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Topic Review
Plant Phenolics
Phenolic compounds are secondary metabolites widely spread throughout the plant kingdom that can be categorized as flavonoids and non-flavonoids. 
  • 5.9K
  • 24 Dec 2020
Topic Review
Zwitterionic Dental Biomaterials
Biofilms are formed on surfaces inside the oral cavity covered by the acquired pellicle and develop into a complex, dynamic, microbial environment. Oral biofilm is a causative factor of dental and periodontal diseases. Accordingly, novel materials that can resist biofilm formation have attracted significant attention. Zwitterionic polymers (ZPs) have unique features that resist protein adhesion and prevent biofilm formation while maintaining biocompatibility. Recent literature has reflected a rapid increase in the application of ZPs as coatings and additives with promising outcomes. 
  • 5.9K
  • 29 Dec 2020
Topic Review
Red Algae
Red algae, or Rhodophyta (/roʊˈdɒfɪtə/, /ˌroʊdəˈfaɪtə/; from grc ῥόδον (rhódon) 'rose', and φυτόν (phutón) 'plant'), are one of the oldest groups of eukaryotic algae. The Rhodophyta also comprises one of the largest phyla of algae, containing over 7,000 currently recognized species with taxonomic revisions ongoing. The majority of species (6,793) are found in the Florideophyceae (class), and mostly consist of multicellular, marine algae, including many notable seaweeds. Red algae are abundant in marine habitats but relatively rare in freshwaters. Approximately 5% of red algae species occur in freshwater, environments with greater concentrations found in warmer areas. Except for two coastal cave dwelling species in the asexual class Cyanidiophyceae, there are no terrestrial species, which may be due to an evolutionary bottleneck in which the last common ancestor lost about 25% of its core genes and much of its evolutionary plasticity. The red algae form a distinct group characterized by having eukaryotic cells without flagella and centrioles, chloroplasts that lack external endoplasmic reticulum and contain unstacked (stroma) thylakoids, and use phycobiliproteins as accessory pigments, which give them their red color. Red algae store sugars as floridean starch, which is a type of starch that consists of highly branched amylopectin without amylose, as food reserves outside their plastids. Most red algae are also multicellular, macroscopic, marine, and reproduce sexually. The red algal life history is typically an alternation of generations that may have three generations rather than two. The coralline algae, which secrete calcium carbonate and play a major role in building coral reefs, belong here. Red algae such as dulse (Palmaria palmata) and laver (nori/gim) are a traditional part of European and Asian cuisines and are used to make other products such as agar, carrageenans and other food additives.
  • 5.8K
  • 11 Nov 2022
Topic Review
Almond Kernel
This entry is about Non-Lipid Components and Minor Fat-Soluble Bioactive Compounds of Almond Kernel.
  • 5.8K
  • 08 Dec 2020
Topic Review
Causes of Transsexuality
The study of the causes of transsexuality investigates gender identity formation of transgender people, especially those who are transsexual. Transgender people have a gender identity that does not match their assigned sex, often resulting in gender dysphoria. The causes of transsexuality have been studied for decades. The most studied factors are biological, especially brain structure differences in relation to biology and sexual orientation. Environmental factors have also been proposed. Transgender brain studies, especially those on trans women who are sexually attracted to women (gynephilic), and those on trans men who are sexually attracted to men (androphilic), are limited, as they include a small number of tested individuals. The available research indicates that the brain structure of androphilic trans women with early-onset gender dysphoria is closer to the brain structure of cisgender women's and less like cisgender men's. It also reports that both androphilic trans women and trans women with late-onset gender dysphoria who are gynephilic have different brain phenotypes, and that gynephilic trans women differ from both cisgender female and male controls in non-dimorphic brain areas. Cortical thickness, which is generally thicker in cisgender women's brains than in cisgender men's brains, may also be thicker in trans women's brains, but is present in a different location to cisgender women's brains. For trans men, research indicates that those with early-onset gender dysphoria and who are gynephilic have brains that generally correspond to their assigned sex, but that they have their own phenotype with respect to cortical thickness, subcortical structures, and white matter microstructure, especially in the right hemisphere. Hormone use can also affect transgender people's brain structure; it can cause transgender women's brains to become closer to those of cisgender women, and morphological increments observed in the brains of trans men might be due to the anabolic effects of testosterone. Twin studies suggest that there are likely genetic causes of transsexuality, although the precise genes involved are not fully understood. One study published in the International Journal of Transgender Health found that 20% of identical twin pairs in which at least one twin was trans were both trans, compared to only 2.6% of non-identical twins who were raised in the same family at the same time, but were not genetically identical. Ray Blanchard created a taxonomy of male-to-female transsexualism that proposes two distinct etiologies for androphilic and gynephilic individuals that has become controversial, supported by J. Michael Bailey, Anne Lawrence, James Cantor and others, but opposed by Charles Allen Moser, Julia Serano, and the World Professional Association for Transgender Health.
  • 5.8K
  • 20 Oct 2022
Topic Review
Holobiont
A holobiont is an assemblage of a host and the many other species living in or around it, which together form a discrete ecological unit, though there is controversy over this discreteness. The components of a holobiont are individual species or bionts, while the combined genome of all bionts is the hologenome. The concept of the holobiont was initially defined by Dr. Lynn Margulis in her 1991 book Symbiosis as a Source of Evolutionary Innovation, though the concept has subsequently evolved since the original definition. Holobionts include the host, virome, microbiome, and other members, all of which contribute in some way to the function of the whole. Well-studied holobionts include reef-building corals and humans.
  • 5.7K
  • 14 Oct 2022
Topic Review
Vitamin D Synthesis and Metabolism
Vitamin D, conventionally considered a nutrient, is a potent hormone regulating many physiological functions. Vitamin D exists as a prohormone that needs to be transformed into biologically active products that bind to their cognate nuclear receptors to regulate diverse physiological processes.
  • 5.7K
  • 13 Apr 2022
Topic Review
Land Suitability Assessment
Land suitability assessment is a method of land evaluation, which identifies the major limiting factors for planting a particular crop. Land suitability assessment includes qualitative and quantitative evaluation. In the qualitative land suitability evaluations, information about climate, hydrology, topography, vegetation, and soil properties is considered and in quantitative assessment, the results are more detailed and yield is estimated. At present study we prepared land suitability assessment map for rain-fed wheat and barley crops based on FAO "land suitability assessment framework" using parametric method and machine learning algorithms in Kurdistan Province, located in west of Iran. This is a unique study that compared two machine learning-based and traditional-based approaches for mapping current and potential future land suitability classes. Moreover, potential yield of rain-fed wheat and barley crop were computed by FAO model.
  • 5.7K
  • 30 Oct 2020
Topic Review
Melatonin Protects Mitochondria and Adenosine Triphosphate Production
Melatonin (N-acetyl-5-methoxytryptamine) is a ubiquitous, mitochondria-targeted molecule present in all tested eukarya and bacteria. In March 2022, the first discovery of the serotonin N-acetyltransferase (SNAT) gene—responsible for the penultimate formation of N-acetylserotonin (NAS) before its final conversion into melatonin — in archaea further consolidates the status of melatonin as a regulator of biomolecular condensates in all three domains of life in the cellular empire. RNA viruses including SARS-CoV-2 contain proteins with intrinsically disordered regions that undergo liquid-liquid phase separation (LLPS). Liquid-liquid phase separation (LLPS) of these proteins form membraneless condensates that act as “viral factories” to facilitate and enhance replication. Phase separation of the SARS-CoV-2 nucleocapsid (N) protein is associated with mitochondrial dysfunction and rewiring of energy production away from oxidative phosphorylation (OXPHOS) to favor aerobic glycolysis in cytoplasm. Increased adenosine triphosphate (ATP) in cytoplasm supports viral replication. Melatonin protects mitochondria from damage, maintains adequate levels to disassemble “viral factories”, and prevents suppression of host antiviral immune responses by inhibiting nucleocapsid phase separation via antioxidant-dependent and -independent means.
  • 5.6K
  • 05 Sep 2022
Topic Review
Brainstem Encephalitis
Brainstem encephalitis refers to inflammatory diseases affecting the midbrain, pons, and medulla oblongata. The causes of brainstem encephalitis include infections, autoimmune diseases, and paraneoplastic syndromes. Listeria is a common etiology of infectious rhombencephalitis. The trigeminal nerve has been proposed as a pathway through which Listeria monocytogenes reaches the brainstem after entering damaged oropharyngeal mucosa or periodontal tissues. Listeria monocytogenes may also invade the brainstem along the vagus nerve after it infects enteric neurons in the walls of the gastrointestinal tract.
  • 5.6K
  • 22 Oct 2020
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