Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic. For video creation, please contact our Academic Video Service.
Version Summary Created by Modification Content Size Created at Operation
1 handwiki Rita Xu -- 3232 2022-10-09 01:36:19

Video Upload Options

We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
No, upload directly Yes
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
HandWiki. Meningococcal Disease. Encyclopedia. Available online: https://encyclopedia.pub/entry/28716 (accessed on 24 September 2026).
HandWiki. Meningococcal Disease. Encyclopedia. Available at: https://encyclopedia.pub/entry/28716. Accessed September 24, 2026.
HandWiki. "Meningococcal Disease" Encyclopedia, https://encyclopedia.pub/entry/28716 (accessed September 24, 2026).
HandWiki. (2022, October 10). Meningococcal Disease. In Encyclopedia. https://encyclopedia.pub/entry/28716
HandWiki. "Meningococcal Disease." Encyclopedia. Web. 10 October, 2022.
Meningococcal Disease
Edit
The content is sourced from: https://handwiki.org/wiki/Medicine:Meningococcal_disease

Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed meningococcus). It has a high mortality rate if untreated but is vaccine-preventable. While best known as a cause of meningitis, it can also result in sepsis, which is an even more damaging and dangerous condition. Meningitis and meningococcemia are major causes of illness, death, and disability in both developed and under-developed countries. There are approximately 2,600 cases of bacterial meningitis per year in the United States, and on average 333,000 cases in developing countries. The case fatality rate ranges between 10 and 20 percent. The incidence of endemic meningococcal disease during the last 13 years ranges from 1 to 5 per 100,000 in developed countries, and from 10 to 25 per 100,000 in developing countries. During epidemics the incidence of meningococcal disease approaches 100 per 100,000. Meningococcal vaccines have sharply reduced the incidence of the disease in developed countries. The disease's pathogenesis is not fully understood. Neisseria meningitidis colonises a substantial proportion of the general population harmlessly, but in a very small percentage of individuals it can invade the bloodstream, affecting the entire body, most notably limbs and brain, causing serious illness. Over the past few years, experts have made an intensive effort to understand specific aspects of meningococcal biology and host interactions; however, the development of improved treatments and effective vaccines is expected to depend on novel efforts by workers in many different fields. While meningococcal disease is not as contagious as the common cold (which is spread through casual contact), it can be transmitted through saliva and occasionally through close, prolonged general contact with an infected person.

meningococcal disease meningococcal bacterial meningitis

References

  1. "Meningococcal septicaemia in college students". Essortment. 2002. http://ncnc.essortment.com/meningitissepti_ride.htm. 
  2. "Glass Test". http://www.meningitisnow.org/meningitis-info/signs-and-symptoms/glass-test/. 
  3. "Control of epidemic meningococcal disease. WHO practical guidelines. 2nd edition". World Health Organisation. https://www.who.int/csr/resources/publications/meningitis/WHO_EMC_BAC_98_3_EN/en/. 
  4. Sanford Guide to antimicrobial therapy 2014 44th edition
  5. Centers for Disease Control and Prevention. Meningococcal disease among college students: ACIP modifies recommendations for meningitis vaccination. Press release. 1999 Oct 20
  6. Jeeri R. Reddy and Thiombiano S. Rigobert. Infections à méningocoques Maladies infectieuses et Africa. West Africa. Med. Bull. 2007
  7. Press Release (22 January 2013). "Novartis receives EU approval for Bexsero, first vaccine to prevent the leading cause of life-threatening meningitis across Europe". Novartis. http://www.novartis.com/newsroom/media-releases/en/2013/1672036.shtml. 
  8. "Conjugate Meningococal Vaccine Benefits". http://www.acha.org/projects_programs/meningitis/Conjugate_Menin_Vaccine_Benefits.pdf. 
  9. "Mass vaccination campaign following community outbreak of meningococcal disease". Emerging Infect. Dis. 8 (12): 1398–403. December 2002. doi:10.3201/eid0812.040421. PMID 12498654.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2738498
  10. "Effectiveness of meningococcal serogroup C conjugate vaccine 4 years after introduction". Lancet 364 (9431): 365–7. 2004. doi:10.1016/S0140-6736(04)16725-1. PMID 15276396. https://www.semanticscholar.org/paper/6f618e95af2f8bcec2229d37b207c4cb5f7af9e7. 
  11. Bilukha OO, Rosenstein N; Rosenstein; National Center For Infectious Diseases (May 2005). "Prevention and control of meningococcal disease. Recommendations of the Advisory Committee on Immunization Practices (ACIP)". MMWR Recomm Rep 54 (RR-7): 1–21. PMID 15917737. https://www.cdc.gov/mmwr/preview/mmwrhtml/rr5407a1.htm. 
  12. American Academy of Pediatrics Committee on Infectious Diseases (August 2005). "Prevention and control of meningococcal disease: recommendations for use of meningococcal vaccines in pediatric patients". Pediatrics 116 (2): 496–505. doi:10.1542/peds.2005-1314. PMID 15995007. http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=15995007. 
  13. "Comparative trial of the safety and immunogenicity of quadrivalent (A, C, Y, W-135) meningococcal polysaccharide-diphtheria conjugate vaccine versus quadrivalent polysaccharide vaccine in two- to ten-year-old children". Pediatr. Infect. Dis. J. 24 (1): 57–62. January 2005. doi:10.1097/01.inf.0000148928.10057.86. PMID 15665711.  https://dx.doi.org/10.1097%2F01.inf.0000148928.10057.86
  14. American Academy of Pediatrics Committee on Infectious Diseases (January 2006). "Recommended childhood and adolescent immunization schedule--United States, 2006". Pediatrics 117 (1): 239–40. doi:10.1542/peds.2005-2790. PMID 16396888.  https://dx.doi.org/10.1542%2Fpeds.2005-2790
  15. Centers for Disease Control and Prevention (December 1997). "Immunization of health-care workers: recommendations of the Advisory Committee on Immunization Practices (ACIP) and the Hospital Infection Control Practices Advisory Committee (HICPAC)". MMWR Recomm Rep 46 (RR-18): 1–42. PMID 9427216. https://www.cdc.gov/mmwr/preview/mmwrhtml/00050577.htm. 
  16. Janoff EN, Tasker S, Opstad NL et al. Impact of immunization of recent HIV-1 seroconverters. Proceedings of ICAAC New Orleans 1996. Abstract No. I60
  17. Kroon FP, Bruisten S, Swieten PV et al. No increase in HIV-load following immunization with conjugate pneumococcal vaccine, Pneumovax, or Typhim-Vi. Proceedings of ICAAC New Orleans 1996. Abstract No. I61
  18. Tasker SA, Treanor J, Rossetti R et al. Whole virion influenza vaccine has protective efficacy in the setting of HIV infection. Proceedings of ICAAC New Orleans 1996. Abstract No. I88
  19. Obaro S (April 2000). "Control of meningococcal disease in west Africa". Lancet 355 (9210): 1184–5. doi:10.1016/S0140-6736(05)72263-7. PMID 10791403. https://www.semanticscholar.org/paper/02bbc2d06e9bdec136c7e8b0b28818f23cd4eaf2. 
  20. Akpede GO (1995). "Presentation and outcome of sporadic acute bacterial meningitis in children in the African meningitis belt: recent experience from Northern Nigeria highlighting emergent factors in outcome". West African Journal of Medicine 14 (4): 217–26. PMID 8634227.  http://www.ncbi.nlm.nih.gov/pubmed/8634227
  21. "Spread of meningococcal infection within households". Lancet 1 (7869): 1275–8. June 1974. doi:10.1016/S0140-6736(74)90022-1. PMID 4134961.  https://dx.doi.org/10.1016%2FS0140-6736%2874%2990022-1
  22. Control and Prevention of Meningococcal Disease: Recommendations of the Advisory Committee on Immunization Practices (ACIP): VIRGINIA EPIDEMIOLOGY BULLETIN, July 1997, Volume 97, Number 7
  23. Jeeri R. Reddy, Safety and Immunogenicity of Meningococcal Meningitis Quadrivalent (A, C, Y & W-135) Polysaccharide Vaccine "PHASE III MULTICENTER CLINICAL TRIAL IN SUB-SAHARAN AFRICA" 2008; West African Journal of Medicine (in press)
  24. Greenwood BM, Wali SS; Wali (April 1980). "Control of meningococcal infection in the African meningitis belt by selective vaccination". Lancet 1 (8171): 729–32. doi:10.1016/S0140-6736(80)91230-1. PMID 6103155. https://www.semanticscholar.org/paper/5ff262ee31d6eedb3f03d4a67cc65a9fe5ba6efa. 
  25. "Pathophysiology, treatment and outcome of meningococcemia: a review and recent experience". Pediatr. Infect. Dis. J. 15 (11): 967–78; quiz 979. November 1996. doi:10.1097/00006454-199611000-00009. PMID 8933544.  https://dx.doi.org/10.1097%2F00006454-199611000-00009
  26. Ross SC, Densen P; Densen (September 1984). "Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiency". Medicine (Baltimore) 63 (5): 243–73. doi:10.1097/00005792-198409000-00001. PMID 6433145.  https://dx.doi.org/10.1097%2F00005792-198409000-00001
  27. "Deficiency of the sixth component of complement and susceptibility to Neisseria meningitidis infections: studies in 10 families and five isolated cases". Immunology 62 (2): 249–53. October 1987. PMID 3679285.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1453963
  28. "Killing of Neisseria meningitidis by human neutrophils: implications for normal and complement-deficient individuals". J. Infect. Dis. 155 (6): 1266–75. June 1987. doi:10.1093/infdis/155.6.1266. PMID 3106511.  https://dx.doi.org/10.1093%2Finfdis%2F155.6.1266
  29. "Natural serum bactericidal activity against Neisseria meningitidis isolates from disseminated infections in normal and complement-deficient hosts". J. Infect. Dis. 152 (6): 1332–5. December 1985. doi:10.1093/infdis/152.6.1332. PMID 3934293.  https://dx.doi.org/10.1093%2Finfdis%2F152.6.1332
  30. Al'Aldeen AA, Cartwright KA; Cartwright (November 1996). "Neisseria meningitidis: vaccines and vaccine candidates". J. Infect. 33 (3): 153–7. doi:10.1016/S0163-4453(96)92081-2. PMID 8945702.  https://dx.doi.org/10.1016%2FS0163-4453%2896%2992081-2
  31. Mayon-White RT, Heath PT; Heath (March 1997). "Preventative strategies on meningococcal disease". Arch. Dis. Child. 76 (3): 178–81. doi:10.1136/adc.76.3.178. PMID 9135255.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1717118
  32. "Vaccination and the role of capsular polysaccharide antibody in prevention of recurrent meningococcal disease in late complement component-deficient individuals". J. Infect. Dis. 168 (1): 227–31. July 1993. doi:10.1093/infdis/168.1.227. PMID 8515116.  https://dx.doi.org/10.1093%2Finfdis%2F168.1.227
  33. "Recurrent meningococcal septicaemia and properdin deficiency". J. Infect. 31 (1): 67–8. July 1995. doi:10.1016/S0163-4453(95)91550-8. PMID 8522838.  https://dx.doi.org/10.1016%2FS0163-4453%2895%2991550-8
  34. Centers for Disease Control and Prevention (June 2000). "Prevention and Control of Meningococcal Disease. Recommendations of the Advisory Committee on Immunization Practices (ACIP)". MMWR Recomm Rep 49 (RR-7): 1–10. PMID 10902834. https://www.cdc.gov/mmwr/preview/mmwrhtml/rr4907a1.htm. 
  35. Centers for Disease Control and Prevention (April 1993). "Recommendations of the Advisory Committee on Immunization Practices (ACIP): use of vaccines and immune globulins for persons with altered immunocompetence". MMWR Recomm Rep 42 (RR-4): 1–18. PMID 8474421. https://www.cdc.gov/mmwr/preview/mmwrhtml/00023141.htm. 
  36. Zalmanovici Trestioreanu, Anca; Fraser, Abigail; Gafter-Gvili, Anat; Paul, Mical; Leibovici, Leonard (2013-10-25). Cochrane Acute Respiratory Infections Group. ed. "Antibiotics for preventing meningococcal infections" (in en). Cochrane Database of Systematic Reviews (10): CD004785. doi:10.1002/14651858.CD004785.pub5. PMID 24163051.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6698485
  37. Wane, Joanna. "The case for vaccination". http://www.biocsl.co.nz/docs/957/642/NorthSouth_case-for-accination.pdf. 
  38. Sudarsanam, Thambu D.; Rupali, Priscilla; Tharyan, Prathap; Abraham, Ooriapadickal Cherian; Thomas, Kurien (14 June 2017). "Pre-admission antibiotics for suspected cases of meningococcal disease". The Cochrane Database of Systematic Reviews 2017 (6): CD005437. doi:10.1002/14651858.CD005437.pub4. ISSN 1469-493X. PMID 28613408.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6481530
  39. AFRICA: Climate change linked to spread of disease http://www.irinnews.org/Report.aspx?ReportId=77675
  40. Meningococcal meningitis https://www.who.int/mediacentre/factsheets/fs141/en/
  41. FASO: Meningitis kills more than 400 http://www.irinnews.org/Report.aspx?ReportId=49125BURKINA
  42. Enserink M (December 2008). "Meningitis. Less vaccine can be more". Science 322 (5907): 1449. doi:10.1126/science.322.5907.1449a. PMID 19056945.  https://dx.doi.org/10.1126%2Fscience.322.5907.1449a
  43. BURKINA FASO: 5 million at risk as meningitis death toll climbs http://www.irinnews.org/Report.aspx?ReportId=76537
  44. NIGER: Nearly 1,000 deaths from meningitis http://www.irinnews.org/Report.aspx?ReportId=15998
  45. Meningococcal Disease: Frequently Asked Questions https://www.cdc.gov/meningitis/bacterial/faqs.htm
  46. Thomas, Naomi (23 June 2022). "CDC investigates 'one of the worst outbreaks of meningococcal disease' in US history among gay and bisexual men in Florida". CNN. https://www.cnn.com/2022/06/22/health/florida-meningococcal-disease-outbreak/index.html. 
  47. Anthes, Emily (22 June 2022). "An Outbreak of Meningococcal Disease in Florida Is Growing, the C.D.C. Says". The New York Times. https://www.nytimes.com/2022/06/22/health/meningococcal-outbreak-florida.html. 
  48. Henry, Ronnie (July 2017). "Etymologia: Meningococcal Disease". Emerg Infect Dis 23 (7): 1187. doi:10.3201/eid2307.ET2307. "citing public domain text from the CDC".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5512471
More
©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.
Upload a video for this entry
Information
Subjects: Microbiology
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
HandWiki
View Times: 1.8K
Entry Collection: HandWiki
Revision: 1 time (View History)
Update Date: 10 Oct 2022
Table of Contents
    Notice
    You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
    OK
    Confirm
    Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
    Yes
    No
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    There is no comment~
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    ${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
    Submit
    Cancel
    Confirm
    Are you sure to Delete?
    Yes No
    Academic Video Service
    Feedback