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Topic Review
Solubility and Aggregation of Proteins
Protein solubility is based on the compatibility of the specific protein surface with the polar aquatic environment. The exposure of polar residues to the protein surface promotes the protein’s solubility in the polar environment. The application of 3D GAuss function allows identification of accordant/discordant regions in proteis. The discordant ones usually represent the localisation of biological activity. 
  • 1.7K
  • 11 Oct 2021
Topic Review
Inter-Organizational Relationship Performance
Inter-Organizational Relationship Performance (IORP) was directly affected by trust, commitment, coordination, and frequency of interaction directly, while simultaneously, communication and participation have indirect impacts on IORP. 
  • 1.7K
  • 17 Aug 2021
Topic Review
Heparin-Grafted Hemodialysis Membranes
Hemodialysis (HD) is a life-sustaining extracorporeal blood purifying treatment for end-stage renal disease (ESRD) patients. However, this membrane-based therapy is associated with acute side effects, life-threatening chronic conditions, and unacceptably high morbidity and mortality rates. Numerous surface coatings have been developed to improve the blood compatibility of biomaterials. Heparin is a widely used anticoagulant substance that increases the clotting time and increases the membrane hemocompatibility in terms of platelet adhesion and protein adsorption and anti-clotting activity. However, using heparin is challenging due to its severe or life-threatening side effects such as heparin-induced thrombocytopenia (HIT), in addition to heparin induced thrombocytopenia and thrombosis (HITT). In addition, heparin is strongly electronegative and exhibits a binding affinity for the positive active sites of human serum proteins, which is an additional challenge. Consequently, covalently immobilized heparin would create a more charged surface to induce more blood–membrane interactions, and consequently more adsorbed human serum proteins and biochemical pathway activations, which can negatively affect dialysis patients.
  • 1.7K
  • 01 Sep 2022
Topic Review
Boeing–Sikorsky RAH-66 Comanche
The Boeing–Sikorsky RAH-66 Comanche is an American stealth armed reconnaissance and attack helicopter designed for the United States Army. Following decades of development, during 2004, the RAH-66 program was canceled prior to mass production commencing, by which point nearly US$7 billion had been already spent on the program. During the early 1980s, the U.S. Army started to formulate requirements for the replacement of its helicopters then in service, which resulted in the launch of the Light Helicopter Experimental (LHX) program. Nearly a decade later, following the refinement of requirements, evaluation of submissions, and the rebranding of the program as the Light Helicopter (LH) program, during April 1991, the Army announced the selection of the Boeing–Sikorsky team's design as the contest winner, shortly after which a contract for construction of prototypes was awarded. The Comanche was to incorporate several advanced elements, such as stealth technologies, and a number of previously untried design features. Operationally, it was to employ advanced sensors in its reconnaissance role, where it was intended to designate targets for the AH-64 Apache. It was also armed with one rotary cannon and could carry missiles and rockets in internal bays and optionally on stub wings for light attack duties. Two RAH-66 prototypes were constructed and underwent flight testing between 1996 and 2004. On 1 June 2000, the program entered its $3.1 billion engineering and manufacturing development (EMD) phase. However, during 2002, the Comanche program underwent heavy restructuring; the number of Comanches that were to be purchased was cut to 650. At the time, the projected total cost for the full production of the Comanche in such numbers stood at $26.9 billion. As early as the late 1990s, the Government Accountability Office (GAO) had reported that it had "serious doubts" about the program, observing that the Comanche would "consume almost two thirds of the whole Aviation budget by Fiscal Year 2008". Multiple government agencies had acted to cut the number of Comanches on order, but, as a consequence of the heavy reductions to the numbers to be procured, the unit costs soared. On 23 February 2004, the U.S. Army announced the termination of the Comanche program, stating they had determined that the RAH-66 would require numerous upgrades to be viable on the battlefield and that the service would instead direct the bulk of its rotary systems funds to renovating its existing attack, utility, and reconnaissance helicopters. The Army also announced new plans to accelerate the development of unmanned aerial vehicles (UAVs), which could also perform the scouting role intended for the Comanche, but with less risk. Since program cancellation, both of the prototypes have been placed on public display.
  • 1.7K
  • 17 Nov 2022
Topic Review
Structure and Function of Sorting Nexin 27
SNX27 belongs to the sorting nexin (SNX) family of proteins that play a critical role in protein sorting and trafficking in the endocytosis pathway. This protein family is characterized by the presence of a Phox (PX) domain; however, SNX27 is unique in containing an additional PDZ (post-synaptic density 95/discs large/zonula occludens-1) domain.
  • 1.7K
  • 29 Jan 2023
Topic Review
Haloanisoles in Wine
Haloanisoles in wine have devastating effects on the aroma and quality of the wine. 2,4,6-trichloroanisole (TCA) was discovered and coined as “cork taint” in 1982. There are many more haloanisoles that contribute to these musty odors, including 2,4,6-Tribromoanisiole (TBA), 2,3,4,6-tetrachloroanisole (TeCA), and pentachloroanisole (PCA). While TCA, TeCA, and PCA can all be traced back to the cork, TBA’s phenol precursor is ubiquitous in building material as a fire retardant, making it a much larger vector. All haloanisoles have the ability to aerosolize and resettle onto surfaces in the winery, making this a very difficult problem to eliminate. 
  • 1.7K
  • 23 Mar 2023
Topic Review
The Role of TNF-α in Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that represents the most common cause of dementia in the elderly. Tumor necrosis factor (TNF)-α, a proinflammatory cytokine, has attracted attention due to its multifaceted and still not fully characterized role in AD and the fact that it could potentially represent a future therapeutic target. Indeed, TNF-α has many roles, not only in inflammation, but also in cell death and proliferation, and is crucial in maintaining CNS homeostasis. TNF-α is primarily produced by microglia, astrocytes, and neurons in response to various stimuli. Although TNF-α has a fundamental role in modulating excitotoxicity, neuroinflammation, blood-brain barrier permeability, regulation of oligodendrocyte survival, myelin formation and repair, its excessive or dysregulated production can have detrimental effects on neuronal health, contributing to the development of neurodegeneration.
  • 1.7K
  • 04 Jan 2024
Topic Review
Galapagos Fur Seal
The Galapagos Fur Seal, scientifically known as Arctocephalus galapagoensis, is a marine mammal endemic to the Galapagos Islands. With its dense, dark brown fur and slender physique, this species is well-adapted to its coastal habitat. Despite its name, the Galapagos Fur Seal is not a true seal but rather belongs to the fur seal family, Otariidae, distinguishing it by its ability to rotate its hind flippers forward for efficient movement on land.
  • 1.7K
  • 15 Mar 2024
Topic Review
Zephaniah Kingsley
Zephaniah Kingsley Jr. (December 4, 1765 – September 14, 1843), a Quaker born in England who moved as a child with his family to South Carolina, became a planter, slave trader, and merchant who built several plantations in the Spanish colony of Florida in what is now Jacksonville, Florida. He served on the Florida Territorial Council after Florida was acquired by the United States in 1821. Kingsley Plantation, which he owned and where he lived for 25 years, has been preserved as part of the Timucuan Ecological and Historic Preserve, run by the United States National Park Service. Kingsley was a relatively lenient slaveholder, who allowed his slaves the opportunity to be hired out and earn their freedom. He took four enslaved African women as common-law wives, practicing polygamy. His first wife, Anna Madgigine Jai Kingsley, was 13 years old when Kingsley purchased her in Havana. He said that he had married her, which he never said of his three other common-law wives. He emancipated Anna Jai when she turned 18, and trusted her with running his plantation when he was away on business. He had a total of nine mixed-race children with his wives. He educated his children to high standards and worked to ensure he could settle his estate on them and his wives. His interracial family and his business interests resulted in Kingsley being deeply invested in the Spanish system of slavery and society. As in the French colonies, certain rights were provided to a class of free people of color, and multiracial natural children were allowed to inherit property from white fathers. "In the Spanish Floridas free people of color ... enjoyed tremendously elevated status when compared to virtually any other person of African descent in North America.":61 Kingsley became involved in politics when control of the Florida colony passed in 1821 from Spain to the United States. He tried to persuade the new territorial government to maintain the special status of the population of free people of color, who were mostly multi-racial. He was unsuccessful in this effort, and in 1828 he published a pamphlet that defended a system of slavery that would allow slaves to purchase their freedom, and give rights to free blacks and free people of color. Faced with American laws that forbade interracial marriage, and discouraged "free people of color" (see Free black#Free negroes unwelcome) being allowed to stay or settle in the state, between 1835 and 1837, Kingsley relocated his large family to Haiti. (At that time it controlled part of what is today the Dominican Republic.) After his death, his estate in Florida was the subject of dispute between his widow Anna Jai and other members of Kingsley's family, but she was successful in gaining the estate he had bequeathed to her.
  • 1.7K
  • 11 Oct 2022
Topic Review
Natural Blockers of PD-1/PD-L1 Interaction
The limited treatment options for triple-negative breast cancer with brain metastasis (TNBC-BM) have left the door of further drug development for these patients wide open. Although immunotherapy via monoclonal antibodies has shown some promising results in several cancers including TNBC, it cannot be considered the most effective treatment for brain metastasis. This is due to the protective role of the blood–brain barrier (BBB) which limits the entrance of most drugs, especially the bulky ones such as antibodies, to the brain. For a drug to traverse the BBB via passive diffusion, various physicochemical properties should be considered. 
  • 1.7K
  • 11 Jan 2023
Topic Review
Electrodialysis Bipolar Membrane for Reverse-Osmosis Concentrate Recovery
Electrochemical processes such as electrodialysis (ED) and electrodialysis bipolar membrane (EDBM) can contribute to soft-water production and the evaluation of waste fluxes. EDBM is a new technology that combines the separation function of electrodialysis with water separation at the bipolar membrane interface, which can convert salts into corresponding acids and bases without adding external components. In this system, anions and cations are separated from wastewater separately and combined with H+ and OH− ions via bipolar membranes to form acidic and alkaline solutions.
  • 1.7K
  • 14 Jan 2022
Topic Review
Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid malignancies. The complex mechanism underlying the development and progression of PDAC includes interactions between genomic, epigenomic, and signaling pathway alterations. PDAC remains a devastating disease, despite extensive research efforts focused on the discovery of early diagnostic biomarkers and efficient therapeutic approaches, showing a high resistance to treatment that significantly contributes to poor survival. The success of epi-drugs in hematological malignancies and the robust body of evidence supporting the hypothesis about their ability to synergize with other anti-cancer drugs, sensitizing resistant tumor cells in preclinical models, have encouraged the search for these agents suitable for the future clinical management of PDAC.
  • 1.7K
  • 27 Oct 2020
Topic Review
CRISPR-Cas9
CRISPR-Cas9 is a simple two-component system that allows researchers to accurately edit any sequence in the genome of an organism. This is achieved by the guide RNA, which recognizes the target sequence, and the CRISPR-associated endonuclease (Cas) that cuts the targeted sequence.
  • 1.7K
  • 16 Dec 2020
Topic Review
Anaerobic Digestion
Anaerobic digestion is a well-known technology with wide application in the treatment of high-strength organic wastes. The oxidation of the organic material is carried out in the absences of oxygen by microorganisms leading to the release of biogas with methane and carbon dioxide being the main components. The microbial process also produces a slurry known as digestate. This stream contains recalcitrant compounds, complex polymeric substances and biomass residual material .
  • 1.7K
  • 06 Mar 2021
Topic Review
Edible food plants Hepatoprotective Potential
Alcoholic liver disease (ALD) is one type of liver disease, causing a global healthcare problem and mortality. The liver undergoes tissue damage by chronic alcohol consumption because it is the main site for metabolism of ethanol. Chronic alcohol exposure progresses from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which further lead to fibrosis, cirrhosis, and even hepatocellular cancer. Therapeutic interventions to combat ALD are very limited such as use of corticosteroids. However, these therapeutic drugs are not effective for long-term usage. Therefore, additional effective and safe therapies to cope with ALD are urgently needed. Previous studies confirmed that edible food plants and their bioactive compounds exert a protective effect against ALD.
  • 1.7K
  • 23 Jun 2021
Topic Review
Wastewater Based Epidemiology
Wastewater-Based epidemiology (WBE) is spreading of any disease or disorder caused by the chemicals or pathogens that come from waste materials such as urine, fecal materials, medical waste  or any solid or liquid waste product. The extraction, detection, analysis, and interpretation of chemical/biological compounds (biomarkers) excreted in the sewage system can eventually contribute to WBE. So wastewater analysis could be equivalent to community-based urine and fecal analysis that can subsequently give a reflection  of community health. Under pandemic situation with time limitations and restrict access to massive diagnostic, an alternative approach as a complementary tool to investigate virus circulation in the community is essential. In the situation of limited and time-consuming diagnostic tests, monitoring sewage systems could better estimate the spread of the virus and determine whether there are potential cases because wastewater surveillance can also account for those who contract mild or asymptomatic state.
  • 1.7K
  • 06 Sep 2021
Topic Review
Acoustic Emission Spectroscopy
Acoustic emission (AE) spectroscopy has become the method of choice in many fieldsbecause it is highly sensitive. For example, the AE system constructed by the Vallen company, Germany, has a sampling rate that can reach up to 10 MHz, an arrival time resolution of 100 ns, and an energy resolution of 1.8 × 10−18V2s (i.e., in the attojoule regime, aJ) referred to sensor signal at 34 dB preamplifier gain.
  • 1.7K
  • 28 Oct 2021
Topic Review
Eosinophils in the Gastrointestinal Tract
Eosinophils are innate immune granulocytes actively involved in defensive responses and in local and systemic inflammatory processes. Beyond these effector roles, eosinophils are fundamental to maintaining homeostasis in the tissues they reside. Gastrointestinal eosinophils modulate barrier function and mucosal immunity and promote tissue development through their direct communication with almost every cellular component. This is possible thanks to the variety of receptors they express and the bioactive molecules they store and release, including cytotoxic proteins, cytokines, growth factors, and neuropeptides and neurotrophines. A growing body of evidence points to the eosinophil as a key neuro-immune player in the regulation of gastrointestinal function, with potential implications in pathophysiological processes. Eosinophil–neuron interactions are facilitated by chemotaxis and adhesion molecules, and the mediators released may have excitatory or inhibitory effects on each cell type, with physiological consequences dependent on the type of innervation involved. Of special interest are the disorders of the brain–gut interaction (DBGIs), mainly functional dyspepsia (FD) and irritable bowel syndrome (IBS), in which mucosal eosinophilia and eosinophil activation have been identified. 
  • 1.7K
  • 27 May 2022
Topic Review
Medication-associated Osteonecrosis of the Jaw
Medication-related osteonecrosis of the jaw (MON, MRONJ) is progressive death of the jawbone in a person exposed to a medications known to increase the risk of disease, in the absence of a previous radiation treatment. It may lead to surgical complication in the form of impaired wound healing following oral and maxillofacial surgery, periodontal surgery, or endodontic therapy. Particular medications can result in MRONJ, a serious but uncommon side effect in certain individuals. Such medications are frequently used to treat diseases that cause bone resorption such as osteoporosis, or to treat cancer. The main groups of drugs involved are anti-resorptive drugs, and anti-angiogenic drugs. This condition was previously known as bisphosphonate-related osteonecrosis of the jaw because osteonecrosis of the jaws correlating with bisphosphate treatment was frequently encountered, with its first incident occurring in 2003. Denosumab, another antiresorptive drug were also related to this condition. However, newer medications such as anti-angiogenic drugs has been established over the years which were reported to be related to osteonecrosis of the jaw as a side-effect too, hence this condition has been renamed as MRONJ. BON was been nicknamed "bis-phossy jaw" based on its similarity with phossy jaw. There is no known prevention for bisphosphonate-associated osteonecrosis of the jaw. Avoiding the use of bisphosphonates is not a viable preventive strategy on a general-population basis because the medications are beneficial in the treatment and prevention of osteoporosis (including prevention of bony fractures) and treatment of bone cancers. It usually develops after dental treatments involving exposure of bone or trauma, or may arise spontaneously. Patients who develop MRONJ may experience prolonged healing, pain, swelling, infection, exposed bone, after dental procedures, though some patients may have no signs/symptoms.
  • 1.7K
  • 19 Oct 2022
Topic Review
Cerebral Edema
Cerebral edema is excess accumulation of fluid (edema) in the intracellular or extracellular spaces of the brain. This typically causes impaired nerve function, increased pressure within the skull, and can eventually lead to direct compression of brain tissue and blood vessels. Symptoms vary based on the location and extent of edema and generally include headaches, nausea, vomiting, seizures, drowsiness, visual disturbances, dizziness, and in severe cases, coma and death. Cerebral edema is commonly seen in a variety of brain injuries including ischemic stroke, subarachnoid hemorrhage, traumatic brain injury, subdural, epidural, or intracerebral hematoma, hydrocephalus, brain cancer, brain infections, low blood sodium levels, high altitude, and acute liver failure. Diagnosis is based on symptoms and physical examination findings and confirmed by serial neuroimaging (computed tomography scans and magnetic resonance imaging). The treatment of cerebral edema depends on the cause and includes monitoring of the person's airway and intracranial pressure, proper positioning, controlled hyperventilation, medications, fluid management, steroids. Extensive cerebral edema can also be treated surgically with a decompressive craniectomy. Cerebral edema is a major cause of brain damage and contributes significantly to the mortality of ischemic strokes and traumatic brain injuries. As cerebral edema is present with many common cerebral pathologies, the epidemiology of the disease is not easily defined. The incidence of this disorder should be considered in terms of its potential causes and is present in most cases of traumatic brain injury, central nervous system tumors, brain ischemia, and intracerebral hemorrhage. For example, malignant brain edema was present in roughly 31% of people with ischemic strokes within 30 days after onset.
  • 1.7K
  • 07 Nov 2022
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