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Topic Review
Discovery and Development of Non-nucleoside Reverse-transcriptase Inhibitors
Non-nucleoside reverse-transcriptase inhibitors (NNRTIs) are antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV). NNRTIs inhibit reverse transcriptase (RT), an enzyme that controls the replication of the genetic material of HIV. RT is one of the most popular targets in the field of antiretroviral drug development. Discovery and development of NNRTIs began in the late 1980s and in the end of 2009 four NNRTI had been approved by regulatory authorities and several others were undergoing clinical development. Drug resistance develops quickly if NNRTIs are administered as monotherapy and therefore NNRTIs are always given as part of combination therapy, the highly active antiretroviral therapy (HAART).
  • 1.9K
  • 09 Nov 2022
Topic Review
Role of Langerhans Cells in Skin Inflammation
Langerhans cells (LCs) constitute a cellular immune network across the epidermis. Because they are located at the skin barrier, they are considered immune sentinels of the skin. These antigen-presenting cells are capable of migrating to skin draining lymph nodes to prime adaptive immune cells, namely T- and B-lymphocytes, which will ultimately lead to a broad range of immune responses.  LCs have been shown to possess important roles in the anti-cancer immune responses.
  • 1.9K
  • 26 Dec 2022
Topic Review
Artificial Intelligence in Agriculture: Benefits, Challenges, and Trends
The world’s population has reached 8 billion and is projected to reach 9.7 billion by 2050, increasing the demand for food production. Artificial intelligence (AI) technologies that optimize resources and increase productivity are vital in an environment that has tensions in the supply chain and increasingly frequent weather events. 
  • 1.9K
  • 05 Jul 2023
Topic Review
Potassium Channels in PAH
Pulmonary arterial hypertension (PAH) is a rare and severe cardiopulmonary disease without curative treatments. PAH is a multifactorial disease that involves genetic predisposition, epigenetic factors, and environmental factors (drugs, toxins, viruses, hypoxia, and inflammation), which contribute to the initiation or development of irreversible remodeling of the pulmonary vessels. The recent identification of loss-of-function mutations in KCNK3 (KCNK3 or TASK-1) and ABCC8 (SUR1), or gain-of-function mutations in ABCC9 (SUR2), as well as polymorphisms in KCNA5 (Kv1.5), which encode two potassium (K+) channels and two K+ channel regulatory subunits, has revived the interest of ion channels in PAH. This entry focuses on KCNK3, SUR1, SUR2, and Kv1.5 channels in pulmonary vasculature and discusses their pathophysiological contribution to and therapeutic potential in PAH.
  • 1.9K
  • 28 Sep 2020
Topic Review
Pepper vein banding virus (PVBV)
The entry talks about Pepper vein banding virus (PVBV) and its encoded proteins, particularly focusing on the polyprotein processing and its regulation. Moreover, PVBV as a nanoparticle and its potential applications in immunodiagnostics and therapeutics has also been discussed.
  • 1.9K
  • 20 Oct 2020
Topic Review
Light Quality Effects on Plants
Effect of light quality on indoor experiments, aiming to reach near to natural growth.
  • 1.9K
  • 26 Oct 2020
Topic Review
Cardiovascular Complications Associated with COVID-19
An infectious coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is accompanied with elevated risk and adverse outcome among infected patients, even sudden death due to significant multiple organ dysfunction, including dire cardiovascular complications. Myocardial impairment due to invasion of SARS-CoV-2 virus via angiotensin-converting enzyme 2 receptor to cardiovascular cells/tissue leads to endothelial inflammation and dysfunction, de-stabilization of vulnerable atherosclerotic plaques, stent thrombosis and cardiac stress, caused by diminished oxygen supply and cardiac muscle damage and myocardial infarction. A number of promising therapeutic approaches are currently under clinical trials to avoid a massive surge of COVID-19 patients with prevalence of adverse cardiac events.
  • 1.9K
  • 19 Apr 2021
Topic Review
Apoplast
The apoplast comprises the intercellular space, the cell walls, and the xylem. Important functions for the plant, such as nutrient and water transport, cellulose synthesis, and the synthesis of molecules involved in plant defense against both biotic and abiotic stresses, take place in it. The most important molecules are ROS, antioxidants, proteins, and hormones. Even though only a small quantity of ROS is localized within the apoplast, apoplastic ROS have an important role in plant development and plant responses to various stress conditions. In the apoplast, like in the intracellular cell compartments, a specific set of antioxidants can be found that can detoxify the different types of ROS produced in it. These scavenging ROS components confer stress tolerance and avoid cellular damage. Moreover, the production and accumulation of proteins and peptides in the apoplast take place in response to various stresses. Hormones are also present in the apoplast where they perform important functions. In addition, the apoplast is also the space where microbe-associated molecular Patterns (MAMPs) are secreted by pathogens. In summary, the diversity of molecules found in the apoplast highlights its importance in the survival of plant cells.
  • 1.9K
  • 03 Jun 2021
Topic Review
Group Algebra
In functional analysis and related areas of mathematics, group algebras are constructions that generalize the concept of group ring to some classes of topological groups with the aim to reduce the theory of representations of topological groups to the theory of representations of topological algebras. There are several nonequivalent definitions of group algebra, each of which is considered convenient in a particular situation.
  • 1.9K
  • 02 Nov 2022
Topic Review
Spirit (Animating Force)
In folk belief, spirit is the vital principle or animating force within all living things. As recently as 1628 and 1633 respectively, both William Harvey and René Descartes still speculated that somewhere within the body, in a special locality, there was a "vital spirit" or "vital force", which animated the whole bodily frame, just as the engine in a factory moves the machinery in it. People have frequently conceived of spirit as a supernatural being, or non-physical entity; for example, a demon, ghost, fairy, or angel. In ancient Islamic terminology however, the term spirit (rūḥ), applies only to "pure" spirits, but not to other invisible creatures, such as jinn, demons and angels. Historically, spirit has been used to refer to a "subtle" as opposed to "gross" material substance, as put forth in the notable last paragraph of Sir Isaac Newton's Principia Mathematica. In English Bibles, "the Spirit" (with a capital "S"), specifically denotes the Holy Spirit. The concepts of spirit and soul often overlap, and some systems propose that both survive bodily death. "Spirit" can have the sense of "ghost", i.e. a manifestation of the spirit of a deceased person. "Spirit" is also often used to refer to the consciousness or personality.
  • 1.9K
  • 10 Nov 2022
Topic Review
XCore Architecture
The XCore Architecture is a 32-bit RISC microprocessor architecture designed by XMOS. The architecture is designed to be used in multi-core processors for embedded systems. Each XCore executes up to eight concurrent threads, each thread having its own register set, and the architecture directly supports inter-thread and inter-core communication and various forms of thread scheduling. Two versions of the XCore architecture exist: the XS1 architecture and the XS2 architecture. Processors with the XS1 architecture include the XCore XS1-G4 and XCore XS1-L1. Processors with the XS2 architecture include xCORE-200. The architecture encodes instructions compactly, using 16 bits for frequently used instructions (with up to three operands) and 32 bits for less frequently used instructions (with up to 6 operands). Almost all instructions execute in a single cycle, and the architecture is event-driven in order to decouple the timings that a program needs to make from the execution speed of the program. A program will normally perform its computations and then wait for an event (e.g. a message, time, or external I/O event) before continuing.
  • 1.9K
  • 24 Nov 2022
Topic Review
Global Intellectual History
Global intellectual history is the history of thought in the world across the span of human history, often understood from the invention of writing to the present. The discipline is part of the field of intellectual history, also known as history of ideas, and can also be termed global history of ideas. In recent years, historians such as C. A. Bayly have been calling for a global intellectual history to be written. They stress that to understand the history of ideas across time and space, it is necessary to study from a cosmopolitan or global point of view the connections and the parallels in intellectual development across the world. Yet these separate histories and their convergence in the modern period have yet to be brought together into a single historical narrative. Nonetheless, some global histories, like Bayly's own Birth of the Modern World or David Armitage's The Declaration of Independence: A Global History offer contributions to the huge and necessarily collaborative project of writing the history of thought in a comparative and especially connective way. Other examples of transnational intellectual histories include Albert Hourani's Arabic Thought in the Liberal Age. In 2013, Samuel Moyn and Andrew Sartori published the anthology Global Intellectual History. In 2016, the Routledge journal Global Intellectual History (ed. Richard Whatmore) was established. In January 2019 the historian J. G. A. Pocock stated in that journal: "The beginnings of the ‘global’ critique are well known and may as well be accepted as common ground. They reduce to the assertion that ‘Cambridge’ scholarship in this field is ‘Eurocentric’; that is, that it has dealt exclusively with the ‘political thought’ generated in the Greco-Roman Mediterranean, transmitted to medieval and modern Europe, and taken up in the Euro-colonized Americas and a world (or ‘globe’) subjected to European or ‘western’ domination. This is obviously true, and calls for reformation." It has been argued that the historians of ideas Arthur O. Lovejoy and Hajime Nakamura should be read as modern founders of the discipline global intellectual history. Other recent contributors are Siep Stuurman, Sanjay Subrahamnyam, and Martin Mulsow. The origins of human intellectual history arguably began before the invention of writing, but historians are by definition only concerned with the eras in which writing was present. In the spirit of a historiographic project that is relevant to all human beings and that has yet to be completed, the sections that follow briefly review currents of thought in pre-modern and modern history of the world, and are organized by geographic area (and within each section, chronologically).
  • 1.9K
  • 25 Nov 2022
Topic Review
Agar-Agar in the Synthesis of Functional Film
The food industry produces an exorbitant amount of solid waste of petrochemical origin as a result of the increase in the development of new products. Natural polymers are an alternative to this theme; however, their development with adequate properties is a challenge. The union of different polymers in the synthesis of packaging is usually carried out to improve these properties. The combination of agar-agar and chitosan biopolymers show particular advantages through hydrogen bonds and electrostatic attraction between oppositely charged groups, presenting a promising source of studies for the synthesis of green packaging. When combined with natural extracts with active properties, these polymers allow an increase in the microbiological stability of foods associated with lower chemical preservative content and greater environmental sustainability.
  • 1.9K
  • 30 May 2023
Topic Review
Evaluation of Digital Applications
Digitalization is a transformation process which has already affected many parts of industry and society and is expected to yet increase its transformative speed and impact. In the energy sector, many digital applications have already been implemented. However, a more drastic change is expected during the next decades. Good understanding of which digital applications are possible and what are the associated benefits as well as risks from the different perspectives of the impacted stakeholders is of high importance. On the one hand, it is the basis for a broad societal and political discussion about general targets and guidelines of digitalization. On the other hand, it is an important piece of information for companies in order to develop and sustainably implement digital applications. This entry suggests a methodology to holistically analyze digital applications in the energy sector. The intended purpose of the suggested methodology is to provide a complexity-reduced fact base as input for societal and political discussions and for the development of new digital products, services, or business models. While the methodology is outlined in this entry, in a follow-up article the application of the methodology will be presented and the use of the approach reflected.
  • 1.9K
  • 05 Nov 2020
Topic Review
Adolescent Sleep Deprivation
At this stage of adolescence, several environmental and biological factors may affect both circadian and homeostatic regulation of sleep. A large part of this population does not experience adequate sleep, leading to chronic sleep restriction and/or disrupted sleep-wake cycles.
  • 1.9K
  • 01 Feb 2021
Topic Review
TILs in rabbit mammary carcinomas
Tumor infiltrating lymphocytes (TILs) are key components of the tumor microenvironment that mediate the anti-tumor immune response. In breast cancer of humans, TILs represent prognostic and predictive biomarkers. For their standardized evaluation in routinely (hematoxylin and eosin) stained tissue sections, international guidelines exist. Recently, TILs have also been analyzed in pet rabbit mammary carcinomas according to these international guidelines. Results of the study on rabbit mammary carcinomas showed a statistically significant association between higher TIL numbers in stromal TIL hotspot areas and microscopic parameters indicative of a better tumor differentiation, i.e. decreased mitotic count, lower histological tumor grade and higher percentage of calponin positive tumor cells. These findings suggest that in rabbit mammary carcinomas TIL hotspot areas may exert an influence on the biological behavior of these tumors. The present study contributes to comparative pathology. In addition, it provides the basis for further investigations into the impact of TILs on clinical parameters of pet rabbit mammary carcinomas.
  • 1.9K
  • 27 Oct 2020
Topic Review
Hybrid Protein–DNA Nanotechnology
Proteins and DNA exhibit key physical chemical properties that make them advantageous for building nanostructures with outstanding features. Both DNA and protein nanotechnology have growth notably and proved to be fertile disciplines. The combination of both types of nanotechnologies is helpful to overcome the individual weaknesses and limitations of each one, paving the way for the continuing diversification of structural nanotechnologies. Recent studies have implemented a synergistic combination of both biomolecules to assemble unique and sophisticate protein–DNA nanostructures. These hybrid nanostructures are highly programmable and display remarkable features that create new opportunities to build on the nanoscale.
  • 1.9K
  • 03 Jun 2021
Topic Review
Boron Chemicals
Boron-based bioactive compounds have provided amphiphilic properties to facilitate interaction with protein targets. Indeed, the spectrum of boron-based entities as drug candidates against many diseases has grown tremendously since the first clinically tested boron-based drug, Velcade. 
  • 1.9K
  • 27 Apr 2022
Topic Review
Excipients Used for Modified Nasal Drug Delivery
Intranasal absorption is a favored route because it avoids the gastrointestinal and hepatic metabolism, leading to an increase in drug bioavailability, and a reduction in the side effects and the required dose administered. The ongoing challenging task in the field of nasal drug delivery is the maintenance of an efficient concentration of the active substance in the target area for an adequate period of time. 
  • 1.9K
  • 27 Sep 2022
Topic Review
Passover (Christian Holiday)
Some Christians observe a form of the Jewish holiday of Passover. The practice is found among Assemblies of Yahweh, Messianic Jews, and some congregations of the Church of God (Seventh Day). It is often linked to the Christian holiday and festival of Easter. Often, only an abbreviated seder is celebrated to explain the meaning in a time-limited ceremony. The redemption from the bondage of sin through the sacrifice of Christ is celebrated, a parallel of the Jewish Passover's celebration of redemption from bondage in the land of Egypt. Christian Passover ceremonies are held on the evening corresponding to 14 Nisan (e.g. April 5, 2012) or 15 Nisan, depending whether the particular church uses a quartodeciman or quintodeciman application. In other cases, the holiday is observed according to the Jewish calendar on 15 Nisan, which is also used by Samaritans.
  • 1.9K
  • 16 Nov 2022
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