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Topic Review
Development of Fencing Blade Materials
Using two fencing swords manufactured in Europe and China, we investigated the typical materials used for fencing blades and compared the experimental results with the nominal compositions of a variety of steels. By combining the requirements for the safety of athletes, mechanical behaviors of different steels, and production costs for industry, there is possible directions for the heat treatments and processing methods that have the potential to enhance performance and overcome the limitations of previous materials. 
  • 1.9K
  • 17 Feb 2022
Topic Review
Green Entrepreneurship in the Agriculture Industry
Agriculture is one of those industries that is contributing significantly to environmental degradation. Globally, the agriculture industry causes soil erosion, pollutes lakes, rivers, sea, and ground water, pollutes the top layer of earth through the excess amount of chemical in the form of fertilizer, and causes the extinction of living species. Academic research suggests that one of the solutions to environmental degradation caused by the agriculture industry is promoting green agriculture enterprises and integrating agriculture with advanced sophisticated sustainable technology through green agriculture entrepreneurship. Green agriculture allows the achievement of established threshold sustainable criteria while advancing rural communities with regard to food, energy, and technological independence.
  • 1.9K
  • 06 Apr 2022
Topic Review
Repurposing Approved Drugs in Colon Cancer
Despite improvements in standardized screening methods and the development of promising therapies for colorectal cancer (CRC), survival rates are still low. Drug repurposing offers an affordable solution to achieve new indications for previously approved drugs that could play a protagonist or adjuvant role in the treatment of CRC. 
  • 1.9K
  • 18 May 2022
Topic Review
Interracial Adoption
Interracial adoption (also referred to as transracial adoption) refers to the act of placing a child of one racial or ethnic group with adoptive parents of another racial or ethnic group. Interracial adoption is not inherently the same as transcultural or international adoption. However, in some circumstances an adoption may be interracial, international, and transcultural at the same time (or some combination of two of those).
  • 1.9K
  • 29 Sep 2022
Topic Review
Brass Era Car
The Brass Era is an American term for the early period of automotive manufacturing, named for the prominent brass fittings used during this time for such things as lights and radiators. It is generally considered to encompass 1896 through 1915, a time when these vehicles were often referred to as horseless carriages. Elsewhere in the world this period would be considered by antique car enthusiasts to consist of the veteran (pre-1904), and Edwardian eras, although these terms are really not meaningful outside the former British Empire.
  • 1.9K
  • 25 Nov 2022
Biography
Horace Romano Harré
Horace Romano Harré (/ˈhæreɪ/;[1] 18 December 1927 – 17 October 2019),[2][3] known widely as Rom Harré, was a New Zealand-British philosopher and psychologist. Harré was born in Apiti, in northern Manawatu, near Palmerston North, New Zealand,[4] but held British citizenship.[5] He studied chemical engineering and later graduated with a BSc in mathematics (1948) and a Master's in Philo
  • 1.9K
  • 30 Nov 2022
Topic Review
Autophagy and Chronic Kidney Disease
Autophagy is a lysosomal protein degradation system that eliminates cytoplasmic components such as protein aggregates, damaged organelles, and even invading pathogens. Autophagy is an evolutionarily conserved homoeostatic strategy for cell survival in stressful conditions and has been linked to a variety of biological processes and disorders. It is vital for the homeostasis and survival of renal cells such as podocytes and tubular epithelial cells, as well as immune cells in the healthy kidney. Autophagy activation protects renal cells under stressed conditions, whereas autophagy deficiency increases the vulnerability of the kidney to injury, resulting in several aberrant processes that ultimately lead to renal failure.
  • 1.9K
  • 25 Apr 2023
Topic Review Peer Reviewed
Special Educational Needs Prevalence in Irish-Immersion Schools
For the purposes of this entry, special educational needs (SEN) refers to a condition where a student requires additional support to access education due to a disability, learning difficulty, or other developmental challenges. In this entry, an overview is provided of the prevalence of and categories of SEN in Irish-immersion primary and post-primary schools across the island of Ireland. This entry examines the prevalence and categories of SEN in Irish-immersion (IM) primary and post-primary schools across the island of Ireland. With immersion education playing a significant role in fostering bilingual proficiency, understanding SEN prevalence within these settings is critical for ensuring inclusive educational practices. The entry analyses trends over the past two decades in SEN prevalence, highlighting an increase in SEN identification, particularly in IM post-primary schools. It also explores regional disparities, comparing Gaeltacht and IM schools outside of the Gaeltacht, as well as differences between IM and English-medium education sectors. Factors such as socio-economic disadvantage, diagnostic advancements, and policy developments are considered when interpreting SEN trends. The findings contribute to the limited international research on SEN prevalence in immersion education and offer insights into recommendations in the areas of policy and practice to further support students with diverse learning needs in bilingual settings.
  • 1.9K
  • 03 Jul 2025
Topic Review
Insulin-Degrading Enzyme
Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed metalloprotease that degrades insulin and several other intermediate-size peptides. For many decades, IDE had been assumed to be involved primarily in hepatic insulin clearance, a key process that regulates availability of circulating insulin levels for peripheral tissues. Emerging evidence, however, suggests that IDE has several other important physiological functions relevant to glucose and insulin homeostasis, including the regulation of insulin secretion from pancreatic β-cells. Investigation of mice with tissue-specific genetic deletion of Ide in the liver and pancreatic β-cells (L-IDE-KO and B-IDE-KO mice, respectively) has revealed additional roles for IDE in the regulation of hepatic insulin action and sensitivity.
  • 1.9K
  • 21 Feb 2021
Topic Review
Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 in Medicine
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) belong to a group of gastrointestinal hormones called incretins. Insulin released from the beta cells of the islets of Langerhans after ingestion of food is the major regulator of GIP and GLP-1 secretion.
  • 1.9K
  • 25 Feb 2022
Topic Review
Anomaly
In quantum physics an anomaly or quantum anomaly is the failure of a symmetry of a theory's classical action to be a symmetry of any regularization of the full quantum theory. In classical physics, a classical anomaly is the failure of a symmetry to be restored in the limit in which the symmetry-breaking parameter goes to zero. Perhaps the first known anomaly was the dissipative anomaly in turbulence: time-reversibility remains broken (and energy dissipation rate finite) at the limit of vanishing viscosity. In quantum theory, the first anomaly discovered was the Adler–Bell–Jackiw anomaly, wherein the axial vector current is conserved as a classical symmetry of electrodynamics, but is broken by the quantized theory. The relationship of this anomaly to the Atiyah–Singer index theorem was one of the celebrated achievements of the theory. Technically, an anomalous symmetry in a quantum theory is a symmetry of the action, but not of the measure, and so not of the partition function as a whole.
  • 1.9K
  • 04 Nov 2022
Biography
Hans Joachim Schellnhuber
Hans Joachim "John" Schellnhuber (born 7 June 1950)[1][2] is a German atmospheric physicist, climatologist and founding director of the Potsdam Institute for Climate Impact Research (PIK) and former chair of the German Advisory Council on Global Change (WBGU).[3] Schellnhuber studied mathematics and physics, obtaining a doctorate in theoretical physics from the University of Regensburg in 198
  • 1.9K
  • 15 Nov 2022
Topic Review
Application of Unmanned Aerial Vehicles in Logistics
Unmanned Aerial Vehicles (UAVs)/drones are used in the logistics field because of their flexibility, low cost, environmental protection and energy-saving advantages, which can achieve both economic benefits and social benefits.
  • 1.9K
  • 24 Nov 2022
Topic Review
Path-Planning Approaches for Multiple Mobile Robots
Numerous path-planning studies have been conducted due to the challenges of obtaining optimal solutions. The multi-robot path-planning approaches have been classified as classical approaches, heuristic algorithms, bio-inspired techniques, and artificial intelligence approaches. Bio-inspired techniques are the most employed approaches, and artificial intelligence approaches have gained more attention. 
  • 1.9K
  • 15 Sep 2022
Topic Review
Membrane Lipid Switches
Peripheral membrane proteins are required for signal propagation upon ligand-induced receptor activation at the plasma membrane. The translocation of this amphitropic peripheral proteins from or to the plasma membrane enables signal cascade propagation into the cells. This translocation greatly depends on the membrane’s lipid composition and, consequently, regulation of the lipid bilayer emerges as a novel therapeutic strategy. Indeed, relevant changes in membrane lipids can induce massive translocation of peripheral signaling proteins from or to the plasma membrane, which controls how cells behave. We called these changes “lipid switches”, as they alter the cell’s status (e.g., proliferation, differentiation, death, etc.) in response to the modulation of membrane lipids. This discovery enables therapeutic interventions focused on modifying the bilayer’s lipids, an approach known as membrane-lipid therapy (MLT) or melitherapy.
  • 1.9K
  • 28 Oct 2020
Topic Review
Genetic Engineering of Actinomycetes
The first antibiotic-producing actinomycete (Streptomyces antibioticus) was described by Waksman and Woodruff in 1940. This discovery initiated the “actinomycetes era”, in which several species were identified and demonstrated to be a great source of bioactive compounds. However, the remarkable group of microorganisms and their potential for the production of bioactive agents were only partially exploited. This is caused by the fact that the growth of many actinomycetes cannot be reproduced on artificial media at laboratory conditions. In addition, sequencing, genome mining and bioactivity screening disclosed that numerous biosynthetic gene clusters (BGCs), encoded in actinomycetes genomes are not expressed and thus, the respective potential products remain uncharacterized. Therefore, a lot of effort was put into the development of technologies that facilitate the access to actinomycetes genomes and activation of their biosynthetic pathways. In this review  (Antibiotics 2020, 9(8), 494; https://doi.org/10.3390/antibiotics9080494), we mainly focus on molecular tools and methods for genetic engineering of actinomycetes that have emerged in the field in the past five years (2015–2020). In addition, we highlight examples of successful application of the recently developed technologies in genetic engineering of actinomycetes for activation and/or improvement of the biosynthesis of secondary metabolites.
  • 1.9K
  • 28 Dec 2020
Topic Review
Vision-Based Vibration Monitoring
Contactless structural monitoring has in recent years seen a growing number of applications in civil engineering. Indeed, the elimination of physical installations of sensors is very attractive, especially for structures that might not be easily or safely accessible, yet requiring the experimental evaluation of their conditions, for example following extreme events such as strong earthquakes, explosions, and floods. Among contactless technologies, vision-based monitoring is possibly the solution that has attracted most of the interest of civil engineers, given that the advantages of contactless monitoring can be potentially obtained thorough simple and low-cost consumer-grade instrumentations.
  • 1.9K
  • 07 Jan 2021
Topic Review
Fake News in Social Networking
Fake news is defined as news that is intentionally and demonstrably false, or as any information presented as news that is factually incorrect and designed to mislead the news consumer into believing it to be true.
  • 1.9K
  • 17 Feb 2021
Topic Review
Bioactive Ceramic Scaffolds
A wide variety of bioactive ceramic scaffolds, which encompass CaP, doped HA and CS, bioactive glasses and ceramics, and their respective composites, have been used as the constructs for replacing cancellous bone (restoration of the bone loss), shown in. Synthetic HA, which is similar to the CaP minerals within bones and teeth, is successfully applied as a bone implant with suitable mechanical strength and osteoconductivity. Bioactive scaffolds processed through PBSLP with the various modes of functionalization through the incorporation of drugs, stem cells, and growth factors facilitate bone regeneration and ameliorate critical-sized bone defects based on the fracture site length for personalized medicine. The keyhole pores, apart from the designed porosity from the CAD design, usually affect the mechanical strength of the scaffolds when fabricated through powder bed selective laser processing techniques.
  • 1.9K
  • 24 Sep 2021
Topic Review
Virtual Reality and Language Learning
Although VR technology can provide an ideal learning and application environment for learners’ language skill acquisition, the learning performance of different types of learners in virtual environments and differences in their knowledge transfer ability from the virtual to the real environment still need further discussion. In addition, the cognitive style and test environment have an impact on the effect of VR-based oral learning. 
  • 1.9K
  • 12 Nov 2021
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