products. It is also an element associated with tolerance to biotic and abiotic stress in plants. In agricultural practice, sulfur has broad use in the form of sulfate fertilizers and, to a lesser extent, as sulfite biostimulants.
  • 267
  • 20 Nov 2023
Topic Review
Selenium and Sulfur to Produce Allium Functional Crops
Selenium is an element that must be considered in the nutrition of many crops since its use allows the obtaining of biofortified crops with a positive impact on human health. 
  • 119
  • 20 Nov 2023
  • Page
  • of
  • 1815
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
ScholarVision Creations
Feedback