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Topic Review
SARS-CoV-2 and Oral Health
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in Wuhan, China, was first reported to the China Ministry of Health and the World Health Organization (WHO), on 31 December 2019. These initial cases were linked to an animal wet market. The SARS-CoV-2 and its virulent variants cause coronavirus disease 2019 (COVID-19), which is highly contagious and spreads rapidly. The WHO declared it a global emergency on 30 January 2020, and a global pandemic on 11 March 2020. The SARS-CoV-2 genome was identified to be 70–80% identical to the severe acute respiratory syndrome coronavirus (SARS-CoV) and several bat coronaviruses. The similarity between these coronaviruses suggests that the bat may be the natural host and potential reservoir for SARS-CoV-2, which may have been inadvertently transmitted to humans. SARS-CoV-2 transmits readily via droplet transmission; other modes of transmission may include aerosol and oral-fecal routes. It can also be transmitted via contact with infected surfaces and oral fluids. This puts dentists and healthcare professionals at risk of COVID-19 infections, and highlights dental and medical offices as a main risk setting for cross infection of patients and healthcare professionals. Mask, face shields, handwashing, and personal protective equipment (PPE) are currently used in dental and medical facilities for COVID-19 prevention consistent with CDC guidelines.
  • 452
  • 01 Jul 2022
Topic Review
Sarcopenia and Oral Status
Aging is accompanied by profound changes in many physiological functions, leading to a decreased ability to cope with stressors. Many changes are subtle, but can negatively affect nutrient intake, leading to overt malnutrition. Poor oral health may affect food selection and nutrient intake, leading to malnutrition and, consequently, to frailty and sarcopenia. 
  • 471
  • 21 Jul 2021
Topic Review
Salivary myeloperoxidase in Patients with Systemic Diseases
Salivary myeloperoxidase (MPO) is a key mediator of the oral immune system, acting as an enzyme that utilises H2O2 to generate molecules with high bactericidal activity. While MPO determination in plasma is quite common, the use of saliva is still rare.
  • 240
  • 01 Aug 2023
Topic Review
Rotary Nickel-Titanium Instruments
Nickel–titanium alloy (Ni-Ti) rotary instruments must exert torque to cut and eradicate septic dentin during canal preparation; torsional stress, associated with friction between the instrument and dentin wall, accumulates in the instruments.
  • 343
  • 18 May 2021
Topic Review
Role of Sex Hormones in OSCC and Periodontitis
Sex hormones may also influence gingival microcirculation, thus impacting the spatial progression of periodontitis. The specific role of sex hormones in the onset and prognostic features of oral cancer must also be considered. 
  • 285
  • 11 Oct 2022
Topic Review
Role of Oral Microbiome on Oral Cancer
Oral cancer (OC) is the most common neoplasm in the head and neck region. OCs are defined as cancers of the tongue, the floor of the oral cavity, the lining of the cheeks, the roof of the oral cavity, the gums, and the lips but do not include laryngeal and pharyngeal cancers. The majority of OCs comprise oral squamous cell carcinomas (OSCCs). The oral microbiome hosts more than 750 common oral species. A healthy microbiome usually consists of Streptococci, Staphylococci, Neisseria species, and about 50 other aerobes. The consensus is that a normal mouth microbiome consists mainly of aerobes, while the percentage of anaerobes increases with OC (and other pathological oral conditions). The connection that exists between microbes and carcinoma is complex and influenced by a number of factors, such as the vulnerability and genetic makeup of the host, as well as environmental conditions, including the host’s dietary regime, oral hygiene, and tobacco and alcohol use.
  • 422
  • 19 May 2023
Topic Review
Role of Mitochondrial Dysfunction in Oral Inflammatory Diseases
Oral inflammatory diseases (OIDs) include many common diseases such as periodontitis and pulpitis. The causes of OIDs consist microorganism, trauma, occlusal factors, autoimmune dis-eases and radiation therapy. When treated unproperly, such diseases not only affect oral health but also pose threat to people’s overall health condition. Therefore, identifying OIDs at an early stage and exploring new therapeutic strategies are important tasks for oral-related research. Mitochondria are crucial organelles for many cellular activities and disruptions of mitochondrial function not only affect cellular metabolism but also indirectly influence people’s health and life span. Increasing evidence suggests that mitochondrial dysfunction plays a critical role in the development and progression of OIDs and its associated systemic diseases. 
  • 297
  • 02 Nov 2023
Topic Review
Role of Chitosan Hydrogels in Clinical Dentistry
Biopolymers are organic polymers that can be treated into intricate designs with porous characteristics that mimic essential biologic components. Due to their superior biosafety, biodegradability, biocompatibility, etc., they have been utilized immensely in biomedical engineering, regeneration, and drug delivery. To obtain the greatest number of results, a literature search was undertaken in scientific search engines utilizing keywords. Chitosan is used in a variety of medical sectors, with the goal of emphasizing its applications and benefits in the clinical dental industry. Chitosan can be dissolved in liquid form and combined with other substances to create a variety of products, including fibers, hydrogels, membranes, microspheres, resins, sponges, pastes, tablets, and micro granules. Chitosan has been studied in a variety of dental applications. Chitosan is used in the prevention of caries and wear, in pulpotomy to accelerate osteogenesis in guided tissue regeneration due to its hemostatic property, and primarily to benefit from its antimicrobial activity by adding it to materials, such as glass ionomer cement, calcium hydroxide, and adhesive systems. With its antibacterial activity and biocompatibility, chitosan is leading the pack as a promising ingredient in the production of dental materials. 
  • 175
  • 08 Sep 2023
Topic Review
Role of Arecoline in Oral Carcinogenesis
Arecoline is the primary active carcinogen found in areca nut and has been implicated in the pathogenesis of oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSF). 
  • 186
  • 19 Dec 2023
Topic Review
Rigenera® Micrografts in Oral Regeneration
Biomaterials derive either from nature or synthesized in the laboratory using chemical approaches utilizing metallic components, polymers, ceramics, or composite materials. They are often used and adapted for medical applications. A biomaterial is also defined as autograft, allograft, or xenograft used as a transplant material. In the last decade also tissue engineering and stem cells were deeply studied trying to make better autologous biomaterials ready to be used in regenerative procedures. Micrografts are a new concept of biomaterial, they are enriched of progenitor cells that are a particular type of stem cell excellent in enhancing the regenerative potential. Moreover, another advantage is the easy handling and tissue availability.
  • 1.5K
  • 29 Oct 2020
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