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Topic Review
Electric Fields for Cancers Treatment
The biological impact of exogenous, alternating electric fields (AEFs) and direct-current electric fields has a long history of study, ranging from effects on embryonic development to influences on wound healing. Tumor treating fields (TTFields) is a form of alternating electric fields (AEF) therapy that is delivered to the tumor via electrodes placed on the skin.
  • 1.6K
  • 16 Jun 2021
Topic Review
Iron Deficiency in Celiac Disease
Iron deficiency anemia (IDA) is the most recognized type of anemia in patients with celiac disease (CD) and may be present in over half of patients at the time of diagnosis. Folate and vitamin B12 malabsorption, nutritional deficiencies, inflammation, blood loss, development of refractory CD, and concomitant Heliobacter pylori infection are other causes of anemia in such patients. The decision to replenish iron stores and the route of administration (oral or intravenous) are controversial due, in part, to questions surrounding the optimal formulation and route of administration.
  • 1.6K
  • 09 Oct 2021
Topic Review
Drone-Based Package Delivery Logistics Systems
Autonomous Drone Delivery (ADD) modes are expected to become an important pillar of the future logistics industry for small parcel delivery at the last mile, as well as meal delivery service for fast food (e.g., pizza, etc.) and restaurants.
  • 1.6K
  • 19 Apr 2022
Topic Review
Vitamin D Deficiency Status in Malaysia
Vitamin D is essential for maintaining serum calcium levels, ensuring sufficient bone mineralization, immunomodulatory properties, and a protective effect on the cardiovascular system, renal disease, cancer, as well as in pregnancy. Vitamin D deficiency can be managed with pharmacological or non-pharmacological approaches, depending on the severity. The objective is to raise serum vitamin D to a normal level, hence, relieving the symptoms and reducing the adverse health outcomes. Despite no clear guidelines in treating vitamin D deficiency in Malaysia, this condition can be prevented with taking adequate vitamin D in food resources, sun exposure, or supplementation. Special attention should be given to high-risk groups including infants, obese patients, and the elderly.
  • 1.6K
  • 11 Feb 2022
Topic Review
Improving Dust Collector Efficiency for Pneumatic Conveying
A dust collection system removes the dust contents of an industrial environment to provide a comfortable work environment and meet safety and health regulations. The system takes the dust particles and carries them outside for disposal or reuse possibilities.
  • 1.6K
  • 28 Feb 2022
Topic Review
Raman Spectroscopy
Cancer still constitutes one of the main global health challenges. Novel approaches towards understanding the molecular composition of the disease can be employed as adjuvant tools to current oncological applications. Raman spectroscopy has been contemplated and pursued to serve as a noninvasive, real time, in vivo tool which may uncover the molecular basis of cancer and simultaneously offer high specificity, sensitivity, and multiplexing capacity, as well as high spatial and temporal resolution.
  • 1.6K
  • 11 Mar 2022
Topic Review
Machine Learning from Drone Forensics
Drones are flying Internet of Things (IoT) objects that are an embodiment of hardware designed to be driven by software-based controls. Drones are programmed to fly according to user-defined specifications and have on-device IoT sensors and cameras augmented with a Global Positioning System (GPS) controller to facilitate their flight and all activity relevant to their operations. Drones are useful for several civilian applications.
  • 1.6K
  • 12 May 2022
Topic Review
Machine-Learning-Based Digital Twin in Manufacturing
The Digital Twin (DT) concept in the manufacturing industry has received considerable attention from researchers because of its versatile application potential. Machine Learning (ML) adds a new dimension to DT by enhancing its functionality.
  • 1.6K
  • 06 Jul 2022
Topic Review
Ras Subfamily
Ras is a family of related proteins which is expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. Mutations in ras genes can lead to the production of permanently activated Ras proteins. As a result, this can cause unintended and overactive signaling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRas, KRas, and NRas) are the most common oncogenes in human cancer; mutations that permanently activate Ras are found in 20% to 25% of all human tumors and up to 90% in certain types of cancer (e.g., pancreatic cancer). For this reason, Ras inhibitors are being studied as a treatment for cancer and other diseases with Ras overexpression.
  • 1.6K
  • 04 Nov 2022
Biography
Lynn Gelhar
Lynn Gelhar is an American civil engineer focusing in hydrology and is currently Professor Emeritus at Massachusetts Institute of Technology.[1][2] He is recognized for pioneering research in stochastic subsurface hydrology, has leading research in the area of field-scale contaminant transport experiments, and has extensive experience on the hydrologic aspects of nuclear waste disposal. Lynn
  • 1.6K
  • 08 Dec 2022
Topic Review
Present Status of Biocomposite Materials
Since the complete replacement of fossil-based products is not feasible due to cost and performance, bio-based composite materials may have bio-based polymers, bio-based reinforcement, and fillers, or both, while having other ingredients from fossil fuel sources. As for reinforcement, nature can offer wooden and non-wooden fibers (bast, leaf, seed, core, grass, and reed) as composite reinforcements. Cellulosic non-wooden fibers offer tensile strengths ranging from 80 MPa for sisal to 938 MPa for ramie. Applications of biocomposites in structures and infrastructures have proven useful in terms of their moderate mechanical properties, lower cost, availability, biodegradability, and environmental considerations.. Hemp has been used in composite materials. However, it presents challenges; hemp fibers contain a high level of moisture, as plant-based sources are hydrophilic in nature. Its mechanical, thermal, and physical properties, such as tensile strength, wettability, flammability, and swelling, vary. These properties change with changes in plant anatomy, fiber processing conditions, growth conditions, and experimental methods.
  • 1.6K
  • 09 Jan 2023
Topic Review
NMR-Based Metabolomics in Food Quality Assessment
The ability of nuclear magnetic resonance spectroscopy (NMR) to extract chemical information from a complex mixture is invaluable and widely described in literature. Many applications of this technique in the foodomics field have highlighted how NMR could characterize food matrices, and it can be used all along its “life chain”: from farm to fork and from fork to the digestion process. 
  • 1.6K
  • 19 Jan 2023
Topic Review
Mitochondrial Calcium
Mitochondria calcium is a double-edged sword. The low levels of calcium are essential to maintain optimal rates of ATP production, extreme levels of calcium overcoming the mitochondrial calcium retention capacity leads to loss of mitochondrial function. In moderate amounts, ATP synthesis rates are inhibited in a calcium-titratable manner.
  • 1.6K
  • 31 Jan 2023
Topic Review
Noise in Designing a Transmission Electron Microscopy Laboratory
The proper design of a transmission electron microscopy facility is mandatory to fully use the advanced performances of modern equipment, capable of atomic resolution imaging and spectroscopies, and it is a prerequisite to conceive new methodologies for future advances of the knowledge. When quantitatively evaluating the effects of noise on TEM (Transmission Electron Microscopy)/STEM (Scanning Transmission Electron Microscopy) experiments, there are three main parameters to be considered: spatial resolution, signal amplitude, and signal-to-noise ratio. All of them can be negatively affected by the presence of external sources of noise, whose removal is crucial for TEM/STEM experiments to exploit the highest instrumental performance and capabilities. All noise sources of interest and relevant mitigation approaches are analyzed in detail. 
  • 1.6K
  • 09 May 2023
Topic Review
Magnetic Resonance Imaging of the Gastrointestinal Tract
Magnetic resonance imaging (MRI) performed with the more advanced imaging techniques allows an accurate assessment of many intestinal disorders, particularly inflammatory bowel disease and rectal cancer; in most of these diseases, MRI is invaluable for diagnosis, staging, and monitoring under treatment. Several MRI parameters are currently considered activity biomarkers for inflammatory and neoplastic diseases. Furthermore, in younger patients with acute or chronic GI disease, MRI can be safely used for short-term follow-up studies in many critical clinical situations because it is radiation-free. MRI assessment of functional gastro-esophageal and small bowel disorders is still in its infancy but very promising, while it is well established and widely used for dynamic assessment of anorectal and pelvic floor dysfunction; MRI motility biomarkers have also been described. 
  • 1.6K
  • 07 Aug 2023
Topic Review
Citrus Pruning in the Mediterranean Climate
Pruning is a common practice in citrus for various reasons. These include controlling and shaping the canopy; improving phytosanitary health, productivity, and fruit quality; and facilitating operations such as harvesting and phytosanitary treatments. Because pruning is an expensive operation, its need is sometimes questioned. However, it has been proven to be particularly important in Mediterranean citriculture, which is oriented towards producing fruits for a high-quality demanding fresh market.
  • 1.6K
  • 07 Oct 2023
Topic Review Peer Reviewed
Fatal Software Failures in Spaceflight
Space exploration has become an integral part of modern society, and since its early days in the 1960s, software has grown in importance, becoming indispensable for spaceflight. However, software is boon and bane: while it enables unprecedented functionality and cost reductions and can even save spacecraft, its importance and fragility also make it a potential Achilles heel for critical systems. Throughout the history of spaceflight, numerous accidents with significant detrimental impacts on mission objectives and safety have been attributed to software, although unequivocal attribution is sometimes difficult. In this Entry, we examine over two dozen software-related mishaps in spaceflight from a software engineering perspective, focusing on major incidents and not claiming completeness. This Entry article contextualizes the role of software in space exploration and aims to preserve the lessons learned from these mishaps. Such knowledge is crucial for ensuring future success in space endeavors. Finally, we explore prospects for the increasingly software-dependent future of spaceflight.
  • 1.6K
  • 13 Jun 2024
Topic Review
Āyatana
Āyatana (Pāli; Sanskrit: आयतन) is a Buddhist term that has been translated as "sense base", "sense-media" or "sense sphere". In Buddhism, there are six internal sense bases (Pali: ajjhattikāni āyatanāni; also known as, "organs", "gates", "doors", "powers" or "roots") and six external sense bases (bāhirāni āyatanāni or "sense objects"; also known as vishaya or "domains"). There are six internal-external (organ-object) saḷāyatana (Pāli; Skt. ṣaḍāyatana), pairs of sense bases:[note 1][note 2] Buddhism and other Indian epistemologies identify six "senses" as opposed to the Western identification of five. In Buddhism, "mind" denotes an internal sense organ which interacts with sense objects that include sense impressions, feelings, perceptions and volition.
  • 1.6K
  • 18 Oct 2022
Topic Review
Tire-Derived Rubber Recycle
Rubber, as elastomer, is difficult to recycle. Today, the main end of life routes of tyres and other rubber products are landfilling, incineration in e.g. cement plants, and grinding to a fine powder, with huge quantities lacking sustainable recycling of this valuable material. Devulcanization, i.e. the breaking up of sulfur bonds by chemical, thermo-physical or biological means, is a promising route that has been investigated for more than 50 years. This review article presents and update on the state-of-the art in rubber devulcanization. This review article addresses established devulcanization technologies and novel processes described in the scientific and patent literatures. It is expected that the public discussion of environmental impacts of thermoplastics will soon spill over to thermosets and elastomers. Therefore, the industry needs to develop and market solutions proactively. Tyre recycling through devulcanization has a huge lever, since approx. 40 million tons of tyres are discarded annually.
  • 1.6K
  • 27 Oct 2020
Topic Review
GPCR, ER Stress, and EMT
Endoplasmic reticular stress (ERS) is a dynamics adaptive mechanism that is triggered upon perturbations in ER homeostasis. Hence unfolded protein response (UPR) is activated by ERS as a distress signal. UPR is involved in cancer progression by aiding cells to adapt harsh environments and evading cell death. We have made a significant discovery in the area of ERS and cell death in colonic epithelial cells where have previously unraveled the relationship between ERS and anti- apoptotic protein Survivin in colon cancer cells. We established a time point for an aggressive ERS environment with the help of ERS dynamics thereby creating a perfect environment for testing drugs. However, the role of ERS in cancer is still perplexing. G-protein coupled receptors (GCPR) are another large family of cell surface receptors that respond to a variety of external signals. GPCRs are said to have an active association with ERS in order to trigger some key processes like epithelial mesenchymal transition (EMT) which is a prime step in metastasis. However, there are some essential candidates that play a role in hindering cancer progression through numerous pathways. We therefore wish to provide the readers with an exhaustive views and insights of ER stress biology.
  • 1.6K
  • 12 Oct 2020
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