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Topic Review
Profiles of Underutilized Grain Crops
Underutilized grain crops are an essential part of the food system that supports humankind, such as barley, buckwheat, broomcorn millet, foxtail millet, oat, and sorghum, which have characteristics such as containing more nutritional elements, being resistant to biotic and abiotic stresses, and having strong adaptability to poor environments.
  • 1.8K
  • 29 Sep 2022
Topic Review
Liquefied Dimethyl Ether Extraction Technology for Microalgae
Microalgae are a sustainable source for the production of biofuels and bioactive compounds. Dimethyl ether (DME), which is characterized by its low boiling point and safety as an organic solvent, exhibits remarkable properties that enable high extraction rates of various active compounds, including lipids and bioactive compounds, from high-water-content microalgae without the need for drying.
  • 1.8K
  • 30 Jan 2024
Topic Review Peer Reviewed
Underground Built Heritage
The Underground Built Heritage (UBH) class, introduced at a methodological and theoretical level in 2021, collects cultural assets excavated throughout history from underground that, today, are significant elements of local cultural heritage, having strongly impacted on the “sense of place” of local communities. Those cultural assets have been at the core of several national and international regeneration processes, and, recently, new tools have been developed to support their classification and sustainable reuses. This entry introduces tools for the classification of historical uses of UBH elements and their historical reuses, as well providing guidelines for their sustainable regeneration for the social and economic benefit of local populations based on the analysis of some worldwide case studies.
  • 1.8K
  • 04 Jul 2025
Topic Review
Plant-Derived Nutraceuticals
The term nutraceutical combines the words nutrition and pharmaceutical and indicates those nutrient principles that are found within foods. These have beneficial health effects. Nutraceutical substances derive mainly from plants, food, and microbial sources. 
  • 1.8K
  • 12 Oct 2022
Topic Review Peer Reviewed
Likert-Type Scale
The Likert-type scale is a widely used psychometric instrument for measuring attitudes, opinions, or perceptions in research contexts. It presents respondents with a series of statements accompanied by symmetrical response options, typically structured on a five-point scale ranging from “Strongly Disagree” to “Strongly Agree”. Each point on the scale represents a gradation of agreement or sentiment, allowing researchers to transform subjective responses into quantifiable data for statistical analysis and interpretation.
  • 1.8K
  • 13 Mar 2025
Topic Review
Hot Electrons in Plasmon-Sensitized TiO2
Hot carriers are electron-hole pairs formed by Landau damping or chemical interface damping of particle plasmons. The term “hot electrons” not only describes the individual electrons themselves, but also describes the Fermi–Dirac distribution of electrons in a solid albeit with an elevated effective temperature—the effective temperatures involved when considering the carrier kinetic energies and carrier densities in the solid, and not that of the solid itself- as opposed to thermal equilibrium. Typically, hot carriers lose their excess energy and relax to thermal equilibrium within a few picoseconds of formation due to a variety of scattering processes. Therefore, it is very difficult to extract useful work from hot carriers with thermodynamic efficiencies that are of interest for practical devices. However, heterojunctions of TiO2 with coinage metals have been consistently shown to be effective in utilizing hot carriers to perform useful work, such as driving a chemical reaction or generating an electric current. A secondary benefit of such TiO2-coinage metal heterojunctions is the "visible light sensitization" effect which allows broader harvesting of visible light. 
  • 1.8K
  • 24 May 2021
Topic Review
Phytochemicals mitigate AD mitochondrial dysfunctions
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a decline in cognitive function and neuronal damage. Although the precise pathobiology of AD remains elusive, accumulating evidence suggests that mitochondrial dysfunction is one of the underlying causes of AD. Mutations in mitochondrial or nuclear DNA that encode mitochondrial components may cause mitochondrial dysfunction. In particular, the dysfunction of electron transport chain complexes, along with the interactions of mitochondrial pathological proteins are associated with mitochondrial dysfunction in AD. Mitochondrial dysfunction causes an imbalance in the production of reactive oxygen species, leading to oxidative stress (OS) and vice versa. Neuroin-flammation is another potential contributory factor that induces mitochondrial dysfunction. Phy-tochemicals or other natural compounds have the potential to scavenge oxygen free radicals and enhance cellular antioxidant defense systems, thereby protecting against OS-mediated cellular damage. Phytochemicals can also modulate other cellular processes, including autophagy and mitochondrial biogenesis.
  • 1.8K
  • 25 Mar 2021
Topic Review
PCM-Enhanced Buildings
The incorporation of phase change materials (PCM) in buildings has the potential to enhance the thermal efficiency of buildings, reduce energy cost, shift peak load, and eventually reduce air pollution and mitigate global warming. However, the initial capital cost of PCM is still high, and thus the establishment of a control strategy has become essential to optimize its use in buildings in an effort to lower investment costs.
  • 1.8K
  • 23 Apr 2021
Topic Review
Secure Cloud Infrastructure Review
Cloud computing is currently becoming a well-known buzzword in which business titans, such as Microsoft, Amazon, and Google, among others, are at the forefront in developing and providing sophisticated cloud computing systems to their users in a cost-effective manner. Security is the biggest concern for cloud computing and is a major obstacle to users adopting cloud computing systems. Maintaining the security of cloud computing is important, especially for the infrastructure.
  • 1.8K
  • 13 Oct 2021
Topic Review
Fruit and Vegetable Wastes
Food waste (FW) is already acknowledged as a major global issue that threatens the long-term viability of the food supply chain.
  • 1.8K
  • 26 Oct 2021
Topic Review
Eurasian Development Bank
The Eurasian Development Bank (EDB) is a regional development bank established by the Russian Federation and the Republic of Kazakhstan in 2006. It has six member states located in both Asia and Europe, primarily in the former territory of the Soviet Union, including Armenia, Belarus , Kyrgyzstan, and Tajikistan. Other states and international organisations are able to become members by signing up to the bank's founding agreement.
  • 1.8K
  • 14 Oct 2022
Topic Review
Gomocup
Gomocup is a worldwide tournament of artificial intelligences (AI) playing Gomoku and Renju. The tournament has been played since 2000 and takes place every year. As of 2016, it is the most famous and largest Gomoku AI tournament in the world, with around 40 participants from about 10 countries.
  • 1.8K
  • 21 Oct 2022
Topic Review
Cold Plasma Technology in Food Packaging
Cold plasma (CP) is an effective strategy to alter the limitations of biopolymer materials for food packaging applications. Biopolymers such as polysaccharides and proteins are known to be sustainable materials with excellent film-forming properties.
  • 1.8K
  • 22 Dec 2022
Topic Review Peer Reviewed
The Social Aspect of Children and Adolescents with Chronic Respiratory Diseases
Chronic respiratory diseases (CRDs) are common among children and adolescents. Asthma and cystic fibrosis are two main conditions that affect this population. Young patients face physical limitations due to structural and functional abnormalities of the airways and other lung structures. Moreover, the route of everyday life is influenced by responsibilities derived from treatments, and exacerbations imposed by the disease impacting silently their social life. To date, discussions in the literature have mostly focused on the physical limitations that face children and adolescents. On the contrary, social aspects are less investigated, even their important role in rehabilitation patterns. On this basis, we provide an overview of the social determinants that affect children and adolescents with CRDs in different social environments, such as family and school; discuss coping strategies that can be developed to attenuate the impact of CRDs on youngsters’ lives; and present the role of healthcare professionals and digital technology in social support. 
  • 1.8K
  • 01 Jul 2025
Topic Review
Blockchain and the Physical Internet
Integrating triple bottom line (TBL) goals into supply chains (SCs) is a challenging task which necessitates the careful coordination of numerous stakeholders’ individual interests. Recent technological advancements can impact TBL sustainability by changing the design, structure and management of modern SCs. Blockchain technology enables immutable data records and facilitates a shared data view along the supply chain. The Physical Internet (PI) is an overarching framework that can be applied to create a layered and comprehensive view of the SC. In this conceptual paper I define and combine these technologies and derive several high-level research areas and research questions to investigate adoption, management as well as structural SC issues. I suggest a theory-based research agenda for the years to come that exploits the strengths of rigorous academic research, while remaining relevant for the industry. Furthermore, I suggest various well-established theories to tackle the respective research questions and provide specific directions for future research.
  • 1.8K
  • 30 Oct 2020
Topic Review
Osteoarthritis
Osteoarthritis (OA) is a most common type of arthritis occur in the aged population. It affects any joint in the body and degenerates the articular cartilage and subchondral bone. Despite the pathophysiology of OA is different, still cartilage resorption is a symbol of osteoarthritis. Matrix metalloproteinases (MMPs) are important proteolytic enzymes that degrade extra-cellular matrix proteins (ECM) in the body. MMPs contribute to the turnover of cartilage and its break down; their levels have increased in the joint tissues of OA patients. Application of chondroprotective drugs neutralize the activities of MMPs. Natural products derived from herbs and plants developed as traditional medicine have paid much attention due to their potential biological effects. Therapeutic value of natural products in OA has increased reputation by presenting clinical impact with insignificant side effects. Several MMPs inhibitor have been used as therapeutic drugs for long time. Recently, different types of compounds have been reviewed for their biological activities. In this review, we summarize numerous natural products for the development as MMPs inhibitors in arthritic diseases and describe the major signaling targets that involved for the treatments of these destructive joint diseases.
  • 1.8K
  • 05 Nov 2020
Topic Review
Lamin-A/C expression in immune cells
Nuclear envelope lamin A/C type-V intermediate filaments are a major constituent of the mammalian nuclear lamina, a dense fibrous protein meshwork located in the nuclear interior. Lamin A/C proteins control nuclear mechanics and structure and modify cellular signaling, gene transcription, epigenetic regulation, cell cycle progression, cell differentiation, and cell migration. The immune system is constituted by the innate and adaptive immunity. Innate immune response is mediated by myeloid cells such as neutrophils, macrophages, and dendritic cells. These cells produce a rapid and nonspecific response through phagocytosis, cytokine production, and complement activation, as well as activating adaptive immunity. Specific adaptive immune response is provoked by antigen presentation by antigen presenting cells (APCs) and the cytokine milieu, and is mainly mediated by the cellular functions of T cells and the production of antibodies by B cells. Unlike most cell types, immune cells regulate their lamin A/C protein expression relatively rapidly to exert their functions, with expression increasing in macrophages, reducing in neutrophils, and increasing transiently in T cells. In this article, it is discussed and summarized studies that have addressed the regulation of the expression of lamin A/C in cells of the innate and adaptive immune system.
  • 1.8K
  • 27 Oct 2020
Topic Review
Date Palm Fruit against Diabetes
 Diabetes is a chronic metabolic disorder triggered by disturbances in carbohydrate, protein, and lipid metabolisms, where either reduced secretion or sensitivity of insulin is observed coupled with poor glucose control. Date palm fruits are one of the fruits reported to have good potential in diabetes treatment due to its presence of polyphenols exerting strong antioxidant activities. Other possible mechanisms of action include the polyphenolic compounds, which can inhibit enzymes like α-amylase and α-glucosidase. Flavonoids in dates can stimulate β-cells by increasing the number of islets and β-cells, recovering endocrine pancreatic tissues, reducing β-cell apoptosis, activating insulin receptors following the increase in insulin secretion, in addition to improving diabetes-induced complications.
  • 1.8K
  • 31 May 2021
Topic Review
Key Management Interoperability Protocol (KMIP)
The Key Management Interoperability Protocol (KMIP) is an extensible communication protocol that defines message formats for the manipulation of cryptographic keys on a key management server. This facilitates data encryption by simplifying encryption key management. Keys may be created on a server and then retrieved, possibly wrapped by other keys. Both symmetric and asymmetric keys are supported, including the ability to sign certificates. KMIP also allows for clients to ask a server to encrypt or decrypt data, without needing direct access to the key. The KMIP standard was first released in 2010. Clients and servers are commercially available from multiple vendors. The KMIP standard effort is governed by the OASIS standards body. Technical details can also be found on the official KMIP page and wiki.
  • 1.8K
  • 18 Oct 2022
Topic Review
Geochemical Modeling
Geochemical modeling is the practice of using chemical thermodynamics, chemical kinetics, or both, to analyze the chemical reactions that affect geologic systems, commonly with the aid of a computer. It is used in high-temperature geochemistry to simulate reactions occurring deep in the Earth's interior, in magma, for instance, or to model low-temperature reactions in aqueous solutions near the Earth's surface, the subject of this article.
  • 1.8K
  • 26 Oct 2022
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