Topic Review
Tooth Diversity
Although the evolution of tooth structure seems highly conserved, remarkable diversity exists among species due to different living environments and survival requirements. Along with the conservation, this diversity of evolution allows for the optimized structures and functions of teeth under various service conditions, providing valuable resources for the rational design of biomimetic materials. 
  • 17
  • 03 Feb 2023
Topic Review
Effects of Prosthetic Restorative Biomaterials on the Periodontium
The success of a prosthetic treatment is closely related to the periodontal health of the individual. The periodontium constitutes the tissues that support the teeth. It is made up of two soft tissues (which are the gingiva and periodontal ligament) and two hard tissues (which are the root cementum and alveolar bone).
  • 24
  • 31 Jan 2023
Topic Review
Resveratrol against Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is one of the most prevailing and aggressive head and neck cancers, featuring high morbidity and mortality. The available conventional treatments suffer from several adverse effects and are often inefficient in terms of their survival rates. Thus, seeking novel therapeutic agents and adjuvants is of the utmost importance for modern society. Natural polyphenolic compounds have recently emerged as promising chemopreventive and anticancer agents. Specifically, the natural compound resveratrol (RSV) has recently gained momentum for this purpose. RSV is useful for treating OSCC due to its antiproliferative, antimetastatic, and proapoptotic effects. Additionally, RSV acts against tumor cells while synergically cooperating with chemotherapeutics, overcoming drug resistance phenomena.
  • 21
  • 17 Jan 2023
Topic Review
Fluorescence in situ Hybridization in Oral Microbial Detection
Varieties of microorganisms reside in the oral cavity contributing to the occurrence and development of microbes associated with oral diseases; however, the distribution and in situ abundance in the biofilm are still unclear. In order to promote the understanding of the ecosystem of oral microbiota and the diagnosis of oral diseases, it is necessary to monitor and compare the oral microorganisms from different niches of the oral cavity in situ. The fluorescence in situ hybridization (FISH) has proven to be a powerful tool for representing the status of oral microorganisms in the oral cavity. FISH is one of the most routinely used cytochemical techniques for genetic detection, identification, and localization by a fluorescently labeled nucleic acid probe, which can hybridize with targeted nucleic acid sequences. It has the advantages of rapidity, safety, high sensitivity, and specificity. FISH allows the identification and quantification of different oral microorganisms simultaneously. It can also visualize microorganisms by combining with other molecular biology technologies to represent the distribution of each microbial community in the oral biofilm. In this review, we summarized and discussed the development of FISH technology and the application of FISH in oral disease diagnosis and oral ecosystem research, highlighted its advantages in oral microbiology, listed the existing problems, and provided suggestions for future development.
  • 43
  • 16 Jan 2023
Topic Review
Association between Periodontitis and Peri-Implantitis
Dental implants to replace lost teeth are a common dentistry practice nowadays. Titanium dental implants display a high success rate and improved safety profile. Nevertheless, there is an increasing peri-implantitis (PI), an inflammatory disease associated with polymicrobial infection that adversely affects the hard and soft tissues around the implant. Studies have demonstrated that oral microbiota (microorganisms residing in the oral cavity collectively known as oral microbiota) associated with periodontitis (PE) is involved in the infections related to PI, indicating a common link between PE and PI.
  • 66
  • 16 Jan 2023
Topic Review
Systemic Diseases and Biological Dental Implant Complications
The relationship between periodontitis and such systemic disorders as diabetes, cardiovascular disease and obesity has been extensively investigated. There is less scientific evidence available, however, regarding the influence of systemic diseases on the risk of late failure of dental implant rehabilitation due to peri-implantitis. Most of the literature concludes for no association between diabetes, cardiovascular disease, hypertension or osteoporosis and the risk of peri-implantitis. On the other hand, almost all the studies that investigated obesity as a risk factor for implant rehabilitation found a positive association between the two.
  • 40
  • 12 Jan 2023
Topic Review
Applications of Nanoparticles in Dentistry
Interest in the topic of nanoparticles (NPs) and nanomaterials used in dentistry is growing in research as well as clinical settings. An increasing number of nanomaterials have been developed and tested, enabling novel solutions unavailable in dentistry before. The shape and size of these particles influences the physicochemical properties of a substance, which in turn impacts their absorption characteristics. Nanomaterials have unique structures and properties that distinguish them from other materials. In the dental field, nanoparticles have a variety of applications, such as nanocomposites, antimicrobial nanomaterials and bio-mineralization systems.
  • 28
  • 11 Jan 2023
Topic Review
Materials Used for Customized Healing Abutment
A customized healing abutment is designed by modifying the size and transmucosal shape of the healing abutment to mimic the natural profile of an emerging tooth. 
  • 139
  • 22 Dec 2022
Topic Review
Effects of Irrigating Solutions on Dentin
Irrigating solutions play an important role in the eradication of intracanal microbes and debris dissolution during endodontic treatment. Different combinations of solutions and protocols have been advocated, with sodium hypochlorite (NaOCl), ethylenediamine tetra acetic acid (EDTA), and chlorhexidine (CHX) remaining the most widely used ones by many clinicians. Although these solutions provide efficient inorganic dissolution and antimicrobial capacity, their use has also been reported to cause undesired effects on root dentin composition and mechanical and biomechanical properties, such as microhardness, surface roughness, bond strength, and matrix metalloproteinase (MMP) activity.
  • 40
  • 19 Dec 2022
Topic Review
Ceramic Nanomaterials in Caries Prevention
Ceramic nanomaterials are nanoscale inorganic metalloid solids that can be synthesised by heating at high temperatures followed by rapid cooling. Researchers are developing ceramic nanomaterials for dental use because ceramic nanoparticles are more stable and cheaper in production than metallic nanoparticles. Ceramic nanomaterials can be used to prevent dental caries because some of them have mineralising properties to promote the remineralisation of tooth tissue. 
  • 105
  • 14 Dec 2022
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