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Topic Review
Clays and the Origin of Life
Clays are able to replicate and drive the evolution of metabolism; they have the catalytic ability to synthesize monomers (amino acids, nucleotides and so on) and polymerize them, resulting in RNA–peptide worlds in which RNA replicates (genes) and, in cooperation with coded peptides, drives the evolution of the cell. 
  • 6.4K
  • 25 Feb 2022
Topic Review
Communication
Communication (from Latin communicare, meaning "to share"or "to be in relation with") is "an apparent answer to the painful divisions between self and other, private and public, and inner thought and outer word." As this definition indicates, communication is difficult to define in a consistent manner, because it is commonly used to refer to a wide range of different behaviors (broadly: "the transfer of information"), or to limit what can be included in the category of communication (for example, requiring a "conscious intent" to persuade). John Peters argues the difficulty of defining communication emerges from the fact that communication is both a universal phenomena (because everyone communicates), and a specific discipline of institutional academic study. One possible definition of communication is the act of developing meaning among entities or groups through the use of sufficiently mutually understood signs, symbols, and semiotic conventions. In Claude Shannon's and Warren Weaver's influential model, human communication was imagined to function like a telephone or telegraph. Accordingly, they conceptualized communication as involving discrete steps: These elements are now understood to be substantially overlapping and recursive activities rather than steps in a sequence. For example, communicative actions can commence before a communicator formulates a conscious attempt to do so, as in the case of phatics; likewise, communicators modify their intentions and formulations of a message in response to real-time feedback (e.g., a change in facial expression). Practices of decoding and interpretation are culturally enacted, not just by individuals (genre conventions, for instance, trigger anticipatory expectations for how a message is to be received), and receivers of any message operationalize their own frames of reference in interpretation. The scientific study of communication can be divided into: The channel of communication can be visual, auditory, tactile/haptic (e.g. Braille or other physical means), olfactory, electromagnetic, or biochemical. Human communication is unique for its extensive use of abstract language. Development of civilization has been closely linked with progress in telecommunication.
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  • 02 Nov 2022
Topic Review
Honda Ridgeline (2006–2014)
{{Infobox automobile | name = Honda Ridgeline (YK1) | image = 2012 Honda Ridgeline Mexican RTL.jpg | caption = 2012 Honda Ridgeline RTL (Mexico) | production = Late 2004 – early 2015 | model_years = 2006–2014 | assembly = Alliston, Ontario, Canada (HCM) (2004–2009)Lincoln, Alabama, United States (HMA) (2008–2015) | body_style = 4-door pickup | layout = Front-engine, four-wheel drive | class = Mid-size pickup truck | related = | engine = 3.5 L J35A9 V6 (2006–2008)3.5 L J35Z5 V6 (2009–2014) | transmission = H5 BJFA 5-speed automatic | wheelbase = 122 in (3,099 mm) | length = 2006–2008: 206.8 in (5,253 mm)2009–2011: 207 in (5,258 mm)2012–2014: 206.9 in (5,255 mm) | width = 77.8 in (1,976 mm) | height = 70.3 in (1,786 mm)2012–2014 RTL: 71.2 in (1,808 mm) | weight = 2006–2008: 4,491–4,552 lb (2,037–2,065 kg)2009–2011: 4,504–4,564 lb (2,043–2,070 kg)2012–2014: 4,491–4,575 lb (2,037–2,075 kg) | successor = Honda Ridgeline (second generation) | manufacturer = Honda Contrary to some media reporting, Honda's publications state that the first generation Ridgeline was a uniquely engineered vehicle with only 7% of its components shared with other Honda vehicles. Its powertrain resembled the one used in the first generation Acura MDX but was "extensively calibrated and strengthened" for heavier hauling and towing duties. The first generation Ridgeline went on sale in March 2005 as a 2006 model year vehicle. Production of the first generation Ridgeline ended in early 2015. According to Honda, the Ridgeline was not designed to steal sales from the more traditional trucks sold in North America, but was developed to "give the 18% of Honda owners who also own pickups a chance to make their garages a Honda-only parking area." Despite the first generation Ridgeline's poor sales, according to the author of Driving Honda, this mid-size pickup was one of the more profitable vehicles for Honda with reported sales in over 20 countries.
  • 6.4K
  • 26 Oct 2022
Topic Review
History of Pregnancy Test
The home pregnancy test is the most frequently performed laboratory test for self-diagnosis (home diagnostic test). It is also the first laboratory test that has been adapted for self-use at home.
  • 6.4K
  • 11 Sep 2023
Topic Review
Wearable Devices for Non-Invasive Sensing
The development of wearable sensors is aimed at enabling continuous real-time health monitoring, which leads to timely and precise diagnosis anytime and anywhere. Unlike conventional wearable sensors that are somewhat bulky, rigid, and planar, research for next-generation wearable sensors has been focused on establishing fully-wearable systems. To attain such excellent wearability while providing accurate and reliable measurements, fabrication strategies should include (1) proper choices of materials and structural designs, (2) constructing efficient wireless power and data transmission systems, and (3) developing highly-integrated sensing systems.
  • 6.4K
  • 09 Feb 2021
Topic Review
The Pathogenesis of Epilepsy
Epilepsy is a chronic neurological disorder characterized by recurring spontaneous seizures. Drug resistance appears in 30% of patients and it can lead to premature death, brain damage or a reduced quality of life. The purpose of the study was to analyze the drug resistance mechanisms, especially neuroinflammation, in the epileptogenesis. The information bases of biomedical literature Scopus, PubMed, Google Scholar and SciVerse were used. To obtain full-text documents, electronic resources of PubMed Central and Research Gate were used. The article examines the recent research of the mechanisms of drug resistance in epilepsy and discusses the hypotheses of drug resistance development (genetic, epigenetic, target hypothesis, etc.). Drug-resistant epilepsy is associated with neuroinflammatory, autoimmune and neurodegenerative processes. Neuroinflammation causes immune, pathophysiological, biochemical and psychological consequences. Focal or systemic unregulated inflammatory processes lead to the formation of aberrant neural connections and hyperexcitable neural networks. Inflammatory mediators affect the endothelium of cerebral vessels, destroy contacts between endothelial cells and induce abnormal angiogenesis (the formation of “leaky” vessels), thereby affecting the blood–brain barrier permeability. Thus, the analysis of pro-inflammatory and other components of epileptogenesis can contribute to the further development of the therapeutic treatment of drug-resistant epilepsy.
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  • 26 May 2021
Topic Review
Battery Energy Storage Systems Ancillary Services
The battery energy storage system (BESS) is significant in providing ancillary services to the grid. The BESS plays a crucial role in facilitating the integration of renewable energy sources (RESs) into the grid by compensating for the fluctuations produced by RESs as intermittent resources. Ancillary services encompass all the services necessary for the grid operator (transmission and distribution operator) to maintain the system’s integrity, stability, and power quality. Grid operators ensure a reliable power supply, frequency, voltage, and power load within certain limits. 
  • 6.4K
  • 28 Feb 2024
Topic Review
Early Chinese Cartography
Early Chinese cartography began in the 5th century BC during the Warring States period when cartographers started to make maps of the Earth's surface. Its scope extended beyond China's borders with the expansion of the Chinese Empire under the Han dynasty. It entered its golden age with the invention of the compass in the 11th century during the Song dynasty, and reached its peak in the 15th century when the Ming dynasty admiral Zheng He went on a series of voyages to the South China Sea, Indian Ocean, and beyond.
  • 6.4K
  • 10 Oct 2022
Topic Review
Pole Weapon
A pole weapon or pole arm is a close combat weapon in which the main fighting part of the weapon is fitted to the end of a long shaft, typically of wood, thereby extending the user's effective range and striking power. Pole weapons are predominantly melee weapons, with a subclass of spear-like designs fit for both thrusting and throwing. Because many pole weapons were adapted from agricultural implements or other fairly abundant tools, and contained relatively little metal, they were cheap to make and readily available. When warfare would break out and the belligerents had a poorer class who could not pay for dedicated military weapons, leaders would often appropriate tools as cheap weapons. The cost of training was comparatively minimal, since these conscripted farmers had spent most of their lives using these "weapons" in the fields. This made polearms the favored weapon of peasant levies and peasant rebellions the world over. Pole arms can be divided into three broad categories: those designed for extended reach and thrusting tactics used in pike square or phalanx combat; those designed to increase leverage (thanks to hands moving freely on a pole) to maximize centrifugal force against cavalry; and those designed for throwing tactics used in skirmish line combat. Because their versatility, high effectiveness and cheap cost, polearms experimentation led to many variants and were the most frequently used weapons on the battlefield: bills, picks, dane axes, spears, glaives, guandaos, pudaos, poleaxes, halberds, harpoons, sovnyas, tridents, naginatas, bardiches, war scythes, and lances are all varieties of pole arms. Pole arms were common weapons on post-classical battlefields of Asia and Europe. Their range and impact force made them effective weapons against armored warriors on horseback, because they could be dismounted and/or penetrate said armor. The Renaissance saw a plethora of varieties. Pole arms in modern times are largely constrained to ceremonial military units such as the Papal Swiss Guard or Yeomen of the Guard, or traditional martial arts. Chinese martial arts in particular have preserved a wide variety of weapons and techniques.
  • 6.4K
  • 09 Nov 2022
Topic Review
Fake News and Potentially Manipulative Content
At the core of numerous definitions of fake news lies a statement that it contains information that does not correlate with facts and that it is directed towards disinforming the public in a conscious manner, which implies that the major features of fake news are untruthfulness/incorrectness and intended deception. For this reason, Jaster and Lanuis attribute the lack of truth and lack of truthfulness to the notion of fake news and, using this as a starting point, they claim that fake news is “wrong or deceptive (lack of truth) and that it is released with the intention of deceiving or, eventually, discrediting or neglecting the truth (lack of truthfulness)”. In her efforts to draw a line between fake news and the contents similar to it, Milica Kulić defines the former as “incorrect information containing unprovable, mostly completely fabricated data or claims, as well as quotations, released with a view to deceiving audiences”.
  • 6.4K
  • 26 Jan 2022
Topic Review
Cousin
Most generally, in the lineal kinship system used in the English-speaking world, a cousin is a type of familial relationship in which two relatives are two or more familial generations away from their most recent common ancestor. Commonly, "cousin" refers to a first cousin – a relative of the same generation whose most recent common ancestor with the subject is a grandparent. Degrees and removals are separate measures used to more precisely describe the relationship between cousins. Degree measures the separation, in generations, from the most recent common ancestor(s) to a parent of one of the cousins (whichever is closest), while removal measures the difference in generations between the cousins themselves, relative to their most recent common ancestor(s). To illustrate usage, a second cousin is a cousin with a degree of two; there are three (not two) generations from the common ancestor(s). When the degree is not specified, first cousin is assumed. A cousin "once removed" is a cousin with one removal. When the removal is not specified, no removal is assumed. Various governmental entities have established systems for legal use that can precisely specify kinship with common ancestors any number of generations in the past; for example, in medicine and in law, a first cousin is a type of third-degree relative.
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  • 25 Oct 2022
Topic Review
Salvia divinorum
Salvia divinorum Epling and Játiva is a psychoactive Mexican mint used for centuries by Mazatec Indian shamans or curanderos of north-eastern Oaxaca, Mexico, for divinatory and religious purposes and physical healing.
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  • 18 Mar 2021
Topic Review
Ynglism
Ynglism (Russian: Инглии́зм, also spelled "Yngliism" or "Inglyism"), institutionally the Ancient Russian Ynglistic Church of the Orthodox Old Believers—Ynglings (Древнерусская Инглиистическая Церковь Православных Староверов—Инглингов, Drevnerusskaya Ingliisticheskaya Tserkov' Pravoslavnykh Staroverov—Inglingov) is a direction of the Slavic Native Faith movement registered with the Ministry of justice of the Russian Federation in the early 1990s by Aleksandr Khinevich from Omsk, in Siberia.({{{1}}}, {{{2}}}) Adepts call themselves "Old Believers-Ynglings", seldom simply "Ynglings". The church is described by scholar Kaarina Aitamurto as having a well-defined doctrine, an authoritative leadership, and focusing on esoteric teachings.({{{1}}}, {{{2}}}) Ynglings regard themselves as perserving the true, orthodox (i.e. in accordance with the universal order), religious tradition of the Russians and of all the Slavs. Rodnover groups in Russia are strongly critical of Ynglism; the international veche (assembly) of Rodnover organisations even declared it a false religion. In the early 2000s the church faced judicial prosecutions for ethnic hatred, and Khinevich himself was imprisoned from 2009 to 2011. The central writings of Ynglism are the four Slavic-Aryan Vedas.
  • 6.4K
  • 25 Nov 2022
Topic Review
Malaysia Waste Management Practices
The three main municipalities of Malaysia, Kuala Lumpur, Penang, and Melaka, were discussed in their actions in household waste management practices and strategies in social, economy, information technology, and governance to achieve success for a better sustainability of the environment.
  • 6.4K
  • 06 Jun 2022
Topic Review
Single-Letter Second-Level Domain
Single-letter second-level domains are domain names in which the second-level domain consists of only one letter, such as x.com. In 1993, the Internet Assigned Numbers Authority (IANA) explicitly reserved all single-letter and single-digit second-level domain names in the top-level domains com, net, and org, and grandfathered those that had already been assigned. In December 2005, ICANN considered auctioning these domains.
  • 6.4K
  • 03 Nov 2022
Topic Review
Corporate Social Responsibility in Saudi Arabia
In Saudi Arabia, as in the international arena, corporate social responsibility (CSR) is a trending phenomenon that has been transforming and influencing government policies, business strategic management, and societal relationships.
  • 6.4K
  • 13 May 2022
Topic Review
Euro Health Consumer Index
Euro Health Consumer Index (EHCI) is a comparison of European health care systems based on waiting times, results, and generosity. The information is presented as a graphic index. EHCI was produced 2005–2009 and 2012–2016 by Health Consumer Powerhouse. The 2014 ranking included 37 countries measured by 48 indicators. It claims to measure the "consumer friendliness" of healthcare systems. It does not claim to measure which European state has the best healthcare system, but it does produce specialist Indexes on Diabetes, Cardiac Care, HIV, Headache and Hepatitis. In 2006 France was the champion with 768 points out of 1000. In the 2015 results the same performance would have given the 13th position among 35 countries because of the widespread improvements in standards. While no bias in favour of any health system was alleged, the index was criticised in the British Medical Journal by Martin McKee and others from the European Observatory on Health Systems and Policies in February 2016. Points they made included: A survey by the Centre for Population Change in 2019 produced results consistent with the index.
  • 6.4K
  • 09 Nov 2022
Topic Review
Abnormality (Behavior)
Abnormality (or dysfunctional behavior) is a behavioral characteristic assigned to those with conditions that are regarded as rare or dysfunctional. Behavior is considered to be abnormal when it is atypical or out of the ordinary, consists of undesirable behavior, and results in impairment in the individual's functioning. Abnormality in behavior, is that in which is considered deviant from specific societal, cultural and ethical expectations. These expectations are broadly dependent on age, gender, traditional and societal categorizations. The definition of abnormal behavior is an often debated issue in abnormal psychology, because of these subjective variables. Abnormal behavior should not be confused with unusual behavior. Behavior that is out of the ordinary is not necessarily indicative of a mental or psychological disorder. Abnormal behavior, on the other hand, while not a mental disorder in itself, is often an indicator of a possible mental and/or psychological disorder. A psychological disorder is defined as an "ongoing dysfunctional pattern of thought, emotion, and behavior that causes significant distress, and is considered deviant in that person's culture or society". It is important to note that abnormal behavior, as it relates to psychological disorders, would be "ongoing" and a cause of "significant distress". A mental disorder describes a patient who has a medical condition whereby the medical practitioner makes a judgement that the patient is exhibiting abnormal behavior based on the DSM-5 criteria. Thus, simply because a behavior is unusual it does not make it abnormal; it is only considered abnormal if it meets these criteria. The Diagnostic and Statistical Manual of Mental Disorders, or DSM-5, is used by both researchers and clinicians in diagnosing a potential mental disorder. The criteria needed to be met in the DSM-5 varies for each mental disorder. Unlike physical abnormalities in ones health whose symptoms are objective, psychology health professionals cannot use objective symptoms when evaluating someone for abnormalities in behavior.
  • 6.4K
  • 03 Nov 2022
Topic Review
Apoptosis
Apoptosis is a multistep process that involves two major pathways to trigger a cascade of events leading to the fragmentation of chromatin, nuclear membrane, and cell shrinkage. However, when this physiological process tended to be dysregulated, many pathological transformations happen to develop cancer.
  • 6.4K
  • 23 Jun 2021
Topic Review
Intermittent Energy Source
An intermittent energy source is any source of energy that is not continuously available for conversion into electricity and outside direct control because the used primary energy cannot be stored. Intermittent energy sources may be predictable but cannot be dispatched to meet the demand of an electric power system. The use of intermittent sources in an electric power system usually displaces storable primary energy that would otherwise be consumed by other power stations. Another option is to store electricity generated by non-dispatchable energy sources for later use when needed, e.g. in the form of pumped storage, compressed air or in batteries. A third option is the sector coupling e.g. by electric heating for district heating schemes. The use of small amounts of intermittent power has little effect on grid operations. Using larger amounts of intermittent power may require upgrades or even a redesign of the grid infrastructure.
  • 6.4K
  • 26 Oct 2022
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