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Topic Review
Infinity
In philosophy and theology, infinity is explored in articles under headings such as the Absolute, God, and Zeno's paradoxes. In Greek philosophy, for example in Anaximander, 'the Boundless' is the origin of all that is. He took the beginning or first principle to be an endless, unlimited primordial mass (ἄπειρον, apeiron). The Jain metaphysics and mathematics were the first to define and delineate different "types" of infinities. The work of the mathematician Georg Cantor first placed infinity into a coherent mathematical framework. Keenly aware of his departure from traditional wisdom, Cantor also presented a comprehensive historical and philosophical discussion of infinity. In Christian theology, for example in the work of Duns Scotus, the infinite nature of God invokes a sense of being without constraint, rather than a sense of being unlimited in quantity.
  • 1.4K
  • 16 Nov 2022
Topic Review
Public Utility Holding Company Act of 1935
The Public Utility Holding Company Act of 1935 (PUHCA), also known as the Wheeler-Rayburn Act, was a US federal law giving the Securities and Exchange Commission authority to regulate, license, and break up electric utility holding companies. It limited holding company operations to a single state, thus subjecting them to effective state regulation. It also broke up any holding companies with more than two tiers, forcing divestitures so that each became a single integrated system serving a limited geographic area. Another purpose of the PUHCA was to keep utility holding companies engaged in regulated businesses from also engaging in unregulated businesses. The act was based on the conclusions and recommendations of the 1928-35 Federal Trade Commission investigation of the electric industry. On March 12, 1935, President Franklin D. Roosevelt released a report he commissioned by the National Power Policy Committee. This report became the template for the PUHCA. The political battle over its passage was one of the bitterest of the New Deal, and was followed by eleven years of legal appeals by holding companies led by the Electric Bond and Share Company, which finally completed its breakup in 1961. On August 26, 1935, President Franklin D. Roosevelt signed the bill into law. The Energy Policy Act of 2005 repealed the PUHCA.
  • 1.4K
  • 18 Nov 2022
Topic Review
Tree Information Modeling
Tree Information Modeling (TIM) is conceived as a digital representation of the physical and functional characteristics of a tree. It is a framework following the same tree description system (TDS) to create the digital twins of trees in real life. This framework enables easier data exchange and knowledge-sharing about trees cross multiple related professions such as urban forestry, arboriculture, and botanic plant modeling. With interdisciplinary cooperations in TIM applications, decision-making and supporting tools can be developed to guide trees' planning and life-long management.
  • 1.4K
  • 08 Dec 2022
Topic Review
Distribution System State Estimation Algorithms
The modern energy requirements and the orientation towards Renewable Energy Sources (RES) integration promote the transition of distribution grids from passive, unidirectional, fossil fuel-based into active, bidirectional, environmental-friendly architectures. For this purpose, advanced control algorithms and optimization processes are implemented, the performance of which relies on the Distribution System State Estimation (DSSE). DSSE algorithms provide the Distribution System Operator (DSO) with detailed information regarding the network’s state in order to derive the optimal decisions. However, this task is quite complex as the distribution system has inherent unbalance issues, often faces lack of adequate measurements, etc.
  • 1.4K
  • 31 Jan 2023
Topic Review
Cell Culture
The cultivation of cells in a favorable artificial environment has become a versatile tool in cellular and molecular biology. Cultured primary cells and continuous cell lines are indispensable in investigations of basic, biomedical, and translational research.
  • 1.4K
  • 10 Mar 2023
Topic Review
Neuropeptide Y in Energy Balance Regulation
Energy balance is regulated by several hormones and peptides, and neuropeptide Y is one of the most crucial in feeding and energy expenditure control. The neuropeptide Y (NPY), is a potent orexigenic peptide pointed out as an obesogenic factor. NPY is regulated by a series of peripheral nervous and humoral signals that are responsive to nutrient sensing, but its role in the energy balance is also intricately related to the energetic status, namely mitochondrial function.
  • 1.4K
  • 25 Apr 2023
Topic Review
Initiation of DNA Replication
DNA replication is fundamental to the maintenance and diversification of life. In eukaryotic cells, DNA replication initiates from multiple origins deployed across the whole genome, implying the need for a tight orchestration of their firing. Complex multi-step regulatory mechanisms coordinate such efforts and ensure that the genome is fully duplicated. Notably, a large excess of DNA replication origins are present throughout the human genome, with only 5–10% of them firing throughout S phase. Based on their usage, DNA replication origins are classified into the following three categories: (1) constitutive origins that invariably fire in all cells of a population, (2) flexible origins (the majority) that only fire in some cells of a population, and (3) dormant origins that are kept silent during normal conditions but can become activated upon DNA damage when a replication fork stalls in the vicinity.
  • 1.4K
  • 04 Jul 2023
Topic Review
Vesicular Nanoformulations for Skin Cancer
Skin cancer can be classified into melanomas from melanocytes and nonmelanoma skin cancer (NMSC) from the epidermally-derived cell. The vesicular nanocarrier system is one of the most preferred delivery systems and is helpful in immunology, membrane biology, diagnostics, and, most recently, genetic engineering.
  • 1.4K
  • 14 Aug 2023
Topic Review
Micropropagation and Its Applications of Eucalyptus Plantations
The genus Eucalyptus is a globally captivated source of hardwood and is well known for its medicinal uses. The hybrid and wild species of Eucalyptus are widely used as exotic plantations due to their renowned potential of adapting to various systems and sites, and rapid large-scale propagation of genetically similar plantlets, which further leads to the extensive propagation of this species. Tissue culture plays a crucial role in the preservation, propagation, and genetic improvement of Eucalyptus species. Despite unquestionable progression in biotechnological and tissue culture approaches, the productivity of plantations is still limited, often due to the low efficiency of clonal propagation from cuttings. 
  • 1.4K
  • 29 Dec 2023
Topic Review
Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease is characterized by disturbed lipid metabolism and increased oxidative stress. These conditions lead to the activation of different cellular response mechanisms, including senescence. Cellular senescence constitutes an important response to injury in the liver. Researches show that chronic oxidative stress can induce senescence, and this might be a driving mechanism for NAFLD progression, aggravating the disturbance of lipid metabolism, organelle dysfunction, pro-inflammatory response and hepatocellular damage. In this context, the modulation of cellular senescence can be beneficial to ameliorate oxidative stress-related damage during NAFLD progression.
  • 1.4K
  • 06 Jun 2022
Topic Review
Ethnobotany, Phytochemistry, Pharmacological Activity of Genus Malachra L.
The genus Malachra L. belongs to the family Malvaceae. It includes herbs or subshrubs of nine accepted species with approximately thirty synonyms, and it has been widely used in community folk medicine to treat health problems including inflammation, nasal obstruction, leishmaniasis, malaria, childbirth, kidney disorders, fever, respiratory tract diseases, among others.
  • 1.4K
  • 10 Nov 2022
Topic Review
Bradoriids and the Cambrian Diversification
Bradoriids, among the earliest arthropods to appear in the fossil record, are extinct, ostracod-like bivalved forms that ranged from the early Cambrian to the Middle Ordovician. Bradoriids are notable for having appeared in the Cambrian fossil record before the earliest trilobites, and considering their rapid ascent to high genus-level diversity, provide key data for our understanding of the evolutionary dynamics of the Cambrian Explosion. This paper presents a broad review of bradoriid paleobiology. 
  • 1.4K
  • 29 Oct 2020
Topic Review
TBP Gene
TATA-box binding protein: The TBP gene provides instructions for making a protein called the TATA box binding protein. 
  • 1.4K
  • 24 Dec 2020
Topic Review
EGFR Gene
Epidermal growth factor receptor
  • 1.4K
  • 04 Jan 2021
Topic Review
Benign Prostatic Hyperplasia (BPH)
Benign prostatic hyperplasia (BPH) is a non-malignant enlargement of the prostate and can cause obstructive and irritating lower urinary tract symptoms (LUTS); this proliferative change affects smooth muscle and epithelial cells within the transition zone of the prostate.
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  • 03 Mar 2021
Topic Review
Aurilide Family
Aurilides are a class of depsipeptides occurring mainly in marine cyanobacteria. Members of the aurilide family have shown to exhibit strong cytotoxicity against various cancer cell lines. These compounds bear a pentapeptide, a polyketide, and an α-hydroxy ester subunit in their structure.
  • 1.4K
  • 18 Mar 2021
Topic Review
Human Cytomegalovirus Infection
Human cytomegalovirus (HCMV), also known as human herpes virus 5 (HHV-5), infects about 83% of the world’s population, approaching 100% in developing countries.
  • 1.4K
  • 05 May 2021
Topic Review
Cytochrome P450 Aromatase
Aromatase is the cytochrome P450 enzyme converting androgens into estrogen in the last phase of steroidogenesis. As estrogens are crucial in reproductive biology, aromatase is found in vertebrates and the invertebrates of the genus Branchiostoma, where it carries out the aromatization reaction of the A-ring of androgens that produces estrogens.
  • 1.4K
  • 07 May 2021
Topic Review
Opportunities of Concentrated Solar Power
Concentrated solar power (CSP) has been considered an emerging technology that could disrupt the energy production sector. The possibility to store the electricity generated during the sunny operating hours in the form of heat enhances energy dispatchability and gives CSP a unique value proposition that conventional renewable energies cannot provide cost-efficiently since it requires the integration of costly large-scale battery systems. 
  • 1.4K
  • 10 May 2021
Topic Review
Solid State NMR Spectroscopy
Solid-state NMR relaxometry has established its position in food science, including the determination of moisture content, solid fat content and much more and shown to be complementary to traditional microscopic techniques in studying the phase morphology of blended materials used in semiconductive polymer-based devices .
  • 1.4K
  • 02 Jul 2021
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