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Topic Review
PCR and NGS in Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a clonal disorder that affects myeloid progenitor cells residing in the bone marrow (BM). This implies altered differentiation with subsequent abnormal proliferation and accumulation of inadequately matured myeloid cells. The detection of leukemic cells moved in the last two decades from immune-phenotyping to polymerase chain reaction (PCR) and real-time quantitative PCR (RT-qPCR). This technique was shown to be reproducible, accurate and highly sensitive for MRD monitoring, with a significant capacity in predicting prognosis, treatment effectiveness and relapse risk. NGS or massively parallel sequencing is a revolutionary method of DNA and RNA sequencing. It is called parallel because it sequences millions of DNA fragments simultaneously. In the early years of its appearance, Next Generation Sequencing (NGS) platforms were used primarily for cancer research purposes. Recently, they are increasingly emerging as irreplaceable diagnostic tools in clinical settings.
  • 1.7K
  • 10 Feb 2022
Topic Review
High-Throughput Sequencing in Aptamer selection
Aptamers, short single-stranded DNA or RNA molecules capable of specific binding to a target of interest, are gaining in research interest due to their versatile application potential as analytical, diagnostic, and therapeutics agents.
  • 1.7K
  • 05 Feb 2021
Topic Review
DOF Transcription Factors in Seed
The DOF (DNA BINDING WITH ONE FINGER) family of plant-specific TF (transcription factors) was first identified in maize in 1995. Since then, DOF proteins have been shown to be present in the whole plant kingdom, including the unicellular alga Chlamydomonas reinhardtii. The DOF TF family is characterised by a highly conserved DNA binding domain (DOF domain), consisting of a CX2C-X21-CX2C motif, which is able to form a zinc finger structure. Early in the study of DOF proteins, their relevance for seed biology became clear. Indeed, the PBF (PROLAMIN BINDING FACTOR), one of the first DOF proteins characterised, controls the endosperm-specific expression of the zein genes in maize. Subsequently, several DOF proteins from both monocots and dicots have been shown to be primarily involved in seed development, dormancy and germination, as well as in seedling development and other light-mediated processes. In the last two decades, the molecular network underlying these processes have been outlined, and the main molecular players and their interactions have been identified. In this review, we will focus on the DOF TFs involved in these molecular networks, and on their interaction with other proteins.  
  • 1.7K
  • 28 Oct 2020
Topic Review
Plant-Based Diet
In recent decades, the food industry has been faced with new challenges and it has had to develop new types of diets and produce new types of foods that can slow down the spread of chronic diseases. The aim of our research is to identify the characteristics of plant-based nutrition based on international and Hungarian literature. The comprehensive analysis has been performed based on the theoretical model called Theory of Planned Behavior, in the course of which the perceived and objective benefits of and barriers to the conversion to a plant-based diet have been examined. According to our results, the main benefits of plant-based nutrition are its many factors associated with a reduction in risk of developing numerous chronic diseases. This is followed by benefits of well-being and satisfaction, followed by ethical and environmental benefits. The most commonly reported inhibitory factor of a vegetarian diet is the enjoyment of eating meat and the difficulty in giving up meat consumption. This is followed by health considerations, e.g., lack of various ingredients in foods. Convenience and taste factors are also important disincentives as well as the irrelevant nature of some plant-based nutrition information sources. Besides, social barriers, negative discrimination and negative effect of mental health associated with them can also be a hindrance, as can financial barriers. The classification developed during our analysis can serve as a relevant guideline for decision-makers, and also as a basis for further primary qualitative and quantitative research.
  • 1.7K
  • 27 Oct 2020
Topic Review
Wink
A wink is a facial expression made by briefly closing one eye. A wink is an informal mode of non-verbal communication usually signaling shared hidden knowledge or intent. However, it is ambiguous by itself and highly dependent upon additional context, without which a wink could become misinterpreted or even nonsensical. For example, in some regions of the world, a wink may be considered rude or offensive. And depending on the relationship of the people involved, a wink could possibly constitute a sexual gesture.
  • 1.7K
  • 07 Oct 2022
Biography
Sabine Hossenfelder
Sabine Hossenfelder (born 18 September 1976) is a German author and theoretical physicist who researches quantum gravity. She is a Research Fellow at the Frankfurt Institute for Advanced Studies where she leads the Superfluid Dark Matter group. She is the author of Lost in Math: How Beauty Leads Physics Astray, which explores the concept of elegance in fundamental physics and cosmology. Hosse
  • 1.7K
  • 15 Nov 2022
Topic Review
L-Carnitine in Autism Spectrum Disorder
L-carnitine plays an important role in the functioning of the central nervous system, and especially in the mitochondrial metabolism of fatty acids. Altered carnitine metabolism, abnormal fatty acid metabolism in patients with autism spectrum disorder (ASD) has been documented. ASD is a complex heterogeneous neurodevelopmental condition that is usually diagnosed in early childhood. Patients with ASD require careful classification as this heterogeneous clinical category may include patients with an intellectual disability or high functioning, epilepsy, language impairments, or associated Mendelian genetic conditions. L-carnitine participates in the long-chain oxidation of fatty acids in the brain, stimulates acetylcholine synthesis (donor of the acyl groups), stimulates expression of growth-associated protein-43, prevents cell apoptosis and neuron damage and stimulates neurotransmission.
  • 1.7K
  • 16 May 2022
Topic Review
Evolution of the Domesticated Cat
The domestic cat originated from Near-Eastern and Egyptian populations of the African wildcat, Felis sylvestris lybica. The family Felidae, to which all living feline species belong, arose about ten to eleven million years ago. This family is divided into eight major phylogenetic lineages. The domestic cat is a member of the Felis lineage. A number of investigations have shown that all domestic varieties of cats come from a single species of the Felis lineage, Felis catus. Variations of this lineage are found all over the world and up until recently scientists have had a hard time pinning down exactly which region gave rise to modern domestic cat breeds. Scientists believed that it was not just one incident that led to the domesticated cat but multiple, independent incidents at different places that led to these breeds. More complications arose from the fact that the wildcat population as a whole is very widespread and very similar to one another. These variations of wild cat can and will interbreed freely with one another when in close contact, further blurring the lines between taxa. Recent DNA studies, advancement in genetic technologies, and a better understanding of DNA and genetics as a whole has helped make discoveries in the evolutionary history of the domestic cat.
  • 1.7K
  • 25 Nov 2022
Topic Review
Rational Vaccine Design
Vaccines are the most effective medical intervention due to their continual success in preventing infections and improving mortality worldwide. Early vaccines were developed empirically however, rational design of vaccines can allow us to optimise their efficacy, by tailoring the immune response. Establishing the immune correlates of protection greatly informs the rational design of vaccines. This facilitates the selection of the best vaccine antigens and the most appropriate vaccine adjuvant to generate optimal memory immune T cell and B cell responses. This review outlines the range of vaccine types that are currently authorised and those under development. We outline the optimal immunological correlates of protection that can be targeted. 
  • 1.7K
  • 29 Apr 2021
Topic Review
Roof Plate in Neural Development
The roof plate is the most dorsal region of the neural tube. The Roof plate serves as an organizing center that controls proliferation and differentiation of dorsal interneurons. In addition, this region is involved in development of neural crest cells, which are the source of migratory neural crest cells. During early development of the spinal cord, roof plate cells secrete signaling molecules, such as Wnt and BMP family proteins, which regulate development of neural crest cells and dorsal spinal cord. After the dorso-ventral pattern is established, spinal cord dynamically changes its morphology. With this morphological transformation, the lumen of the spinal cord gradually shrinks to form the central canal. Accompanied by formation of the central canal, roof plate cells dramatically stretch along the dorso-ventral axis. During this stretching process, the tips of roof plate cells maintain contact with cells surrounding the shrinking lumen of the spinal cord, eventually exposed to the inner surface of the central canal. In this late stage of the spinal cord development, Wnt secreted by stretched roof plate cells regulates transformation of roof plate cells themselves and promotes proliferation of ependymal cells surrounding the central canal, including neural progenitor cells, in the spinal cord.
  • 1.7K
  • 05 Aug 2021
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