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Topic Review
Superficial Spindle Cell Mesenchymal Tumors
Superficial spindle cell mesenchymal tumors form a diverse group of lesions with benign and malignant entities that are often very similar clinically and/or histologically. In children, the patient’s age; the lesion site; the presentation as a mass, nodule, or plaque; and the location in the dermis or subcutis are important features that will guide the dermatologist and the pathologist.
  • 1.6K
  • 02 Oct 2021
Topic Review
Cost-Benefit Analysis
Cost-benefit analysis (CBA) is a method that is used for making investment decisions in public and private sector, and comparing benefits and costs resulting from the investments. This method attempts to determine present value of potential benefits and costs of any intended investment, and selects the project with the most benefits by comparing various projects designed for the investment.
  • 1.6K
  • 29 Oct 2020
Topic Review
Anticancer Activity of Berberine
Berberine is a plant metabolite belonging to the group of isoquinoline alkaloids with strong biological and pharmacological activity. Currently, berberine is receiving considerable interest due to its anticancer activity based on many biochemical pathways, especially its proapoptotic and anti-inflammatory activity. Therefore, the growing number of papers on berberine demands summarizing the knowledge and research trends. The efficacy of berberine in breast and colon cancers seems to be the most promising aspect. Many papers focus on novel therapeutic strategies based on new formulations or search for new active derivatives. The activity of berberine is very important as regards sensitization and support of anticancer therapy in combination with well-known but in some cases inefficient therapeutics. Currently, the compound is being assessed in many important clinical trials and is one of the most promising and intensively examined natural agents.
  • 1.6K
  • 23 Nov 2020
Topic Review
Clinical Trials of Parkinson’s Disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that currently has no cure, but treatments are available to improve PD symptoms and maintain quality of life.
  • 1.6K
  • 03 Aug 2021
Topic Review
Greenhouse Gas Emissions from Reservoirs
Reservoirs are manmade lakes created by building dams on rivers for various purposes: flood control, electricity generation, irrigation, water supply, aquaculture, environmental services, recreational activities, navigation etc. In freshwater ecosystems, several mechanisms are involved in the natural carbon cycle. They receive carbon from terrestrial ecosystems through drainage, capture the carbon through primary production, bury the carbon in sediments, emit GHG through biomass degradation and respiration, and transport the carbon downstream to the seas or oceans. GHG emissions can be increased by human activities around the ecosystem through sewage and agricultural pollution.
  • 1.6K
  • 03 Nov 2021
Topic Review
Temperature and Root System of Two Lupine Species
The aim of this entry was to assess the effect of elevated temperature on the growth, morphology and spatial orientation of lupine roots at the initial stages of development and on the formation of lupine root architecture at later stages. Two lupine species were studied—the invasive Lupinus polyphyllus Lindl. and the non-invasive L. luteus L. The plants were grown in climate chambers under 25 °C and simulated warming at 30 °C conditions. The angle of root curvature towards the vector of gravity was measured at the 48th hour of growth, and during a 4-h period after 90° reorientation. Root biometrical, histological measurements were carried out on 7-day-old and 30-day-old plants. The elevation of 5 °C affected the root formation of the two lupine species differently. The initial roots of L. polyphyllus were characterized by worse spatial orientation, reduced growth and reduced mitotic index of root apical meristem at 30 °C compared with 25 °C. The length of primary roots of 30-day-old lupines and the number of lateral roots decreased by 14% and 16%, respectively. 
  • 1.6K
  • 18 Jan 2022
Topic Review
Nano/Microrobots in Action for Gastrointestinal Tract Diseases
Nano/microrobots (NMRs) are tiny devices that can convert energy into motion and operate at nano/microscales.54 Especially in biomedical research, NMRs have received much attention over the past twenty years because of their excellent capabilities and great potential in various applications, including on-demand drug delivery, gene and cell transport, and precise microsurgery. Reports published in recent years show that synthetic nano/microrobots have promising potential to function in the gastrointestinal (GI) region, particularly in terms of drug delivery.
  • 1.6K
  • 20 Jan 2022
Topic Review
Coffee By-Products and Their Applications
As coffee consumption is on the rise, and the global coffee production creates an excess of 23 million tons of waste per year, a revolutionary transition towards a circular economy via the transformation and valorization of the main by-products from its cultivation and preparation (Coffee Husk (CH), Coffee Pulp (CP), Coffee Silverskin (CS), and Spent Coffee Grounds (SCG)) is inspiring researchers around the world.
  • 1.6K
  • 25 Jan 2022
Topic Review
Geology and Geomorphology of Mare Fecunditatis
Mare Fecunditatis is a ~310,000 km2 flat basalt plain located in the low-latitude area of the Moon. Mare Fecunditatis basin was formed in the pre-Nectarian period, followed by the mare basalts eruption in the Imbrian period, and the volcanic activity continued until the early Eratosthenian period. There is no mass concentration in the center of Mare Fecunditatis, while there are positive Bouguer anomalies on the east and west sides of the basin. A diversity of geological features is found in Mare Fecunditatis.
  • 1.6K
  • 07 Mar 2022
Topic Review
Anesthesiologist Assistant
In the United States , anesthesiologist assistants - known in full as certified anesthesiologist assistants - are master's degree prepared clinicians that practice medicine under the direction of licensed anesthesiologists to implement anesthesia care plans for a patient undergoing surgery. CAAs are integral members of the anesthesia care team as described by the American Society of Anesthesiologists (ASA). All CAAs possess a baccalaureate degree (in any field with a major focus on pre med sciences), and complete an intensive didactic and clinical program at a postgraduate level. CAAs are trained in the delivery and maintenance of all types of anesthesia care as well as advanced patient monitoring techniques under the direction of a physician anesthesiologist. The goal of CAA education is to guide the transformation of student applicants into competent clinicians who aspire to practice in the anesthesia care team.
  • 1.6K
  • 20 Oct 2022
Topic Review
Red Blood Cells
Red blood cells are the most common type of blood cell and the vertebrate body's principal means of delivering oxygen from the lungs or gills to body tissues via the blood. Red blood cells are also known as RBCs or erythrocytes (from Greek erythros for "red" and kytos for "hollow", with cyte nowadays translated as "cell"). A schistocyte is a red blood cell undergoing fragmentation, or a fragmented part of a red blood cell.
  • 1.6K
  • 01 Nov 2022
Topic Review
Mechanisms of Oxidative Stress in Metabolic Syndrome
Metabolic syndrome is characterized by abdominal obesity, high blood pressure, insulin resistance, a proinflammatory and prothrombotic state, atherogenic dyslipidemia , and low high-density lipoprotein cholesterol (HDL-C). Metabolic syndrom is mediated by oxidative stress and inflammation. Although the mechanisms are complicated and not very clear, this entry elucidates the mechanisms and pathways that drive oxidative stress in contributing to metabolic syndrome.
  • 1.6K
  • 09 May 2023
Topic Review
Technological Breakthroughs in Sport
We are currently witnessing an unprecedented era of digital transformation in sports, driven by the revolutions in Artificial Intelligence (AI), Virtual Reality (VR), Augmented Reality (AR), and Data Visualization (DV). These technologies hold the promise of redefining sports performance analysis, automating data collection, creating immersive training environments, and enhancing decision-making processes. Traditionally, performance analysis in sports relied on manual data collection, subjective observations, and standard statistical models. These methods, while effective, had limitations in terms of time and subjectivity.
  • 1.6K
  • 26 Sep 2025
Topic Review
Stroke of Cortical Hand Knob Area
The cortical hand knob region of the brain is a knob-like segment of the precentral gyrus, projecting into the middle genu of the central sulcus. This anatomic landmark is responsible for intricate control of hand motor movements and has often been implicated in motor weakness following stroke.
  • 1.6K
  • 27 Feb 2024
Topic Review
Candida and Candidiasis
One of the most important questions in microbiology nowadays is how apparently harmless, commensal yeasts such as Candida spp. can cause a rising number of infections. The occurrence of the disease requires firstly the attachment to the host cells, followed by the invasion of the tissue. The adaptability translates into a rapid ability to respond to stress factors, to take up nutrients or to multiply under different conditions. By forming complex intracellular networks such as biofilms, Candida spp. become not only more refractive to antifungal therapies but also more prone to cause disease. The inter-microbial interactions can enhance the virulence of a strain. In vivo, the fungal cells face a multitude of challenges and, as a result, they develop complex strategies serving one ultimate goal: survival. This review presents the virulence factors of the most important Candida spp., contributing to a better understanding of the onset of candidiasis and raising awareness of the highly complex interspecies interactions that can change the outcome of the disease.
  • 1.6K
  • 27 Oct 2020
Topic Review
Precision Agriculture for Farming
Precision agriculture (PA) is a technology-enabled, data-driven approach to farming management that observes, measures, and analyzes the needs of individual fields and crops. Precision livestock farming (PLF), relying on the automatic monitoring of individual animals, is used for animal growth, milk production, and the detection of diseases as well as to monitor animal behavior and their physical environment, among others.
  • 1.6K
  • 18 Oct 2021
Topic Review
Alpha-Ketoglutarate and 5-HMF
Clinical and pre-clinical studies of an anti-tumoral solution containing aKG, 5-HMF, N-acetyl-selenomethionine, and N-acetylmethionine for treating tumors showed, on one hand, good therapeutic efficacy during infusion therapy in prostate cancer patients by increasing the PSA doubling time; on the other hand, a reduction of tumoral mass was shown in lung cancer patients.
  • 1.6K
  • 19 Nov 2021
Topic Review
Vitamin A and Pregnancy
Vitamin A is a crucial micronutrient for pregnant women and their fetuses. In addition to being essential for morphological and functional development and for ocular integrity, vitamin A exerts systemic effects on several fetal organs and on the fetal skeleton. 
  • 1.6K
  • 09 Aug 2022
Topic Review
Lane Marking Detection Using Deep Neural Networks
Lane marking recognition is one of the most crucial features for automotive vehicles as it is one of the most fundamental requirements of all the autonomy features of Advanced Driver Assistance Systems (ADAS).
  • 1.6K
  • 27 Oct 2022
Topic Review
Spanish Baccalaureate
The Spanish Baccalaureate (Spanish: Bachillerato) is the post-16 stage of education in Spain, comparable to the A Levels/Higher (Scottish) in the UK, the French Baccalaureate in France or the International Baccalaureate. It follows the ESO (compulsory stage of secondary education). After taking the Bachillerato, a student may enter vocational training (Higher-level Training Cycles, Ciclos Formativos de Grado Superior) or take the "Selectividad" tests for admission to university. There are two parts, a core curriculum with the compulsory subjects and a specialist part with a number of pre-selected branches to choose from.
  • 1.6K
  • 26 Oct 2023
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