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Topic Review
Induced Systemic Resistance and Beneficial Microbes
Plant beneficial microorganisms improve the health and growth of the associated plants. Application of beneficial microbes triggers an enhanced resistance state, also termed as induced systemic resistance (ISR), in the host, against a broad range of pathogens. Upon the activation of ISR, plants employ long-distance systemic signaling to provide protection for distal tissue, inducing rapid and strong immune responses against pathogens invasions. The transmission of ISR signaling was commonly regarded to be a jasmonic acid- and ethylene-dependent, but salicylic acid-independent, transmission. 
  • 1.5K
  • 18 Mar 2022
Topic Review
Norovirus
Noroviruses (NoVs) are one of the emerging and rapidly spreading groups of pathogens threatening human health.  A reduction in sporadic NoV infections was noted following the start of the COVID-19 pandemic, but the return of NoV gastroenteritis during the COVID-19 pandemic has been noted recently. Research in recent years has shown that different virus strains are associated with different clinical characteristics; moreover, there is a paucity of research into extraintestinal or unusual complications that may be associated with NoV. 
  • 1.5K
  • 14 Apr 2022
Topic Review
IoT Adoption Direct Benefit for Organizations
The Internet of Things (IoT) ushered in a new industrial revolution, the fourth industrial revolution (Industry 4.0), resulting in radical changes across all industries. IoT has differentiated itself from other technologies by incorporating smart features that enable it to sense, collect, communicate, and analyze massive amounts of data from various internal and external sources across a global network. These IoT features offer numerous benefits to organizations and make IoT critical to business success in the coming years.
  • 1.5K
  • 13 May 2022
Topic Review
Hippo in Gastric Cancer
The Hippo signalling pathway is one of the most crucial and complex ones in physiology, and there is no doubt that the regulatory mechanisms it possesses are various. The role of this signalisation process in tissue homeostasis makes it keen to lead to cancerous processes when dysregulated. 
  • 1.5K
  • 16 May 2022
Topic Review
Intervention Program to Reduce Religious Prejudice in Education
In a plural society, education has an important role in preparing students to be able to live together with differences, including religious differences. In the context of education, various terminology can be used to describe a prejudice reduction intervention program as a combination of the terms interfaith or inter-religious with learning, education, and dialogue. There are four forms of interfaith learning in educational settings, namely formal academic, informal academic, formal social, and informal social. Intervention program activities can be one or a combination of two or more forms of interfaith learning. Contact theory hypotheses can be applied in interfaith learning in educational settings to reduce religious prejudice through changes in knowledge, attitudes, and skills/behaviors. To obtain a wider impact of intervention programs on educational settings, intervention programs can be integrated with existing learning/curriculum so that they are compulsory for all students.
  • 1.5K
  • 02 Jun 2022
Topic Review
The Relaxin-3 Receptor in Aging-Related Disease
During the aging process human's body becomes less well equipped to deal with cellular stress, resulting in an increase in unrepaired damage. This causes varying degrees of impaired functionality and an increased risk of mortality. One of the most effective anti-aging strategies involves interventions that combine simultaneous glucometabolic support with augmented DNA damage protection/repair. Thus, it seems prudent to develop therapeutic strategies that target this combinatorial approach. Studies have shown that the ADP-ribosylation factor (ARF) GTPase activating protein GIT2 (GIT2) acts as a keystone protein in the aging process. GIT2 can control both DNA repair and glucose metabolism. Through in vivo co-regulation analyses it was found that GIT2 forms a close co-expression based relationship with the relaxin-3 receptor (RXFP3). Cellular RXFP3 expression is directly affected by DNA damage and oxidative stress. Overexpression or stimulation of this receptor, by its endogenous ligand relaxin 3 (RLN3), can regulate the DNA damage response and repair processes. Interestingly, RLN3 is an insulin-like peptide and has been shown to control multiple disease processes linked to aging mechanisms, e.g., anxiety, depression, memory dysfunction, appetite, and anti-apoptotic mechanisms.
  • 1.5K
  • 27 Sep 2022
Topic Review
“Every Earthquake a Precursor According to Scale” Model
The observation that major earthquakes are generally preceded by an increase in the seismicity rate on a timescale from months to decades was embedded in the “Every Earthquake a Precursor According to Scale” (EEPAS) model. EEPAS has since been successfully applied to regional real-world and synthetic earthquake catalogues to forecast future earthquake occurrence rates with time horizons up to a few decades. When combined with aftershock models, its forecasting performance is improved for short time horizons. As a result, EEPAS has been included as the medium-term component in public earthquake forecasts in New Zealand. EEPAS has been modified to advance its forecasting performance despite data limitations. One modification is to compensate for missing precursory earthquakes. Precursory earthquakes can be missing because of the time-lag between the end of a catalogue and the time at which a forecast applies or the limited lead time from the start of the catalogue to a target earthquake. An observed space-time trade-off in precursory seismicity, which affects the EEPAS scaling parameters for area and time, also can be used to improve forecasting performance. Systematic analysis of EEPAS performance on synthetic catalogues suggests that regional variations in EEPAS parameters can be explained by regional variations in the long-term earthquake rate.
  • 1.5K
  • 21 Oct 2022
Topic Review
Supercritical Fluid Extraction as a Green Extraction
Extraction is a technique of isolating components from natural materials using chemical or physical methods. The world has turned to using green extraction as part of its efforts to preserve the environment. Green extraction is based on procedures that require less energy, allow for the use of alternative solvents and sustainable natural resources, and offer a safe and high-quality extract. Supercritical fluid extraction (SFE) procedures are compatible with the principles of green extraction.
  • 1.5K
  • 26 Oct 2022
Topic Review
Sugar
Sugar is a free and open-source desktop environment designed for interactive learning by children. Copyright by SugarLabs. Developed as part of the One Laptop per Child (OLPC) project, Sugar was the default interface on OLPC XO-1 laptop computers. The OLPC XO-1.5 and later provided the option of either the Gnome or Sugar interfaces. Sugar is available as a Live CD, as Live USB, and a package installable through several Linux distributions. It can run in a Linux virtual machine under Windows and Mac OS. Unlike most other desktop environments, Sugar does not use the "desktop", "folder" and "window" metaphors. Instead, Sugar's default full-screen activities require users to focus on only one program at a time. Sugar implements a journal which automatically saves the user's running program session and allows them to later use an interface to pull up their past works by date, an activity used, or file type.
  • 1.5K
  • 08 Nov 2022
Topic Review
Epidemic Dropsy
Epidemic dropsy is a form of edema of extremities due to poisoning by Argemone mexicana (Mexican prickly poppy). Epidemic dropsy is a clinical state resulting from use of edible oils adulterated with Argemone mexicana seed oil. Sanguinarine and dihydrosanguinarine are two major toxic alkaloids of argemone oil, which cause widespread capillary dilatation, proliferation and increased capillary permeability. When mustard oil is adulterated deliberately (as in most cases) or accidentally with argemone oil, proteinuria (specifically loss of albumin) occurs, with a resultant edema as would occur in nephrotic syndrome. Other major symptoms are bilateral pitting edema of extremities, headache, nausea, loose bowels, erythema, glaucoma and breathlessness. Leakage of the protein-rich plasma component into the extracellular compartment leads to the formation of edema. The haemodynamic consequences of this vascular dilatation and permeability lead to a state of relative hypovolemia with a constant stimulus for fluid and salt conservation by the kidneys. Illness begins with gastroenteric symptoms followed by cutaneous erythema and pigmentation. Respiratory symptoms such as cough, shortness of breath and orthopnoea, progressing to frank right-sided congestive cardiac failure, are seen. Mild to moderate anaemia, hypoproteinaemia, mild to moderate renal azotemia, retinal haemorrhages, and glaucoma are common manifestations. There is no specific therapy. Removal of the adulterated oil and symptomatic treatment of congestive cardiac failure and respiratory symptoms, along with administration of antioxidants and multivitamins, remain the mainstay of treatment. Epidemic dropsy occurs as an epidemic in places where use of mustard oil from the seeds of Brassica juncea, commonly known as Indian mustard, as a cooking medium is common.
  • 1.5K
  • 10 Nov 2022
Topic Review
Cartographic Labeling
{{Multiple issues| Cartographic labeling is a form of typography and strongly deals with form, style, weight and size of type on a map. Essentially, labeling denotes the correct way to label features (points, arcs, or polygons).
  • 1.5K
  • 11 Nov 2022
Topic Review
Natural Molecules Prevent Human Papillomavirus
Human papillomavirus (HPV) persistence is the most important risk factor of tumor development, as in the case of cervical cancer, and it still represents a serious clinical challenge. epigallocatechin gallate (EGCG), vitamin B12, folic acid, and hyaluronic acid (HA) are natural molecules that demonstrated beneficial role in treating HPV-induced lesions. Therefore, is reasonable to think that their association may have a promising action against HPV persistence.
  • 1.5K
  • 03 Apr 2023
Topic Review
Mitochondrial Permeability Transition Pores
Substantial evidence has revealed that mitochondrial permeability transition pores (mPTPs) are associated with signaling pathway of cardioprotective models and seem to be an end-effector of cardioprotection. Experimental streptozotocin-induced diabetes mellitus (D) was shown to provide sufficient protection to the myocardium via compensatory mechanisms enabling mitochondria to produce energy under pathological conditions during the acute phase. The hypothesized involvement of mPTPs in these processes prompted us to use liquid chromatography and mass spectrometry-based proteomic analysis to investigate the effects of the acute-phase D condition on the structural and regulatory components of this multienzyme complex and the changes caused by compensation events. We detected ADT1, ATP5H, ATPA, and ATPB as the most abundant mPTP proteins. The between-group differences in protein abundance of the mPTP complex as a whole were significantly upregulated in the D group when compared with the control (C) group (p = 0.0106), but fold changes in individual protein expression levels were not significantly altered except for ATP5H, ATP5J, and KCRS. However, none of them passed the criterion of a 1.5-fold change in differential expression for biologically meaningful change. Visualization of the (dis-)similarity between the C and D groups and pairwise correlations revealed different patterns of protein interactions under the C and D conditions which may be linked to endogenous protective processes, of which beneficial effects on myocardial function were previously confirmed. Our results point to the involvement of mPTP proteins in the endogenous protective processes leading to the preservation of myocardial function under pathological conditions. Proteomic studies with respect to the correlation of mPTP proteins were shown to be one of the most promising options for the advancement of mPTP regulation mechanisms. Subtle changes in mPTP protein expressions, as well as mutual relationships between proteins, may be sufficient to contribute to preserving mitochondrial energy metabolism under the increased energy load represented by experimental D.
  • 1.5K
  • 29 Oct 2020
Topic Review
Proanthocyanidins
PAs’ function as antioxidant, anti-inflammatory drugs, signal pathway regulators remain critical in many diseases.
  • 1.5K
  • 14 Jan 2021
Topic Review
Histamine in Glaucoma
Glaucoma is an optic neuropathy characterized by high intra-ocular pressure (IOP) and  progressive degeneration of retinal ganglionic cells (RGCs). Increased IOP and short-term IOP fluctuation are two of the most critical risk factors in glaucoma progression which can lead to visual field impairment and loss of visual function as a consequence of the damage of optic nerve. Histamine is produced within mast cell and neurons in the Central Nervous System (CNS) and it is a well-characterized neuromodulator.  The secretion of histamine  follows a circadian rhythm, regulates IOP and modulates retinal circuits and vision.
  • 1.5K
  • 02 Nov 2021
Topic Review
Machine Learning for Precision Agriculture with UAV
Unmanned aerial vehicles (UAVs) are increasingly being integrated into the domain of precision agriculture, revolutionizing the agricultural landscape. Specifically, UAVs are being used in conjunction with machine learning techniques to solve a variety of complex agricultural problems. 
  • 1.5K
  • 19 Jun 2023
Topic Review
BIM Impact on Construction Project Time
Building Information Modeling (BIM), a complete process that can improve every aspect of a project, is crucial in the building sector. BIM makes it feasible for design, construction, and engineering teams to employ digital technologies. It typically produces better results overall.
  • 1.5K
  • 15 Sep 2023
Topic Review
Port City Sustainability
In resent years, with the development of society, the sustainability of port cities is increasingly valued. Port cities face huge challenges, and their sustainability needs to be better understood.
  • 1.5K
  • 28 Sep 2021
Topic Review Peer Reviewed
Global Passenger Transport Futures
Global passenger transport consists of all passenger travel by private and public road vehicles, rail passenger travel, air travel, and non-motorized travel. The vehicular travel component expanded an estimated 14-fold between 1950 and 2018, so that now it is not only a major energy user and CO2 emitter, but also the cause of a variety of other negative effects, especially in urban areas. Global transport in future will be increasingly subject to two contradictory forces. On the one hand, the vast present inequality in vehicular mobility between nations should produce steady growth as low-mobility countries raise material living standards. On the other hand, any such vast expansion of the already large global transport task will magnify the negative effects of such travel. The result is a highly uncertain global transport future.
  • 1.5K
  • 13 Apr 2022
Topic Review
Potocki-Lupski Syndrome
Potocki-Lupski syndrome is a condition that results from having an extra copy (duplication) of a small piece of chromosome 17 in each cell. The duplication occurs on the short (p) arm of the chromosome at a position designated p11.2. This condition is also known as 17p11.2 duplication syndrome.
  • 1.5K
  • 24 Dec 2020
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