Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Gain of Function Mutant p53 in Cancer
The tumor suppressor p53, encoded by the TP53 gene and known as “the guardian of the genome”, performs a variety of functions in cancer prevention.
  • 1.8K
  • 17 Nov 2022
Topic Review
Transient Receptor Potential Channels in Migraine Pathophysiology
Migraine is a chronic neurological disorder that affects approximately 12% of the population. The cause of migraine headaches is not yet known, however, when the trigeminal system is activated, neuropeptides such as calcitonin gene-related peptide (CGRP) and substance P (SP) are released, which cause neurogenic inflammation and sensitization. Advances in the understanding of migraine pathophysiology have identified new potential pharmacological targets. Transient receptor potential (TRP) channels have been the focus of attention in the pathophysiology of various pain disorders, including primary headaches. Genetic and pharmacological data suggest the role of TRP channels in pain sensation and the activation and sensitization of dural afferents. TRP channels are widely expressed in the trigeminal system and brain regions which are associated with the pathophysiology of migraine and furthermore, co-localize several neuropeptides that are implicated in the development of migraine attacks. Moreover, there are several migraine trigger agents known to activate TRP channels. Based on these, TRP channels have an essential role in migraine pain and associated symptoms, such as hyperalgesia and allodynia. Mammalian TRP channels are divided into seven subfamilies based on their homology of amino acid sequences: canonical or classic (TRPC), vanilloid (TRPV), melastatin (TRPM), nonmechanoreceptor potential C (NOMP-like, TRPN1) polycystin (TRPP), mucolipin (TRPML), and ankyrin (TRPA). 
  • 1.8K
  • 10 Jan 2023
Topic Review
Sleep Health Promotion Interventions
Sleep health promotion is the public health field that is concerned with improving sleep health in primarily healthy populations. Good sleep health is characterized by subjective satisfaction, appropriate timing, adequate duration, high efficiency, and sustained alertness during waking hours (Buysse,2014). As in the last decade evidence has been mounting that good sleep is crucial for health, sleep health promotion is receiving increasing attention in public health. In this contribution, an overview is provided of the sleep health promotion interventions that have been described in reviews. 
  • 1.8K
  • 31 May 2021
Topic Review
Psophocarpus Tetragonolobus
Natural products, particularly those extracted from plants, have been used as therapy for different diseases for thousands of years. The first written records on the plants used in natural medicine, referred to as “medicinal plants”, go back to about 2600 BC. A thorough and complete understanding of medicinal plants encompasses a multiplex of overlapping and integrated sciences such as botany, pharmacognosy, chemistry, enzymology and genetics. Psophocarpus tetragonolobus, a member of Fabaceae family also called winged bean, is a perennial herbaceous plant characterized by its tuberous roots and its winged pod twinning and a perennial legume rich in proteins, oils, vitamins and carbohydrates. Besides nutrients, winged bean also contains bioactive compounds that have therapeutic activities like anti-oxidant, anti-inflammatory, antinociceptive, antibacterial, antifungal, antiproliferative and cytotoxic activity, a few of which already been reported. This plant can also be used as a medicinal plant for future benefits.
  • 1.8K
  • 04 Jan 2021
Topic Review
Aldose Reductase (AR, ALR2)
Aldose reductase (AR, ALR2), the first enzyme of the polyol pathway, is implicated in the pathophysiology of diabetic complications. Aldose reductase inhibitors (ARIs) thus present a promising therapeutic approach to treat a wide array of diabetic complications. 
  • 1.8K
  • 26 May 2021
Topic Review
Selenoproteins
Selenium is a vital trace element present as selenocysteine (Sec) in proteins that are, thus, known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally characterized as oxidoreductases, where the Sec residue plays a catalytic role in redox regulation and antioxidant activity. Glutathione peroxidase plays a pivotal role in scavenging and inactivating hydrogen and lipid peroxides, whereas thioredoxin reductase reduces oxidized thioredoxins as well as non-disulfide substrates, such as lipid hydroperoxides and hydrogen peroxide. Selenoprotein R protects the cell against oxidative damage by reducing methionine-R-sulfoxide back to methionine. Selenoprotein O regulates redox homeostasis with catalytic activity of protein AMPylation. Moreover, endoplasmic reticulum (ER) membrane selenoproteins (SelI, K, N, S, and Sel15) are involved in ER membrane stress regulation. Selenoproteins containing the CXXU motif (SelH, M, T, V, and W) are putative oxidoreductases that participate in various cellular processes depending on redox regulation.
  • 1.8K
  • 03 Jun 2021
Topic Review
Human Endogenous Retrovirus in Neurodegeneration
Human endogenous retroviruses (HERVs) are ancient retroviral DNA sequences established into germline. They contain regulatory elements and encoded proteins few of which may provide benefits to hosts when co-opted as cellular genes. Their tight regulation is mainly achieved by epigenetic mechanisms, which can be altered by environmental factors, e.g., viral infections, leading to HERV activation. This review summarizes the recent advances on the epigenetic mechanisms controlling HERV expression and the pathogenic effects triggered by HERV de-repression leading to neurological diseases, inflammatory processes and neurodegeneration.
  • 1.8K
  • 04 Jun 2021
Topic Review
Causal Loop Diagramming of Socioeconomic Impacts of COVID-19
The complexity, multidimensionality, and persistence of the COVID-19 pandemic have prompted both researchers and policymakers to turn to transdisciplinary methods in dealing with the wickedness of the crisis. While there are increasing calls to use systems thinking to address the intricacy of COVID-19, examples of practical applications of systems thinking are still scarce. We revealed and reviewed eight studies which developed causal loop diagrams (CLDs) to assess the impact of the COVID-19 pandemic on a broader socioeconomic system. We find that major drivers across all studies are the magnitude of the infection spread and government interventions to curb the pandemic, while the most impacted variables are public perception of the pandemic and the risk of infection.
  • 1.8K
  • 23 Nov 2021
Topic Review
Electrification Mechanism of Smart Textile Triboelectric Nanogenerators
Triboelectrification or contact electrification is a universal phenomenon in which two materials contact each other. A triboelectric nanogenerator (TENG) is a new type of energy collection technology first invented by Wang’s team in 2012. By coupling triboelectric charging and electrostatic induction, various forms of irregular, low-frequency, and distributed mechanical energy, which is common in daily life but usually wasted, can be effectively converted into electric energy, including human movement, vibration, wind, mechanical triggering, water waves, and so on.
  • 1.8K
  • 21 Mar 2022
Topic Review
Complex Lymphatic Anomalies
Complex Lymphatic Anomalies (CLA) are characterized by idiopathic boney lesions caused by abnormal lymphatic invasion. The lymphatic network is a one-way system mainly responsible for maintaining fluid homeostasis, lipid absorption, and immune surveillance. CLAs include four diseases with overlapping and distinct clinical features: Gorham-Stout Disease (GSD), General Lymphatic Anomaly (GLA), Kaposiform Lymphangiomatosis (KLA), and Central Conducting Lymphatic Anomaly (CCLA).In order to highlight the known bone involvement of each CLA, their osteopathic phenotypes are described and illustrated below.
  • 1.8K
  • 17 Aug 2022
Topic Review
Soluble Dietary Fiber
Dietary fiber is a widely recognized nutrient for human health. Previous studies proved that dietary fiber has significant implications for gastrointestinal health by regulating the gut microbiota. Moreover, mechanistic research showed that the physiological functions of different dietary fibers depend to a great extent on their physicochemical characteristics, one of which is solubility.
  • 1.8K
  • 15 Sep 2022
Topic Review
Pharmacological Aspects of Moringa oleifera
Moringa oleifera is an ancient remedy plant, known as the miraculous plant due to its many prominent uses and significant health benefits. It is a nutrient-rich plant, with exceptional bioactive compounds, such as polyphenols that possess several medicinal properties. Many significant studies have been carried out to evaluate the ethnomedicinal and pharmacological properties of M. oleifera in various applications.
  • 1.8K
  • 27 Sep 2022
Topic Review
Vehicular Ad-hoc Network
Vehicular ad-hoc networks (VANETs) are created by applying the principles of mobile ad hoc networks (MANETs) – the spontaneous creation of a wireless network of mobile devices – to the domain of vehicles. VANETs were first mentioned and introduced in 2001 under "car-to-car ad-hoc mobile communication and networking" applications, where networks can be formed and information can be relayed among cars. It was shown that vehicle-to-vehicle and vehicle-to-roadside communications architectures will co-exist in VANETs to provide road safety, navigation, and other roadside services. VANETs are a key part of the intelligent transportation systems (ITS) framework. Sometimes, VANETs are referred as Intelligent Transportation Networks While, in the early 2000s, VANETs were seen as a mere one-to-one application of MANET principles, they have since then developed into a field of research in their own right. By 2015,(p3) the term VANET became mostly synonymous with the more generic term inter-vehicle communication (IVC), although the focus remains on the aspect of spontaneous networking, much less on the use of infrastructure like Road Side Units (RSUs) or cellular networks.
  • 1.8K
  • 11 Oct 2022
Topic Review
DFT Calculations in Designing Polymer-Based Drug Delivery Systems
Drug delivery systems transfer medications to target locations throughout the body. These systems are often made up of biodegradable and bioabsorbable polymers acting as delivery components. The introduction of density functional theory (DFT) has tremendously aided the application of computational material science in the design and development of drug delivery materials. The use of DFT and other computational approaches avoids time-consuming empirical processes.
  • 1.8K
  • 18 Oct 2022
Topic Review
Edentulism
Edentulism or toothlessness is the condition of being toothless to at least some degree; in organisms (such as humans) that naturally have teeth (dentition), it is the result of tooth loss. Loss of some teeth is called partial edentulism, whereas loss of all teeth is called complete edentulism. Persons who have lost teeth are (either partially or completely) edentulous (edentate), whereas those who have not lost teeth can be called dentate by comparison. For example, a scientific study may include a partially edentulous group and a healthy dentate control group. Organisms that never possessed teeth can also be described as edentulous, such as members of the former zoological classification order of Edentata, which included anteaters and sloths, all of which possess no anterior teeth and either no or poorly developed posterior teeth. In naturally dentate species, edentulism is more than just the simple presence or absence of teeth; it is biochemically complex, because the teeth, jaws, and oral mucosa are not static objects; they are dynamic (changing over time). Processes such as bone remodeling (loss and gain of bone tissue) in the jaws and inflammation of soft tissue in response to the oral microbiota are clinically important for edentulous people. For example, bone resorption in the jaw is frequently how the teeth were able to detach in the first place; the jaw in an edentulous area undergoes further resorption even after the teeth are gone; and insertion of dental implants can elicit new bone formation, leading to osseointegration. Meanwhile, bacteria and yeasts of the oral cavity and the immune system of their host create an immensely complicated and constantly changing interplay that presents clinically as gingivitis, caries, stomatitis, and other periodontal pathology.
  • 1.8K
  • 18 Oct 2022
Topic Review
Protein Glutathionylation and Glutaredoxin in Neurodegenerative Diseases
The brain is highly sensitive to oxidative stress due to its high oxygen consumption, abundance of unsaturated fatty acids which are prone to oxidation, and low antioxidant levels. It is a metabolically active and a high energy demanding organ that relies heavily on mitochondria for its energy needs. Majority of oxygen consumed by mitochondria during oxidative phosphorylation is coupled to ATP synthesis while ~4% contributes to the generation of superoxides which are further metabolized to reactive oxygen species (ROS). ROS modify proteins causing functional and structural damage to biomolecules. Prolonged exposure to reactive oxygen species (ROS) also damages DNA, mitochondrial membranes, and lipids, impairing its metabolic functions including synthesis of ATP, fatty acid oxidation and metabolism of essential biomolecules.
  • 1.8K
  • 16 Dec 2022
Topic Review
Water Reuse Treatment Technologies
Treating water for water reuse typically involves treating wastewater in several steps consisting of preliminary treatment, primary treatment, and secondary treatment. Tertiary treatment and advanced treatment may be needed for water reuse purposes. 
  • 1.8K
  • 18 May 2023
Topic Review
Antibiotics Remediation Technologies
Antibiotics are used widely in human medicine, veterinary medicine, and agriculture. However, a portion of these compounds is excreted by treated organisms, entering water bodies through hospital effluents, domestic sewage, and agricultural waste. Furthermore, pharmaceutical production and improper disposal contribute to environmental contamination. The presence of antibiotics in the environment can have highly adverse consequences, such as the development and dissemination of bacterial resistance, reducing the effectiveness of antibiotics in treating infections. Several techniques are available for treating antibiotic contamination in water, including physical, chemical, and biological processes. The variety of techniques allows adaptation to the specific conditions of each case, selecting the most effective and cost-effective method considering the available infrastructure. 
  • 1.8K
  • 19 Jun 2024
Topic Review
Structural Health Monitoring System Based on Deep Learning
Concrete stands as the most widely used construction material globally due to its versatility, encompassing applications ranging from pavement, multifloor structures, and bridges to dams. However, these concrete structures endure structural stress and require close monitoring to prevent accidents and ensure sustainability throughout their complete life cycle. Artificial intelligence (AI) and computer vision (CV) have demonstrated considerable potential in diverse applications within construction engineering, including structural health monitoring (SHM) and inspection processes such as crack and damage detection, as well as rebar exposure. While it is undeniable that CV and deep learning models are transforming the construction industry by offering robust solutions for complex scenarios, there remain numerous challenges pertinent to their applications that require attention.  
  • 1.8K
  • 04 Feb 2024
Topic Review
Bioactive Phytochemicals
Bioactive phytochemicals, including natural compounds, secondary metabolites and their derivatives, have attracted significant attention for use in both medicinal products and cosmetic products. Our review highlights the pharmacological mode-of-action and current biomedical applications of key bioactive compounds applied as anti-inflammatory, bactericidal with antibiotics effects, and pain relief purposes in controlled clinical studies or preclinical studies.
  • 1.8K
  • 09 Jun 2021
  • Page
  • of
  • 2728
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback