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Topic Review
Redox Homeostasis in Muscular Dystrophies
Reactive oxygen species are (ROS) are signaling molecules moderately and continuously produced by skeletal muscles as a consequence of their contractile activity and high mitochondrial oxygen consumption. The main source of ROS production is located in the cytosol through the activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX enzymes), xanthine oxidase (XO), and nitric oxide synthase (NOS), and by the mitochondrial electron transport chain. When ROS exceed the antioxidant buffering capacity of tissues, oxidative stress occurs.
  • 1.8K
  • 15 Jun 2021
Topic Review
Genetic characterization in Korean horse
In modern times, horse breeds, mostly in horse racing, are the Thoroughbred varieties obtained by breeding three Godolphin Arabians with British mares in England. Especially in Jeju Island, Korea, Jeju horses have been introduced from Mongolia since the 13th century. They have contributed a lot to the agricultural community, but their population has been rapidly decreasing due to rapid agricultural industrialization. Therefore, we sympathize with Jeju horse-specific genetic variation and compare and analyze evolutionary correlations by utilizing Whole Genome Sequencing analysis to evaluate the genetic diversity of Jeju horses and preserve genetic information. We explored Jeju horse-specific genetic differences through a comparative analysis of large-capacity genomic data between the public database and a Thoroughbred variety. In order to adapt to the barren external environment, it is predicted that Jeju horses have experienced strong positive selection in the direction of accumulating many genetic variations, enough to cause functional differences in the eqCD1a6 gene to have an efficient immune function. In addition, we further validate the Jeju horse-specific single nucleotide polymorphisms in the eqCD1a6 gene by employing the digital PCR method, a diagnostic technique for genetic variations.
  • 1.8K
  • 08 Jul 2021
Topic Review
Salt Tolerance in Rice
Soil salinization caused by the accumulation of sodium can decrease rice yield and quality. Identification of rice salt tolerance genes and their molecular mechanisms could help breeders genetically improve salt tolerance.
  • 1.8K
  • 15 Nov 2021
Topic Review
Structure of Miruk-Jõn Hall Kumsan-Sa Temple in Korean
The Miruk-jõn Hall of Kumsan-sa Temple (reconstructed in 1635, National Treasure No. 62) is in Gimje-si, Jeollabuk-do in the southern region of Korea. The Miruk-jõn Hall is a pagoda hall with a diminished structure, and the interior is thought to have been built in an ancient style. Miruk-jõn is a three-storied building, and the pillar spacing is five ken (2) (bays) for the first story, five ken for the second story, and three ken for the third story. In the second story, both Hatamas (the last interval between pillars) are narrowed.
  • 1.8K
  • 26 Apr 2022
Topic Review
Corporate Governance and Performance of Pension Funds
Corporate governance has been explained as a mechanism by which operational managers of entities are made to act in the interest of the owners of the entities and other stakeholders. Good stewardship and sustained accountability are expected from firms by society. In pension fund management settings, two sets of factors affect corporate entity’s effectiveness. The first is the internal corporate governance factors relating to pension fund management. This involves effective interactions between internal systems relating to pension funds. The second factor is the external corporate governance factors concerning the regulatory and legal framework under which the pension funds operate.
  • 1.8K
  • 01 Aug 2022
Topic Review
Sustainability in Smart Tourism
Sustainability is a widely accredited concept in economic and territorial development—especially in the tourism sector, where it has become not only an essential working tool that is intimately related to the maintenance of and respect for environmental resources but also a defining element of new conceptualisations in the field of tourism, such as smart tourism destinations (STDs) and so-called sustainable tourism, whose “development is indispensable for economic growth”. Though sustainability must be considered in its entirety in order to cope with the current crisis, actions related to environmental sustainability have been scarce, practically limited to capacity control, and in accordance with health and prevention criteria but not with the protection of environmental resources.
  • 1.8K
  • 08 Aug 2022
Topic Review
Drug Discovery Research around Tetanus Toxin Fragment C
Tetanus caused by the tetanus toxin (TT) is a fatal illness, which despite the existence of a vaccine, led to an estimated 34,684 deaths in 2019. TT is a neurotoxin produced by Clostridium tetani, a Gram-positive pathogenic bacterium, mainly found in soil and the gastrointestinal tracts of animals. TT induces the inhibition of neurotransmitter release, leading to spastic paralysis in a four-step process. First, TT binds to specific receptors, mainly composed of lipids and gangliosides, found at the neuromuscular junction (NMJ). Another receptor is reached by TT after these first bindings: a protein receptor responsible for its internalization (second step). This double receptor binding is responsible for the high affinity between TT and nerve cells. Third, TT is then transported into the cell body via axonal retrograde transport. In the last step, the proteolytic cleavage by TT of the VAMP/synaptobrevin, a neuronal substrate, leads to the inhibition of neurotransmitter release. All of these biological properties can be distinct associated parts of the TT structure. TT is a 150.7 kDa protein composed of a 52.4 kDa light chain and a 98.3 kDa heavy chain linked by a disulfide bond.
  • 1.8K
  • 26 Aug 2022
Topic Review
Hydrogen Production by Wastewater Alkaline Electro-Oxidation
The electro-oxidation of olive mill and biodiesel wastewaters in an alkaline medium with the aim of hydrogen production and simultaneous reduction in the organic pollution content are presented. The process is performed, at laboratory scale, in an own-design single cavity electrolyzer with graphite electrodes and no membrane. The system and the procedures to generate hydrogen under ambient conditions are described. The gas flow generated is analyzed through gas chromatography. The wastewater balance in the liquid electrolyte shows a reduction in the chemical oxygen demand (COD) pointing to a decrease in the organic content. The experimental results confirm the production of hydrogen with different purity levels and the simultaneous reduction in organic contaminants. This wastewater treatment appears as a feasible process to obtain hydrogen at ambient conditions powered with renewable energy sources, resulting in a more competitive hydrogen cost.
  • 1.8K
  • 15 Sep 2022
Topic Review
Meningococcal Disease
Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed meningococcus). It has a high mortality rate if untreated but is vaccine-preventable. While best known as a cause of meningitis, it can also result in sepsis, which is an even more damaging and dangerous condition. Meningitis and meningococcemia are major causes of illness, death, and disability in both developed and under-developed countries. There are approximately 2,600 cases of bacterial meningitis per year in the United States, and on average 333,000 cases in developing countries. The case fatality rate ranges between 10 and 20 percent. The incidence of endemic meningococcal disease during the last 13 years ranges from 1 to 5 per 100,000 in developed countries, and from 10 to 25 per 100,000 in developing countries. During epidemics the incidence of meningococcal disease approaches 100 per 100,000. Meningococcal vaccines have sharply reduced the incidence of the disease in developed countries. The disease's pathogenesis is not fully understood. Neisseria meningitidis colonises a substantial proportion of the general population harmlessly, but in a very small percentage of individuals it can invade the bloodstream, affecting the entire body, most notably limbs and brain, causing serious illness. Over the past few years, experts have made an intensive effort to understand specific aspects of meningococcal biology and host interactions; however, the development of improved treatments and effective vaccines is expected to depend on novel efforts by workers in many different fields. While meningococcal disease is not as contagious as the common cold (which is spread through casual contact), it can be transmitted through saliva and occasionally through close, prolonged general contact with an infected person.
  • 1.8K
  • 10 Oct 2022
Topic Review
Deinonychosauria
Deinonychosauria is a probable stem-bird clade of maniraptoran dinosaurs that lived from the Late Jurassic to the Late Cretaceous periods. Fossils have been found across the globe in North America, Europe, Africa, Japan , China , Mongolia, Manchuria, Madagascar , Argentina , and Antarctica, with fossilized teeth giving credence to the possibility that they inhabited Australia as well. This group of dinosaurs are known for their sickle-shaped toe claws and features in the shoulder bones.
  • 1.8K
  • 24 Oct 2022
Topic Review
Great Republic
Launched on October 4, 1853 Great Republic is noteworthy as the largest wooden clipper ship ever constructed.
  • 1.8K
  • 01 Nov 2022
Topic Review
List of Messier Objects
The Messier objects are a set of 110 astronomical objects catalogued by the French astronomer Charles Messier in his "Catalogue des Nébuleuses et des Amas d'Étoiles" ("Catalogue of Nebulae and Star Clusters"). A preliminary version first appeared in Memoirs of the French Academy of Sciences in 1771, and the last item was added in 1966 by Kenneth Glyn Jones, based on Messier's observations. The first version of Messier's catalogue contained 45 objects and was published in 1774 in the journal of the French Academy of Sciences in Paris. In addition to his own discoveries, this version included objects previously observed by other astronomers, with only 17 of the 45 objects being Messier’s. By 1780 the catalog had increased to 80 objects. The final version of the catalogue containing 103 objects was published in 1781 in the Connaissance des Temps for the year 1784. However, due to what was thought for a long time to be the incorrect addition of Messier 102, the total number remained 102. Other astronomers, using side notes in Messier's texts, eventually filled out the list up to 110 objects. The catalogue consists of a diverse range of astronomical objects, ranging from star clusters, nebula and galaxies. Messier 1 is the supernova remnant of Crab Nebula and the great spiral Andromeda Galaxy is M 31. Many further inclusions followed in the next century when the first addition came from Nicolas Camille Flammarion in 1921, who added Messier 104 after finding Messier’s side note in his 1781 edition exemplar of the catalogue. M105 to M107 were added by Helen Sawyer Hogg in 1947, M108 and M109 by Owen Gingerich in 1960, and M110 by Kenneth Glyn Jones in 1967. Because Messier was interested in finding only comets, he created a list of non-comet objects that frustrated his hunt for them. The compilation of this list, in collaboration with his assistant Pierre Méchain, is known as the Messier catalogue. This catalogue of objects is one of the most famous lists of astronomical objects, and many Messier objects are still referenced by their Messier number.
  • 1.8K
  • 06 Dec 2022
Topic Review
Essential Oils and Terpenoids Effects
Weeds are one of the major constraints in crop production affecting both yield and quality. The excessive and exclusive use of synthetic herbicides for their management is increasing the development of herbicide-resistant weeds and is provoking risks for the environment and human health. Therefore, the development of new herbicides with multitarget-site activity, new modes of action and low impact on the environment and health are badly needed. The study of plant–plant interactions through the release of secondary metabolites could be a starting point for the identification of new molecules with herbicidal activity. Essential oils (EOs) and their components, mainly terpenoids, as pure natural compounds or in mixtures, because of their structural diversity and strong phytotoxic activity, could be good candidates for the development of new bioherbicides or could serve as a basis for the development of new natural-like low impact synthetic herbicides. EOs and terpenoids have been largely studied for their phytotoxicity and several evidences on their modes of action have been highlighted in the last decades through the use of integrated approaches.
  • 1.8K
  • 25 Nov 2020
Topic Review
DPN Pathology at blood–nerve barrier
In diabetic peripheral neuropathy (DPN), metabolic disorder by hyperglycemia progresses in pe-ripheral nerves. In addition to the direct damage to peripheral neural axons, the homeostatic mechanism of peripheral nerves is disrupted by dysfunction of the blood–nerve barrier (BNB) and Schwann cells. The disruption of the BNB, which is a crucial factor in DPN development and ex-acerbation, causes axonal degeneration via various pathways. Although many reports revealed that hyperglycemia and other important factors, such as dyslipidemia-induced dysfunction of Schwann cells, contributed to DPN, the molecular mechanisms underlying BNB disruption have not been sufficiently elucidated, mainly because of the lack of in vitro studies owing to difficulties in establishing human cell lines from vascular endothelial cells and pericytes that form the BNB.
  • 1.8K
  • 05 Jan 2021
Topic Review
Surface-Functionalized Separator
The surface-modified separator plays a role in improving the electrolyte wettability, homogenizing Li+flux, and strengthening the mechanical/thermal property. Due to these favorable benefits, the formation of sharp Li dendrite is efficiently suppressed and the thermal stability of battery is greatly enhanced. In this article, separator-coating materials are classified into six categories in terms of material characteristics to show how each material has different electrochemical properties. We believe that the suggested approach would become a powerful strategy to improve the performance and stability of next-generation batteries such as lithium-metal batteries.
  • 1.8K
  • 23 Sep 2021
Topic Review
Misregulation of Wnt Signaling Pathways
Wnt signaling pathways constitute a group of signal transduction pathways that direct many physiological processes, such as development, growth, and differentiation. Dysregulation of these pathways is thus associated with many pathological processes, including neurodegenerative diseases, metabolic disorders, and cancer. At the same time, alterations are observed in plasma membrane compositions, lipid organizations, and ordered membrane domains in brain and metabolic diseases that are associated with Wnt signaling pathway activation.
  • 1.8K
  • 03 Nov 2021
Topic Review
Ridge Gourd (Luffa acutangula (L.) Roxb.)
Ridge gourd (Luffa acutangula (L.) Roxb.) or Luffa is a multi-harvest vegetable crop grown in the South Asian region. It is commonly called “Torai” in rural areas of India.
  • 1.8K
  • 09 Feb 2022
Topic Review
Gamified Learning Environments
Gamification along with a whole range of other active methodologies are being incorporated into university classrooms due to their potential benefits for student learning.
  • 1.8K
  • 12 May 2022
Topic Review
Quality of Beef
Quality refers to the characteristics of products that meet the demands and expectations of the end users. Beef quality is a convergence between product characteristics on one hand and consumers’ experiences and demands on the other.
  • 1.8K
  • 29 Jun 2022
Topic Review
Produced Water Treatment
Flowback-produced water (FP) is a waste fluid associated with hydraulic fracturing in unconventional oil and gas development (UOG). Initially, FP reflects the composition of the hydraulic fracturing fluid, which is referred as flowback water (FBW). After the initial months of well production, the waste fluid is predominantly representative of the formation and is known as produced water (PW). 
  • 1.8K
  • 08 Jul 2022
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