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Topic Review
Plant Tissue Culture and Breeding of Asparagus
In vitro plant tissue culture and biotechnology used to assist and support the development of plant breeding when classical methods of propagation must be accelerated or it was necessary to overcome barriers inaccessible by classical approaches. In asparagus, to improve multiple breeding tasks, a high number of in vitro methods have been used, such as plant regeneration methods through organogenesis, embryogenesis, manipulation of ploidy, protoplast isolation, genetic manipulation (protoplast fusion, genetic transformation), embryo rescue and germplasm preservation (in vitro, in vitro slow growth, cryopreservation). Plant tissue culture methods can overcome multiple problems in asparagus breeding such as, barriers of self and cross-incompatibility between asparagus species through embryo rescue of interspecific hybrids and protoplast fusion or genetic transformation, introgression of new genes, clonal propagation of elite genotypes of asparagus, mass screening, and the generation of haploid and polyploid genotypes, among others, becoming the tool of choice for asparagus breeding programs. Some of these in vitro methods are still under development.
  • 1.2K
  • 23 May 2022
Topic Review
Ratio of Fatty Acids in Different Foods
The biological effects of the ω-3 and ω-6 fatty acids are mediated by their mutual interactions, but it is unclear whether the dietary ratio of omega-3 fatty acids and omega-6 fatty acids is important for human health.
  • 1.2K
  • 21 Nov 2022
Topic Review
Delivery Platforms for miRNA-Based Cancer Therapeutics
Restoration of microRNA (miRNA) expression or downregulation of aberrantly expressed miRNAs using miRNA mimics or anti-miRNA inhibitors (anti-miRs/antimiRs), respectively, continues to show therapeutic potential for the treatment of cancer. Although the manipulation of miRNA expression presents a promising therapeutic strategy for cancer treatment, it is predominantly reliant on nucleic acid-based molecules for their application, which introduces an array of hurdles, with respect to in vivo delivery. Because naked nucleic acids are quickly degraded and/or removed from the body, they require delivery vectors that can help overcome the many barriers presented upon their administration into the bloodstream.
  • 1.2K
  • 25 Aug 2022
Topic Review
Monkeys in Chinese Culture
Monkeys, particularly macaques and monkey-like gibbons, have played significant roles in Chinese culture for over two thousand years. Some examples familiar to English speakers include the zodiacal Year of the Monkey, the Monkey King Sun Wukong in the novel Journey to the West, and Monkey Kung Fu.
  • 1.2K
  • 25 Nov 2022
Topic Review
Paeonia Suffruticosa
Paeonia suffruticosa is a name used for a group of culture varieties of tree peonies that are the result of hybridisation with species exclusively belonging to the subsection Vaginatae. The common name used in China is mǔdān (Chinese: 牡丹). Plants belonging to this group have been cultivated for millennia in China, initially only as a source of traditional Chinese medicine particularly the skin of its roots (牡丹皮; mǔdān pí). Already early on the plant was also cultivated for its ornamental value, and it is highly revered in Chinese culture.
  • 1.2K
  • 30 Nov 2022
Topic Review
Mechanisms and Impact of Biofilms
Biofilms comprising aggregates of microorganisms or multicellular communities have been a major issue as they cause resistance against antimicrobial agents and biofouling. To date, numerous biofilm-forming microorganisms have been identified, which have been shown to result in major effects including biofouling and biofilm-related infections. Quorum sensing (which describes the cell communication within biofilms) plays a vital role in the regulation of biofilm formation and its virulence. As such, elucidating the various mechanisms responsible for biofilm resistance (including quorum sensing) will assist in developing strategies to inhibit and control the formation of biofilms in nature. Employing biological control measures (such as the use of bioactive compounds) in targeting biofilms is of great interest since they naturally possess antimicrobial activity among other favorable attributes and can also possibly act as potent antibiofilm agents.
  • 1.2K
  • 13 Oct 2021
Topic Review
Cerberin
Cerberin is a type of cardiac glycoside, a steroidal class found in the seeds of the dicotyledonous angiosperm genus Cerbera; including the suicide tree (Cerbera odollam) and the sea mango (Cerbera manghas). This class includes digitalis-like agents, channel-blockers that as a group have found historic uses as cardiac treatments, but which at higher doses are extremely toxic; in the case of cerberin, consumption of the C. odollam results in poisoning with presenting nausea, vomiting, and abdominal pain, often leading to death. The natural product has been structurally characterized, its toxicity is clear—it is often used as an intentional human poison in third-world countries, and accidental poisonings with fatalities have resulted from individuals even indirectly consuming the agent—but its potentially therapeutic pharmacologic properties are very poorly described.
  • 1.2K
  • 10 Nov 2022
Topic Review
DNA Dyes
Cell quantification is widely used both in basic and applied research. A typical example of its use is drug discovery research. Presently, plenty of methods for cell quantification are available. In this review, the basic techniques used for cell quantification, with a special emphasis on techniques based on fluorescent DNA dyes, are described. 
  • 1.2K
  • 23 Sep 2021
Topic Review
Flashbulb Memory
A flashbulb memory is a highly detailed, exceptionally vivid "snapshot" of the moment and circumstances in which a piece of surprising and consequential (or emotionally arousing) news was learned about. The term "flashbulb memory" suggests the surprise, indiscriminate illumination, detail, and brevity of a photograph; however flashbulb memories are only somewhat indiscriminate and are far from complete. Evidence has shown that although people are highly confident in their memories, the details of the memories can be forgotten. Flashbulb memories are one type of autobiographical memory. Some researchers believe that there is reason to distinguish flashbulb memories from other types of autobiographical memory because they rely on elements of personal importance, consequentiality, emotion, and surprise. Others believe that ordinary memories can also be accurate and long-lasting if they are highly distinctive, personally significant, or repeatedly rehearsed. Flashbulb memories have six characteristic features: place, ongoing activity, informant, own affect, other affect, and aftermath. Arguably, the principal determinants of a flashbulb memory are a high level of surprise, a high level of consequentiality, and perhaps emotional arousal.
  • 1.2K
  • 17 Nov 2022
Topic Review
PH-Sensitive Cubosome Liquid Crystalline Nanocarriers
Cubosomes are soft biocontinuous nanoparticles whose 3D geometry can be engineered to render the structures responsive to pH variations, which is of large interest to the production of efficient drug delivery materials. We have reviewed the literature to provide a state of the art in this regard and shed lights on prominent perspectives and strategies for pH-sensitive cubosomes development, taking advantage of the pH changes of the biological media at targeted application sites.
  • 1.2K
  • 27 Oct 2020
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