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Topic Review
3D Cell Culture Technology
Unlike the 2D cultures, which grow by attaching to the bottom as a monolayer, 3D cell culture refers to cells aggregated and expressed as a single tissue or form. Moreover, the 3D-cultured cells are attached to an artificially created ECM environment to interact with or grow with the surrounding environment. Therefore, unlike 2D cell cultures, cell growth in a 3D environment allows cells to grow in multiple directions rather than in a single direction in vitro, which is similar to in vivo conditions. Upon comparison, the 3D cell culture exhibits several advantages: (1) A similar biomimetic model, which is more physiologically relevant. (2) A 3D culture exhibits a high level of structural complexity and maintains homeostasis for longer. (3) 3D models can indicate how different types of cells interact. (4) 3D cultures can reduce the use of animal models. (5) They are a good simulator for the treatment of disease groups including cancer tumors.
  • 1.1K
  • 17 Nov 2021
Topic Review
Methodologies and Wearable Devices to Monitor Sleep Dysfunctions
Sleep is crucial for human health from metabolic, mental, emotional, and social points of view; obtaining good sleep in terms of quality and duration is fundamental for maintaining a good life quality. Several systems have been proposed in the scientific literature and on the market to derive metrics used to quantify sleep quality as well as detect sleep disturbances and disorders. In this field, wearable systems have an important role in the discreet, accurate, and long-term detection of biophysical markers useful to determine sleep quality.
  • 1.1K
  • 07 Sep 2022
Topic Review
Capacitive Field-Effect Bio-Chemical Sensors
       Electrolyte-insulator-semiconductor (EIS) field-effect sensors belong to a new generation of electronic chips for biochemical sensing, enabling a direct electronic readout. The review gives an overview on recent advances and current trends in the research and development of chemical sensors and biosensors based on the capacitive field-effect EIS structure—the simplest field-effect device, which represents a biochemically sensitive capacitor. Fundamental concepts, physicochemical phenomena underlying the transduction mechanism and application of capacitive EIS sensors for the detection of pH, ion concentrations, and enzymatic reactions, as well as the label-free detection of charged molecules (nucleic acids, proteins, and polyelectrolytes) and nanoparticles, are presented and discussed.
  • 1.1K
  • 19 Apr 2022
Topic Review
Magnetic Guiding
Magnetic guidance is understood as a remote, untethered and contact-free control of the movements of an object via magnetic interactions. The movements should happen on arbitrary trajectories inside a container caused by an external device. The concept of remote magnetic guiding is developed from the underlying physics for bijective force generation over the inner volume of magnet systems. This concept can equally be implemented by electro- or permanent magnets. 
  • 1.1K
  • 07 Dec 2021
Topic Review
Quenchbody
The detection of viruses, disease biomarkers, physiologically active substances, drugs, and chemicals is of great significance in many areas of our lives. Immunodetection technology is based on the specificity and affinity of antigen–antibody reactions. Compared with other analytical methods such as liquid chromatography coupled with mass spectrometry, which requires a large and expensive instrument, immunodetection has the advantages of simplicity and good selectivity and is thus widely used in disease diagnosis and food/environmental monitoring. Quenchbody (Q-body), a new type of fluorescent immunosensor, is an antibody fragment labeled with fluorescent dyes. When the Q-body binds to its antigen, the fluorescence intensity increases. The detection of antigens by changes in fluorescence intensity is simple, easy to operate, and highly sensitive.
  • 1.1K
  • 20 Apr 2021
Topic Review
Application of Hydrogels for Bone Regeneration
Hydrogels are versatile biomaterials characterized by three-dimensional, cross-linked, highly hydrated polymeric networks. These polymers exhibit a great variety of biochemical and biophysical properties, which allow for the diffusion of diverse molecules, such as drugs, active ingredients, growth factors, and nanoparticles. Meanwhile, these polymers can control chemical and molecular interactions at the cellular level. The polymeric network can be molded into different structures, imitating the structural characteristics of surrounding tissues and bone defects. Interestingly, the application of hydrogels in bone tissue engineering (BTE) has been gathering significant attention due to the beneficial bone improvement results that have been achieved.
  • 1.1K
  • 29 Jun 2023
Topic Review
Magnetic Polymers for Microfluidic Sorting
Magnetophoresis offers many advantages for manipulating magnetic targets in microsystems. The integration of micro-flux concentrators and micro-magnets allows achieving large field gradients and therefore large reachable magnetic forces. However, the associated fabrication techniques are often complex and costly, and besides, they put specific constraints on the geometries. Magnetic composite polymers provide a promising alternative in terms of simplicity and fabrication costs, and they open new perspectives for the microstructuring, design, and integration of magnetic functions.
  • 1.1K
  • 30 Jul 2021
Topic Review
Dental Prosthetics or Implants
Dental implants or prosthetics are used to replace missing teeth and treat partially or fully damaged teeth. The dental implant success rate is more than 90% after ten years, ensuring long-term reliability. There are three primary types of dental implants: endosteal or endosseous, subperiosteal, and transosteal. Dental implants are a continuously growing market for both medical and cosmetic purposes. Modern science has allowed dentists to offer a wide variety of implants, such as crowns, screws, dental bridges, dentures, and braces. Implant reliability and proper design are essential for patient comfort and usage. The selection of suitable materials, depending on the patient’s oral health and implant objectives, is the primary criteria for proper implant design.
  • 1.1K
  • 17 Jan 2023
Topic Review
LED-Based Photoacoustic System
Photoacoustics, being a noninvasive and functional modality, has the potential for small-animal imaging. However, the conventional photoacoustic tomographic systems use pulsed lasers, making it expensive, bulky, and require long acquisition time. We have developed a photoacoustic and ultrasound tomographic imaging system with LEDs as the light source and acoustic detection using a linear transducer array. We have demonstrated full-view tomographic imaging of a mouse.
  • 1.1K
  • 29 Apr 2021
Topic Review
Metal Ion Detection by Glutathione
Low cost, sensitive, selective, and rapid methods for heavy metal ion (HMI) detection are of growing demand, and HMI biosensors have great potential in meeting this need due to their timeliness, cost-effectiveness and convenience in operation. The most widely reported peptide probe for HMI detection is glutathione (GSH), especially in case of lead ion (Pb2+) detection. GSH is highly stable, cost-effective, and easy to immobilize on a sensor. 
  • 1.1K
  • 10 Jun 2021
Topic Review
Polymer–Metal Composites Materials for Healthcare Device
An ideal medical implant requires optimized properties on both bulk and microscopic scale that can hardly be accomplished by using a single material. Metallic implants such as titanium-based implants possess excellent mechanical properties in general but suffer from corrosion; polymeric implants can be multifunctional and biodegradable, however, difficult to provide some crucial mechanical properties like ductility. With the advance in polymer science and metallurgy, the polymer–metal composite materials serve as an emerging class of healthcare device with optimized bulk and microscopic properties, such polymer–metal composite devices provide good mechanical support, good bio-integration, good hygiene, and minimize bacterial infection and reduced hypersensitivity reactions.
  • 1.1K
  • 27 Sep 2022
Topic Review
Electroencephalography
Electroencephalography (EEG) is a noninvasive, safe, and relatively convenient technique to record brain activities, which allows quantitative methods to detect changes and patterns of EEG signals related to DOC. The best feature of EEG data is neural oscillations. From the perspective of biophysics, EEGs are extracellular currents that reflect the total dendritic postsynaptic potentials in millions of parallel pyramidal cells.
  • 1.1K
  • 20 Oct 2021
Topic Review
Printed Electrochemical Biosensors
Printing technologies represent powerful tools to combine simpler and more customizable fabrication of electrochemical biosensors with high resolution, miniaturization and integration with more complex microfluidic and electronics systems. Considering this framework, this review provides an overview of the opportunities offered by printed electrochemical biosensors in terms of transducing principles, metrological characteristics and enlargement of the application field, as well as of the main metrological challenges related.
  • 1.0K
  • 14 Dec 2020
Topic Review
Deep Learning Applications for Optical Coherence Tomography
With non-invasive and high-resolution properties, optical coherence tomography (OCT) has been widely used as a retinal imaging modality for the effective diagnosis of ophthalmic diseases. The retinal fluid is often segmented by medical experts as a pivotal biomarker to assist in the clinical diagnosis of age-related macular diseases, diabetic macular edema, and retinal vein occlusion. In recent years, the advanced machine learning methods, such as deep learning paradigms, have attracted more and more attention from academia in the retinal fluid segmentation applications. The automatic retinal fluid segmentation based on deep learning can improve the semantic segmentation accuracy and efficiency of macular change analysis, which has potential clinical implications for ophthalmic pathology detection.
  • 1.0K
  • 07 May 2022
Topic Review
Optical Properties of Mn-Doped CuGa(In)S-ZnS Nanocrystals (NCs)
Mn-doped binary NCs have average fluorescence lifetimes in the range of sub-milliseconds and/or need high energy for excitation, or they contain the toxic elements of Cd and/or Se against biosensing/imaging applications.
  • 1.0K
  • 11 Apr 2022
Topic Review
Antimicrobial Properties of Lignocellulosic Materials
Pathogenic microbes are a major source of health and environmental problems, mostly due to their easy proliferation on most surfaces. Currently, new classes of antimicrobial agents are under development to prevent microbial adhesion and biofilm formation. However, they are mostly from synthetic origin and present several disadvantages. The use of natural biopolymers such as cellulose, hemicellulose, and lignin, derived from lignocellulosic materials as antimicrobial agents has a promising potential. Lignocellulosic materials are one of the most abundant natural materials from renewable sources, and they present attractive characteristics, such as low density and biodegradability, are low-cost, high availability, and environmentally friendly.
  • 1.0K
  • 08 Apr 2021
Topic Review
Photodynamic Therapy
Photodynamic therapy (PDT) is a promising therapeutic strategy for cancers where surgery and radiotherapy cannot be effective. PDT relies on the photoactivation of photosensitizers, most of the time by lasers to produced reactive oxygen species and notably singlet oxygen. The major drawback of this strategy is the weak light penetration in the tissues. To overcome this issue, recent studies proposed to generate visible light in situ with radioactive isotopes emitting charged particles able to produce Cerenkov radiation. In vitro and preclinical results are appealing, but the existence of a true, lethal phototherapeutic effect is still controversial.
  • 1.0K
  • 15 Dec 2020
Topic Review
Foot/Ankle Prostheses Design Approach
There are different alternatives when selecting removable prostheses for below the knee amputated patients. The designs of these prostheses vary according to their different functions. These prostheses designs can be classified into Energy Storing and Return (ESAR), Controlled Energy Storing and Return (CESR), active, and hybrid. This paper aims to identify the state of the art related to the design of these prostheses of which ESAR prostheses are grouped into five types, and active and CESR are categorized into four groups. Regarding patent analysis, 324 were analyzed over the last six years.
  • 1.0K
  • 29 Jun 2021
Topic Review
Hepatic Vessel Skeletonization
Hepatic vessel skeletonization serves as an important means of hepatic vascular analysis and vessel segmentation. Skeletonization provides an effective and compact representation of an image object by reducing its dimensionality to a centerline while preserving the original topologic and geometric properties. Hepatic vascular analysis plays a critical role in the diagnosis and treatment of many liver diseases, classification of liver function regions and inquiry into the nature of vascular growth. Hepatic vessel skeletonization serves as an important means of hepatic vascular analysis, particularly because a hepatic vessel is a kind of thin tubular object satisfying the growth principle of Murray’s law.
  • 1.0K
  • 15 Apr 2022
Topic Review
Time Series Classification Techniques Used in Biomedical Applications
Time series classification (TSC) is very commonly used for modeling digital clinical measures. Time Series Classification (TSC) involves building predictive models that output a target variable or label from inputs of longitudinal or sequential observations across some time period. These inputs could be from a single variable or multiple variables measured across time, where the measurements can be ordinal or numerical (discrete or continuous).
  • 1.0K
  • 07 Nov 2022
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