Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Geochemical Modeling Applications
The geochemical computer model is an important innovation that exponentially evolved in the last decades, and that now plays a vital role in several areas of study, ranging from developing new models for surface complexation, reactive transport models, or the generation of thermodynamic data used to simulate or predict solubility reactions. An important application of geochemical modeling involves supporting the explanation or characterization of engineering systems related to waste management, wastewater reuse, evaluation of water quality from a landfill, metal speciation within soils in industrial areas, new technologies or process for waste treatment, and even the evaluation of the potential to use solid wastes in carbon sequestering processes.
  • 1.6K
  • 03 Aug 2021
Topic Review
Diet and Male Fertility
Nutrition can affect, negatively or positively, sperm quality and this effect depends on both quantitative and qualitative aspects of the diet, such as calorie content of each macronutrient (carbohydrates, protein, and fats), as well as on the specific fatty acid composition, carbohydrates, and protein profiles. While a Western diet is considered a risk factor for male infertility, the Mediterranean diet seems to protect against male infertility; moreover, the role of a vegetarian habitus in the preservation of sperm quality is controversial. Since diet may be an important modifiable determinant of male reproductive potential,  the role of daily nutrient exposure needs to be highlighted to preserve male fertility or to prevent male infertility. 
  • 1.6K
  • 06 May 2023
Topic Review
Ivacaftor (VX-770)
Ivacaftor possesses a molecular structure characterized by the presence of an N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxamide moiety. The quinolone scaffold within its composition is a crucial pharmacophore, significantly influencing drug discovery. This scaffold holds prominence as one of the primary classes of nitrogen-containing heterocycles found in various biologically active compounds and blockbuster drugs, as highlighted in the literature. The amide group serves as a crucial link between the “privileged building block” and the di-tert-butylphenol in ivacaftor’s structure. This linkage is of considerable importance in medicinal chemistry due to its multifaceted role.
  • 1.6K
  • 17 Feb 2024
Topic Review
Actinobacteria and Environmental Adaptations
Actinobacteria are among the secondary metabolites producers and hold high pharmacological and commercial interest. It has great capability to produce secondary metabolites such as immunomodulators, antibiotics, anti-cancer drugs, growth factors, anthelminthic enzymes and herbicides.describes the historical isolation of bioactive compounds from Actinobacteria from the first isolation by Selman Waksman.
  • 1.6K
  • 05 Aug 2021
Topic Review
Applications of Molecular Dynamics Simulation in Protein Study
Molecular Dynamics (MD) Simulations is increasingly used as a powerful tool to study protein structure-related questions. Starting from the early simulation study on the photoisomerization in rhodopsin in 1976, MD Simulations has been used to study protein function, protein stability, protein–protein interaction, enzymatic reactions and drug–protein interactions, and membrane proteins.
  • 1.6K
  • 08 Sep 2022
Topic Review
Dietary Flavonoids
Over the past few years, interest in health research has increased, making improved health a global goal for 2030. The purpose of such research is to ensure healthy lives and promote wellbeing across individuals of all ages. It has been shown that nutrition plays a key role in the prevention of some chronic diseases such as obesity, cardiovascular disease, diabetes, and cancer. One of the aspects that characterises a healthy diet is a high intake of vegetables and fruits, as both are flavonoid-rich foods. Flavonoids are one of the main subclasses of dietary polyphenols and possess strong antioxidant activity and anti-carcinogenic properties. Moreover, some population-based studies have described a relationship between cancer risk and dietary flavonoid intake.
  • 1.6K
  • 03 Sep 2021
Topic Review
Meermin (VOC Ship)
Meermin (Dutch pronunciation: [ˈmeːrmɪn] (listen)) was an 18th-century Dutch cargo ship of the hoeker type, one of many built and owned by the Dutch East India Company. She was laid down in 1759 and fitted out as a slave ship before her maiden voyage in 1761, and her career was cut short by a mutiny of her cargo of Malagasy people. They had been sold to Dutch East India Company officials on Madagascar , to be used as company slaves in its Cape Colony in southern Africa. Half her crew and almost 30 Malagasy lost their lives in the mutiny; the mutineers deliberately allowed the ship to drift aground off Struisbaai, now in South Africa, in March 1766, and she broke up in situ. As of 2013, archaeologists are searching for the Meermin's remains.
  • 1.6K
  • 26 Oct 2022
Topic Review
miRNAs in Cancer
Scientific investigations have shown the involvement of microRNAs (miRNAs) as a new key factor for cancer development and progression. Owing to their role in the regulation of gene expression and their stability (resistance to endogenous RNase activity) in body fluids, miRNAs have been extensively shown to be of particular interest for diagnosis, recurrence, identification, and treatment of cancer metastasis.  Despite miRNAs being considered small conserved regulators with the limitation of target specificity, we outline the dual role of melanoma-associated miRNAs, as oncogenic and/or tumor suppressive factors, compared to other tumors. 
  • 1.6K
  • 27 Oct 2020
Topic Review
Skin Photoprotection by Polyphenols
Polyphenols are phytochemicals with proven antioxidant and antiinflammatory properties. Premature aging and UV-induced skin conditions could be better overcome by topical polyphenols nanoformulations. Further, polyphenols nanoformulations can be of great interest for the cosmetic industries and any individuals who want to improve their skin appearance. Examples in this regard are provided and the potential toxicity issues related to the use of nanomaterials are highlighted.
  • 1.6K
  • 26 Nov 2020
Topic Review
Unrecognizable Memory Phenotype CD8+ T-cells
Virtual memory T (TVM) cells are a recently described population of conventional CD8+ T cells that, in spite of their antigen inexperience, express markers of T cell activation. TVM cells exhibit rapid responsiveness to both antigen-specific and innate stimuli in youth but acquire intrinsic antigen-specific response defects in the elderly.
  • 1.6K
  • 09 Dec 2020
Topic Review
Muscular Dystrophies
Muscle dystrophy is a muscle disease that leads to a progressive loss of muscle mass and a weakened musculoskeletal system in accordance with age of onset, severity, and the group of muscles affected.
  • 1.6K
  • 21 Jan 2021
Topic Review
Biodiesel Production Technologies
Dependence on fossil fuels for meeting the growing energy demand is damaging the world’s environment. There is a dire need to look for alternative fuels that are less potent to greenhouse gas emissions. Biofuels offer several advantages with less harmful effects on the environment. Biodiesel is synthesized from the organic wastes produced extensively like edible, non-edible, microbial, and waste oils.
  • 1.6K
  • 18 Feb 2021
Topic Review
PKA-p38MAPK-NFAT5-Pathway and Duchenne Muscular Dystrophy
In Duchenne muscular dystrophy (DMD), the absence of dystrophin from the dystrophin-associated protein complex (DAPC) causes muscle membrane instability, which leads to myofiber necrosis, hampered regeneration, and chronic inflammation. The resulting disabled DAPC-associated cellular pathways have been described both at the molecular and the therapeutical level, with the Toll-like receptor nuclear factor kappa-light-chain-enhancer of activated B cells pathway (NF-ƘB), Janus kinase/signal transducer and activator of transcription proteins, and the transforming growth factor-β pathways receiving the most attention. The protein kinase A/ mitogen-activated protein kinase/nuclear factor of activated T-cells 5/organic osmolytes (PKA-p38MAPK-NFAT5-organic osmolytes) pathway. This pathway plays an important role in osmotic homeostasis essential to normal cell physiology via its regulation of the influx/efflux of organic osmolytes. Besides, NFAT5 plays an essential role in cell survival under hyperosmolar conditions, in skeletal muscle regeneration, and in tissue inflammation, closely interacting with the master regulator of inflammation NF-ƘB. 
  • 1.6K
  • 26 Apr 2021
Topic Review
Myokine Irisin in Cancer
Regular exercise/physical activity is beneficial for the health of an individual and lowers the risk of getting different diseases, including cancer. How exactly exercise results in these health benefits is not known. Recent studies suggest that the molecule irisin released by muscles into the blood stream after exercise may be responsible for these effects.
  • 1.6K
  • 17 Jun 2021
Topic Review
Influence of Lamination Process on Lithium-Ion Batteries
In lithium-ion battery manufacturing, wetting of active materials is a time-critical process. Consequently, the impact of possible process chain extensions such as lamination needs to be explored to potentially improve the efficiency of the electrode and separator stacking process in battery cell manufacturing. 
  • 1.6K
  • 26 Nov 2021
Topic Review
Bioaccumulation of Fluoride and Its Microbially Assisted Remediation
Fluoride is widely found in soil–water systems due to anthropogenic and geogenic activities that affect millions worldwide. Fluoride ingestion results in chronic and acute toxicity, including skeletal and dental fluorosis, neurological damage, and bone softening in humans. 
  • 1.6K
  • 17 Dec 2021
Topic Review
Signal Processing of Pulsed Thermography for Enhanced Detectability
Non-destructive testing (NDT) is a broad group of testing and analysis techniques used in science and industry to evaluate the properties of a material, structure, or system for characteristic defects and discontinuities without causing damage. Recently, infrared thermography is one of the most promising technologies as it can inspect a large area quickly using a non-contact and non-destructive method. Moreover, thermography testing has proved to be a valuable approach for non-destructive testing and evaluation of structural stability of materials. Pulsed thermography is one of the active thermography technologies that utilizes external energy heating. However, due to the non-uniform heating, lateral heat diffusion, environmental noise, and limited parameters of the thermal imaging system, there are some difficulties in detecting and characterizing defects.
  • 1.6K
  • 17 Jan 2022
Topic Review
Allosteric Modulation of Adenosine A2A Receptors
Adenosine is a naturally occurring purine nucleoside that regulates various physiologic functions, including inflammation and wound healing, cardiac contraction, blood vessel formation, vasodilation, learning, memory, sleep, and arousal. Adenosine is released by neurons and glial cells. Extracellular adenosine modulates neuronal excitability, synaptic plasticity, and the release and reuptake of several neurotransmitters. The effects of extracellular adenosine are modulated via four subtypes of G-protein coupled adenosine receptors (GPCRs), denoted A1, A2A, A2B, and A3. Adenosine A2A receptors (A2ARs) are broadly expressed in the brain, cardiovascular system, blood vessels, spleen, thymus, leukocytes, and lung, making them an important drug target. The therapeutic potential of targeting adenosine A2ARs is immense due to their broad expression in the body and central nervous system. The role of A2ARs in cardiovascular function, inflammation, sleep/wake behaviors, cognition, and other primary nervous system functions has been extensively studied. 
  • 1.6K
  • 29 Mar 2022
Topic Review
Municipal Solid Waste Landfilling Approaches
Finding a sustainable approach for municipal solid waste (MSW) management is becoming paramount. However, as with many urban areas in developing countries, the approach applied to MSW management in Karachi is neither environmentally sustainable nor suitable for public health. Due to adoption of an inefficient waste management system, society is paying intangible costs such as damage to public health and environment quality. In order to minimize the environmental impacts and health issues associated with waste management practices, a sustainable waste management and disposal strategy is required. 
  • 1.6K
  • 25 Mar 2022
Topic Review
Community-Specific Overview of Knowledge Graph Research
Knowledge graphs (KGs) have rapidly emerged as an important area in AI over the last ten years. Building on a storied tradition of graphs in the AI community, a KG may be simply defined as a directed, labeled, multi-relational graph with some form of semantics. In part, this has been fueled by increased publication of structured datasets on the Web, and well-publicized successes of large-scale projects such as the Google Knowledge Graph and the Amazon Product Graph. However, another factor that is less discussed, but which has been equally instrumental in the success of KGs, is the cross-disciplinary nature of academic KG research. Arguably, because of the diversity of this research, a synthesis of how different KG research strands all tie together could serve a useful role in enabling more ‘moonshot’ research and large-scale collaborations.
  • 1.6K
  • 01 Apr 2022
  • Page
  • of
  • 2728
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback