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Topic Review
Fisetin in Cancer
Fisetin is a flavonoid naturally occurring in various plants that possesses anticancer activity. It has the power to stop cancers from growing quickly, becoming invasive, and spreading to multiple tissues.
  • 1.7K
  • 10 May 2023
Topic Review
Ring-tailed Mongoose
The Ring-tailed Mongoose (Galidia elegans) is a small carnivorous mammal native to Madagascar, recognized for its distinctive ringed tail and agile arboreal lifestyle. With a slender body and sharp claws, it navigates the dense forests of Madagascar with ease, preying on a variety of small animals including insects, reptiles, and small mammals. Despite its elusive nature, the Ring-tailed Mongoose plays a significant role in the island's ecosystem dynamics, contributing to predator-prey interactions and biodiversity maintenance.
  • 1.7K
  • 15 Mar 2024
Topic Review
Cisplatin
Cisplatin, also referred to as cis-diamminedichloroplatinum (II) (CDDP), is a widely used, Pt-based anti-cancer chemotherapeutic agent. This transition metal coordination complex has a square planar molecular geometry and presents as a solid, yellow powder at room temperature. CDDP is fairly insoluble in most substances; however, it can be dissolved in dimethylformamide, and is somewhat soluble in water, but most preferable in saline sodium. In solid form, CDDP is stable for about two years if stored at room temperature in dry conditions and light protected; however, it is known to convert slowly to its trans-form. The stability of CDDP in sodium chloride solution is dependent on the chloride ion concentration; it is more stable when suspended in normal saline (0.9% sodium chloride). Saline also provides a reno-protective function, increasing hydration and aiding in excretion of CDDP from the kidneys.
  • 1.7K
  • 14 Dec 2022
Topic Review
Urban Futures Lab
Fonded in 2018 by Dr. Steffen Lehmann, the interdisciplinary  Urban Futures Lab is a collaboration between three units at the University of Nevada at Las Vegas: UNLV School of ArchitectureUNLV Howard R. Hughes College of EngineeringUNLV Greenspun College of Urban AffairsThe Urban Futures Lab (UFLab) has partners from industry and government contributing to the following research program.
  • 1.7K
  • 12 Apr 2021
Topic Review
Glycosylation role in Alzheimer’s Disease
Glucose uptake in the brain decreases because of normal aging but this decline is accelerated in Alzheimer’s disease (AD) patients. In fact, positron emission tomography (PET) studies have shown that metabolic reductions in AD patients occur decades before the onset of symptoms, suggesting that metabolic deficits may be an upstream event in at least some late-onset cases. A decrease in the availability of glucose content induces a considerable impairment/downregulation of glycosylation, which is an important post-translational modification. Glycosylation is an important and highly regulated mechanism of secondary protein processing within cells and it plays a crucial role in modulating the stability of proteins, as carbohydrates are important in achieving the proper three-dimensional conformation of glycoproteins. Moreover, glycosylation acts as a metabolic sensor that links glucose metabolism to normal neuronal functioning. All the proteins involved in β-amyloid (Aβ) precursor protein metabolism have been identified as candidates of glycosylation highlighting the possibility that Aβ metabolism could be regulated by their glycosylation. Within this framework, the present review aims to summarize the current understanding on the role of glycosylation in the etiopathology of AD, emphasizing the idea that the glucose metabolic pathway may represent an alternative therapeutic option for targeting AD. From this perspective, the pharmacological modulation of glycosylation levels may represent a ‘sweet approach’ to treat AD targeting new mechanisms independent of the amyloid cascade and with comparable impacts in familial and sporadic AD.
  • 1.7K
  • 10 Nov 2020
Topic Review
Perovskite Solar Cells with g-C3N4
Perovskite solar cells (PSCs) have attracted great research interest in the scientific community due to their extraordinary optoelectronic properties and the fact that their power conversion efficiency (PCE) has increased rapidly in recent years, surpassing other 3rd generation photovoltaic (PV) technologies. Graphitic carbon nitride (g-C3N4) presents exceptional optical and electronic properties and its use was recently expanded in the field of PSCs. The addition of g-C3N4 in the perovskite absorber and/or the electron transport layer (ETL) resulted in PCEs exceeding 22%, mainly due to defects passivation, improved conductivity and crystallinity as well as low charge carriers’ recombination rate within the device. Significant performance increase, including stability enhancement, was also achieved when g-C3N4 was applied at the PSC interfaces and the observed improvement was attributed to its wetting (hydrophobic/hydrophilic) nature and the fine tuning of the corresponding interface energetics. 
  • 1.7K
  • 26 Apr 2021
Topic Review
SARS-CoV-2 Vaccination-Associated Coagulopathy
Coronavirus Disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is frequently complicated by thrombosis. In some cases of severe COVID-19, fibrinolysis may be markedly enhanced within a few days, resulting in fatal bleeding. In the treatment of COVID-19, attention should be paid to both coagulation activation and fibrinolytic activation. Various thromboses are known to occur after vaccination with SARS-CoV-2 vaccines. Vaccine-induced immune thrombotic thrombocytopenia (VITT) can occur after adenovirus-vectored vaccination, and is characterized by the detection of anti-platelet factor 4 antibodies by enzyme-linked immunosorbent assay and thrombosis in unusual locations such as cerebral venous sinuses and visceral veins. Treatment comprises high-dose immunoglobulin, argatroban, and fondaparinux. Some VITT cases show marked decreases in fibrinogen and platelets and marked increases in D-dimer, suggesting the presence of enhanced-fibrinolytic-type disseminated intravascular coagulation with a high risk of bleeding. In the treatment of VITT, evaluation of both coagulation activation and fibrinolytic activation is important, adjusting treatments accordingly to improve outcomes.
  • 1.7K
  • 21 Mar 2022
Topic Review
Cellulose Nanocrystals
Cellulose has both highly ordered crystalline and amorphous regions in varying proportions, depending on its source. Removing the amorphous region influences the structure and crystallinity of the cellulose, resulting in the formation of CNCs. CNCs are needle-like particles made up of cellulose chain segments that have been organized in an almost defect-free crystalline structure with at least one dimension less-than-or-equal-to 100 nm. CNCs are also known as cellulose nanowhiskers, cellulose whiskers, and nanocrystalline cellulose, but CNCs is the most used term. CNCs have a high thermal stability, surface area, and crystallinity compared to bulk cellulose, which has more amorphous fractions. Different types of LCB waste have been used to extract CNCs such as cotton, pineapple leaf, sugarcane bagasse, walnut shell, soy hulls, bamboo fibre, and many more.
  • 1.7K
  • 29 Apr 2022
Topic Review
Apiaceae Family in Agriculture
Synthetic chemicals are used to protect crops and agricultural products, thereby producing high yields. However, intensive use of these synthetic chemicals significantly affects the environment and sustainable agriculture production. Moreover, direct or indirect exposure to these synthetic chemicals may cause acute or chronic toxicity in humans and animals. Due to their biodegradability, low toxicity, and being environmentally friendly, secondary metabolites derived from plant sources are being studied as a sustainable approach. Apiaceae family crops are a good source of bioactive phytochemicals. Many studies have found that Apiaceae extracts and essential oils possess various biocidal activities: antibacterial, antifungal, herbicidal, insecticidal or repellent, and larvicidal activities, among others. These various potent bioactivities make the Apiaceae an excellent alternative source for synthetic chemicals. 
  • 1.7K
  • 13 Jul 2022
Topic Review
Boeing–Sikorsky RAH-66 Comanche
The Boeing–Sikorsky RAH-66 Comanche is an American stealth armed reconnaissance and attack helicopter designed for the United States Army. Following decades of development, during 2004, the RAH-66 program was canceled prior to mass production commencing, by which point nearly US$7 billion had been already spent on the program. During the early 1980s, the U.S. Army started to formulate requirements for the replacement of its helicopters then in service, which resulted in the launch of the Light Helicopter Experimental (LHX) program. Nearly a decade later, following the refinement of requirements, evaluation of submissions, and the rebranding of the program as the Light Helicopter (LH) program, during April 1991, the Army announced the selection of the Boeing–Sikorsky team's design as the contest winner, shortly after which a contract for construction of prototypes was awarded. The Comanche was to incorporate several advanced elements, such as stealth technologies, and a number of previously untried design features. Operationally, it was to employ advanced sensors in its reconnaissance role, where it was intended to designate targets for the AH-64 Apache. It was also armed with one rotary cannon and could carry missiles and rockets in internal bays and optionally on stub wings for light attack duties. Two RAH-66 prototypes were constructed and underwent flight testing between 1996 and 2004. On 1 June 2000, the program entered its $3.1 billion engineering and manufacturing development (EMD) phase. However, during 2002, the Comanche program underwent heavy restructuring; the number of Comanches that were to be purchased was cut to 650. At the time, the projected total cost for the full production of the Comanche in such numbers stood at $26.9 billion. As early as the late 1990s, the Government Accountability Office (GAO) had reported that it had "serious doubts" about the program, observing that the Comanche would "consume almost two thirds of the whole Aviation budget by Fiscal Year 2008". Multiple government agencies had acted to cut the number of Comanches on order, but, as a consequence of the heavy reductions to the numbers to be procured, the unit costs soared. On 23 February 2004, the U.S. Army announced the termination of the Comanche program, stating they had determined that the RAH-66 would require numerous upgrades to be viable on the battlefield and that the service would instead direct the bulk of its rotary systems funds to renovating its existing attack, utility, and reconnaissance helicopters. The Army also announced new plans to accelerate the development of unmanned aerial vehicles (UAVs), which could also perform the scouting role intended for the Comanche, but with less risk. Since program cancellation, both of the prototypes have been placed on public display.
  • 1.7K
  • 17 Nov 2022
Topic Review
Public Acceptance of Autonomous Vehicles in Public Transportation
The field of autonomous vehicles (AVs) is advancing rapidly, with prototype development and on-road testing of AVs frequently occurring, suggesting that AV deployment for public transportation may soon become a reality.
  • 1.7K
  • 11 May 2023
Topic Review
Electromagnetic Interference Shielding
Graphene is the first two-dimensional material that becomes the center material in various research areas of material science, chemistry, condensed matter, and engineering due to its advantageous properties, including larger specific area, lower density, outstanding electrical conductivity, and ease of processability. These properties attracted the attention of material researchers resulted in a large number of publications on EMI shielding in a short time and play a central role in addressing the problems and challenges faced in this modern era of electronics by electromagnetic interference. After the popularity of graphene, the community of material researchers investigated other two-dimensional materials like MXenes, hexagonal boron nitride, black phosphorous, transition metal dichalcogenides, and layered double hydroxides, to additionally enhance the EMI shielding response of materials.
  • 1.7K
  • 14 Aug 2023
Topic Review
Chinese Herbal Medicine for Depression
Depression is a mood disorder that causes a loss of interest and constant sadness. Central nervous system (CNS)-targeted medications alone are insufficient for the treatment of depression. Multidrug and multitarget Chinese Herbal Medicine (CHM) has great potential to assist in the development of novel medications for the systematic and effective pharmacotherapy of depression.
  • 1.7K
  • 02 Feb 2021
Topic Review
Microbiota
The human gut microflora comprises over 1000 species and more than 7000 strains, representing 1013–1014 bacterial cells, which is ten times more numerous than other cells. Healthy gut microbiota is mainly composed of the phyla Firmicutes and Bacteroidetes, representing around 90% of the human gut flora, followed by Actinobacteria, Verrucomicrobia, and Proteobacteria.
  • 1.7K
  • 18 Jan 2022
Topic Review
Blue Cheeses
Blue cheeses are those whose matrix is veined with a blue, blue-grey, or blue-green colour due to the development of Penicillium roqueforti. There are more than 45 varieties of blue cheese produced worldwide, with some distinct features, although the manufacture process is similar. In addition to P. roqueforti, complex microbial populations interact and succeed throughout the manufacturing and ripening at the cheese’s surface (the rind) and interior (matrix). The microbiota of blue cheeses is made up of a vast array of both prokaryotic and eukaryotic microorganisms. Proteolysis is the most complex and important primary biochemical process involved in blue-veined cheeses during ripening, with P. roqueforti being considered the main proteolytic agent. Lipolysis is also strong, originating aroma compounds characteristic of blue-veined cheeses. In addition, several bioactive compounds are produced during ripening. The biochemical activities, mainly of microbial origin, are responsible for the sensory characteristics of these very appreciated cheese varieties worldwide.
  • 1.7K
  • 20 Jul 2023
Topic Review
Enamel Phenotypes
Dental enamel is a specialized tissue that has adapted over millions of years of evolution to enhance the survival of a variety of species. In humans, enamel evolved to form the exterior protective layer for the crown of the exposed tooth crown. Its unique composition, structure, physical properties and attachment to the underlying dentin tissue allow it to be a resilient, although not self-repairing, tissue. The process of enamel formation, known as amelogenesis, involves epithelial-derived cells called ameloblasts that secrete a unique extracellular matrix that influences the structure of the mineralizing enamel crystallites.
  • 1.7K
  • 17 Mar 2023
Topic Review
Deubiquitinases in Breast Cancer
Deubiquitinase (DUB) is an essential component in the ubiquitin-proteasome system (UPS) by removing ubiquitin chains from substrates, thus modulating the expression, activity, and localization of many proteins that contribute to tumor development and progression. DUBs have emerged as promising prognostic indicators and drug targets. DUBs have shown significant roles in regulating breast cancer growth, metastasis, resistance to current therapies, and several canonical oncogenic signaling pathways. In addition, specific DUB inhibitors have been identified and are expected to benefit breast cancer patients in the future. 
  • 1.7K
  • 09 Nov 2021
Topic Review
Renewable Waste-to-Energy in SEA
Renewable waste-to-energy in Southeast Asia is a kind of renewable and alternative energy gained from waste resource that most Southeast Asian countries explore and utilize not only to minimize the waste crisis but also to meet the actual fossil-free high demand [2] but also to reduce greenhouse gas emissions and other environmental impacts from the energy sector [9] across the region.
  • 1.7K
  • 16 Nov 2020
Topic Review
Polymeric Pipeline Coatings Time-Dependent Performance
The barrier performance of organic coatings is a direct function of mass transport and long-term stability of the polymeric structure. A predictive assessment of the protective coating cannot be conducted a priori of degradation effects on transport. Epoxy-based powder coatings are an attractive class of coatings for pipelines and other structures because application processing times are low and residual stresses between polymer layers are reduced. 
  • 1.7K
  • 27 May 2021
Topic Review
Neurodegeneration with Brain Iron Accumulation
The syndromes of neurodegeneration with brain iron accumulation (NBIA) encompass a group of invalidating and progressive rare diseases that share the abnormal accumulation of iron in the basal ganglia. The onset of NBIA disorders ranges from infancy to adulthood. Main clinical signs are related to extrapyramidal features (dystonia, parkinsonism and choreoathetosis), and neuropsychiatric abnormalities. Ten NBIA forms are widely accepted to be caused by mutations in the genes PANK2, PLA2G6, WDR45, C19ORF12, FA2H, ATP13A2, COASY, FTL1, CP, and DCAF17. However, many patients remain without a genetic diagnosis, and therefore, there must be additional yet undiscovered NBIA genes. The genetic heterogeneity and the corresponding encoded proteins emphasize that several pathways are involved in NBIA syndromes: iron and lipid metabolism, mitochondrial dynamics, and autophagy. Moreover, for these forms as well as for many neurodegenerative conditions, mitochondrial dysfunction and oxidative stress are common mechanisms of disease.
  • 1.7K
  • 22 Sep 2021
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