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Topic Review
Urban Futures Lab
Fonded in 2018 by Dr. Steffen Lehmann, the interdisciplinary  Urban Futures Lab is a collaboration between three units at the University of Nevada at Las Vegas: UNLV School of ArchitectureUNLV Howard R. Hughes College of EngineeringUNLV Greenspun College of Urban AffairsThe Urban Futures Lab (UFLab) has partners from industry and government contributing to the following research program.
  • 1.7K
  • 12 Apr 2021
Topic Review
Glycosylation role in Alzheimer’s Disease
Glucose uptake in the brain decreases because of normal aging but this decline is accelerated in Alzheimer’s disease (AD) patients. In fact, positron emission tomography (PET) studies have shown that metabolic reductions in AD patients occur decades before the onset of symptoms, suggesting that metabolic deficits may be an upstream event in at least some late-onset cases. A decrease in the availability of glucose content induces a considerable impairment/downregulation of glycosylation, which is an important post-translational modification. Glycosylation is an important and highly regulated mechanism of secondary protein processing within cells and it plays a crucial role in modulating the stability of proteins, as carbohydrates are important in achieving the proper three-dimensional conformation of glycoproteins. Moreover, glycosylation acts as a metabolic sensor that links glucose metabolism to normal neuronal functioning. All the proteins involved in β-amyloid (Aβ) precursor protein metabolism have been identified as candidates of glycosylation highlighting the possibility that Aβ metabolism could be regulated by their glycosylation. Within this framework, the present review aims to summarize the current understanding on the role of glycosylation in the etiopathology of AD, emphasizing the idea that the glucose metabolic pathway may represent an alternative therapeutic option for targeting AD. From this perspective, the pharmacological modulation of glycosylation levels may represent a ‘sweet approach’ to treat AD targeting new mechanisms independent of the amyloid cascade and with comparable impacts in familial and sporadic AD.
  • 1.7K
  • 10 Nov 2020
Topic Review
Liposomal Delivery Systems
The versatility of liposomal carriers does not just simply rely on their capability to encapsulate various types of therapeutic substances, but also on the large array of components used for constructing liposome-based nanoformulations that allow for a straightforward control over targeting and the release of the encapsulated contents. This leads to a wide array of design strategies which can be easily adapted to any desired theraupetic effect, rendering liposomes one of the most promising systems for drug delivery. 
  • 1.7K
  • 20 Jan 2021
Topic Review
Chinese Herbal Medicine for Depression
Depression is a mood disorder that causes a loss of interest and constant sadness. Central nervous system (CNS)-targeted medications alone are insufficient for the treatment of depression. Multidrug and multitarget Chinese Herbal Medicine (CHM) has great potential to assist in the development of novel medications for the systematic and effective pharmacotherapy of depression.
  • 1.7K
  • 02 Feb 2021
Topic Review
Microbiota
The human gut microflora comprises over 1000 species and more than 7000 strains, representing 1013–1014 bacterial cells, which is ten times more numerous than other cells. Healthy gut microbiota is mainly composed of the phyla Firmicutes and Bacteroidetes, representing around 90% of the human gut flora, followed by Actinobacteria, Verrucomicrobia, and Proteobacteria.
  • 1.7K
  • 18 Jan 2022
Topic Review
Edible Insects
Edible insects have been considered as either nutritious food items per se, or as wholesome ingredients to various dishes and components of traditional subsistence. Protein, fat, mineral and vitamin contents in insects generally satisfy the requirements of healthy food, although there is considerable variation associated with insect species, collection site, processing method, insect life stage, rearing technology and insect feed. A comparison of available data(based on dry weight) showed that processing can improve the nutrient content, taste, flavour, appearance and palatability of insects, but that there are additional factors, which can impact the content and composition of insect species that have been recommended for consumption by humans.
  • 1.7K
  • 28 Sep 2021
Topic Review
Pathological Mechanisms of Asthma
Although asthma is classified into Th2-high and Th2-low asthma, the disease can be induced by mixed airway inflammation. Patients may have Th2-high asthma in the early stage and have Th2-low asthma in a later stage or vice versa; or Th2-high asthma and Th2-low asthma occur concurrently.
  • 1.7K
  • 26 Sep 2022
Topic Review
Molecular Pathology and Biomarkers of Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis due to the lack of methods or biomarkers for early diagnosis and its resistance to conventional treatment modalities, targeted therapies, and immunotherapies. PDACs are a heterogenous group of malignant epithelial neoplasms with various histomorphological patterns and complex, heterogenous genetic/molecular landscapes. The newly proposed molecular classifications of PDAC based on extensive genomic, transcriptomic, proteomic and epigenetic data have provided significant insights into the molecular heterogeneity and aggressive biology of this deadly disease. Studies characterizing the tumor microenvironment (TME) have shed light on the dynamic interplays between the tumor cells and the immunosuppressive TME of PDAC, which is essential to disease progression, as well as its resistance to chemotherapy, newly developed targeted therapy and immunotherapy. There is a critical need for the development of predictive markers that can be clinically utilized to select effective personalized therapies for PDAC patients.
  • 1.7K
  • 02 Dec 2022
Topic Review
Battery Management System Application
Electric Vehicles (EV) and Hybrid EV (HEV) use Lithium (Li) ion battery packs to drive them. These battery packs possess high specific density and low discharge rates. However, some of the limitations of such Li ion batteries are sensitivity to high temperature and health degradation over long usage. The Battery Management System (BMS) protects the battery against overvoltage, overcurrent etc., and monitors the State of Charge (SOC) and the State of Health (SOH). SOH is a complex phenomenon dealing with the effects related to aging of the battery such as the increase in the internal resistance and decrease in the capacity due to unwanted side reactions. The battery life can be extended by estimating the SOH accurately.
  • 1.7K
  • 06 Apr 2022
Topic Review
Real-Time Water Quality Monitoring with Chemical Sensors
Water quality is one of the most critical indicators of environmental pollution and it affects all of us. Water contamination can be accidental or intentional and the consequences are drastic unless the appropriate measures are adopted on the spot. 
  • 1.7K
  • 09 Sep 2022
Topic Review
Piezoelectric MEMS Laterally Vibrating Resonators
Piezoelectric MEMS Laterally Vibrating Resonators (LVRs), which belong to one type of micromachined resonators that uses piezoelectric transduction, are characterized by dominant mechanical vibration in the lateral direction (within the plane of the device). In piezoelectric MEMS LVRs, the electric field is mainly applied across the thickness of the piezoelectric film to generate a lateral strain within the plane of the device with suspended free edges. Due to the lithographically definable resonant frequency, piezoelectric LVRs feature wide operation frequency coverage (from tens of MHz to several GHz) and provide a pathway towards realizing a multi-frequency integrated solution on a single chip. Depending on the structure of resonators, piezoelectric MEMS LVRs can be categorized into two types. The first type of LVRs consists of a piezoelectric film, both as the transducer and acoustic cavity. The second type of LVRs uses the thin piezoelectric film as a transducer only while having most of the acoustic energy propagating in the underlying thicker substrate. Such resonators are usually referred to as thin-film piezoelectric-on-substrate (TPoS) resonators. Typical applications of piezoelectric MEMS LVRs include resonant sensors, oscillators and RF filters.
  • 1.7K
  • 14 Sep 2020
Topic Review
Dietary zeaxanthin occurrence and bioaccessibility
This entry provides a comprehensive and exhaustive overview of natural food sources of zeaxanthin and their respective zeaxanthin bioaccessibility, while also placing emphasis on the importance of this oxygenated carotenoid in human health. The content of zeaxanthin in foods of different origin (plant-, animal- and microalgal-based food sources) has been reviewed and the in vitro accessibility results obtained by various research groups through the standardized INFOGEST protocol were compared among the different zeaxanthin food sources.
  • 1.7K
  • 14 Sep 2020
Topic Review
MiRNA-Mediated Epigenetic Mechanisms
This entry discuss the role of ncRNAs as mediators of epigenetic pathways associated with carcinogenesis, and provides an overview on how deregulated microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) alter the expression of cancer-promoting genes.  Overall, miss regulated expression of ncRNAs alter cell cycle progression and apoptosis to increase proliferation, thereby facilitating cellular transformation into malignancies. The potential for using ncRNAs as targets for early prognosis and for developing cancer therapies is discussed.
  • 1.7K
  • 16 Dec 2020
Topic Review
Glioblastoma Multiforme
To date, surgical resection along with chemotherapy and radiation therapy represent the standard of care in the treatment of high-grade gliomas. Despite, some advancement in diagnostic and therapy, the long-term outcome remains poor in this subset of brain tumors. Since it's discovery, leptin and associated receptor ObR have been shown to exist in several isofroms in various brain regions. Experimental studies suggest an association between obesity/diabetes, glucose lowering drugs (metformin) with the therapeutic outcome of gliobalstoma. Contrary, conflicting findings were observed in retrospective conducted and prospective observational human trials. Although leptin and related pathways represent novel targets for diagnosis and therapy of brain tumors, randomized-controlled Trials have yet to determine it's potential value and are currently on the way. 
  • 1.7K
  • 22 Dec 2020
Topic Review
Epilepsy in Mitochondrial Diseases
Mitochondrial diseases are a heterogeneous group of diseases resulting from energy deficit and reduced adenosine triphosphate (ATP) production due to impaired oxidative phosphorylation. The manifestation of mitochondrial disease is usually multi-organ. Epilepsy is one of the most common manifestations of diseases resulting from mitochondrial dysfunction, especially in children.
  • 1.7K
  • 28 Sep 2021
Topic Review
SARS-CoV-2 Vaccination-Associated Coagulopathy
Coronavirus Disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is frequently complicated by thrombosis. In some cases of severe COVID-19, fibrinolysis may be markedly enhanced within a few days, resulting in fatal bleeding. In the treatment of COVID-19, attention should be paid to both coagulation activation and fibrinolytic activation. Various thromboses are known to occur after vaccination with SARS-CoV-2 vaccines. Vaccine-induced immune thrombotic thrombocytopenia (VITT) can occur after adenovirus-vectored vaccination, and is characterized by the detection of anti-platelet factor 4 antibodies by enzyme-linked immunosorbent assay and thrombosis in unusual locations such as cerebral venous sinuses and visceral veins. Treatment comprises high-dose immunoglobulin, argatroban, and fondaparinux. Some VITT cases show marked decreases in fibrinogen and platelets and marked increases in D-dimer, suggesting the presence of enhanced-fibrinolytic-type disseminated intravascular coagulation with a high risk of bleeding. In the treatment of VITT, evaluation of both coagulation activation and fibrinolytic activation is important, adjusting treatments accordingly to improve outcomes.
  • 1.7K
  • 21 Mar 2022
Topic Review
Vaginal Anomalies
Vaginal anomalies are abnormal structures that are formed (or not formed) during the prenatal development of the female reproductive system and are rare congenital defects that result in an abnormal or absent vagina. When present, they are often found with uterine, skeletal and urinary abnormalities. This is because these structures, like the vagina, are most susceptible to disruption during crucial times of organ-genesis. Many of these defects are classified under the broader term Müllerian duct anomalies. Müllerian duct anomalies are caused by a disturbance during the embryonic time of genitourinary development. The other isolated incidents of vaginal anomalies can occur with no apparent cause. Oftentimes vaginal anomalies are part of a cluster of defects or syndromes. In addition, inheritance can play a part as can prenatal exposure to some teratogens. Many vaginal anomalies are not detected at birth because the external genitalia appear to be normal. Other organs of the reproductive system may not be affected by an abnormality of the vagina. The uterus, fallopian tubes and ovaries can be functional despite the presence of a defect of the vagina and external genitalia. A vaginal anomaly may not affect fertility. Though it depends on the extent of the vaginal defect, it is possible for conception to occur. In instances where a functional ovary exists, IVF may be successful. Functioning ovaries in a woman with a vaginal defect allows the implantation of a fertilized ovum into the uterus of an unaffected gestational carrier, usually another human. A successful conception and can occur. Vaginal length varies from 6.5 to 12.5 cm. Since this is slightly shorter than older descriptions, it may impact the diagnosis of women with vaginal agenesis or hypoplasia who may unnecessarily be encouraged to undergo treatment to increase the size of the vagina. Vaginal anomalies may cause difficulties in urination, conception, pregnancy, impair sex. Psychosocial effects can also exist.
  • 1.7K
  • 24 Oct 2022
Topic Review
Æternity
æternity is a public, open-source, blockchain-based distributed computing and digital-asset platform that builds upon decentralized cryptographic P2P technology. Real-world data can interface with smart contracts through "oracles". Scalability and trustless Turing-complete state channels set æternity apart from Blockchain 2.0 projects. æternity provides a virtual machine which can execute scripts implementing a so-called "smart contracts" using an decentralized global network of public nodes maintaining the blockchain. State channels enable smart contracts to remain private and scalable as long as there is no disagreement between the counterparties. Inherently integrated in æternity is a value token called an "æon" or "AE token", which can be transferred between participants and is used to compensate participant nodes for computations performed. AE tokens are used to pay for space and computation time on the virtual machine and prevent spam on the network while allocating storage and computation time proportionally to the incentive offered by the request.
  • 1.7K
  • 18 Nov 2022
Topic Review
Magnetic Catalysts in Ullmann-Type N-Arylation Reactions
Ullmann-type C–N heterocoupling reactions have been applied for the syntheses of N-arylated amines. Transition metal-catalyzed N-arylations have been recognized as particularly efficient procedures for the preparation of nitrogen-containing aromatic systems. These reactions typically carried out under optimized conditions, have also been found to be suitable for the synthesis of complex molecules with other functional groups, including natural products, drugs, or pharmaceuticals. Most importantly, copper-catalyzed N-arylations have been studied and employed in the total synthesis of biologically active compounds. The construction of fused N-heterocyclic compounds also remained the subject of extensive research because of their potential applications in drug discovery and the development of functional materials. 
  • 1.7K
  • 02 Aug 2023
Topic Review
Generation of Reactive Oxygen Species by Mitochondria
Reactive oxygen species (ROS) are series of chemical products originated from one or several electron reductions of oxygen. ROS are involved in physiology and disease and can also be both cause and consequence of many biological scenarios. Mitochondria are the main source of ROS in the cell and, particularly, the enzymes in the electron transport chain are the major contributors to this phenomenon. 
  • 1.7K
  • 24 May 2022
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