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Topic Review
Space Weather on Human Physiopathology
While the exact nature and mechanisms of action still need to be better understood, some adverse effects of space weather have been related to the occurrence of magnetic storms. Triggered by solar emissions, it takes about one to three days for the effects to be felt on Earth, thus leaving enough time for a warning to be issued. Such a warning system is already in place, for instance in aviation and other human endeavors. Applications in the healthcare system have also emerged. Precisely because non-photic environmental cycles are notoriously wobbly, mapping their non-stationary characteristics in specific frequency ranges as they change over time may lay the foundation to research which features of space weather may influence what aspects of human physio-pathology. Mapping long-term periodicities shared between the environment and biota will facilitate making connections between the presence of non-photic cycles in the cosmos, how they may be affecting the ionosphere and influence weather on Earth, and how these changes can impact agriculture, nutrition, the presence of pathogens, and overall human health.
  • 1.2K
  • 30 Oct 2020
Topic Review
Planctomycetes
The Planctomycetes are a phylum of widely distributed bacteria, occurring in both aquatic and terrestrial habitats. They play a considerable role in global carbon and nitrogen cycles, with many species of this phylum capable of anaerobic ammonium oxidation, also known as anammox. Many planctomycetes occur in relatively high abundance as biofilms, often associating with other organisms such as macroalgae and marine sponges. Planctomycetes are included in the PVC superphylum along with Verrucomicrobia, Chlamydiae, Lentisphaerae, Kiritimatiellaeota, and Candidatus Omnitrophica. The phylum Planctomycete is composed of the classes Planctomycetia and Phycisphaerae. First described in 1924, members of the Planctomycetes were identified as eukaryotes and were only later described as bacteria in 1972. Early examination of members of the Planctomycetes suggested a cell plan differing considerably from other bacteria, although they are now confirmed as Gram-negative bacteria, but with many unique characteristics. Bacteria in the Planctomycetes are often small, spherical cells, but a large amount of morphological variation is seen. Members of the Planctomycetes also display distinct reproductive habits, with many species dividing by budding, in contrast to all other free-living bacteria, which divide by binary fission. Interest is growing in the Planctomycetes regarding biotechnology and human applications, mainly as a source of bioactive molecules. In addition, some Planctomycetes were recently described as human pathogens. The species Gemmata obscuriglobus has been identified specifically as comprising bacteria with unique characteristics among the Planctomycetes, such as their ability to synthesize sterols.
  • 1.2K
  • 16 Nov 2022
Topic Review
Golden Berry Fruit and Insulin
La baya dorada (Physalis peruviana L.) es una fruta de gran importancia comercial en algunos países africanos y latinoamericanos, donde se consume localmente y con frecuencia se exporta a los mercados del norte, principalmente Europa y Estados Unidos. Esta fruta tradicionalmente reporta características nutricionales, antioxidantes y fitoquímicas en múltiples países, variedades y estados de madurez. El fruto de Physalis peruviana L. contiene una amplia variedad de compuestos bioquímicos.Los witanólidos y sus derivados son los metabolitos más emblemáticos de la especie Physalis, y se ha demostrado que ejercen una amplia gama de actividades farmacológicas in vitro, como inmunomoduladores, inhibidores de la angiogénesis, anticolinesterasa, antioxidantes, antibacterianos y en algunos casos, sus extractos han mostrado citotoxicidad. hacia las células cancerosas. Esta familia de compuestos con columna vertebral esteroidal ha llamado la atención de los farmacólogos, ya que estas lactonas esteroides llamadas conhanólidos y sus derivados se concentran principalmente en las partes aéreas de las plantas, como las hojas. También se detectaron en la pulpa de la fruta, pero en concentraciones bajas y probablemente no estén biodisponibles como tales después de la ingestión oral.Pero la baya dorada es rica en carotenoides, sesquiterpenoides, fitoesteroles entre otros que pueden ser responsables del efecto en la salud observado.
  • 1.2K
  • 30 Sep 2021
Topic Review
Bile Acids in Retinal Diseases
Bile acids (BAs) are amphipathic sterols primarily synthesized from cholesterol in the liver and released in the intestinal lumen upon food intake. BAs play important roles in micellination of dietary lipids, stimulating bile flow, promoting biliary phospholipid secretion, and regulating cholesterol synthesis and elimination. Emerging evidence, however, suggests that, aside from their conventional biological function, BAs are also important signaling molecules and therapeutic tools. In the last decade, the therapeutic applications of BAs in the treatment of ocular diseases have gained great interest. 
  • 1.2K
  • 22 Sep 2021
Topic Review
O-Acetyl Sialylation
The recently emerged SARS-CoV-2 is the cause of the global health crisis of the coronavirus disease 2019 (COVID-19) pandemic. No evidence is yet available for CoV infection into hosts upon zoonotic disease outbreak, although the CoV epidemy resembles influenza viruses, which use sialic acid (SA). Currently, information on SARS-CoV-2 and its receptors is limited. O-acetylated SAs interact with the lectin-like spike glycoprotein of SARS CoV-2 for the initial attachment of viruses to enter into the host cells. SARS-CoV-2 hemagglutinin-esterase (HE) acts as the classical glycan-binding lectin and receptor-degrading enzyme. Most β-CoVs recognize 9-O-acetyl-SAs but switched to recognizing the 4-O-acetyl-SA form during evolution of CoVs. Type I HE is specific for the 9-O-Ac-SAs and type II HE is specific for 4-O-Ac-SAs. The SA-binding shift proceeds through quasi-synchronous adaptations of the SA-recognition sites of the lectin and esterase domains. The molecular switching of HE acquisition of 4-O-acetyl binding from 9-O-acetyl SA binding is caused by protein–carbohydrate interaction (PCI) or lectin–carbohydrate interaction (LCI). The HE gene was transmitted to a β-CoV lineage A progenitor by horizontal gene transfer from a 9-O-Ac-SA–specific HEF, as in influenza virus C/D. HE acquisition, and expansion takes place by cross-species transmission over HE evolution. This reflects viral evolutionary adaptation to host SA-containing glycans. Therefore, CoV HE receptor switching precedes virus evolution driven by the SA-glycan diversity of the hosts. The PCI or LCI stereochemistry potentiates the SA–ligand switch by a simple conformational …
  • 1.2K
  • 26 Oct 2020
Topic Review
Candida Infection
Candida species are common global opportunistic pathogens that could repeatedly and chronically cause oral mucosa infection and create an inflammatory environment, leading to organ dysfunction. Oral Candida infections may cause temporary or permanent damage to salivary glands, resulting in the destruction of acinar cells and the formation of scar tissue. Restricted function of the salivary glands leads to discomfort and diseases of the oral mucosa, such as dry mouth and associated infection.
  • 1.2K
  • 23 Feb 2021
Topic Review
Teak Allelopathy and Agroforestry
Teak (Tectona grandis L.f.) is one of the most valuable timber species, and is cultivated in agroforestry systems in many countries across the tropical and subtropical regions of the world.
  • 1.2K
  • 09 Jan 2022
Topic Review
Poxviruses
Poxviruses possess a single, linear double-stranded DNA (dsDNA) genome, which ranges in size from 127 to 456 kb and encodes several hundred gene products. Unlike most other DNA viruses, poxviruses replicate exclusively within the cytoplasm of permissive cells.
  • 1.2K
  • 24 Jul 2021
Topic Review
LCA of Edible Flower Production
The globalization of the floricultural sector creates more competition, challenging the innovation and reorganization of some ornamental and horticultural nurseries, which started to look at flowers as food products. This research aims to quantify the environmental impact of the emerging productive process of edible flowers through the LCA – Life Cycle Analysis method, due to the higher awareness towards sustainability. Two model species and two types of final products were chosen, using a “cradle to gate” approach.
  • 1.2K
  • 26 Oct 2020
Topic Review
Application of Environmental Enrichment Strategies in Sea Turtles
Environmental enrichment (EE) is a series of techniques and methods aimed to improve the welfare of animals in captivity and/or under rehabilitation. It uses external stimuli to enhance their psychological and physiological wellbeing to promote natural abilities and behaviors.
  • 1.2K
  • 09 Feb 2022
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