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Topic Review
Blue Light on Acne Vulgaris
Acne is a dermatosis that affects almost 90% of the adolescent population worldwide and its treatment is performed with retinoids, antimicrobials, acids, and topical or systemic antibiotics. Side effects such as skin irritation in addition to microbial resistance to antibiotics are the main side effects found. Phototherapy with blue light is being used as an alternative treatment.
  • 1.7K
  • 11 Nov 2021
Topic Review
Zero Solid Waste in the Sedimentary Phosphate Industry
The phosphate industry produces huge volumes of waste (hundred million tons per year). These wastes are generally surface landfilled, leading to significant environmental impacts and a large footprint. All the waste streams generated during the life cycle of phosphoric acid production going from the extraction of phosphate rock to its enrichment and transformation are considered. Great circularity opportunities have been identified and they aim (i) to recover the residual phosphorus and other critical minerals and metals, and (ii) to consider phosphate wastes as alternative resources in the civil engineering and building sectors. The purpose is to shift from linear thinking to circular thinking where synergy between different mining and other industries is highly encouraged. 
  • 1.7K
  • 16 Nov 2021
Topic Review
Drought Stress in Grain Legumes
Grain legumes are important sources of proteins, essential micronutrients and vitamins and for human nutrition. Climate change, including drought, is a severe threat to grain legume production throughout the world. The yield loss of grain legumes varies from species to species, even variety to variety within a species, depending upon the severity of drought stress and several other factors, such as phenology, soil textures and agro-climatic conditions. Closure of stomata leads to an increase in leaf temperature by reducing the transpiration rate, and, so, the legume plant faces another stress under drought stress. The biosynthesis of reactive oxygen species (ROS) is the most detrimental effect of drought stress. Legumes can adapt to the drought stress by changing their morphology, physiology and molecular mechanism. Improved root system architecture (RSA), reduced number and size of leaves, stress-induced phytohormone, stomatal closure, antioxidant defense system, solute accumulation (e.g., proline) and altered gene expression play a crucial role in drought tolerance. 
  • 1.7K
  • 30 Nov 2021
Topic Review
Agri-Food Traceability System User Intention
Scientists believed the outbreak of COVID-19 could be linked to the consumption of wild animals, so food safety and hygiene have become the top concerns of the public. An agri-food traceability system becomes very important in this context because it can help the government to trace back the entire production and delivery process in case of food safety concerns. The traceability system is a complicated digitalized system because it integrates information and logistics systems. Previous studies used the technology acceptance model (TAM), information systems (IS) success model, expectation confirmation model (ECM), or extended model to explain the continuance intention of traceability system users.
  • 1.7K
  • 16 Mar 2022
Topic Review
The Concept of Genus
The genus concept and its implication in classifying pathogenic relevant microorganisms:  The Brucella and Ochrobactrum
  • 1.7K
  • 31 Mar 2022
Topic Review
Branchiomeric Muscle Development
Branchiomeric skeletal muscles are a subset of head muscles originating from skeletal muscle progenitor cells in the mesodermal core of pharyngeal arches. These muscles are involved in facial expression, mastication, and function of the larynx and pharynx. Branchiomeric muscles have been the focus of many studies over the years due to their distinct developmental programs and common origin with the heart muscle.
  • 1.7K
  • 06 Sep 2022
Topic Review
Polymer–Metal Composites Materials for Healthcare Device
An ideal medical implant requires optimized properties on both bulk and microscopic scale that can hardly be accomplished by using a single material. Metallic implants such as titanium-based implants possess excellent mechanical properties in general but suffer from corrosion; polymeric implants can be multifunctional and biodegradable, however, difficult to provide some crucial mechanical properties like ductility. With the advance in polymer science and metallurgy, the polymer–metal composite materials serve as an emerging class of healthcare device with optimized bulk and microscopic properties, such polymer–metal composite devices provide good mechanical support, good bio-integration, good hygiene, and minimize bacterial infection and reduced hypersensitivity reactions.
  • 1.7K
  • 27 Sep 2022
Topic Review
Using Remote Sensing in Soil Salinization Mapping
Meeting current needs without compromising future generations’ ability to meet theirs is the only path toward achieving environmental sustainability. As the most valuable natural resource, soil faces global, regional, and local challenges, from quality degradation to mass losses brought on by salinization. These issues affect agricultural productivity and ecological balance, undermining sustainability and food security. Therefore, timely monitoring and accurate mapping of salinization processes are crucial, especially in semi-arid and arid regions where climate variability impacts have already reached alarming levels. Salt-affected soil mapping has enormous potential thanks to recent progress in remote sensing.
  • 1.7K
  • 29 May 2023
Topic Review
Epigenetics in Crop Breeding
Epigenetic regulation has the potential to revolutionize plant breeding and improve crop yields by regulating gene expression in plants. DNA methylation and histone modifications are key epigenetic modifications that can impact plant development, stress responses, productivity, and yields. 
  • 1.7K
  • 11 Aug 2023
Topic Review
Powder Bed Fusion Process
The ability to manufacture parts with complex geometry by sending a model from CAD directly to the manufacturing machine has attracted much attention in the industry, driving the development of additive manufacturing technology. However, studies have shown that components manufactured using additive manufacturing technology have several problems, namely high tensile residual stresses, cracks, and voids, which are known to have a major impact on material performance (in service).
  • 1.7K
  • 24 Oct 2023
Topic Review
Molecularly Imprinted Polymers in Sample Preparation
Molecularly Imprinted Polymers (MIPs) are synthetic polymeric materials with imprinted sites complementary to a specific molecule and high affinity over analytes with analogous molecular structure. Extraction can benefit from the production of MIPs that can be applied as sorbents for the extraction of specific antibiotics. 
  • 1.7K
  • 17 Jul 2023
Topic Review
Punicalagin in Cancer Prevention
Punicalagin, present in pomegranate, myrobalan, yellow wood, tropical almond, and pink rock-rose, belongs to ellagitannins - a subgroup of hydrolyzable tannins. In vitro studies, based on cell line experiments, have demonstrated punicalagin anti-cancer actions on human cervical, ovarian, breast, lung, thyroid, colorectal, central nervous system, bone, as well as other cancer types. Punicalagin seems to work through a redirection of signal-transduction pathways from survival and proliferation into cell-cycle arrest, apoptosis, senescence or autophagy (thus compromising neoplastic progression). However, since it readily undergoes hydrolysis releasing e.g. ellagic acid, these might be its products which are responsible for the observed effects. Moreover, when practical application of punicalagin in chemoprevention is addressed, its biotransformation in the human organism should be considered (including both host and microbiome enzymatic impact). Therefore, however promising punicalagin antineoplastic properties seem to be, in vivo-based research should be conducted before translating the results obtained from in vitro studies into practice.
  • 1.7K
  • 26 Aug 2021
Topic Review
Hybrid Ejector-Absorption Refrigeration Systems
Absorption Refrigeration Systems (ARS) are potential alternatives to direct expansion (DX) refrigeration systems. This review focuses on the incorporation of an ejector into absorption refrigeration cycles to constitute Hybrid Ejector-Absorption Refrigeration Systems (HEARS). The ejector adds several advantages to the absorption refrigeration systems depending on its location in the cycle. The two prevalent configurations of HEARS are Triple pressure level (TPL-HEARS), and Low Pressure Condenser (LPC-HEARS). Previous studies revealed the preference of the later configuration as it allows lower circulation ratios, enhances the refrigeration effect, and could achieve a COP up to 1. Moreover, LPC configuration is suitable with single, double, and variable effect absorption systems with a COP of above unity. In turn, the TPL-HEARS notably enhances the absorption process particularly when a variable geometry ejector is utilized. This configuration could obtain a COP around 1.1, but only with high-density refrigerant vapor. Lately, to attain the advantages of both configurations; some studies investigated the viability of adding two ejectors to the cycle. This paper meticulously reviews investigations conducted on the emerging dual ejectors-absorption refrigeration technology. This paper reveals the general performance trend and the maximum attainable COP by each type of hybrid ejector-absorption refrigeration system. DEARS and Ejector-driven absorption refrigeration systems (ED-ARS) could achieve COP that ranges between 1.2 and 1.46. The use of a flash tank and a RHE is essential in NH3/H2O HEARS. At high generator temperatures of (120 – 170 °C), DEARS was found to be the system with the less complexity and best performance. Nevertheless, the performance of the DEARS might drop significantly if the heat source temperature is fluctuating. Thence, the variable effect HEARS is considered the best alternative. The capability of HEARS to be integrated with different power generation cycles is also highlighted. Finally, the review presents possible future research opportunities to improve the absorption refrigeration technology.
  • 1.7K
  • 01 Nov 2021
Topic Review
Cell Migration
Directional migration of cells is essential for multicellular organisms development and survival. In this review we outline the importance of calcium signaling, and in particular store-operated calcium entry, in regulating cell migration in nomral and metastatic cells. Interestingly, calcium signaling is polarized and differentially regulates focal adhesion and the cytoskeleton at the front and rear ends of the cell. 
  • 1.7K
  • 25 May 2021
Topic Review
Multidrug Resistant Gram-Negative Bacteria
Antibiotic resistance has increased markedly in Gram-negative bacteria, causing severe infections intractable with traditional drugs and amplifying mortality and healthcare costs. Consequently, to find novel antimicrobial compounds, active on multidrug resistant bacteria, is mandatory. In this regard, cationic antimicrobial peptides (CAMPs)—able to kill pathogens on contact—could represent an appealing solution. However, low selectivity, hemolytic toxicity and cost of manufacturing, hamper their massive clinical application. In the recent years—starting from CAMPs as template molecules—less toxic and lower-cost synthetic mimics of CAMPs, including cationic peptides, polymers and dendrimers, have been developed. Although the pending issue of hemolytic toxicity and biodegradability is still left not completely solved, cationic antimicrobial polymers (CAPs), compared to small drug molecules, thanks to their high molecular weight, own appreciable selectivity, reduced toxicity toward eukaryotic cells, more long-term activity, stability and non-volatility. With this background, an updated overview concerning the state of the art of the main manufactured types of CAPs, active on Gram-negative bacteria, is herein reported, including synthetic procedure and action’s mechanism. Information about the antibacterial activity, advantages and drawbacks of the most appealing compounds was also provided.
  • 1.7K
  • 28 Oct 2020
Topic Review
Deep Brain Stimulation Selection Criteria
Selection criteria for deep brain stimulation (DBS) in Parkinson’s disease (PD) still rely on a document published in 1999 called ‘Core Assessment Program for Surgical Interventional Therapies in Parkinson’s Disease’. These criteria are useful in supporting the selection of candidates but could be considered both restrictive and out-of-date. Starting from the original CAPSIT-PD document, we addressed the following topics which may impact the DBS selection process: early versus delayed DBS; the evolution of the levodopa challenge test; the relevance of axial symptoms; new focus on patient-centered outcome measures; the relevance of non-motor symptoms; and a new role for genetics.
  • 1.7K
  • 09 Feb 2021
Topic Review
Akkermansia muciniphila
Akkermansia muciniphila is one of the early occupants (in first year of life) of the intestinal tract with 108 cell/gm or more than 1% of total faecal microbes.
  • 1.7K
  • 05 Aug 2021
Topic Review
Hexapod Robots
The static stability of hexapods motivates their design for tasks in which stable locomotion is required, such as navigation across complex environments. This task is of high interest due to the possibility of replacing human beings in exploration, surveillance and rescue missions. For this application, the control system must adapt the actuation of the limbs according to their surroundings to ensure that the hexapod does not tumble during locomotion.
  • 1.7K
  • 25 Aug 2021
Topic Review
Smart City Collaboration
Collaboration is problematic in the public sector, yet many smart city theorists advocate relationships fully dependent upon collaboration to address the intense complexity encountered by city governments and achieve city objectives of quality of life, efficiency, effectiveness, and economic and environmental sustainability.
  • 1.7K
  • 27 Aug 2021
Topic Review
Udwadia–Kalaba Equation
In theoretical physics, the Udwadia–Kalaba equation is a method for deriving the equations of motion of a constrained mechanical system. The equation was first described by Firdaus E. Udwadia and Robert E. Kalaba in 1992. The approach is based on Gauss's principle of least constraint. The Udwadia–Kalaba equation applies to both holonomic constraints and nonholonomic constraints, as long as they are linear with respect to the accelerations. The equation generalizes to constraint forces that do not obey D'Alembert's principle.
  • 1.7K
  • 14 Oct 2022
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