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Topic Review
Aging and Its Molecular Mechanism
Aging is a continuous process over time that is mainly related to natural alterations in mechanical–biological processes. This phenomenon is due to several factors, including the time and energy of biological processes. Aging can be attributed to biological factors such as oxidative stress, cell longevity, and stem cell senescence.
  • 7.1K
  • 22 Apr 2022
Topic Review
University Social Responsibility
University Social Responsibility (USR) enhances educational development and the impact of universities on society. As a stakeholder in USR, it is imperative to develop a comprehensive literacy scale that reflects the development of students’ citizenship in social engagement.
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  • 26 Apr 2022
Topic Review
Thiazoles and Bisthiazoles
Thiazole, a five-membered heteroaromatic ring, is an important scaffold of a large number of synthetic compounds. Its diverse pharmacological activity is reflected in many clinically approved thiazole-containing molecules, with an extensive range of biological activities, such as antibacterial, antifungal, antiviral, antiparasitic, antitumor, antiparkinsonian, and anti-inflammatory effects.
  • 7.1K
  • 29 Mar 2021
Topic Review
Cydonia (Region of Mars)
Cydonia (/sɪˈdoʊniə/, /saɪˈdoʊniə/) is a region on the planet Mars that has attracted both scientific and popular interest. The name originally referred to the albedo feature (distinctively coloured area) that was visible from Earthbound telescopes. The area borders plains of Acidalia Planitia and the Arabia Terra highlands. The area includes the regions: "Cydonia Mensae", an area of flat-topped mesa-like features, "Cydonia Colles", a region of small hills or knobs, and "Cydonia Labyrinthus", a complex of intersecting valleys. As with other albedo features on Mars, the name Cydonia was drawn from classical antiquity, in this case from Kydonia, a historic polis (or "city-state") on the island of Crete. Cydonia contains the "Face on Mars", located about halfway between Arandas Crater and Bamberg Crater.
  • 7.1K
  • 25 Oct 2022
Topic Review
Aesthetics
Aesthetics, or esthetics, is a branch of philosophy that deals with the nature of beauty and taste, as well as the philosophy of art (its own area of philosophy that comes out of aesthetics). It examines aesthetic values, often expressed through judgments of taste. Aesthetics covers both natural and artificial sources of experiences and how we form a judgment about those sources. It considers what happens in our minds when we engage with objects or environments such as viewing visual art, listening to music, reading poetry, experiencing a play, watching a fashion show, movie, sports or even exploring various aspects of nature. The philosophy of art specifically studies how artists imagine, create, and perform works of art, as well as how people use, enjoy, and criticize art. Aesthetics considers why people like some works of art and not others, as well as how art can affect moods or even our beliefs. Both aesthetics and the philosophy of art ask questions like "What is art?," "What is a work of art?," and "What makes good art?" Scholars in the field have defined aesthetics as "critical reflection on art, culture and nature". In modern English, the term "aesthetic" can also refer to a set of principles underlying the works of a particular art movement or theory (one speaks, for example, of a Renaissance aesthetic).
  • 7.1K
  • 04 Nov 2022
Topic Review
Urban Legend
An urban legend, urban myth, urban tale, or contemporary legend is a genre of folklore comprising stories circulated as true, especially as having happened to a friend or family member, often with horrifying or humorous elements. These legends can be entertainment, but often concern mysterious peril or troubling events, such as disappearances and strange objects. They may also be confirmation of moral standards, or reflect prejudices, or be a way to make sense of societal anxieties. Urban legends are most often circulated orally, but can be spread by any media, including newspapers, e-mail and social media. Some urban legends have passed through the years with only minor changes to suit regional variations. Recent legends tend to reflect modern circumstances: for instance, the common legend of a person being ambushed and anesthetized, only to wake up and realize that they are now missing a kidney that was supposedly surgically removed for transplantation.
  • 7.0K
  • 04 Oct 2022
Topic Review
Bilaminar Blastocyst
Bilaminar blastocyst or bilaminar disc refers to the epiblast and the hypoblast, evolved from the embryoblast. These two layers are sandwiched between two balloons: the primitive yolk sac and the amniotic cavity. The inner cell mass, the embryoblast, begins to transform into two distinct epithelial layers just before implantation occurs. The epiblast is the outer layer that consists of columnar cells. The inner layer is called the hypoblast, or primitive endoderm, which is composed of cuboidal cells. As the two layers become evident, a basement membrane presents itself between the layers. The final two layers of the embryoblast are known collectively as the bilaminar embryonic disc as well as the bilaminar blastocyst or bilaminar blastoderm. This bilaminar blastocyst also defines the primitive dorsal ventral axis. Blastocyst implantation will occur during the second week of fetal development in the endometrium of the uterus; the epiblast is dorsal and the hypoblast is ventral.
  • 7.0K
  • 19 May 2023
Topic Review
Kraft Lignin
After cellulose, lignin is the second most abundant biopolymer worldwide. Lignins are non-toxic and renewable, and hence may play an essential role during the change-over from a fossil-based to a bio-based economy. Lignin isolation from Kraft cooking is state of the art, the three state of the art processes are summarized and discussed, further the concept of sequerntial liquid lignin recovery is introduced.
  • 7.0K
  • 12 May 2021
Topic Review
Second Bulgarian Empire
The Second Bulgarian Empire (Bulgarian: Второ българско царство, Vtorо Bălgarskо Tsarstvo) was a medieval Bulgarian state that existed between 1185 and 1396. A successor to the First Bulgarian Empire, it reached the peak of its power under Tsars Kaloyan and Ivan Asen II before gradually being conquered by the Ottomans in the late 14th and early 15th centuries. It was succeeded by the Principality and later Kingdom of Bulgaria in 1878. Until 1256, the Second Bulgarian Empire was the dominant power in the Balkans, defeating the Byzantine Empire in several major battles. In 1205 Emperor Kaloyan defeated the newly established Latin Empire in the Battle of Adrianople. His nephew Ivan Asen II defeated the Despotate of Epiros and made Bulgaria a regional power again. During his reign, Bulgaria spread from the Adriatic to the Black Sea and the economy flourished. In the late 13th century, however, the Empire declined under constant invasions by Mongols, Byzantines, Hungarians, and Serbs, as well as internal unrest and revolts. The 14th century saw a temporary recovery and stability, but also the peak of Balkan feudalism as central authorities gradually lost power in many regions. Bulgaria was divided into three parts on the eve of the Ottoman invasion. Despite strong Byzantine influence, Bulgarian artists and architects created their own distinctive style. In the 14th century, during the period known as the Second Golden Age of Bulgarian culture, literature, art and architecture flourished. The capital city Tarnovo, which was considered a "New Constantinople", became the country's main cultural hub and the centre of the Eastern Orthodox world for contemporary Bulgarians. After the Ottoman conquest, many Bulgarian clerics and scholars emigrated to Serbia, Wallachia, Moldavia, and Russian principalities, where they introduced Bulgarian culture, books, and hesychastic ideas.
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  • 10 Oct 2022
Topic Review
Weapons of the Cambodian–Vietnamese War
This article is about the weapons used in the Cambodian–Vietnamese War, involved the Vietnam (Army: People's Army of Vietnam (PAVN)), People's Republic of Kampuchea (Army: Kampuchean People's Revolutionary Armed Forces (KPRAF)) which of the Khmer Rouge (Army:Kampuchean Revolutionary Army), Khmer People's National Liberation Front (Army: Khmer People's National Liberation Armed Forces), FUNCINPEC and Thailand (Army: Royal Thai Armed Forces (Thai: กองทัพไทย; RTGS: Kong Thap Thai)) (border clashes) From Vietnam and People's Republic of Kampuchea supported by Soviet Union and other country socialist. From Khmer Rouge supported by China , Khmer People's National Liberation Front and FUNCINPEC supported by United States and United Kingdom
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  • 22 Nov 2022
Topic Review
Construction 4.0
Construction 4.0 is a variety of interdisciplinary technologies, methodologies and concepts that digitize, automate and integrate the construction process at all stages of the value chain
  • 7.0K
  • 27 Mar 2023
Topic Review
Mercator 1569 World Map
The Mercator world map of 1569 is titled Nova et Aucta Orbis Terrae Descriptio ad Usum Navigantium Emendate Accommodata (Renaissance Latin for "New and more complete representation of the terrestrial globe properly adapted for use in navigation"). The title shows that Gerardus Mercator aimed to present contemporary knowledge of the geography of the world and at the same time 'correct' the chart to be more useful to sailors. This 'correction', whereby constant bearing sailing courses on the sphere (rhumb lines) are mapped to straight lines on the plane map, characterizes the Mercator projection. While the map's geography has been superseded by modern knowledge, its projection proved to be one of the most significant advances in the history of cartography, inspiring map historian Nordenskiöld to write "The master of Rupelmonde stands unsurpassed in the history of cartography since the time of Ptolemy." The projection heralded a new era in the evolution of navigation maps and charts and it is still their basis. The map is inscribed with a great deal of text. The framed map legends (or cartouches) cover a wide variety of topics: a dedication to his patron and a copyright statement; discussions of rhumb lines, great circles and distances; comments on some of the major rivers; accounts of fictitious geography of the north pole and the southern continent. The full Latin texts and English translations of all the legends are given below. Other minor texts are sprinkled about the map. They cover such topics as the magnetic poles, the prime meridian, navigational features, minor geographical details, the voyages of discovery and myths of giants and cannibals. These minor texts are also given below. A comparison with world maps before 1569 shows how closely Mercator drew on the work of other cartographers and his own previous works, but he declares (Legend 3) that he was also greatly indebted to many new charts prepared by Portuguese and Spanish sailors in the portolan tradition. Earlier cartographers of world maps had largely ignored the more accurate practical charts of sailors, and vice versa, but the age of discovery, from the closing decade of the fifteenth century, stimulated the integration of these two mapping traditions: Mercator's world map is one of the earliest fruits of this merger.
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  • 22 Nov 2022
Topic Review
Tetrodotoxin
Tetrodotoxin (TTX) is a crystalline, weakly basic, colorless organic substance and is one of the most potent marine toxins known. Although TTX was first isolated from pufferfish, it has been found in numerous other marine organisms and a few terrestrial species. 
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  • 18 Jan 2022
Topic Review
Taiwanese Romanization System
The Taiwanese Romanization System (Taiwanese Romanization: Tâi-uân Lô-má-jī Phing-im Hong-àn, Chinese: 臺灣閩南語羅馬字拼音方案; pinyin: Táiwān Mǐnnányǔ Luómǎzì Pīnyīn Fāng'àn; Pe̍h-ōe-jī: Tâi-ôan Lô-má-jī Pheng-im Hong-àn; often referred to as Tâi-lô) is a transcription system for Taiwanese Hokkien. It is derived from Pe̍h-ōe-jī and since 2006 has been one of the officially promoted phonetic notation system by Taiwan's Ministry of Education. It is nearly identical to Taiwanese Language Phonetic Alphabet (TLPA) Romanization for Hakka apart from using ts tsh j instead of c ch j for the fricatives /ts tsʰ dz/.
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  • 10 Nov 2022
Topic Review
Digital twins in pharmaceutical manufacturing
The development and application of emerging technologies of Industry 4.0 enable the realization of digital twins (DT), which facilitates the transformation of the manufacturing sector to a more agile and intelligent one. DTs are virtual constructs of physical systems that mirror the behavior and dynamics of such physical systems. A fully developed DT consists of physical components, virtual components, and information communications between the two. Integrated DTs are being applied in various processes and product industries. Although the pharmaceutical industry has evolved recently to adopt Quality-by-Design (QbD) initiatives and is undergoing a paradigm shift of digitalization to embrace Industry 4.0, there has not been a full DT application in pharmaceutical manufacturing. Therefore, there is a critical need to examine the progress of the pharmaceutical industry towards implementing DT solutions. The aim of this entry is to give an overview of the current status of DT development and its application in pharmaceutical and biopharmaceutical manufacturing. State-of-the-art Process Analytical Technology (PAT) developments, process modeling approaches, and data integration studies are reviewed. Challenges and opportunities for future research in this field are also discussed.
  • 7.0K
  • 09 Mar 2022
Topic Review
Black Belt (U.S. Region)
The Black Belt is a region of the Southern United States. The term originally described the prairies and dark fertile soil of central Alabama and northeast Mississippi. Because this area in the 19th century was historically developed for cotton plantations based on enslaved African American labor, the term became associated with these conditions. It was generally applied to a much larger agricultural region in the Southern United States, which was characterized by a history of cotton plantation agriculture in the 19th century and a high percentage of African Americans outside metropolitan areas. The enslaved peoples were freed after the American Civil War, and many continued to work in agriculture afterward. Their descendants make up much of the African-American population of the United States. During the first half of the 19th Century, as many as one million enslaved Africans were transported through sales in the domestic slave trade to the Deep South in a forced migration to work as laborers for the region's cotton plantations. After having lived enslaved for several generations in the area, many remained as rural workers, tenant farmers and sharecroppers after the Civil War and emancipation. Beginning in the early 20th century and up to 1970, a total of six million black people left the South in the Great Migration to find work and other opportunities in the industrial cities of the Northeast, Midwest, and West. Because of relative isolation and lack of economic development, the rural communities in the Black Belt have historically faced acute poverty, rural exodus, inadequate education programs, low educational attainment, poor health care, urban decay, substandard housing, and high levels of crime and unemployment. In December 2017, the Special Rapporteur of the Office of the United Nations High Commissioner for Human Rights declared that Alabama was the most impoverished area in the developed world. Given the history of decades of racial segregation into the late 20th century, African-American residents have been the most disproportionately affected, although these problems apply broadly to all ethnic groups in the rural Black Belt. The region and its boundaries have varying definitions, but it is generally considered a band through the center of the Deep South, although stretching from as far north as Delaware to as far west as East Texas.
  • 7.0K
  • 31 Oct 2022
Topic Review
Morphea
Morphea, also known as localized scleroderma (LoS), comprises a set of autoimmune sclerotic skin diseases. It is characterized by inflammation and limited thickening and induration of the skin; however, in some cases, deeper tissues might also be involved. Although morphea is not considered a life-threatening disease, the apparent cosmetic disfigurement, functional or psychosocial impairment affects multiple fields of patients' quality of life. Therapy for LoS is often unsatisfactory with numerous treatments that have only limited effectiveness or considerable side effects.
  • 7.0K
  • 12 Aug 2021
Topic Review
Polymers for Pharmaceutical Coating
Coating the solid dosage form, such as tablets, is considered common, but it is a critical process that provides different characteristics to tablets. It increases the value of solid dosage form, administered orally, and thus meets diverse clinical requirements. As tablet coating is a process driven by technology, it relies on advancements in coating techniques, equipment used for the coating process, evaluation of coated tablets, and coated material used. Although different techniques were employed for coating purposes, which may be based on the use of solvents or solvent-free, each of the methods used has its advantages and disadvantages, and the techniques need continued modification too. During the process of film coating, several inter-and intra-batch uniformity of coated material on the tablets is considered a critical point that ensures the worth of the final product, particularly for those drugs that contain an active medicament in the coating layer. Meanwhile, computational modeling and experimental evaluation were actively used to predict the impact of the operational parameters on the final product quality and optimize the variables in tablet coating. The efforts produced by computational modeling or experimental evaluation not only save cost in optimizing the coating process but also saves time.
  • 7.0K
  • 13 Sep 2022
Topic Review
Wife-carrying
Wife carrying (Finnish: eukonkanto or akankanto, Estonian: naisekandmine, Swedish: kärringkånk) is a contest in which male competitors race while each carrying a female teammate. The objective is for the male to carry the female through a special obstacle track in the fastest time. The sport was first introduced at Sonkajärvi, Finland . Several types of carrying may be practised: either a classic piggyback, a fireman's carry (over the shoulder), or Estonian-style (wife upside-down on his back with her legs over the neck and shoulders).
  • 7.0K
  • 11 Oct 2022
Topic Review
Morel Cultivation Industry in China
Morels are one of the most highly prized edible and medicinal mushrooms worldwide. Therefore, historically, there has been a large international interest in their cultivation. Numerous ecological, physiological, genetic, taxonomic, and mycochemical studies have been previously developed. At the beginning of 21th century, China finally achieved artificial cultivation and started a high-scale commercial development in 2012. Due to its international interest, its cultivation scale and area expanded rapidly in this country. However, along with the massive industrial scale, a number of challenges, including the maintenance of steady economic profits, arise. In order to contribute to the solution of these challenges, formal research studying selection, species recognition, strain aging, mating type structure, life cycle, nutrient metabolism, growth and development, and multi-omics has recently been boosted.
  • 7.0K
  • 29 Aug 2023
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