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Topic Review
Toll-Like Receptor 2
TLRs are one of four major families of pattern recognition receptor (PRRs), which include also NOD-like receptors (NLRs), RIG-like receptors (RLRs), C-type lectin receptors (CLRs), and represent the cornerstone of the innate immune response. TLR2, together with TLR1, TLR3, TLR4, and TLR5, was first identified and characterized in 1998. TLR2 is the only TLR that forms functional heterodimers with more than two other types of TLRs, forming dimers with TLR1, TLR6, and in some cases with TLR4. TLR2 recognizes molecules frequently associated with pathogens, the so-called pathogen-associated molecular patterns (PAMPs), leading to activation of downstream signal transduction pathways, which result in the production of inflammatory cytokines, type I interferons (IFNs), and other mediators necessary for the development of effective immune responses. Moreover, TLR2 is involved in the recognition of damage-associated molecular patterns (DAMPs), released by damaged tissues.
  • 1.7K
  • 18 Dec 2020
Topic Review
Small Spirocyclic, Xanthene-Based Fluorescent Probes
The use of fluorescent probes in a multitude of applications is still an expanding field. This review covers the recent progress made in small molecular, spirocyclic xanthene-based probes containing different heteroatoms (e.g., oxygen, silicon, carbon) in position 10′. After a short introduction, we will focus on applications like the interaction of probes with enzymes and targeted labeling of organelles and proteins, detection of small molecules, as well as their use in therapeutics or diagnostics and super-resolution microscopy. Furthermore, the last part will summarize recent advances in the synthesis and understanding of their structure–behavior relationship including novel computational approaches. 
  • 1.7K
  • 07 Jan 2021
Topic Review
Water Land Resources Degradation Index
Natural resources are gradually coming under continuous and increasing pressure due to anthropogenic interventions and climate variabilities. The result of these pressures is reflected in the sustainability of natural resources. Significant scientific efforts during the recent years focus on mitigating the effects of these pressures and on increasing the sustainability of natural resources. Hence, there is a need to develop specific indices and indicators that will reveal the areas having the highest risks. The Water and Land Resources Degradation Index (WLDI) was developed for this purpose. WLDI consists of eleven indicators and its outcome results from the spatiotemporal performance of these indicators. The WLDI is based on the Standardized Drought Vulnerability Index (SDVI) and the Environmentally Sensitive Areas Index (ESAI). 
  • 1.7K
  • 27 Jan 2022
Topic Review
Conversion of Carbon Dioxide into Methanol
As an energy source, methanol presents the advantage of being liquid at environmental temperature, which makes it easier to transport and store.
  • 1.7K
  • 21 Apr 2022
Topic Review
Deepfake Attacks and Electrical Network Frequency Fingerprints Approach
With the fast development of Fifth-/Sixth-Generation (5G/6G) communications and the Internet of Video Things (IoVT), a broad range of mega-scale data applications emerge (e.g., all-weather all-time video). These network-based applications highly depend on reliable, secure, and real-time audio and/or video streams (AVSs), which consequently become a target for attackers. While modern Artificial Intelligence (AI) technology is integrated with many multimedia applications to help enhance its applications, the development of General Adversarial Networks (GANs) also leads to deepfake attacks that enable manipulation of audio or video streams to mimic any targeted person. Deepfake attacks are highly disturbing and can mislead the public, raising further challenges in policy, technology, social, and legal aspects. As a primary cause of misinformation, an imminent need for fast and reliable authentication techniques is of a high priority.
  • 1.7K
  • 23 May 2022
Topic Review
Managerial in the Tourism Industry
Globalization and intense competition force organizations to be flexible and adaptable to constant changes in the market. According to many researchers, innovation is a crucial source of competitive advantage in the continuously changing environment. Many studies in the area of management present innovation as one of the most significant factors for enhancing organizational performance.
  • 1.7K
  • 27 May 2022
Topic Review
Overview of Marine Bioactive Peptides against HIV
Marine bioactive peptides (MBAPs) that are present in many marine species, including fish, sponges, cyanobacteria, fungi, ascidians, seaweeds, and mollusks, have gained widespread attention for their health-promoting benefits. MBAPs obtained from marine species have ameliorating potential against many health conditions, such as hypertension, diabetes, obesity, HIV, cancer, oxidation, and inflammation. Various research studies have indicated that MBAPs can be utilized as novel lead structures for the treatment of HIV in conjunction with pharmaceuticals and functional foods owing to their potential therapeutic, and antiretroviral (ARV) activities.
  • 1.7K
  • 31 Aug 2022
Topic Review
Climate-Smart Agriculture in African Countries
The agricultural sector contributes approximately 10–20% of the total anthropogenic greenhouse gas (GHGs) emissions. Consequently, climate change can negatively affect crop yields and livestock production thus threatening food security, especially in a vulnerable continent like Africa. Climate-smart agriculture (CSA) practices are classified as follows: agricultural practices, restoration practices of degraded lands, forest and cropland regeneration practices, practices in the livestock sub-sector, water resources and use of weather and climate information services.
  • 1.7K
  • 21 Nov 2022
Topic Review
Health Risk Assessment
A health risk assessment (also referred to as a health risk appraisal and health & well-being assessment) is a questionnaire about a person's medical history, demographic characteristics and lifestyle. It is one of the most widely used screening tools in the field of health promotion and is often the first step in multi-component health promotion programs.
  • 1.7K
  • 07 Nov 2022
Topic Review
Megapnosaurus Rhodesiensis
Coelophysis rhodesiensis is an extinct species of coelophysid theropod dinosaur that lived approximately 188 million years ago during the early part of the Jurassic Period in what is now Africa. The species was a small to medium-sized, lightly built, ground-dwelling, bipedal carnivore, that could grow up to 3 m (9.8 ft) long. It was formerly called Syntarsus, but that name was already taken by a beetle, and was subsequently given the name Megapnosaurus by Ivie, Ślipiński & Węgrzynowicz, in 2001, though many subsequent studies have classified it in the genus Coelophysis.
  • 1.7K
  • 28 Nov 2022
Topic Review
Animal-Derived Polysaccharides
Polysaccharides are biomolecules found in microorganisms, plants, and animals that constitute living organisms. Glycosaminoglycans, unique acidic polysaccharides in animal connective tissue, are often combined with proteins in the form of covalent bonds due to their potent biological activity, low toxicity, and minimal side effects, which have the potential to be utilized as nutrition healthcare and dietary supplements.
  • 1.7K
  • 11 Jan 2024
Topic Review
Ontological Argument
Ontological is derived from ontos, the greek word being. The name is intended to convey the intent of the argument to prove God's existence by virtue of his existence being necessary. It was first proposed by the medieval philosopher Anselm of Canterbury in his Proslogion, and important variations have been developed by philosophers such as René Descartes, Gottfried Leibniz, Norman Malcolm, Charles Hartshorne, and Alvin Plantinga. A modal logic version of the argument was devised by mathematician Kurt Gödel. The ontological argument has been controversial in philosophy and many philosophers have famously criticized or opposed it, including Anselm's contemporary Gaunilo of Marmoutiers, as well as David Hume, Immanuel Kant, and Gottlob Frege. Some of these opponents have preferred to rely on cosmological arguments for the existence of God instead. It continues to garner discus ion to the present.
  • 1.7K
  • 21 Oct 2022
Topic Review
Oxygen, pH, Lactate, and Metabolism for Wound Treatment
Over time, we have come to recognize a very complex network of physiological changes enabling wound healing. An immunological process allows the body to distinguish damaged cells and begin a cleaning mechanism by separating damaged proteins and cells with matrix metalloproteinases, a complement reaction, and free radicals. A wide variety of cell functions help to rebuild new tissue, dependent on energy provision and oxygen supply. Topically applied lactate can improve this.
  • 1.7K
  • 12 Nov 2021
Topic Review
Sorcin in cancer drug resistance
The development of drug resistance is one of the main causes of failure in anti-cancer treatments. Tumor cells adopt many strategies to counteract the action of chemotherapeutic agents, e.g., enhanced DNA damage repair, inactivation of apoptotic pathways, alteration of drug targets, drug inactivation, and overexpression of ABC (Adenosine triphosphate-binding cassette, or ATP-binding cassette) transporters. These are broad substrate-specificity ATP-dependent efflux pumps able to export toxins or drugs out of cells; for instance, ABCB1 (MDR1, or P-glycoprotein 1), overexpressed in most cancer cells, confers them multidrug resistance (MDR). The gene coding for sorcin (SOluble Resistance-related Calcium-binding proteIN) is highly conserved among mammals and is located in the same chromosomal locus and amplicon as the ABC transporters ABCB1 and ABCB4, both in human and rodent genomes (two variants of ABCB1, i.e., ABCB1a and ABCB1b, are in rodent amplicon). Sorcin was initially characterized as a soluble protein overexpressed in multidrug (MD) resistant cells and named “resistance-related” because of its co-amplification with ABCB1.
  • 1.7K
  • 21 Dec 2020
Topic Review
Neo-Vascular Lesions after Delivery/Miscarriage
The concept of intrauterine neo-vascular lesions after pregnancy, initially called placental polyps, has changed gradually. Now, based on diagnostic imaging, such lesions are defined as retained products of conception (RPOC) with vascularization. The lesions appear after delivery or miscarriage, and they are accompanied by frequent abundant vascularization in the myometrium attached to the remnant. Many of these vascular lesions have been reported to resolve spontaneously within a few months. Acquired arteriovenous malformations (AVMs) must be considered in the differential diagnosis of RPOC with vascularization. AVMs are errors of morphogenesis. The lesions start to be constructed at the time of placenta formation. These lesions do not show spontaneous regression. Although these two lesions are recognized as neo-vascular lesions, neo-vascular lesions on imaging may represent conditions other than these two lesions (e.g., peritrophoblastic flow, uterine artery pseudoaneurysm, and villous-derived malignancies). Detecting vasculature at the placenta–myometrium interface and classifying vascular diseases according to hemodynamics in the remnant would facilitate the development of specific treatments.
  • 1.7K
  • 17 Mar 2021
Topic Review
Cold Plasma Systems for Medicine
Plasma is the predominant state of matter in the known universe (it is estimated that up to 99% of matter is plasma), although not on our planet, where the conditions of pressure and temperature make normal the states of matter—solid, liquid, and gas—that in global terms are exotic.  If we add energy to a gas, we will partially or totally ionize it. In this way, we reach a new state of matter, plasma, made up of free electrons, atoms and molecules (electrically neutral particles), and ions. The energy needed to generate plasma can be supplied through electrical discharges in gases, in which free electrons take energy field and lose it through excitation and ionization processes of the atoms and molecules in the gas. The interaction of a plasma with a surface, either solid, liquid or belonging to a live system, is a complex process involving many different active species and reactions. The use of cold plasma for medical applications is at present in the rise as it has been proven as a powerful therapeutic tool for healing, desinfection  and surface functionalization
  • 1.7K
  • 01 Apr 2021
Topic Review
Protamine-Based Strategies for RNA Transfection
Protamine is a natural cationic peptide mixture mostly known as a drug for the neutralization of heparin and as a compound in formulations of slow-release insulin. Protamine is also used for cellular delivery of nucleic acids due to opposite charge-driven coupling. This year marks 60 years since the first use of Protamine as a transfection enhancement agent. Since then, Protamine has been broadly used as a stabilization agent for RNA delivery. It has also been involved in several compositions for RNA-based vaccinations in clinical development. Protamine stabilization of RNA shows double functionality: it not only protects RNA from degradation within biological systems, but also enhances penetration into cells. A Protamine-based RNA delivery system is a flexible and versatile platform that can be adjusted according to therapeutic goals: fused with targeting antibodies for precise delivery, digested into a cell penetrating peptide for better transfection efficiency or not-covalently mixed with functional polymers.
  • 1.7K
  • 07 Jul 2021
Topic Review
Nanoplastic and the Gut-Brain Axis
The widespread usage of plastic places a significant burden on the environment and impacts numerous aquatic and terrestrial species. Humans in particular can be affected by plastic pollution, predominantly via inhalation and ingestion, as well as trophic transfer along the food chain. Under natural conditions synthetic materials undergo degradation into micro- and nanoparticles, especially prone to interact with biological systems. Organisms exposed to nanoplastic accumulate it in multiple tissues, including the gut and the brain. The scarce but consistent evidence shows that exposure to plastic nanoparticles can indeed affect both the digestive and the nervous system, therefore, potentially pose a threat to the complex network of mutual interactions between them, known as the gut-brain axis.
  • 1.7K
  • 28 Mar 2022
Topic Review
G Protein-Coupled Receptors
GPCRs arguably represent the most effective current therapeutic targets for a plethora of diseases. GPCRs also possess a pivotal role in the regulation of the physiological balance between healthy and pathological conditions; thus, their importance in systems biology cannot be underestimated. The molecular diversity of GPCR signaling systems is likely to be closely associated with disease-associated changes in organismal tissue complexity and compartmentalization, thus enabling a nuanced GPCR-based capacity to interdict multiple disease pathomechanisms at a systemic level. GPCRs have been long considered as controllers of communication between tissues and cells. This communication involves the ligand-mediated control of cell surface receptors that then direct their stimuli to impact cell physiology.
  • 1.7K
  • 28 Feb 2022
Topic Review
Nanocomposite Coatings
The development of nanocomposite coatings is a rapidly growing field in the domain of nanotechnology. Nanocomposite coatings are rapidly being inducted in the sectors of aerospace, marine, automobiles, sensors, dental implants and electronics. Factors that affect the functionality of nanocomposite coatings include properties of matrices and fillers, spatial dispersion of fillers, surface morphology and deposition techniques.
  • 1.7K
  • 29 Apr 2022
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