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Topic Review
Echocardiography
Diabetes mellitus is a major factor contributing to the development of cardiovascular disease. As morbidity and mortality rates rise dramatically, when target organ damage develops, presymptomatic assessment is critical for the management of diabetic patients. Echocardiography is a noninvasive and reproductible method that may aid in risk stratification and in evaluation of treatment effects. Aim of this review is to analyze the echocardiographic techniques that can detect early alteration in cardiac function in patients with diabetes.
  • 1.4K
  • 02 Mar 2021
Topic Review
Pomegranate Peel Extracts
Pomegranate Peel Extracts as a source of bioactive components are natural alternative means to control plant diseases and prevent food spoilage. 
  • 1.4K
  • 23 Mar 2021
Topic Review
HGPS and Cardiovascular Disease
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disease that recapitulates many symptoms of physiological aging and precipitates death. Patients develop severe vascular alterations, mainly massive vascular smooth muscle cell loss, vessel stiffening, calcification, fibrosis, and generalized atherosclerosis, as well as electrical, structural, and functional anomalies in the heart. As a result, most HGPS patients die of myocardial infarction, heart failure, or stroke typically during the first or second decade of life. No cure exists for HGPS, and therefore it is of the utmost importance to define the mechanisms that control disease progression in order to develop new treatments to improve the life quality of patients and extend their lifespan. Since the discovery of the HGPS-causing mutation, several animal models have been generated to study multiple aspects of the syndrome and to analyze the contribution of different cell types to the acquisition of the HGPS-associated cardiovascular phenotype.
  • 1.4K
  • 22 Sep 2021
Topic Review
Micromegas Detectors for Physics
Micromegas (MICRO-MEsh GAseous Structure) detectors have found common use in different applications since their development in 1996 by the group of I. Giomataris and G. Charpak. 
  • 1.4K
  • 23 Jun 2021
Topic Review
Resource Allocation Schemes for 5G Network
Resource allocation is an important aspect of any cellular network environment. It plays a significant part in maintaining friendly access for end-users, business partners, and customers of cellular-based applications. Resource allocation has great benefits for the cellular network environment.
  • 1.4K
  • 21 Oct 2021
Topic Review
TRIMbody-Away Technique
TRIMbody-Away technique is a novel technology that could be utilized to acute and rapid destruction of specific intracellular proteins. This technology is based on a new type of fusion protein, designated as TRIMbody, by fusing the truncated form of tripartite motif 21 (TRIM21) with the nanobody. The truncated TRIM21 retained only the N-terminal RBCC domain and deleted the C-terminal PRY-SPRY domain. Therefore, TRIMbody possesses the functions of TRIM21 and mAbs, but has much smaller size. TRIMbody-Away technique could expand the landscape of the applications of degrader technologies and provide an alternative approach for potential therapeutic benefit in future.
  • 1.4K
  • 25 Oct 2021
Topic Review
Cooling Loads of Buildings and Shading Devices
It is estimated that almost 40% of the world’s energy is consumed by buildings’ heating, ventilation, and air conditioning systems. This consumption increases by 3% every year and will reach 70% by 2050 due to rapid urbanisation and population growth. In Darwin, building energy consumption is even higher and accounts for up to 55% due to the hot and humid weather conditions. Singapore has the same weather conditions but less energy consumption, with only 38% compared to Darwin. Solar radiation can be defined as electromagnetic radiation emitted by the Sun and the Darwin area receives a large amount of solar radiation. Windows that are capable of blocking excessive radiation can improve the cooling load of a building. In contrast, windows and other façades with high transmission values can increase the cooling load
  • 1.4K
  • 19 Apr 2022
Topic Review
Abnormal Uterine Bleeding in Perimenopausal Women
Abnormal uterine bleeding (AUB) is a frequent symptom in perimenopausal women. It is defined as uterine bleeding in which the duration, frequency, or amount of bleeding is considered excessive and negatively affects the woman’s quality of life (QoL) and psychological well-being.
  • 1.4K
  • 24 May 2022
Topic Review
Quantum Natural Language Processing
Quantum Natural Language Processing (QNLP) is a hybrid field that combines aspects derived from Quantum Computing (QC) with tasks of Natural Language Processing (NLP).
  • 1.4K
  • 14 Jun 2022
Topic Review
Microglia as Therapeutic Target for Radiation-Induced Brain Injury
Radiation-induced brain injury (RIBI) after radiotherapy has become an increasingly important factor affecting the prognosis of patients with head and neck tumor. With the delivery of high doses of radiation to brain tissue, microglia rapidly transit to a pro-inflammatory phenotype, upregulate phagocytic machinery, and reduce the release of neurotrophic factors. 
  • 1.4K
  • 12 Aug 2022
Topic Review
In Situ Smart Hydrogels
With the advances in biomaterials and the understanding of the tumor microenvironment, in situ stimulus-responsive hydrogels, also called in situ smart hydrogels, have been extensively investigated for local anticancer therapy due to their injectability, compatibility and responsiveness to various stimuli (pH, enzyme, heat, light, magnetic fields, electric fields etc.).
  • 1.4K
  • 08 Oct 2022
Topic Review
Vesicular Systems for Advanced Drug Delivery
Erythromycin (ERY) is a macrolide compound with a broad antimicrobial spectrum which is currently being used to treat a large number of bacterial infections affecting the skin, respiratory tract, intestines, bones and other systems, proving great value from a clinical point of view. Despite this major advantage, ERY has low water solubility and is not stable under acidic conditions which leads to a limited efficacy and bioavailability. Apart from this, higher doses promote drug resistance and undesirable effects. In order to overcome these disadvantages, during the past decades, a large variety of ERY formulations, including nanoparticles, have emerged. This work presents the preparation and performances reported for ERY vesicles, such as liposomes, ethosomes, niosomes, micelles, cubosomes and solid lipid nano(micro) particles. 
  • 1.4K
  • 19 Oct 2022
Topic Review
Risk Aversion (Psychology)
Risk aversion is a preference for a sure outcome over a gamble with higher or equal expected value. Conversely, the rejection of a sure thing in favor of a gamble of lower or equal expected value is known as risk-seeking behavior. The psychophysics of chance induce overweighting of sure things and of improbable events, relative to events of moderate probability. Underweighting of moderate and high probabilities relative to sure things contributes to risk aversion in the realm of gains by reducing the attractiveness of positive gambles. The same effect also contributes to risk seeking in losses by attenuating the aversiveness of negative gambles. Low probabilities, however, are overweighted, which reverses the pattern described above: low probabilities enhance the value of long-shots and amplify aversion to a small chance of a severe loss. Consequently, people are often risk seeking in dealing with improbable gains and risk averse in dealing with unlikely losses.
  • 1.4K
  • 27 Oct 2022
Topic Review
Pulse Forming Network
A pulse forming network (PFN) is an electric circuit that accumulates electrical energy over a comparatively long time, then releases the stored energy in the form of a relatively square pulse of comparatively brief duration for various pulsed power applications. In a PFN, energy storage components such as capacitors, inductors or transmission lines are charged by means of a high voltage power source, then rapidly discharged into a load via a high voltage switch, such as a spark gap or hydrogen thyratron. Repetition rates range from single pulses to about 104 per second. PFNs are used to produce precise nanosecond-length pulses of electricity to power devices such as klystron or magnetron tube oscillators in radar sets, pulsed lasers, particle accelerators, flashtubes, and high voltage utility test equipment. Much high energy research equipment is operated in a pulsed mode, both to keep heat dissipation down and because high energy physics often occurs at short time scales, so large PFNs are widely used in high energy research. They have been used to produce nanosecond length pulses with voltages of up to 106 - 107 volts and currents up to 106 amps, with peak power in the terawatt range, similar to lightning bolts.
  • 1.4K
  • 01 Nov 2022
Topic Review
Nickel Allergy
Nickel allergy or nickel allergic contact dermatitis (Ni-ACD) is a form of allergic contact dermatitis (ACD) caused by exposure to the chemical element nickel. It typically causes a rash that is red and itchy and that may be bumpy or scaly. The main treatment is avoiding contact with nickel-releasing metals, such as wearing inexpensive jewelry.
  • 1.4K
  • 28 Apr 2023
Topic Review
Vegetable Beverages from Carob, Tiger Nut and Rice
Rice, tiger nut and carob are Mediterranean products suitable for developing new foods, such as fermented beverages, due to their nutritional properties. These crops have a high carbohydrate content, are gluten and lactose-free and have a low allergenicity index. The development of fermented beverages from these crops can contribute to the Sustainable Development Goals by promoting human health and sustainable production and consumption.
  • 1.4K
  • 07 Jun 2023
Topic Review Peer Reviewed
Oblique Aerial Images: Geometric Principles, Relationships and Definitions
Aerial images captured with the camera optical axis deliberately inclined with respect to the vertical are defined as oblique aerial images. Throughout the evolution of aerial photography, oblique aerial images have held a prominent place since its inception. While vertical airborne images dominated in photogrammetric applications for over a century, the advancements in photogrammetry and computer vision algorithms, coupled with the growing accessibility of oblique images in the market, have propelled the rise of oblique images in recent times. Their emergence is attributed to inherent advantages they offer over vertical images. In this entry, basic definitions, geometric principles and relationships for oblique aerial images, necessary for understanding their underlying geometry, are presented.
  • 1.4K
  • 02 Feb 2024
Topic Review
Gray Fox
The Gray Fox (Urocyon cinereoargenteus) is a species of fox native to North and Central America, recognized for its distinctive grayish fur, bushy tail, and characteristic black stripe running along its back. Unlike other fox species, the Gray Fox is adept at climbing trees, utilizing its semi-retractable claws to ascend and evade predators or hunt for prey. With a diverse diet including small mammals, birds, insects, fruits, and vegetation, the Gray Fox occupies a variety of habitats ranging from forests and woodlands to suburban areas, making it a versatile and adaptable carnivore.
  • 1.4K
  • 28 Feb 2024
Topic Review
Cromemco Dazzler
Cromemco's Dazzler (or TV DAZZLER) is a graphics card for S-100 bus computers. Released in 1976, it is the first commercial color bit-mapped graphics card available for microcomputers. Multiple Dazzler cards could be installed in a single machine and synced together, a feature which could, with minor modification, be used to genlock. Genlocked Dazzler cards drove ColorGraphics Weather Systems displays that generated most of the weather imagery seen on US television in the early 1980s.
  • 1.4K
  • 11 Nov 2022
Topic Review
Cancer-Associated Gangliosides as Tumor Markers
Aberrant expression of glycosphingolipids is a hallmark of cancer cells and is associated with their malignant properties. Disialylated gangliosides GD2 and GD3 are considered as markers of tumors from neuroectoderm origin, whereas fucosyl-GM1 is expressed in very few normal tissues but overexpressed in a variety of cancers, especially in small cell lung carcinoma. These gangliosides are absent in most normal adult tissues, making them targets of interest in immuno-oncology. Passive and active immunotherapy strategies have been developed and have shown promising results in clinical trials.
  • 1.4K
  • 22 Jun 2021
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