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Topic Review
Biogas Desulphurisation
The agriculture and livestock industry generate waste used in anaerobic digestion to produce biogas containing methane (CH4), useful in the generation of electricity and heat. However, although biogas is mainly composed of CH4 (~65%) and CO2 (~34%), among the 1% of other compounds present is hydrogen sulphide (H2S) which deteriorates engines and power generation fuel cells that use biogas, generating a foul smell and contaminating the environment. As a solution to this, anoxic biofiltration, specifically with biotrickling filters (BTFs), stands out in terms of the elimination of H2S as it is cost-effective, efficient, and more environmentally friendly than chemical solutions. BTFs are a devices in which a microbial biofilm (mainly bacteria) formed on a packing material, degrades the pollutants (in this case hydrogen sulphide).
  • 1.8K
  • 23 Apr 2021
Topic Review
ANO1 in Cystic Fibrosis
Cystic fibrosis (CF) is the most common of rare hereditary diseases in Caucasians, and it is estimated to affect 75,000 patients globally. CF is a complex disease due to the multiplicity of mutations found in the CF transmembrane conductance regulator (CFTR) gene causing the CFTR protein to become dysfunctional. Although CFTR is the main chloride channel in the lungs, others could, e.g., anoctamin-1 (ANO1 or TMEM16A), compensate for the deficiency of CFTR. 
  • 1.8K
  • 26 Oct 2021
Topic Review
Measurement of Compact Muon Solenoid Magnetic Field
The Compact Muon Solenoid (CMS) is a general-purpose detector at the Large Hadron Collider. The goal of CMS experiment is to investigate a wide range of physics, including the search for the Higgs boson, extra dimensions, and particles that could make up dark matter. The CMS magnetic field is provided by a wide-aperture superconducting thin solenoid with a diameter of 6 m and a length of 12.5 m, where a central magnetic flux density of 3.8 T is created by an operational direct current of 18.164 kA.
  • 1.8K
  • 15 Feb 2022
Topic Review
Arbuscular Mycorrhizal Fungi Symbiosis to Enhance Plant–Soil Interaction
Arbuscular mycorrhizal fungi (AMF) form a symbiotic relationship with plants; a symbiotic relationship is one in which both partners benefit from each other. Fungi benefit plants by improving uptake of water and nutrients, especially phosphorous, while plants provide 10–20% of their photosynthates to fungus. AMF tend to make associations with 85% of plant families and play a significant role in the sustainability of an ecosystem. Plants’ growth and productivity are negatively affected by various biotic and abiotic stresses. AMF proved to enhance plants’ tolerance against various stresses, such as drought, salinity, high temperature, and heavy metals.
  • 1.8K
  • 15 Jul 2022
Topic Review
Deep Underground Neutrino Experiment
The Deep Underground Neutrino Experiment (DUNE) is a neutrino experiment under construction, with a near detector at Fermilab and a far detector at the Sanford Underground Research Facility that will observe neutrinos produced at Fermilab. An intense beam of trillions of neutrinos from the production facility at Fermilab (in Illinois) will be sent over a distance of 1,300 kilometers (810 mi) with the goal of understanding the role of neutrinos in the universe. More than 1,000 collaborators work on the project. The experiment is designed for a 20-year period of data collection. The primary science objectives of DUNE are The science goals are so compelling that the 2014 Particle Physics Project Prioritization Panel (P5) ranked this as "the highest priority project in its timeframe" (recommendation 13).[10] The importance of these goals has led to proposals for competing projects in other countries, particularly the Hyper-Kamiokande experiment in Japan, scheduled to begin data-taking in 2027. The DUNE project, overseen by Fermilab, has suffered delays to its schedule and growth of cost from less than $2B to $3B, leading to articles in the journals Science and Scientific American described the project as "troubled."[11][12] As of 2022, the DUNE experiment has a neutrino-beam start-date in the early-2030's, and the project is now phased.[11][12]
  • 1.8K
  • 02 Oct 2022
Topic Review
Common Heritage of Mankind
Common heritage of mankind (also termed the common heritage of humanity, common heritage of humankind or common heritage principle) is a principle of international law that holds that defined territorial areas and elements of humanity's common heritage (cultural and natural) should be held in trust for future generations and be protected from exploitation by individual nation states or corporations.
  • 1.8K
  • 27 Oct 2022
Topic Review
Whisking in Animals
Whisking is a behaviour in which the facial whiskers (vibrissae) of an animal are repetitively and rapidly swept back and forth. This behaviour occurs particularly during locomotion and exploration. The whisking movements occur in bouts of variable duration, and at rates between 3 and 25 whisks/second. Movements of the whiskers are closely co-ordinated with those of the head and body, allowing the animal to locate interesting stimuli through whisker contact, then investigate them further using both the macrovibrissae and an array of shorter, non-actuated microvibrissae on the chin and lips. Whisking has been reported in a wide range of mammals, including two species of marsupial. Whisking contributes both to exploratory movements, which function to acquire sensory inputs, and to palpation movements, which are used in the discrimination of objects and in the control of spatial navigation.
  • 1.8K
  • 03 Nov 2022
Topic Review
G Protein-Coupled Receptor with the Aging-Related Mechanisms
G protein-coupled receptors (GPCRs) represent one of the most functionally diverse classes of transmembrane proteins. GPCRs and their associated signaling systems have been linked to nearly every physiological, and also pathophysiological, process. G protein-coupled receptor 19 (GPR19), is a novel orphan GPCR that likely represents an important new target for novel remedial strategies for pathological disease conditions associated with aging-related cellular and tissue damage.
  • 1.8K
  • 16 Nov 2022
Topic Review
Postfix
Postfix is a free and open-source mail transfer agent (MTA) that routes and delivers electronic mail. It is released under the IBM Public License 1.0 which is a free software license. Alternatively, starting with version 3.2.5, it is available under the Eclipse Public License 2.0 at the user's option. Originally written in 1997 by Wietse Venema at the IBM Thomas J. Watson Research Center in New York, and first released in December 1998, Postfix continues (As of 2022) to be actively developed by its creator and other contributors. The software is also known by its former names VMailer and IBM Secure Mailer. The name Postfix is a compound of "post" (which is another word for "mail") and "fix "(which is for other software that inspired Postfix development). In a study published on June 1, 2022 by E-Soft, Inc., approximately 34% of the publicly reachable mail-servers on the Internet ran Postfix, making it the second most popular mail server behind Exim. Note: this survey covers less than 25% of the 4+ million reachable SMTP servers on the Internet.
  • 1.8K
  • 21 Nov 2022
Topic Review
Underwater Cultural Heritage
Underwater cultural heritage (UCH) means "all traces of human existence having a cultural, historical or archaeological character which have been partially or totally under water, periodically or continuously, for at least 100 years such as (i) sites, structures, buildings, artifacts and human remains, together with their archaeological and natural context; (ii) vessels, aircraft, other vehicles or any part thereof, their cargo or other contents, together with their archaeological and natural context; and (iii) objects of prehistoric character".
  • 1.8K
  • 19 Dec 2023
Topic Review
Microscopium
Microscopium is a small and faint constellation located in the southern celestial hemisphere. It was first introduced by the French astronomer Nicolas Louis de Lacaille during the 18th century, who named it in honor of the microscope, reflecting the era's burgeoning interest in scientific instrumentation. Despite its modest visibility, it contains several notable celestial objects, including a few galaxies and a planetary nebula.
  • 1.8K
  • 15 Mar 2024
Topic Review
History of Fair Trade
The fair trade movement has undergone several important changes since its early days following World War II. Fair trade, first seen as a form of charity advocated by religious organizations, has radically changed in structure, philosophy and approach. The past fifty years have witnessed massive changes in the diversity of fair trade proponents, the products traded and their distribution networks.
  • 1.8K
  • 23 Nov 2022
Topic Review
Lactate Dehydrogenase Deficiency
Lactate dehydrogenase deficiency is a condition that affects how the body breaks down sugar to use as energy in cells, primarily muscle cells.
  • 1.8K
  • 23 Dec 2020
Topic Review
Ohdo Syndrome, Say-Barber-Biesecker-Young-Simpson Variant
The Say-Barber-Biesecker-Young-Simpson (SBBYS) variant of Ohdo syndrome is a rare condition characterized by genital abnormalities in males, missing or underdeveloped kneecaps (patellae), intellectual disability, distinctive facial features, and abnormalities affecting other parts of the body.
  • 1.8K
  • 24 Dec 2020
Topic Review
Sensogenomics and the Biological Background Underlying Musical Stimuli
The impact of musical stimulus in the human genome opens a new era of research. We hereby introduce and develop the term Sensogenomics, referring to the still unexplored field of research focused on the response of our genome to sensorial stimuli.
  • 1.8K
  • 21 Jan 2022
Topic Review
SGLT2 Inhibitors
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of oral glucose-lowering agents. Apart from their glucose-lowering effects, large clinical trials assessing certain SGLT2 inhibitors have revealed cardiac and renal protective effects in non-diabetic patients. These excellent outcomes motivated scientists and clinical professionals to revisit their underlying mechanisms. In addition to the heart and kidney, redox homeostasis is crucial in several human diseases, including liver diseases, neural disorders, and cancers, with accumulating preclinical studies demonstrating the therapeutic benefits of SGLT2 inhibitors.
  • 1.8K
  • 18 Apr 2022
Topic Review
Overview of Cdc25 Phosphatases
The cell division cycle 25 (Cdc25) phosphatases are dual-specificity phosphatases (DSPs) that catalyze the dephosphorylation of the Cdk/Cyc protein complex, an important regulator of the human cell cycle. In human cells, three Cdc25 phosphatases are characterized, Cdc25A, Cdc25B, and Cdc25C, which share the similarity of amino acids identity from 20 to 25% for N-terminal and 60% similarity for C-terminal, and are differentially expressed in the cell division cycle. Cdc25 phosphatases have been considered promising targets for anticancer development due to the correlation of their overexpression with a wide variety of cancers. In the past decades, the interest in this subject has considerably increased and many publications have been launched concerning this issue.
  • 1.8K
  • 21 Apr 2022
Topic Review
Modern Pascal
Modern Pascal (sometimes stylized as ModernPascal) is a closed source, cross-platform, interpreter, compiler, and runtime system (environment) for command line, server-side and networking applications. Modern Pascal applications are written in Pascal and Object Pascal, and can be run within the Modern Pascal runtime on the operating systems Microsoft Windows, Linux, macOS, FreeBSD, Solaris and DOS/32. Its work is hosted and supported by the 3F, LLC and partner MP Solutions, LLC. Modern Pascal provides a blocking I/O application programming interface (API) technology commonly used for operating system applications. Modern Pascal CodeRunner contains a built-in library to allow applications to act as a Web server without software such as Apache HTTP Server or Internet Information Services (IIS).
  • 1.8K
  • 04 Nov 2022
Topic Review
Stencil Code
Stencil codes are a class of iterative kernels which update array elements according to some fixed pattern, called a stencil. They are most commonly found in the codes of computer simulations, e.g. for computational fluid dynamics in the context of scientific and engineering applications. Other notable examples include solving partial differential equations, the Jacobi kernel, the Gauss–Seidel method, image processing and cellular automata. The regular structure of the arrays sets stencil codes apart from other modeling methods such as the Finite element method. Most finite difference codes which operate on regular grids can be formulated as stencil codes.
  • 1.8K
  • 16 Nov 2022
Topic Review
Cerebral Organoid Glioma ‘GLICO’ Model for Drug Screening
Glioblastoma, a grade IV astrocytoma, is regarded as the most aggressive primary brain tumour with an overall median survival of 16.0 months following the standard treatment regimen of surgical resection, followed by radiotherapy and chemotherapy with temozolomide. The ability to understand and manipulate complex cancers such as glioblastoma requires disease models to be clinically and translationally relevant and encompass the cellular heterogeneity of such cancers. Therefore, brain cancer research models need to aim to recapitulate glioblastoma stem cell function, whilst remaining amenable for analysis. The development of 3D cultures has overcome some of these challenges, and cerebral organoids are emerging as cutting-edge tools in glioblastoma research. The opportunity to generate cerebral organoids via induced pluripotent stem cells, and to perform co-cultures with patient-derived cancer stem cells (GLICO model), has enabled the analysis of cancer development in a context that better mimics brain tissue architecture.
  • 1.8K
  • 31 Jan 2023
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