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Topic Review
Pre-Clinical Murine Models of Colitis
Crohn’s disease (CD) and ulcerative colitis (UC) are both highly inflammatory diseases of the gastrointestinal tract, collectively known as inflammatory bowel disease (IBD). Although the cause of IBD is still unclear, several experimental IBD murine models have enabled researchers to make great inroads into understanding human IBD pathology. Murine experimental models of human IBD exhibit immune pathological signatures resembling Crohn’s disease (CD) or ulcerative colitis (UC). These models include the chemical-induced trinitrobenzene sulfonic acid (TNBS) model, oxazolone and dextran sulfate sodium (DSS) models, the gene-deficient I-kappa-B kinase gamma (Iκκ-γ) and interleukin(IL)-10 models, and the CD4+ T-cell transfer model. Although most pre-clinical murine models do not fully recapitulate the complexity of human IBD, these models have added to our knowledge about the causes of disease and have provided targets for developing new treatments. 
  • 1.8K
  • 26 Sep 2022
Topic Review
Postinternet
Postinternet denotes an idea in arts and criticism that refers to society and modes of interaction following the widespread adoption of the internet. The term emerged from discussions about Internet Art by Marisa Olson, Gene McHugh, and Artie Vierkant. Guthrie Lonergan and Cory Arcangel have mentioned it as a term for being "internet aware", which some believe to be more accurate. Generally it is described as art that is about the internet's effects on aesthetics, culture and society. Critics of the term claim that it falsely implies that there is a kind of art made after the internet has ceased to exist (and artists such as Rafael Rozendaal have criticized the ambiguity of "post-" in this instance).
  • 1.8K
  • 04 Nov 2022
Topic Review
Beacons and BIM Models
This research work uses a simplified approach to combine location information from a beacon's propagation signal interaction with a mobile device sensor (accelerometer and gyroscope) with local building information to give real-time location and guidance to a user inside a building. This is an interactive process with visualisation information that can help user's orientation inside unknown buildings and the data stored from different users can provide useful information about users’ movements inside a public building. Beacons installed on the building at specific pre-defined positions emit signals that give a geographic position with an associated imprecision, related with Bluetooth’s range. This uncertainty is handled by building layout and users' movement in a developed system that maps users' position, gives guidance, and stores user movements. This system is based on an App (Find Me!) for Android OS (Operating System) which captures the Bluetooth Low Energy (BLE) signal coming from the beacon(s) and shows, through a map, the location of the user's smartphone and guide him to the desired destination. Also, the beacons can deliver relevant context information. The application was tested by a panel of new and habitual campus users against traditional wayfinding alternatives yielding navigation times about 30% smaller, respectively.
  • 1.8K
  • 04 Jun 2021
Topic Review
Oral Tissue Engineering and Regeneration
The reconstruction or repair of oral and maxillofacial functionalities and aesthetics is a priority for patients affected by tooth loss, congenital defects, trauma deformities, or various dental diseases. Therefore, in dental medicine, tissue reconstruction represents a major interest in oral and maxillofacial surgery, periodontics, orthodontics, endodontics, and even daily clinical practice. The current clinical approaches involve a vast array of techniques ranging from the traditional use of tissue grafts to the most innovative regenerative procedures, such as tissue engineering. In recent decades, a wide range of both artificial and natural biomaterials and scaffolds, genes, stem cells isolated from the mouth area (dental follicle, deciduous teeth, periodontal ligament, dental pulp, salivary glands, and adipose tissue), and various growth factors have been tested in tissue engineering approaches in dentistry, with many being proven successful. However, to fully eliminate the problems of traditional bone and tissue reconstruction in dentistry, continuous research is needed.
  • 1.8K
  • 04 Dec 2020
Topic Review
Perovskite Solar Cell
Organic-inorganic hybrid perovskite materials have attracted tremendous attention as a key material in various optoelectronic devices. Distinctive optoelectronic properties, such as a tunable energy band position, long carrier diffusion lengths, and high charge carrier mobility, have allowed rapid progress in various perovskite-based optoelectronic devices (solar cells, photodetectors, light emitting diodes (LEDs), and lasers). Interestingly, the developments of each field are based on different characteristics of perovskite materials which are suitable for their own applications. 
  • 1.8K
  • 20 Jan 2021
Topic Review
Hibernation
Torpor and hibernation are natural physiological processes. Torpor refers to a pe-riod of metabolic suppression with a duration from a few hours to several weeks. The state of torpor is probably older in evolutionary terms and was likely a survival strate-gy of protomammals. Hibernation is a more elaborate behavior, structured in many long bouts of torpor separated by brief interbouts of arousal.
  • 1.8K
  • 23 Feb 2021
Topic Review
Barriers to Sustainable Farming Practices
Research has a critical role in supporting the implementation of farming practices that are appropriate for meeting food and climate security for a growing global population. Notwithstanding progress towards more sustainable agricultural production, the rate of change varies across and within regions and is, overall, too slow. Understanding what is and is not working at the implementation level and, critically, providing justified explanations on outcomes, is an important contribution of the literature. It is suggested that a greater application of theory in adoption research could increase the contribution of the literature. 
  • 1.8K
  • 10 May 2021
Topic Review
Salts Hydrates and Composites
Salt hydrates are alloys of salts and water. Salt hydrates display high theoretical energy densities, which are promising materials in thermal energy storage (TES).
  • 1.8K
  • 25 Jan 2022
Topic Review
HER2-Positive Breast Cancer
Up to one-third of all breast cancers are classified as the aggressive HER2-positive subtype, which is associated with a higher risk of recurrence compared to HER2-negative breast cancers. The HER2 hyperactivity associated with this subtype drives tumor growth by up-regulation of mTOR pathways and metabolic adaptation. Combination therapies that simultaneously target HER2 and mTOR improve clinical outcomes compared with HER2 inhibition alone. Drugs that mimic glucose deprivation in HER2-positive breast cancer patients have not been evaluated; however, preclinical studies have shown that the growth of HER2-positive breast tumors is reduced in response to combining the glycolytic inhibitor 2-DG with mTOR inhibitors.
  • 1.8K
  • 02 Jul 2021
Topic Review
Bioisosteric Replacement in Anti-HIV Drug Design
Bioisosteric replacement is a powerful tool for modulating the drug-like properties, toxicity, and chemical space of experimental therapeutics. The use of bioisosteres and the introduction of structural changes to the lead compound allows the chemist to alter the compound’s size, shape, electronic distribution, polarizability, dipole, polarity, lipophilicity, and pKa, while still retaining potent target engagement.
  • 1.8K
  • 11 Mar 2022
Topic Review
Democracy 2.1
Janeček Method (D21) is an electoral system created by Czech mathematician Karel Janeček. Janeček Method (D21) is a modern voting and electoral method. Its main advantage is an effect of multiple votes which enables casting multiple plus votes, and in certain cases, also a minus vote. Multiple votes enable us to express a wider scope of preferences, thereby reflecting the complexities of social choice more accurately. The system was developed ostensibly in response to corruption within the Czech political system. Though it has not yet been used in any general elections, D21 has found use in several participatory budgeting programs conducted by cities and countries around the world, including the New York City. The game Prezident 21 was introduced in 2016 in order to help familiarize people with the D21 system.
  • 1.8K
  • 31 Oct 2022
Topic Review
Vehicle Tracking System
A vehicle tracking system combines the use of automatic vehicle location in individual vehicles with software that collects these fleet data for a comprehensive picture of vehicle locations. Modern vehicle tracking systems commonly use GPS or GLONASS technology for locating the vehicle, but other types of automatic vehicle location technology can also be used. Vehicle information can be viewed on electronic maps via the Internet or specialized software. Urban public transit authorities are an increasingly common user of vehicle tracking systems, particularly in large cities.
  • 1.8K
  • 04 Nov 2022
Topic Review
Dragon Boat
A dragon boat is a human-powered watercraft originating from the Pearl River Delta region of China 's southern Guangdong Province. These were made of teak, but in other parts of China, different kinds of wood are used. It is one of a family of traditional paddled long boats found throughout Asia, Africa, the Pacific islands, and Puerto Rico. The sport of dragon boat racing has its roots in an ancient folk ritual of contending villagers, which dates back 2000 years throughout southern China, and even further to the original games of Olympia in Ancient Greece . Both dragon boat racing and the ancient Olympiad included aspects of religious observances and community celebrations, along with competitions. Dragon boat racing has been a traditional Chinese paddled watercraft activity for over 2000 years and began as a modern international sport in Hong Kong in 1976. These boats are typically made of carbon fiber, fiberglass, and other lightweight materials. For competition events, dragon boats are generally rigged with decorative Chinese dragon heads and tails. At other times (such as during training), decorative regalia is usually removed, although the drum often remains aboard for drummers to practice. For races, there are 18-20 people in a standard boat, and 8-10 in a small boat, not including the steersperson (helm) and the drummer. In December 2007, the central government of the People's Republic of China added the Dragon Boat Festival, along with the Qingming and Mid-Autumn festivals, to the schedule of national holidays.
  • 1.8K
  • 05 Nov 2022
Topic Review
Icelandic Phallological Museum
The Icelandic Phallological Museum (Icelandic: Hið íslenzka reðasafn), located in Reykjavík, Iceland, houses the world's largest display of penises and penile parts. As of early 2020 the museum moved to a new location in Hafnartorg, three times the size of the previous one, and the collection holds well over 300 penises from more than 100 species of mammal. Also the museum holds 22 penises from creatures and peoples of Icelandic folklore. In July 2011, the museum obtained its first human penis, one of many promised by would-be donors. Its detachment from the donor's body did not go according to plan and it was reduced to a greyish-brown shriveled mass that was pickled in a jar of formalin. The museum continues to search for "a younger and a bigger and better one." Founded in 1997 by since-then retired teacher Sigurður Hjartarson and now run by his son Hjörtur Gísli Sigurðsson, the museum grew out of an interest in penises that began during Sigurður's childhood when he was given a cattle whip made from a bull's penis. He obtained the organs of Icelandic animals from sources around the country, with acquisitions ranging from the 170 cm (67 in) front tip of a blue whale penis to the 2 mm (0.08 in) baculum of a hamster, which can only be seen with a magnifying glass. The museum claims that its collection includes the penises of elves and trolls, though, as Icelandic folklore portrays such creatures as being invisible, they cannot be seen. The collection also features phallic art and crafts such as lampshades made from the scrotums of bulls. The museum has become a popular tourist attraction with thousands of visitors a year and has received international media attention, including a Canadian documentary film called The Final Member, which covers the museum's quest to obtain a human penis. According to its mission statement, the museum aims to enable "individuals to undertake serious study into the field of phallology in an organized, scientific fashion."
  • 1.8K
  • 22 Nov 2022
Topic Review
GeForce 400 Series
Serving as the introduction of Fermi, the GeForce 400 series is a series of graphics processing units developed by Nvidia. Its release was originally slated in November 2009; however, after delays, it was released on March 26, 2010 with availability following in April 2010.
  • 1.8K
  • 23 Nov 2022
Topic Review
Confederation (Poland)
A konfederacja (Polish: [kɔ̃fɛdɛˈrat͡sja] (listen), "confederation") was an ad hoc association formed by Polish-Lithuanian szlachta (nobility), clergy, cities, or military forces in the Polish-Lithuanian Commonwealth for the attainment of stated aims. A konfederacja often took the form of an armed rebellion aimed at redressing perceived abuses or trespasses of some (e.g. royal) authority. Such "confederations" acted in lieu of state authority or to force their demands upon that authority. They could be seen as a primary expression of direct democracy and right of revolution in the Commonwealth, and as a way for the nobles to act on their grievances and against the state's central authority.
  • 1.8K
  • 23 Nov 2022
Topic Review
Dietary Interventions in Attention Deficit Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders in childhood, affecting ~7% of children and adolescents. Specific dietary interventions have been proposed as coadjuvant treatments in this disorder. These include nutritional supplements with vitamins, minerals, and polyunsaturated fatty acids; microbiome-targeted interventions with pre-, pro-, and synbiotics; and specific diets such as restriction or elimination diets. Regarding nutritional supplements, only vitamin D and vitamin D + magnesium appear to improve ADHD symptoms when baseline levels of vitamin D are insufficient/deficient. As for biotics, evidence has only been found for Lactobacillus rhamnosus GG and for multi-species probiotic supplementation. Elimination diets have scarce evidence and lead to nutritional deficiencies, so caution is advised.
  • 1.8K
  • 30 Nov 2022
Topic Review
Blood–Brain Barrier for CNS Drug Delivery
Blood Brain Barrier is a diffusional interface between the brain tissue and the blood vasculature. 
  • 1.8K
  • 22 Feb 2023
Topic Review
Electrochemical Biosensors for Monitoring the Water Quality
Electrochemical biosensors are advantageous analytical devices or tools that convert a bio-signal by biorecognition elements into a significant electrical response. Biosensors have many advantages over the conventional lab-based method, including low costs, portability, fast response time, less usage of reagents, and the capability to continuous monitor the complex wastewater. Such sensors significantly benefit from sensing the minimum level in polluted water, such as wastewater.
  • 1.8K
  • 14 Jul 2023
Topic Review
The Industry 5.0
The Industry 5.0 emerges as a new paradigm for the industry by considering sustainability, human-centered approaches, organizational resilience, and interaction between humans and machines as its core values. This new trend for the future of the industry is referred to as neoindustrialization.
  • 1.8K
  • 11 Aug 2023
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