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Topic Review
Cydonia (Region of Mars)
Cydonia (/sɪˈdoʊniə/, /saɪˈdoʊniə/) is a region on the planet Mars that has attracted both scientific and popular interest. The name originally referred to the albedo feature (distinctively coloured area) that was visible from Earthbound telescopes. The area borders plains of Acidalia Planitia and the Arabia Terra highlands. The area includes the regions: "Cydonia Mensae", an area of flat-topped mesa-like features, "Cydonia Colles", a region of small hills or knobs, and "Cydonia Labyrinthus", a complex of intersecting valleys. As with other albedo features on Mars, the name Cydonia was drawn from classical antiquity, in this case from Kydonia, a historic polis (or "city-state") on the island of Crete. Cydonia contains the "Face on Mars", located about halfway between Arandas Crater and Bamberg Crater.
  • 7.0K
  • 25 Oct 2022
Topic Review
Aesthetics
Aesthetics, or esthetics, is a branch of philosophy that deals with the nature of beauty and taste, as well as the philosophy of art (its own area of philosophy that comes out of aesthetics). It examines aesthetic values, often expressed through judgments of taste. Aesthetics covers both natural and artificial sources of experiences and how we form a judgment about those sources. It considers what happens in our minds when we engage with objects or environments such as viewing visual art, listening to music, reading poetry, experiencing a play, watching a fashion show, movie, sports or even exploring various aspects of nature. The philosophy of art specifically studies how artists imagine, create, and perform works of art, as well as how people use, enjoy, and criticize art. Aesthetics considers why people like some works of art and not others, as well as how art can affect moods or even our beliefs. Both aesthetics and the philosophy of art ask questions like "What is art?," "What is a work of art?," and "What makes good art?" Scholars in the field have defined aesthetics as "critical reflection on art, culture and nature". In modern English, the term "aesthetic" can also refer to a set of principles underlying the works of a particular art movement or theory (one speaks, for example, of a Renaissance aesthetic).
  • 7.0K
  • 04 Nov 2022
Topic Review
Hydrolyzed Collagen
Hydrolyzed collagen (HC) is a group of peptides with low molecular weight (3–6 KDa) that can be obtained by enzymatic action in acid or alkaline media at a specific incubation temperature. HC can be extracted from different sources such as bovine or porcine.  Recently research has shown good properties of the HC found in skin, scale, and bones from marine sources. Type and source of extraction are the main factors that affect HC properties, such as molecular weight of the peptide chain, solubility, and functional activity. HC is widely used in several industries including food, pharmaceutical, cosmetic, biomedical, and leather industries. 
  • 7.0K
  • 11 Dec 2021
Topic Review
Construction 4.0
Construction 4.0 is a variety of interdisciplinary technologies, methodologies and concepts that digitize, automate and integrate the construction process at all stages of the value chain
  • 7.0K
  • 27 Mar 2023
Topic Review
Thiazoles and Bisthiazoles
Thiazole, a five-membered heteroaromatic ring, is an important scaffold of a large number of synthetic compounds. Its diverse pharmacological activity is reflected in many clinically approved thiazole-containing molecules, with an extensive range of biological activities, such as antibacterial, antifungal, antiviral, antiparasitic, antitumor, antiparkinsonian, and anti-inflammatory effects.
  • 7.0K
  • 29 Mar 2021
Topic Review
Wife-carrying
Wife carrying (Finnish: eukonkanto or akankanto, Estonian: naisekandmine, Swedish: kärringkånk) is a contest in which male competitors race while each carrying a female teammate. The objective is for the male to carry the female through a special obstacle track in the fastest time. The sport was first introduced at Sonkajärvi, Finland . Several types of carrying may be practised: either a classic piggyback, a fireman's carry (over the shoulder), or Estonian-style (wife upside-down on his back with her legs over the neck and shoulders).
  • 7.0K
  • 11 Oct 2022
Topic Review
May 22: 1960 Great Chilean Earthquake
Great Chilean Earthquake (1960) is the most powerful earthquake ever recorded, occurring on May 22, 1960, with a magnitude of 9.5–9.6. Originating off the coast of southern Chile, it caused widespread destruction, significant loss of life, and a massive tsunami that affected countries across the Pacific Ocean. The event led to advancements in seismology, tsunami warning systems, and disaster preparedness.
  • 7.0K
  • 21 May 2025
Topic Review
Weapons of the Cambodian–Vietnamese War
This article is about the weapons used in the Cambodian–Vietnamese War, involved the Vietnam (Army: People's Army of Vietnam (PAVN)), People's Republic of Kampuchea (Army: Kampuchean People's Revolutionary Armed Forces (KPRAF)) which of the Khmer Rouge (Army:Kampuchean Revolutionary Army), Khmer People's National Liberation Front (Army: Khmer People's National Liberation Armed Forces), FUNCINPEC and Thailand (Army: Royal Thai Armed Forces (Thai: กองทัพไทย; RTGS: Kong Thap Thai)) (border clashes) From Vietnam and People's Republic of Kampuchea supported by Soviet Union and other country socialist. From Khmer Rouge supported by China , Khmer People's National Liberation Front and FUNCINPEC supported by United States and United Kingdom
  • 7.0K
  • 22 Nov 2022
Topic Review
Digital twins in pharmaceutical manufacturing
The development and application of emerging technologies of Industry 4.0 enable the realization of digital twins (DT), which facilitates the transformation of the manufacturing sector to a more agile and intelligent one. DTs are virtual constructs of physical systems that mirror the behavior and dynamics of such physical systems. A fully developed DT consists of physical components, virtual components, and information communications between the two. Integrated DTs are being applied in various processes and product industries. Although the pharmaceutical industry has evolved recently to adopt Quality-by-Design (QbD) initiatives and is undergoing a paradigm shift of digitalization to embrace Industry 4.0, there has not been a full DT application in pharmaceutical manufacturing. Therefore, there is a critical need to examine the progress of the pharmaceutical industry towards implementing DT solutions. The aim of this entry is to give an overview of the current status of DT development and its application in pharmaceutical and biopharmaceutical manufacturing. State-of-the-art Process Analytical Technology (PAT) developments, process modeling approaches, and data integration studies are reviewed. Challenges and opportunities for future research in this field are also discussed.
  • 7.0K
  • 09 Mar 2022
Topic Review
Hazard
A hazard is an agent which has the potential to cause harm to a vulnerable target. The terms "hazard" and "risk" are often used interchangeably. However, in terms of risk assessment, they are two very distinct terms. A hazard is any agent that can cause harm or damage to humans, property, or the environment. Risk is defined as the probability that exposure to a hazard will lead to a negative consequence, or more simply, a hazard poses no risk if there is no exposure to that hazard. Hazards can be dormant or potential, with only a theoretical probability of harm. An event that is caused by interaction with a hazard is called an incident. The likely severity of the undesirable consequences of an incident associated with a hazard, combined with the probability of this occurring, constitute the associated risk. If there is no possibility of a hazard contributing towards an incident, there is no risk. Hazards can be classified as different types in several ways. One of these ways is by specifying the origin of the hazard. One key concept in identifying a hazard is the presence of stored energy that, when released, can cause damage. Stored energy can occur in many forms: chemical, mechanical, thermal, radioactive, electrical, etc. Another class of hazard does not involve release of stored energy, rather it involves the presence of hazardous situations. Examples include confined or limited egress spaces, oxygen-depleted atmospheres, awkward positions, repetitive motions, low-hanging or protruding objects, etc. Hazards may also be classified as natural, anthropogenic, or technological. They may also be classified as health or safety hazards, by the populations that may be affected, and the severity of the associated risk. In most cases a hazard may affect a range of targets, and have little or no effect on others. Identification of hazards assumes that the potential targets are defined, and is the first step in performing a risk assessment.
  • 7.0K
  • 26 Oct 2022
Topic Review
UAV-based IoT
The Internet of Things (IoT), which consists of a large number of small low-cost devices, has become a leading solution for smart cities, smart agriculture, smart buildings, smart grids, e-healthcare, etc. Integrating unmanned aerial vehicles (UAVs) with IoT can result in an airborne UAV-based IoT (UIoT) system and facilitate various value-added services from sky to ground. In addition to wireless sensors, various kinds of IoT devices are connected in UIoT, making the network more heterogeneous. In a UIoT system, for achieving high throughput in an energy-efficient manner, it is crucial to design an efficient medium access control (MAC) protocol because the MAC layer is responsible for coordinating access among the IoT devices in the shared wireless medium. Thus, various MAC protocols with different objectives have been reported for UIoT.
  • 7.0K
  • 07 Dec 2020
Topic Review
Kraft Lignin
After cellulose, lignin is the second most abundant biopolymer worldwide. Lignins are non-toxic and renewable, and hence may play an essential role during the change-over from a fossil-based to a bio-based economy. Lignin isolation from Kraft cooking is state of the art, the three state of the art processes are summarized and discussed, further the concept of sequerntial liquid lignin recovery is introduced.
  • 7.0K
  • 12 May 2021
Topic Review
Cierva Air Horse
The Cierva W.11 Air Horse was a helicopter developed by the Cierva Autogiro Company in the United Kingdom during the mid-1940s. The largest helicopter in the world at the time of its debut, the Air Horse was unusual for using three rotors mounted on outriggers, and driven by a single engine mounted inside the fuselage.
  • 7.0K
  • 09 Oct 2022
Topic Review
Morphea
Morphea, also known as localized scleroderma (LoS), comprises a set of autoimmune sclerotic skin diseases. It is characterized by inflammation and limited thickening and induration of the skin; however, in some cases, deeper tissues might also be involved. Although morphea is not considered a life-threatening disease, the apparent cosmetic disfigurement, functional or psychosocial impairment affects multiple fields of patients' quality of life. Therapy for LoS is often unsatisfactory with numerous treatments that have only limited effectiveness or considerable side effects.
  • 7.0K
  • 12 Aug 2021
Topic Review
Aquaporin Inhibitors
Aquaporins (AQPs) are water channel proteins that are essential to life, being expressed in all kingdoms. In humans, there are 13 AQPs, at least one of which is found in every organ system. The structural biology of the AQP family is well-established and many functions for AQPs have been reported in health and disease. AQP expression is linked to numerous pathologies including tumor metastasis, fluid dysregulation, and traumatic injury. The targeted modulation of AQPs therefore presents an opportunity to develop novel treatments for diverse conditions. Various techniques such as video microscopy, light scattering and fluorescence quenching have been used to test putative AQP inhibitors in both AQP-expressing mammalian cells and heterologous expression systems. The inherent variability within these methods has caused discrepancy and many molecules that are inhibitory in one experimental system (such as tetraethylammonium, acetazolamide, and anti-epileptic drugs) have no activity in others. Some heavy metal ions (that would not be suitable for therapeutic use) and the compound, TGN-020, have been shown to inhibit some AQPs. Clinical trials for neuromyelitis optica treatments using anti-AQP4 IgG are in progress. However, these antibodies have no effect on water transport. More research to standardize high-throughput assays is required to identify AQP modulators for which there is an urgent and unmet clinical need.
  • 7.0K
  • 06 Sep 2021
Topic Review
Propranolol in Post-Traumatic Stress Disorder
Propranolol, a non-cardioselective β1,2 blocker, is most commonly recognised for its application in the therapy of various cardiovascular conditions, such as hypertension, coronary artery disease, and tachyarrhythmias. However, due to its ability to cross the blood–brain barrier and affinity towards multiple macromolecules, not only adrenoreceptors, it has also found application in other fields. For example, it is one of the very few medications successfully applied in the treatment of stage fright. 
  • 7.0K
  • 07 Sep 2022
Topic Review
Synthesis of Fragrances via Cycloaddition or Formal Cycloaddition
Fragrances, short for fragrance ingredients, is a type of compounds with a sweet smell or pleasant odor that has wide applications in the fine chemical industry, especially in perfumes, cosmetics, detergents and food additives. Since the discovery of the Diels–Alder reaction, the cycloaddition of π reactants serves as one of the most powerful methods for the construction of carbocycles, which has a broad application in the fragrance industry.
  • 7.0K
  • 21 Jun 2022
Topic Review
Taiwanese Romanization System
The Taiwanese Romanization System (Taiwanese Romanization: Tâi-uân Lô-má-jī Phing-im Hong-àn, Chinese: 臺灣閩南語羅馬字拼音方案; pinyin: Táiwān Mǐnnányǔ Luómǎzì Pīnyīn Fāng'àn; Pe̍h-ōe-jī: Tâi-ôan Lô-má-jī Pheng-im Hong-àn; often referred to as Tâi-lô) is a transcription system for Taiwanese Hokkien. It is derived from Pe̍h-ōe-jī and since 2006 has been one of the officially promoted phonetic notation system by Taiwan's Ministry of Education. It is nearly identical to Taiwanese Language Phonetic Alphabet (TLPA) Romanization for Hakka apart from using ts tsh j instead of c ch j for the fricatives /ts tsʰ dz/.
  • 7.0K
  • 10 Nov 2022
Topic Review
Polymers for Pharmaceutical Coating
Coating the solid dosage form, such as tablets, is considered common, but it is a critical process that provides different characteristics to tablets. It increases the value of solid dosage form, administered orally, and thus meets diverse clinical requirements. As tablet coating is a process driven by technology, it relies on advancements in coating techniques, equipment used for the coating process, evaluation of coated tablets, and coated material used. Although different techniques were employed for coating purposes, which may be based on the use of solvents or solvent-free, each of the methods used has its advantages and disadvantages, and the techniques need continued modification too. During the process of film coating, several inter-and intra-batch uniformity of coated material on the tablets is considered a critical point that ensures the worth of the final product, particularly for those drugs that contain an active medicament in the coating layer. Meanwhile, computational modeling and experimental evaluation were actively used to predict the impact of the operational parameters on the final product quality and optimize the variables in tablet coating. The efforts produced by computational modeling or experimental evaluation not only save cost in optimizing the coating process but also saves time.
  • 7.0K
  • 13 Sep 2022
Topic Review
Perinuclear Anti-Neutrophil Cytoplasmic Antibodies (P-ANCA)
Perinuclear anti-neutrophilic cytoplasmic antibodies (P-ANCA) recognize heterogeneous antigens, including myeloperoxidase (MPO), lactoferrin, elastase, cathepsin-G and bactericidal/permeability-increasing protein. Although P-ANCA have diagnostic utility in vasculitides, they may also be found in patients with various other systemic autoimmune rheumatic diseases (SARDs). Nevertheless, the clinical significance and the targets recognized by P-ANCA in such patients remain unclear. For this purpose, herein we investigated the occurrence of ANCA-related antigenic specificities in 82 P-ANCA-positive sera by multiplex ELISA, as well as their association with other autoantibodies. The P-ANCA-positive sera corresponded to patients with vasculitides (n = 24), systemic lupus erythematosus (n = 28), antiphospholipid syndrome (n = 5), Sjögren’s syndrome (n = 7), rheumatoid arthritis (n = 3), systemic scleroderma (n = 1), sarcoidosis (n = 1) and Hashimoto′s thyroiditis (n = 13). In most P-ANCA-positive patients studied (51/82, 62.3%), these autoantibodies occurred in high titers (>1:160). The analysis of P-ANCA-positive sera revealed reactivity to MPO in only 50% of patients with vasculitides, whereas it was infrequent in the other disease groups studied. Reactivity to other P-ANCA-related autoantigens was also rarely detected. Our findings support that high P-ANCA titers occur in SARD. The P-ANCA-positive staining pattern is associated with MPO specificity in vasculitides, while in other autoimmune diseases, it mostly involves unknown autoantigens. 
  • 7.0K
  • 27 Aug 2021
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