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Topic Review
Drug Delivery Systems for Natural Bioactive Molecules
Drug delivery systems are believed to increase pharmaceutical efficacy and the therapeutic index by protecting and stabilizing bioactive molecules, such as protein and peptides, against body fluids’ enzymes and/or unsuitable physicochemical conditions while preserving the surrounding healthy tissues from toxicity. Liposomes are biocompatible and biodegradable and do not cause immunogenicity following intravenous or topical administration. Still, their most important characteristic is the ability to load any drug or complex molecule uncommitted to its hydrophobic or hydrophilic character. Selecting lipid components, ratios and thermo-sensitivity is critical to achieve a suitable nano-liposomal formulation. Nano-liposomal surfaces can be tailored to interact successfully with target cells, avoiding undesirable associations with plasma proteins and enhancing their half-life in the bloodstream. Macropinocytosis-dynamin-independent, cell-membrane-cholesterol-dependent processes, clathrin, and caveolae-independent mechanisms are involved in liposome internalization and trafficking within target cells to deliver the loaded drugs to modulate cell function. 
  • 1.6K
  • 23 Dec 2022
Topic Review
Acidophilic Lactic Acid Bacteria in Foods and Health
Acidophilic lactic acid bacteria (LAB) are the most commonly used low-pH microorganisms in the healthcare, pharmaceutical, and food industries.
  • 1.6K
  • 08 Aug 2023
Topic Review
The Lifetime of Organic Light-Emitting Diodes
Organic light-emitting diodes (OLEDs) have emerged as a promising technology for various applications owing to their advantages, including low-cost fabrication, flexibility, and compatibility. However, a limited lifetime hinders the practical application of OLEDs in electronic devices. OLEDs are prone to degradation effects during operation, resulting in a decrease in device lifetime and performance. 
  • 1.6K
  • 29 Nov 2023
Topic Review
Iron and Glucose Metabolism
Iron is essential for energy metabolism, and states of iron deficiency or excess are detrimental for organisms and cells. Therefore, iron and carbohydrate metabolism are tightly regulated. Serum iron and glucose levels are subjected to hormonal regulation by hepcidin and insulin, respectively. Hepcidin is a liver-derived peptide hormone that inactivates the iron exporter ferroportin in target cells, thereby limiting iron efflux to the bloodstream. Insulin is a protein hormone secreted from pancreatic β-cells that stimulates glucose uptake and metabolism via insulin receptor signaling. There is increasing evidence that systemic, but also cellular iron and glucose metabolic pathways are interconnected. 
  • 1.6K
  • 27 Apr 2021
Topic Review
Ciguatera in the Indian Ocean
Ciguatera poisoning is regarded globally as the most significant non-bacterial poisoning associated with fish consumption. It is usually limited to the consumption of toxic fish from regions between the latitudes 35° N and 35° S. Studies have shown a strong positive correlation between Gambierdiscus abundance and algal macrophytes. Some earlier studies proposed a standardized methodology for estimating Gambierdiscus abundance based on sampling macroalgae.
  • 1.6K
  • 17 Aug 2021
Topic Review
Adipogenic Transcription Factors
Adipogenic transcription factors including CCAAT/enhancer binding protein alpha (C/EBPα), C/EBP beta (C/EBPβ) and peroxisome proliferator-associated receptor gamma (PPARγ) are also expressed by osteoclastogenic cells. However, in contrast to MSCs, activation of these adipogenic transcription factors in HSCs promotes the differentiation of osteoclast precursors into mature osteoclasts. Herein, we discuss the molecular mechanisms that link adipogenic transcription factors to the osteoclast differentiation program.
  • 1.6K
  • 28 Oct 2020
Topic Review
Advances in Histone Demethylase KDM3A
Lysine-specific histone demethylase 3 (KDM3) subfamily proteins are H3K9me2/me1 histone demethylases that promote gene expression. The KDM3 subfamily primarily consists of four proteins (KDM3A−D). All four proteins contain the catalytic Jumonji C domain (JmjC) at their C-termini, but whether KDM3C has demethylase activity is under debate. In addition, KDM3 proteins contain a zinc-finger domain for DNA binding and an LXXLL motif for interacting with nuclear receptors. Of the KDM3 proteins, KDM3A is especially deregulated or overexpressed in multiple cancers, making it a potential cancer therapeutic target. However, no KDM3A-selective inhibitors have been identified to date because of the lack of structural information. Uncovering the distinct physiological and pathological functions of KDM3A and their structure will give insight into the development of novel selective inhibitors.
  • 1.6K
  • 19 Oct 2020
Topic Review
KIT Gene
KIT proto-oncogene receptor tyrosine kinase
  • 1.6K
  • 23 Dec 2020
Topic Review
BET Inhibitors in AIDS Therapy
A critical burden of AIDS therapy is the evasive nature of HIV-1 in face of host immune responses, the so-called “latency.” Recently, a promising approach, the “Shock and Kill” strategy, was proposed to eliminate latently HIV-1-infected cell reservoirs. This therapeutic concept involves two crucial steps: HIV-1 reactivation from its latency stage using a latency-reversing agent (LRA) followed by host immune responses to destroy HIV-1-infected cells in combination with reinforced antiretroviral therapy to kill the progeny virus. Looking at epigenetics of HIV-1 infection, researchers proved that some bromodomains and extra-terminal motif protein inhibitors (BETis) can reactivate HIV-1 from latency. However, to date, only a few BETis have shown HIV-1-reactivating functions, and none of them have yet been approved for clinical trial.  
  • 1.6K
  • 29 Jun 2021
Topic Review
Impacts of Phytoestrogens on Grazing Livestock
Phytoestrogens are secondary plant metabolites that play a role in plant defense, and when ingested by livestock have numerous functions related to reproduction, metabolism, immunological functions and livestock growth and performance. Phytoestrogens are found across various plant species, with the most biologically active of these, isoflavones and coumestans, abundant in legume species.
  • 1.6K
  • 27 Oct 2022
Topic Review
Rational ClearQuest
ClearQuest is an enterprise level workflow automation tool from the Rational Software division of IBM. Commonly, ClearQuest is configured as a bug tracking system, but it can be configured to act as a CRM tool or to track a complex manufacturing process. It can also implement these functions together. IBM provides a number of predefined "schemas" for common tasks such as software defect tracking which can themselves be further customized if required.
  • 1.6K
  • 31 Oct 2022
Topic Review
Louvain Modularity
The Louvain Method for community detection is a method to extract communities from large networks created by Blondel et al. from the University of Louvain (affiliation of authors has given the method its name). The method is a greedy optimization method that appears to run in time [math]\displaystyle{ O(n \log n) }[/math].
  • 1.6K
  • 10 Nov 2022
Topic Review
KRAS in Non-Small Cell Lung Cancer
In NSCLC (Non-Small Cell Lung Cancer), KRAS (Kirsten Rat sarcoma virus) mutations occur in up to 30% of all cases, most frequently at codon 12 and 13. KRAS mutations have been linked to adenocarcinoma histology, positive smoking history, and Caucasian ethnicity, although differences have been described across KRAS mutational variants subtypes. KRAS mutations often concur with other molecular alterations, notably TP53, STK11, and KEAP1, which could play an important role in treatment efficacy and patient outcomes.
  • 1.6K
  • 02 Dec 2022
Biography
Seth Andrews
Template:Infobox author Seth Andrews (born April 12, 1968) is an author and speaker on the subject of atheism. He is the creator and host of The Thinking Atheist online community, podcast, and YouTube channel, and the author of the self-published books Deconverted and Sacred Cows. Prior to his atheist activism, he was a fundamentalist Christian and had a ten-year career as a Christian radio host
  • 1.6K
  • 13 Dec 2022
Topic Review
Nanotechnology for Precision Agriculture
By adopting nanotechnology-based precision agricultural practices, the farming community can reduce agrochemicals while maintaining high crop productivity, protecting soil and water health, and contributing to a cleaner environment.
  • 1.6K
  • 14 Jun 2023
Topic Review
Sugarcane Bagasse as a Feedstock for Bioethanol Production
Lignocellulosic biomass is a powerful approach to produce sustainable biofuels and the further achievement of the goal of biomass conversion into a second-generation clean energy that can cope with the depletion of fossil reserves and rising energy requirements. In the conversion process, a pretreatment is essential to overcome the recalcitrance of the lignocellulosic biomass; accelerate its disintegration into cellulose, hemicellulose, and lignin; and, in turn, obtain an optimal yield of fermentable sugars in the enzymatic hydrolysis. In addition to this, it should be industrially scalable and capable of enhancing fuel properties and feedstock processability. Here, steam explosion technology has stood out due to its results and advantages, such as wide applicability, high efficiency in the short term, or lack of contamination despite its conventionality. 
  • 1.6K
  • 10 Nov 2023
Topic Review
Ethiopian Anticancer Plants
This entry provides an overview on the active phytochemical constituents of twenty-seven medicinal plants that are traditionally used to manage cancer in Ethiopia. It is compiled and discusses the potential anticancer, antiproliferative, and cytotoxic agents based on the types of secondary metabolites, such as terpenoids, phenolic compounds, alkaloids, steroids, and lignans. Among the anticancer secondary metabolites reported in this review, only few have been isolated from plants that are originated and collected in Ethiopia, and the majority of compounds are reported from plants belonging to different areas of the world. Thus, based on the available bioactivity reports, extensive and more elaborate ethnopharmacology-based bioassay-guided studies have to be conducted on selected traditionally claimed Ethiopian anticancer plants, which inherited from a unique and diverse landscape, with the aim of opening a way forward to conduct anticancer drug discovery program.
  • 1.6K
  • 21 Oct 2020
Topic Review
Oral–Gut Microbiome Axis
The oral cavity and gut are the two largest microbial ecosystems. The oral-to-gut and gut-to-oral microbial transmission can regulate pathogenesis, indicating the presence of the oral–gut microbiome axis. 
  • 1.6K
  • 12 May 2021
Topic Review
Molecular Iodine Capture by Covalent Organic Frameworks
Covalent organic frameworks (COFs) are a class of extended crystalline porous polymers that possess unique architectures with high surface areas, long-range order, and permanent porosity. It is known that the possible radioactive iodine species in the environment are iodate (IO3−), molecular iodine (I2), and organic iodine species (e.g., methyl iodide (CH3I) and ethyl iodide (CH3CH2I)). Different iodine species need to be handled in different ways.
  • 1.6K
  • 14 Feb 2023
Topic Review
Alkyl Levulinates
Alkyl levulinates (AlkLevs) are biobased chemicals that occupy a strategic role in biomass valorization as potential substitutes of several oil-based compounds (fuels, solvents, chemical intermediates).
  • 1.6K
  • 08 Oct 2021
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