Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Five Hundred Meter Aperture Spherical Telescope
The Five-hundred-meter Aperture Spherical radio Telescope (FAST; Chinese: 五百米口径球面射电望远镜), nicknamed Tianyan (天眼, lit. "Heavenly Eye" or "The Eye of Heaven") is a radio telescope located in the Dawodang depression (大窝凼洼地), a natural basin in Pingtang County, Guizhou Province, southwest China. It consists of a fixed 500 m (1,600 ft) diameter dish constructed in a natural depression in the landscape. It is the world's largest filled-aperture radio telescope, and the second-largest single-dish aperture after the sparsely-filled RATAN-600 in Russia. It has a novel design, using an active surface made of metal panels that can be tilted by a computer to help change the focus to different areas of the sky. The cabin containing the feed antenna suspended on cables above the dish is also moved using a digitally-controlled winch by the computer control system to steer the instrument to receive from different directions. Construction on the FAST project began in 2011 and it achieved first light in September 2016. It is currently undergoing testing and commissioning. It observes at wavelengths of 10 cm to 4.3 m.:11 The telescope made its first discovery of two new pulsars in August 2017, barely one year after its first light. The new pulsars PSR J1859-01 and PSR J1931-02, which are also referred to as FAST pulsar #1 and #2 (FP1 and FP2), were detected on 22 and 25 August and are 16,000 and 4,100 light years away, respectively. They were independently confirmed by the Parkes Observatory in Australia on 10 September. The telescope had discovered 44 new pulsars by September, 2018.
  • 1.8K
  • 14 Oct 2022
Topic Review
Youth Road Safety Behavior in Serbia
Road traffic crashes are a leading cause of death for young people. Aberrant driver behaviors, such as drink driving, speeding, not wearing seatbelts, non-compliance with traffic rules and aggressive driving, are key contributors to these crashes. Gender and urban/rural differences are also risk factors. Younger people have the highest road crash and fatality risk.
  • 1.8K
  • 07 Nov 2022
Topic Review
Oscilloscope History
The history of the oscilloscope reaches back to the first recordings of waveforms with a galvanometer coupled to a mechanical drawing system in the second decade of the 19th century. The modern day digital oscilloscope is a consequence of multiple generations of development of the oscillograph, cathode-ray tubes, analog oscilloscopes, and digital electronics.
  • 1.8K
  • 21 Nov 2022
Topic Review
Pluripotency
Following fertilization, in the mammalian embryo, a series of programmed cell divisions occur whereby the arising cells progressively acquire their own cellular and molecular identity, and totipotency narrows until when pluripotency is achieved. The path towards pluripotency involves transcriptome modulation, remodeling of the chromatin epigenetic landscape to which external modulators contribute. Both human and mouse embryos are a source of different types of pluripotent stem cells whose characteristics can be captured and maintained in vitro. 
  • 1.8K
  • 03 Sep 2021
Topic Review
Lipid Phosphate Phosphatases
Lipid phosphate phosphatases (LPPs) consist of three enzymes (LPP1–3), which have been classified as phospholipid phosphatases (PLPP). The LPPs dephosphorylate a wide spectrum of bioactive lipid phosphates, among which lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P) are two important extracellular signaling molecules. The LPPs are integral membrane proteins, which are partly localized on plasma membranes. These activities participate in regulating the concentrations of extracellular LPA and S1P and thus signaling through their families of G protein coupled receptors. The expression of the LPPs on intracellular membranes, including endoplasmic reticulum and Golgi net work, are thought to attenuate signaling downstream of the activation of LPA and protease activates receptors. The LPPs differentially regulate signal transduction in cancer cells. LPP1 and LPP3 have decreased expressions in several caners and this is associated with increased tumor growth and metastasis.  Conversely, LPP2 activity is increased in these cancers and this accelerates progression through the cell cycle. Increasing the relative activities of LPP1 and LPP3 and decreasing LPP2 activity, therefore, provides a novel approach to treating some cancers.
  • 1.8K
  • 11 Sep 2020
Topic Review
Rippling Muscle Disease
Rippling muscle disease is a condition in which the muscles are unusually sensitive to movement or pressure (irritable).
  • 1.8K
  • 24 Dec 2020
Topic Review
Thermosets with Flame Retardants
Epoxy and unsaturated polyester resins are the most used thermosetting polymers.They are commonly used in electronics, construction, marine, automotive and aircraft industries.Moreover, reinforcing both epoxy and unsaturated polyester resins with carbon or glass fibre in a fabric form has enabled them to be used in high-performance applications. However, their organic nature as any other polymeric materials made them highly lammable materials. Enhancing the flame retardancy performance of thermosetting polymers and their composites can be improved by the addition of flame-retardant materials, but this comes at the expense of their mechanical properties. In this regard, a comprehensive review on the recent research articles that studied the flame retardancy of epoxy resin, unsaturated polyester resin and their composites were covered. Flame retardancy performance of different flame retardant/polymer systems was evaluated in terms of Flame Retardancy index (FRI) that was calculated based on the data extracted from the cone calorimeter test. Furthermore, lame retardant selection charts that relate between the flame retardancy level with mechanical properties in the aspects of tensile and lexural strength were presented. This review paper is also dedicated to providing the reader with a brief overview on the combustion mechanism of polymeric materials, their flammability behaviour and the commonly used flammability testing techniques and the mechanism of action of flame retardants.
  • 1.8K
  • 29 Mar 2021
Topic Review
Electrostatic Repulsion Reversed-Phase Liquid Chromatography
Electrostatic Repulsion Reversed-Phase Liquid Chromatography (ERRP) allows the elution of bases in protonated form without peak distorsion (as commonly happen in reversed phase) due to the presence of positive charges in the chromatographic system. 
  • 1.8K
  • 05 Aug 2021
Topic Review
3D Printed Electromagnetic Vibration Harvesters
Energy harvesting is the utilisation of ambient energy in order to power electronics such as wireless sensor nodes (WSN) or wearables without the need of batteries. This allows to operate the node over a much longer time period compared to battery-powered devices along with lower maintenance efforts. Furthermore, the low-maintenance requirements allow to operate these WSNs in environments with limited or no accessibility.
  • 1.8K
  • 05 Nov 2021
Topic Review
Nanostructured Lipid Carriers-Hydrogels System for Drug Delivery
Nanostructured lipid carriers (NLC) are lipid nanoparticles of the second generation made up of solid lipid matrices mixed with liquid lipids (oils). The hybrid system between NLC and hydrogel may results in the enhancement of each component's synergistic properties in the mechanical strength of the hydrogel and concomitantly decrease aggregation of the NLC. Therefore, the advanced hybrid component development in nanotechnology provides superior functionality in the application of scientific knowledge for the drug delivery industry. 
  • 1.8K
  • 25 Jan 2022
Topic Review
Bispecific Antibody-Based Immune-Cell Engagers in Cancer Immunotherapy
Cancer is the second leading cause of death worldwide after cardiovascular diseases. One of the most promising targeted therapies for cancer treatment is antibody therapy. It has a superior targeting ability for antigens that are expressed on cancer cells, which results in prominent antitumor activity and lower toxicity, compared with that of chemotherapeutic agents. Recent progress in recombinant DNA technology and antibody engineering has ushered in a new era of bispecific antibody (bsAb)-based immune-cell engagers (ICEs), including T- and natural-killer-cell engagers.
  • 1.8K
  • 06 Jan 2023
Topic Review
Delphinus
Delphinus, commonly known as the Dolphin, is a small but recognizable constellation in the northern celestial hemisphere. Its distinctive shape resembles a leaping dolphin, making it a charming sight in the night sky.  It is one of the 48 constellations listed by Ptolemy, and one of the 88 modern constellations recognized by the International Astronomical Union (IAU).
  • 1.8K
  • 08 Mar 2024
Topic Review
Salmonella enterica
Salmonella enterica serovars are important pathogens of humans and animals that are responsible for enormous morbidity, mortality and economic loss worldwide.  Models used to study the disease pathology so far have provided valuable advancements, however, the molecular complexity of its pathogenesis remains poorly understood, particularly in humans. Therefore there remains a disconnect between what works at the bench versus at the bedside, especially in case of vaccines. The development of organoids/enteroids offers a tremendous opportunity to bridge this gap by bringing human-specific factors into the research models as well as elevate our understanding of the interactions and crosstalk between multiple cell types and the microbiota with Salmonella. Thus the use of organoids in studying Salmonella biology has the potential for improving clinical outcomes and future prophylactic and therapeutic intervention strategies.
  • 1.8K
  • 29 Oct 2020
Topic Review
Catalysts in Fischer-Tropsch Synthesis
With an increase in energy consumption globally, Fischer-Tropsch (FT) synthesis is a good alternative for producing fuels and chemicals from coal, natural gas or biomass. Among them, coal to liquids has been put into production in countries that have large coal reserves. In this process, Fe-based catalysts are commonly used due to their earth abundance, comparatively wide operation range and ready availability to handle low H2/CO ratio from coal. 
  • 1.8K
  • 13 Jul 2023
Topic Review
Drive Cycles for Electrochemical Propulsion
Automotive drive cycles have existed since the 1960s. They started as requirements as being solely used for emissions testing. During the past decade, they became popular with scientists and researchers in the testing of electrochemical vehicles and power devices. They help simulate realistic driving scenarios anywhere from system to component-level design. 
  • 1.8K
  • 22 Sep 2023
Topic Review
Nutritional Profile of Chilli
Chilli pepper, botanically Capsicum annuum L., is an indispensable vegetable cum spice crop grown commercially worldwide for its immature green and red ripe fruits. Universally, the crop is consumed and appreciated for its flavor, colour, aroma, texture, and preserving foods. The crop was probably first used among folks as medicinal plants for its rich bountiful and diversified nutrients, even before it was used in cooking. The understanding on use of such plants helped the masses to sustain since ancient times.
  • 1.8K
  • 17 Oct 2022
Topic Review
Acute Respiratory Distress Syndrome
The pulmonary endothelium is a metabolically active continuous monolayer of squamous endothelial cells that internally lines blood vessels and mediates key processes involved in lung homoeostasis. Many of these processes are disrupted in acute respiratory distress syndrome (ARDS), which is marked among others by diffuse endothelial injury, intense activation of the coagulation system and increased capillary permeability. Most commonly occurring in the setting of sepsis, ARDS is a devastating illness, associated with increased morbidity and mortality and no effective pharmacological treatment. Endothelial cell damage has an important role in the pathogenesis of ARDS and several biomarkers of endothelial damage have been tested in determining prognosis. By further understanding the endothelial pathobiology, development of endothelial-specific therapeutics might arise. In this review, we will discuss the underlying pathology of endothelial dysfunction leading to ARDS and emerging therapies. Furthermore, we will present a brief overview demonstrating that endotheliopathy is an important feature of hospitalised patients with coronavirus disease-19 (COVID-19).
  • 1.8K
  • 06 Feb 2022
Topic Review
Fibrosis in Osteoarthritis
Osteoarthritis (OA) is a chronic degenerative joint disease where the main characteristics include cartilage degeneration and synovial membrane inflammation. 
  • 1.8K
  • 25 Jan 2021
Topic Review
CCL2
Factors secreted from adipose tissue may induce and/or maintain a local and systemic low-grade activation of the innate immune system. Attraction of macrophages into adipose tissue and altered crosstalk between macrophages, adipocytes, and other cells of adipose tissue are symptoms of metabolic inflammation. Among several secreted factors attracting immune cells to adipose tissue, chemotactic C-C motif chemokine ligand 2 (CCL2) (also described as monocyte chemoattractant protein-1 (MCP-1)) has been shown to play a crucial role in adipose tissue macrophage infiltration. 
  • 1.8K
  • 28 Sep 2021
Topic Review
High-Value Bioactive Primary Metabolites of Microalgae
Microalgae is an aquatic microorganism with a plethora of diverse bioactive compounds including phenolics, carotenoids, vitamin B12 and peptides. Microalgal bioactive compounds have been shown to possess positive health effects such as antihypertensive, anti-obesity, antioxidative, anticancer and cardiovascular protection.
  • 1.8K
  • 08 Jul 2023
  • Page
  • of
  • 2799
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback