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HandWiki. Cerberin. Encyclopedia. Available online: https://encyclopedia.pub/entry/33935 (accessed on 10 October 2026).
HandWiki. Cerberin. Encyclopedia. Available at: https://encyclopedia.pub/entry/33935. Accessed October 10, 2026.
HandWiki. "Cerberin" Encyclopedia, https://encyclopedia.pub/entry/33935 (accessed October 10, 2026).
HandWiki. (2022, November 10). Cerberin. In Encyclopedia. https://encyclopedia.pub/entry/33935
HandWiki. "Cerberin." Encyclopedia. Web. 10 November, 2022.
Cerberin
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The content is sourced from: https://handwiki.org/wiki/Chemistry:Cerberin

Cerberin is a type of cardiac glycoside, a steroidal class found in the seeds of the dicotyledonous angiosperm genus Cerbera; including the suicide tree (Cerbera odollam) and the sea mango (Cerbera manghas). This class includes digitalis-like agents, channel-blockers that as a group have found historic uses as cardiac treatments, but which at higher doses are extremely toxic; in the case of cerberin, consumption of the C. odollam results in poisoning with presenting nausea, vomiting, and abdominal pain, often leading to death. The natural product has been structurally characterized, its toxicity is clear—it is often used as an intentional human poison in third-world countries, and accidental poisonings with fatalities have resulted from individuals even indirectly consuming the agent—but its potentially therapeutic pharmacologic properties are very poorly described.

glycoside natural product odollam

References

  1. Prassas, I.; Diamandis, E. P. (2008). "Novel of therapeutic applications of cardiac glycosides". Nature Reviews Drug Discovery 7 (11): 926–930. doi:10.1038/nrd2682. PMID 18948999.  https://dx.doi.org/10.1038%2Fnrd2682
  2. Chopra R.N. & I.C. Chopra, 1933 [Third reprint, 2006], "Indigenous Drugs Of India," pp. 316–318, Kolkata, India:Academic Publishers, ISBN:818508680X, see [1], accessed 18 June 2015.
  3. Gaillarda, Y.; Krishnamoorthyb, A.; Bevalot, F. (12 August 2004). "Cerbera odollam: a 'suicide tree' and cause of death in the state of Kerala, India". Journal of Ethnopharmacology 95 (2–3): 123–126. doi:10.1016/j.jep.2004.08.004. PMID 15507323.  https://dx.doi.org/10.1016%2Fj.jep.2004.08.004
  4. Nageshkumar G. Rao, 1999, Textbook of Forensic Medicine and Toxicology, pp. 425-434, New Delhi, DL, IND:Jaypee Brothers Medical Publishers, ISBN:8171797350, see [2], accessed 22 June 2015.
  5. Krishan Vij, 1999, "Cardiac Poisons (Ch. 42)," in Textbook of Forensic Medicine and Toxicology: Principles and Practice, 5th Edn., pp. 529-530, Gurgaon, HR, IND:Elsevier India, ISBN:8131226840, see [3], accessed 22 June 2015.
  6. Members of family Apocynaceae that contain cardiac glycosides include the genera Acokanthera, Apocynum, Cerbera, Nerium, Thevetia, and Strophanthus.
  7. Papi, Luigi; Luciani, Alessandro Bassi; Forni, David; Giusiani, Mario (2012). "Unexpected Double Lethal Oleander Poisoning". The American Journal of Forensic Medicine and Pathology 33 (1): 93–97. doi:10.1097/PAF.0b013e31822d33d4. PMID 21926903.  https://dx.doi.org/10.1097%2FPAF.0b013e31822d33d4
  8. Maillaud, C.; Lefebvre, S.; Sebat, C.; Barguil, Y.; Cabalion, P.; Cheze, M.; Hnawia, E.; Nour, M. et al. (2010). "Double Lethal Coconut Crab (Birgus Latro L.) Poisoning". Toxicon 55 (1): 81–86. doi:10.1016/j.toxicon.2009.06.034. PMID 19591858.  https://dx.doi.org/10.1016%2Fj.toxicon.2009.06.034
  9. Maillaud, C.; Barguil, Y.; Mikulski, M.; Cheze, M.; Pivert, C.; Deveaux, M.; Lapostolle, F. (2012). "First Successful Curative Use of Digoxin-specific Fab Antibody Fragments in a Life-threatening Coconut Crab (Birgus Latro L.) Poisoning". Toxicon 60 (6): 1013–017. doi:10.1016/j.toxicon.2012.06.017.  https://dx.doi.org/10.1016%2Fj.toxicon.2012.06.017
  10. Becker, D.E. (2007). "Drug therapy in dental practice: general principles. Part 2 - pharmacodynamic considerations.". Anesthesia Progress 54 (1): 19–24. doi:10.2344/0003-3006(2007)54[19:DTIDPG2.0.CO;2]. PMID 17352523.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1821133
  11. Timbrell, J. A. (2009). Principles of biochemical toxicology.. 
  12. Godfraind, T. (1984). "Mechanism of action of cardiac glycosides". European Heart Journal 5 Suppl F: 303–308. doi:10.1093/eurheartj/5.suppl_f.303. PMID 6099806.  https://dx.doi.org/10.1093%2Feurheartj%2F5.suppl_f.303
  13. Fozzard, H. A.; Sheets, M. F. (1985). "Cellular mechanism of action of cardiac glycosides". Journal of the American College of Cardiology 5 (5 Suppl A): 10A–15A. doi:10.1016/s0735-1097(85)80458-7. PMID 2580874.  https://dx.doi.org/10.1016%2Fs0735-1097%2885%2980458-7
  14. "Digitalisintoxikation: Wertigkeit klinischer und electrokardiographischer Befunde im Vergleich zur Digoxinkonzentration im Serum. 1. Teil: Patienten mit Digitalisinduzierten Rhythmusstörungen." (in de). Zeitschrift für Kardiologie 66 (3): 121–128. 1977. PMID 857452.  http://www.ncbi.nlm.nih.gov/pubmed/857452
  15. Laphookhieo, S.; Cheenpracha, S.; Karalai, C.; Chantrapromma, S.; Rat-a-Pa, T.; Ponglimanont, C.; Chantrapromma, K. (2004). "Cytotoxic cardenolide glycoside from the seeds of Cerbera odollam". Phytochemistry 65: 507–510. doi:10.1016/j.phytochem.2003.10.019.  https://dx.doi.org/10.1016%2Fj.phytochem.2003.10.019
  16. Newman, R. A.; Yang, P.; Pawlus, A. D.; Block, K. I. (2008). "Cardiac Glycosides as Novel Cancer Therapeutic Agents". Molecular Interventions 8 (1): 36–49. doi:10.1124/mi.8.1.8. PMID 18332483.  https://dx.doi.org/10.1124%2Fmi.8.1.8
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