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Topic Review
Lignins as Promising Renewable Biopolymers and Bioactive Compounds
The recycling of biomass into high-value-added materials requires important developments in research and technology to create a sustainable circular economy. Lignin, as a component of biomass, is a multipurpose aromatic polymer with a significant potential to be used as a renewable bioresource in many fields in which it acts both as promising biopolymer and bioactive compound. 
  • 1.5K
  • 21 Aug 2023
Topic Review
Audiovestibular Disorders after COVID-19 Vaccine
The SARS-CoV-2 vaccination campaign is probably one of the most historic public hygiene measures in modern medicine. The drama of the pandemic has forced the scientific community to accelerate the development and commercialization of vaccines, thereby enhancing the phases of active surveillance. Among the adverse events following immunization (AEFI) reported, those of an audiovestibular interest, such as sudden sensorineural hearing loss (SSNHL), tinnitus, dizziness, and vertigo, constitute a very small percentage.
  • 1.5K
  • 05 May 2022
Topic Review
BRCA2
The tumor suppressor BRCA2 functions as a central caretaker of genome stability, and individuals who carry BRCA2 mutations are predisposed to breast, ovarian, and other cancers.
  • 1.5K
  • 28 Sep 2021
Topic Review
Mitochondrial DNA and DOHaD
Mitochondrial dysfunction is known to contribute to mitochondrial diseases, as well as to a variety of aging-based pathologies. Mitochondria have their own genomes (mitochondrial DNA (mtDNA)) and the abnormalities, such as point mutations, deletions, and copy number variations, are involved in mitochondrial dysfunction. In recent years, several epidemiological studies and animal experiments have supported the Developmental Origin of Health and Disease (DOHaD) theory, which states that the environment during fetal life influences the predisposition to disease and the risk of morbidity in adulthood. Mitochondria play a central role in energy production, as well as in various cellular functions, such as apoptosis, lipid metabolism, and calcium metabolism.
  • 1.5K
  • 19 Jul 2021
Topic Review
Skeletal Fluorosis
Fluorine is widely dispersed in nature and has multiple physiological functions. Although it is usually regarded as an essential trace element for humans, this view is not held universally. Moreover, chronic fluorosis, mainly characterized by skeletal fluorosis, can be induced by long-term excessive fluoride consumption. High concentrations of fluoride in the environment and drinking water are major causes, and patients with skeletal fluorosis mainly present with symptoms of osteosclerosis, osteochondrosis, osteoporosis, and degenerative changes in joint cartilage. Etiologies for skeletal fluorosis have been established, but the specific pathogenesis is inconclusive. Currently, active osteogenesis and accelerated bone turnover are considered critical processes in the progression of skeletal fluorosis. In recent years, researchers have conducted extensive studies in fields of signaling pathways (Wnt/β-catenin, Notch, PI3K/Akt/mTOR, Hedgehog, parathyroid hone, and insulin signaling pathways), stress pathways (oxidative stress and endoplasmic reticulum stress pathways), epigenetics (DNA methylation and non-coding RNAs), and their inter-regulation involved in the pathogenesis of skeletal fluorosis.
  • 1.5K
  • 11 Nov 2021
Topic Review
The HMOX1 Pathway
Heme oxygenase (HMOX1) is a key enzyme that catalyzes the rate-limiting first step in the heme degradation process, generating carbon monoxide, ferrous, and biliverdin, and therefore HMOX1 has a cytoprotective role as excess free heme has been shown to induce apoptosis. HMOX1 is expressed at high levels in the lungs and has been shown to mediate the anti-inflammatory effect of interleukin-10 (IL-10) in mice. Given these functions of HMOX1, it has been implicated in a variety of pathological states, including myocardial infarction, diabetes, chronic obstructive pulmonary disease (COPD). The upregulation of HMOX1 has been shown to have a protective role against the oxidative stress produced upon HIV, DENV, HCV, and IAV infections.
  • 1.5K
  • 26 Oct 2020
Topic Review
Notch Signaling
Roles of Notch signaling in human development and cancer are reviewed herein. The four Notch paralogs along with the five Notch ligands are described. Their structures, mode of activation, and functions are briefly summarized based on published works.
  • 1.5K
  • 21 Oct 2020
Topic Review
Adhesins of Brucella
A central aspect of Brucella pathogenicity is its ability to invade, survive, and replicate in diverse phagocytic and non-phagocytic cell types, leading to chronic infections and chronic inflammatory phenomena. Adhesion to the target cell is a critical first step in the invasion process. Several Brucella adhesins have been shown to mediate adhesion to cells, extracellular matrix components (ECM), or both. These include the sialic acid-binding proteins SP29 and SP41, the BigA and BigB proteins that contain an Ig-like domain, the monomeric autotransporters BmaA, BmaB, and BmaC, the trimeric autotransporters BtaE and BtaF, and Bp26.
  • 1.5K
  • 05 Jan 2021
Topic Review
Triple-Negative Breast Cancer and COVID-19
he Coronavirus disease (COVID-19) pandemic has resulted in challenges to cancer management, exacerbated by limited clinical resources and caution in preventing COVID-19 transmission between patients and healthcare professionals. The neglect of breast cancer (in particular, triple-negative breast cancer (TNBC)) patients during the outbreak could negatively impact their overall survival, as delays in treatment and consultations provide vital time for tumor progression and metastasis. Herein, we review the shifting clinical management of TNBCs during the COVID-19 outbreak. The suggested treatment recommendations can hopefully minimize virus exposure without sacrificing patient care during times when healthcare systems are overburdened. Further, we review published RNA-seq data to assess the theoretical infectability of metastatic TNBCs to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. 
  • 1.5K
  • 01 Feb 2021
Topic Review
CAD/CAM in dentistry
CAD/CAM stands for computer-aided design and computer-aided manufacturing. It is applied in different branches of engineering, science or even art as a rapid prototyping method for accelerating the design process and smoothening its transition into manufacturing.
  • 1.5K
  • 12 Apr 2021
Topic Review
Bis-Chalcone-Based Photoinitiators of Polymerization
Over the past several decades, photopolymerization has become an active research field, and the ongoing efforts to develop new photoinitiating systems are supported by the different applications in which this polymerization technique is involved—including dentistry, 3D and 4D printing, adhesives, and laser writing.
  • 1.5K
  • 23 Jun 2021
Topic Review
Adaptive Immune Landscape of Colorectal Adenoma-Carcinoma Sequence
The tumor immune microenvironment exerts a pivotal influence in tumor initiation and progression.
  • 1.5K
  • 08 Oct 2021
Topic Review
E-Commerce in Agri-Food Sector
Agricultural e-commerce (AE) has attracted substantial attention within various research disciplines for several years. In this paper, we present a literature review of the recent state of AE research published from 2000 through to 2021 in 83 journals. Based on Service-Dominant Logic (S-D logic) and Qualitative Comparative Analysis (QCA), we identify six research themes, and a theoretical continuum is applied to reveal how research themes and scholarly approaches fit into the S-D logic framework. A general increasing trend in the number of articles confirms the escalating interest in AE research; however, different themes perform unevenly with S-D logic. Even though research themes such as Consumer Willingness are getting closer to S-D logic premises, and ideologies that are increasingly approaching S-D logic have been applied to analyzing AE topics, unfortunately, there remains a paucity of papers that wield S-D logic in the AE field. Our research focuses on an innovative emerging AE field and, simultaneously, provides an approach of integrating S-D logic into analyzing academic papers in the AE domain. This research may shed some light on future possibilities that S-D logic could support the co-creation of value between consumers and agribusiness managers, and other broader disciplines such as management and marketing.
  • 1.5K
  • 22 Mar 2022
Topic Review
Cytokine Receptors Involved in Antimycobacterial Immune Response
Cytokine receptors are membrane-bound or soluble glycoproteins that serve as cytokine docking sites and inductors of a signaling cascade inside the cells. They are involved in the initiation of intracellular signaling that regulates a diverse range of biological functions including metabolism control, neural stem cell activation, inflammatory responses as well as blood cell and immune cell development and growth. The classification of cytokine receptor families is based on the structural homology of the extracellular cytokine binding domains and common intracellular signaling mechanisms. The main families include type I cytokine receptors, type II cytokine receptors, chemokine receptors, the tumor necrosis factor (TNF) receptor family, the transforming growth factor (TGF)-β receptor family, the immunoglobulin (Ig) superfamily, and the interleukin (IL)-17 receptor family.
  • 1.5K
  • 01 Apr 2022
Topic Review
Gender Equality in Tanzanite Mine-to-Market
In the mining industry, the contemporary concept of mapping artisanal and small-scale mining to the UN Sustainable Development Goals is a newer aspect of sustainability. SDG 5 aims to achieve gender equality and empower all women and girls. However, while there have been initiatives to support gemstone mining in Tanzania and East Africa, to date, the role of women in the lucrative tanzanite mine-to-market (M2M) supply chain has been less visible and a missed opportunity. This is a concern, as in 2019, pre-COVID-19 pandemic, gemstone and precious metals accounted for an incredible 33.2% of Tanzania’s total exports. In contrast, in leading mining countries such as Australia and Canada, the participation of women continues to steadily advance, economically empowering the women involved.
  • 1.5K
  • 02 Apr 2022
Topic Review
In Vivo Brain Glutathione
Glutathione (GSH) is an important antioxidant implicated in several physiological functions, including the oxidation−reduction reaction balance and brain antioxidant defense against endogenous and exogenous toxic agents. Altered brain GSH levels may reflect inflammatory processes associated with several neurologic disorders. An accurate and reliable estimation of cerebral GSH concentrations could give a clear and thorough understanding of its metabolism within the brain, thus providing a valuable benchmark for clinical applications. 
  • 1.5K
  • 21 Apr 2022
Topic Review
The Origin of Regulatory T Cells
In immunology, the discovery of regulatory T (Treg) cells was a major breakthrough. Treg cells play a key role in pregnancy maintenance, in the prevention of autoimmune responses, and in the control of all immune responses, including responses to self cells, cancer, infection, and a transplant.
  • 1.5K
  • 30 May 2022
Topic Review
Augmented Reality in K-12 Education
Augmented Reality (AR) could provide key benefits in education and create a richer user experience by increasing the motivation and engagement of the students. Initially, AR was used as a science-oriented tool, but after its acceptance by students and teachers, it evolved into a modern pedagogical tool that was adopted into the classroom to enhance the educational process. In summary, AR-based technology has become a popular topic in educational fields in the last decade as well as in educational research [26]. Taking into consideration various modern educational disciplines, technologies such as AR must be included in the learning environment in science education; otherwise, the absence of them could possibly negatively affect productivity and learning achievements [27]. However, the educational values of AR in the domain of physical science are not exclusively based on the use of AR technologies themselves. These educational values are more likely connected to how AR is designed, implemented and integrated into formal and informal learning settings [28].
  • 1.5K
  • 12 Aug 2022
Topic Review
Drikung Kagyu
Drikung Kagyu or Drigung Kagyu (Wylie: 'bri-gung bka'-brgyud) is one of the eight "minor" lineages of the Kagyu school of Tibetan Buddhism. "Major" here refers to those Kagyu lineages founded by the immediate disciples of Gampopa (1079-1153) while "minor" refers to all the lineages founded by disciples of Phagmo Drupa (1110-1170), the main disciple of Gampopa.
  • 1.5K
  • 18 Nov 2022
Topic Review
FluxNet
FluxNet is a global network of micrometeorological tower sites that use eddy covariance methods to measure the exchanges of carbon dioxide, water vapor, and energy between the biosphere and atmosphere. Fluxnet is a global 'network of regional networks' that serves to provide an infrastructure to compile, archive and distribute data for the scientific community. It works to ensure that different flux networks are calibrated to facilitate comparison between sites, and it provides a forum for the distribution of knowledge and data between scientists. As of April 2014, there are over 683 tower sites in continuous long-term operation. Researchers also collect data on site vegetation, soil, trace gas fluxes, hydrology, and meteorological characteristics at the tower sites.
  • 1.5K
  • 22 Nov 2022
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