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Topic Review
Metabolic Reprogramming in Cancer Cells
Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth and proliferation. Altered metabolic flux in cancer is controlled by tumor-host cell interactions, key oncogenes, tumor suppressors, and other regulatory molecules, including non-coding RNAs. Changes to metabolic pathways in cancer are dynamic, exhibit plasticity, and are often dependent on the type of tumor and the tumor microenvironment, leading in a shift of thought from the Warburg Effect and the “reverse Warburg Effect” to metabolic plasticity. 
  • 1.7K
  • 27 Jul 2021
Topic Review
Friction Challenge in Hydraulic Fracturing
Hydraulic fracturing has become one of the most popular techniques for exploring sustainable energy sources. However, friction is associated with the entire fracturing process, presenting significant challenges for development. 
  • 1.7K
  • 27 Jan 2022
Topic Review
Antimicrobial Potential of Curcumin
Curcumin is a bioactive compound that is extracted from Curcuma longa and that is known for its antimicrobial properties. Curcuminoids are the main constituents of curcumin that exhibit antioxidant properties. It has a broad spectrum of antibacterial actions against a wide range of bacteria, even those resistant to antibiotics. Curcumin has been shown to be effective against the microorganisms that are responsible for surgical infections and implant-related bone infections, primarily Staphylococcus aureus and Escherichia coli. The efficacy of curcumin against Helicobacter pylori and Mycobacterium tuberculosis, alone or in combination with other classic antibiotics, is one of its most promising antibacterial effects. Curcumin is known to have antifungal action against numerous fungi that are responsible for a variety of infections, including dermatophytosis. Candidemia and candidiasis caused by Candida species have also been reported to be treated using curcumin. Life-threatening diseases and infections caused by viruses can be counteracted by curcumin, recognizing its antiviral potential.
  • 1.7K
  • 16 Mar 2022
Topic Review
The Role of Flavonoids in Plant Terrestrialization
Plants evolved an impressive arsenal of specialized metabolites to cope with the novel environmental pressures imposed by the terrestrial habitat when moving from water. Flavonoids are maybe the most important specilized metabolites that show multifarious roles in the sucess of plant terrestrialization. These compounds modulated auxin transport and signaling and promoted the symbiosis between plants and fungi (e.g., arbuscular mycorrhizal, AM), a central event for the conquest of land by plants. AM improved the ability of early plants to take up nutrients and water from highly impoverished soils. Therefore, flavonoids were essential to plant development in the “new world” scarce of water and nutrients.
  • 1.7K
  • 30 May 2022
Topic Review
Light Interactions and Capsicum Plants
Capsicum is one of the most economically important genera in the Solanaceae family. Capsicum fruits (peppers) are rich in phytochemicals with high nutritional value and significant health-promoting characteristics. The phytochemical profile of peppers consists of capsaicinoids, carotenoids, and phenolics, primarily.
  • 1.7K
  • 19 Jan 2023
Topic Review
Factors Affecting the Quality of Canola Grains
Canola, Brassica napus L., is a major oilseed crop that has various uses in the food, feed, and industrial sectors. It is one of the most widely produced and consumed oilseeds in the world because of its high oil content and favorable fatty acid composition. Canola grains and their derived products, such as canola oil, meal, flour, and bakery products, have a high potential for food applications as they offer various nutritional and functional benefits. However, they are affected by various factors during the production cycle, post-harvest processing, and storage. These factors may compromise their quality and quantity by affecting their chemical composition, physical properties, functional characteristics, and sensory attributes. Therefore, it is important to optimize the production and processing methods of canola grains and their derived products to ensure their safety, stability, and suitability for different food applications. 
  • 1.7K
  • 14 Aug 2023
Topic Review
George Town’s Street Art
Street art is promoted in most countries to intensify the cultural elements of the cityscape. George Town was officially recognized as one of the World Heritage Cities by UNESCO in 2008. As a result, the Penang state government also promoted street art projects between 2009 and 2012 to shape the city’s cultural identity. Therefore, street art is highlighted as one of the cultural elements that cannot be neglected in heritage cities. Street art and heritage city are comparable in terms of promoting tourism activities, especially in George Town. Street art is a form of cultural innovation in transforming public spaces for the purpose of urban regeneration. 
  • 1.7K
  • 11 Jan 2024
Topic Review
Radar-Based Non-Contact Continuous Identity Authentication
Non-contact vital signs monitoring using microwave Doppler radar has shown great promise in healthcare applications. Recently, this unobtrusive form of physiological sensing has also been gaining attention for its potential for continuous identity authentication, which can reduce the vulnerability of traditional one-pass validation authentication systems. Physiological Doppler radar is an attractive approach for continuous identity authentication as it requires neither contact nor line-of-sight and does not give rise to privacy concerns associated with video imaging.
  • 1.7K
  • 01 Jun 2021
Topic Review
Hepatitis B Virus
Hepatitis B virus (HBV) is a globally-distributed pathogen and is a major cause of liver disease. HBV (or closely-related animal hepadnaviruses) can integrate into the host genome, but (unlike retroviruses) this integrated form is replication-defective. 
  • 1.7K
  • 10 Mar 2021
Topic Review
Tracking and Data Relay Satellite
File:TDRS Heart of Communication.ogv File:Tracking Data Relay Satellite (TDRS) Orbital Fleet Communicating with User Spacecraft.ogg File:Tracking Data Relay Satellite (TDRS) Orbital Fleet Communicating with User Spacecraft 2017 - 360 video.webm A tracking and data relay satellite (TDRS) is a type of communications satellite that forms part of the Tracking and Data Relay Satellite System (TDRSS) used by NASA and other United States government agencies for communications to and from independent "User Platforms" such as satellites, balloons, aircraft, the International Space Station, and remote bases like the Amundsen-Scott South Pole Station. This system was designed to replace an existing worldwide network of ground stations that had supported all of NASA's crewed flight missions and uncrewed satellites in low-Earth orbits. The primary system design goal was to increase the amount of time that these spacecraft were in communication with the ground and improve the amount of data that could be transferred. These TDRSS satellites are all designed and built to be launched to and function in geosynchronous orbit, 35,786 km (22,236 mi) above the surface of the Earth. The first seven TDRSS satellites were built by the TRW corporation. The three later versions have been manufactured by the Boeing corporation's Satellite Systems division. Thirteen satellites have been launched; however, one was destroyed in the Challenger disaster. TDRS-1 was decommissioned in October 2009. TDRS-4 was decommissioned in December 2011. Ten TDRSS satellites are currently in service. All of the TDRSS satellites have been managed by NASA's Goddard Space Flight Center. The contract for TDRS versions L & K was awarded to Boeing on December 20, 2007. On November 30, 2011, NASA announced the decision to order an additional third-generation TDRS satellite, TDRS M.
  • 1.7K
  • 04 Nov 2022
Topic Review
Blood-Plasma Self-Separation in Self-Driven Microfluidics
Blood plasma is the most commonly used biofluid in disease diagnostic and biomedical analysis due to it contains various biomarkers. The majority of the blood plasma separation is still handled with centrifugation, which is off-chip and time-consuming. Therefore, in the Lab-on-a-chip (LOC) field, an effective microfluidic blood plasma separation platform attracts researchers’ attention globally. Blood plasma self-separation technologies are usually divided into two categories: active self-separation and passive self-separation. Passive self-separation technologies, in contrast with active self-separation, only rely on microchannel geometry, microfluidic phenomena and hydrodynamic forces. Passive self-separation devices are driven by the capillary flow, which is generated due to the characteristics of the surface of the channel and its interaction with the fluid. Comparing to the active plasma separation techniques, passive plasma separation methods are more considered in the microfluidic platform, owing to their ease of fabrication, portable, user-friendly features.
  • 1.7K
  • 12 Jul 2021
Topic Review
Quercetin
Quercetin (QRC) is a flavonoid belonging to a group of plant-derived nonsteroidal compounds called phytoestrogens. It is a polyphenol-based molecule and it is widely distributed in many vegetables, fruits, seed, grains, and also in tea and wine.
  • 1.7K
  • 26 Jan 2021
Topic Review
Low-Temperature Solid Oxide Fuel Cells
Solid oxide fuel cells (SOFCs) have been considered as promising candidates to tackle the need for sustainable and efficient energy conversion devices. However, the current operating temperature of SOFCs poses critical challenges relating to the costs of fabrication and materials selection. To overcome these issues, many attempts have been made by the SOFC research and manufacturing communities for lowering the operating temperature to intermediate ranges (600–800 °C) and even lower temperatures (below 600 °C). Despite the interesting success and technical advantages obtained with the low-temperature SOFC, on the other hand, the cell operation at low temperature could noticeably increase the electrolyte ohmic loss and the polarization losses of the electrode that cause a decrease in the overall cell performance and energy conversion efficiency. In addition, the electrolyte ionic conductivity exponentially decreases with a decrease in operating temperature based on the Arrhenius conduction equation for semiconductors. 
  • 1.7K
  • 06 Mar 2021
Topic Review
Raman and Fluorescence Enhancement Approaches
The search for novel platforms and metamaterials for the enhancement of optical and particularly Raman signals is still an objective since optical techniques offer affordable, noninvasive methods with high spatial resolution and penetration depth adequate to detect and image a large variety of systems, from 2D materials to molecules in complex media and tissues. Plasmonic platforms produce the most efficient enhancement through the surface enhanced Raman scattering (SERS) process, allowing to reach single molecule detection, and are the most studied ones. The formation of hot-spots is clue to obtain the maximum enhancements but has counterparts regarding reproducibility and homogeneity, which are required for quantification and imaging. Other light enhancement mechanisms such as resonant and interference Raman scattering, as well as their combinations with SERS are being explored. Fluorescence enhancement platforms and strategies, so important for bio-detection and imaging, are also being developed. Graphene and related materials have an important role to play in the design of the platforms.    
  • 1.7K
  • 16 Mar 2021
Topic Review
Mineral Physics
Mineral physics is the study of mineralogical problems through the application of condensed matter physics and solid-state chemistry.  
  • 1.7K
  • 31 May 2021
Topic Review
Printed Electronics
Printed electronics are manufactured in a process of registering thin functional material (ink) layer combinations on a low-cost substrate that may be recycled and/or naturally degraded in nature. Correspondingly, the manufacturing process is composed of three complementary stages: material selection, printing and post-printing. The materials for the printed electronics are principally inks of conducting, semiconducting or dielectric characteristics and substrates, which are derived from synthetic or natural polymers.  The inks are transferred with a master through direct contact to the substrate in case of contact printing, while they are deposited onto the substrate typically through nozzles in case of non-contact printing. Posterior to the printing process, it is often necessary to conduct sintering/curing in order to reach the desired functional ink and substrate characteristics. The inks, substrate and the printing technology along with the post printing requirements must be carefully evaluated for quality, repeatability and life-time aspects of the yield.
  • 1.7K
  • 23 Aug 2021
Topic Review
Myeloid Neoplasms
Myeloid neoplasms encompass a very heterogeneous family of diseases characterized by the failure of the molecular mechanisms that ensure a balanced equilibrium between hematopoietic stem cells (HSCs) self-renewal and the proper production of differentiated cells. The origin of the driver mutations leading to preleukemia can be traced back to HSC/progenitor cells. Many properties typical to normal HSCs are exploited by leukemic stem cells (LSCs) to their advantage, leading to the emergence of a clonal population that can eventually progress to leukemia with variable latency and evolution. In fact, different subclones might in turn develop from the original malignant clone through accumulation of additional mutations, increasing their competitive fitness. This process ultimately leads to a complex cancer architecture where a mosaic of cellular clones—each carrying a unique set of mutations—coexists. The repertoire of genes whose mutations contribute to the progression toward leukemogenesis is broad. It encompasses genes involved in different cellular processes, including transcriptional regulation, epigenetics (DNA and histones modifications), DNA damage signaling and repair, chromosome segregation and replication (cohesin complex), RNA splicing, and signal transduction. Among these many players, transcription factors, RNA splicing proteins, and deubiquitinating enzymes are emerging as potential targets for therapeutic intervention. 
  • 1.7K
  • 23 Aug 2021
Topic Review
Phenol Removals
Phenol acts as a pollutant even at very low concentrations in water. It is classified as one of the main priority pollutants that need to be treated before being discharged into the environment. If phenolic-based compounds are discharged into the environment without any treatments, they pose serious health risks to humans, animals, and aquatic systems.
  • 1.7K
  • 27 Aug 2021
Topic Review
Cooling Integrated, Solid Desiccant Systems
Compared with the traditional vapor-compression cooling system, the solid desiccant evaporative cooling system consumes less electricity, has no harmful refrigerant, controls air humidity effectively and maintains a high level of air quality. The hybrid system usually includes two main processes: the dehumidification process and the evaporative cooling process. The function of the dehumidification process is to remove the moisture, and the evaporative cooling process is responsible for handling the sensible heat of the air.
  • 1.7K
  • 13 Oct 2021
Topic Review
Non-Muscle-Invasive Bladder Cancer
Non-muscle-invasive bladder cancer (NMIBC) is characterized by a high rate of cure, but also by a non-negligible probability of recurrence and risk progression to muscle-invasive disease. NMIBC management requires a proper local resection and staging, followed by a risk-based treatment with intravesical agents. For many years, the current gold standard treatment for patients with intermediate or high-risk disease is transurethral resection of the bladder (TURB) followed by intravesical bacillus Calmette–Guérin (BCG) instillations. Unfortunately, in about half of high-risk patients, intravesical BCG treatment fails and NMIBC persists or recurs early. While radical cystectomy remains the gold standard for these patients, new therapeutic targets are being individuated and studied. Radical cystectomy in fact can provide an excellent long-term disease control, but can deeply interfere with quality of life. In particular, the enhanced immune checkpoints expression shown in BCG-unresponsive patients and the activity of immune checkpoints inhibitors (ICIs) in advanced bladder cancer provided the rationale for testing ICIs in NMIBC. Recently, pembrolizumab has shown promising activity in BCG-unresponsive NMIBC patients, obtaining FDA approval. Meanwhile multiple novel drugs with alternative mechanisms of action have proven to be safe and effective in NMIBC treatment and others are under investigation.
  • 1.7K
  • 29 Mar 2022
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